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31. 发明申请

WO1992003990A1 STENTLESS HEART VALVE AND HOLDER 审中-公开
标题翻译：无缝心阀和支架
公开(公告)号：WO1992003990A1
公开(公告)日：1992-03-19
申请号：PCT/US1991006255
申请日：1991-08-29
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , QUINTERO, Lillian, J. , COSGROVE, Delos, M. , NGUYEN-THIEN-NHON, Diana
IPC分类号： A61F02/24
CPC分类号： A61F2/2427 , Y10S623/90
摘要： A stentless aortic heart valve (13) having a disposable holder (55) with removable handle (71) attached can be manually reversed by the physician during suturing to provide a relatively unobstructed view into the patient's aorta. A covering (32) applied to strategic regions on the exterior and interior of the device provides a firm ground for suturing the prosthetic heart valve into position, and for attaching the detachable holder (55).

32. 发明申请

WO1991019465A2 MITRAL HEART VALVE REPLACEMENTS 审中-公开
标题翻译： MITRAL心脏瓣膜置换
公开(公告)号：WO1991019465A2
公开(公告)日：1991-12-26
申请号：PCT/US1991003834
申请日：1991-06-04
申请人： FRATER, Robert, William, Mayo
IPC分类号： A61F02/24
摘要： A mitral heart valve replacement of essentially flexible bioincorporable material comprising a generally D-shaped (30) sewing ring having an opening (31), with at least one long straight side portion (32), an anterior cusp (33) hinged contiguously from that straight side portion (32) a posterior cusp (34) hinged contiguously from a shorter side portion (35) of the opening (31) opposite the anterior cusp (33), and two lateral cusps (36A & 36B) hinged contiguously one from each of the remaining side portions of the opening (31) extending between adjacent ends of the side portions (35) from which the anterior (33) and posterior cusps (34) are hinged, together with chordae of bioincorporable material extending from edge portions of the cusps for connection to the papillary muscles in the cavity of the ventricle when the sewing ring is sutured to the atrio-ventricular junction of the host or patient heart.

33. 发明申请

WO1991007148A1 HEART VALVE PROSTHESIS 审中-公开
标题翻译：心脏瓣膜预防
公开(公告)号：WO1991007148A1
公开(公告)日：1991-05-30
申请号：PCT/DK1990000287
申请日：1990-11-08
申请人： HASENKAM, John, Michael , NYGAARD, Hans
IPC分类号： A61F02/24
CPC分类号： A61F2/2403
摘要： A heart valve prosthesis (2) of mechanical type and comprising an annular housing (13) wherein the three valves (14) are pivotally mounted about each their respective axes (15) for a symmetrical and synchronous oscillation between an open position (14'') and a closed position (14') is made in such a way that the axes (15) divide each valve (14) into a peripheral part (20) and a central part (21). The axes (15) divide the valves (14) in such a way that the peripheral parts (20) in combination cover an area of the passage (17) of the valve prosthesis (2) which is greater than the area covered by the central parts (21) of the valves (14). Hereby a large central flow is obtained through the central part of the passage (17) together with a large peripheral flow through the peripheral parts of the passage (17). This causes small gradients of velocity to appear when the blood flows through the heart valve prosthesis (2) thereby reducing the risk of thrombi and hemolysis formation.
摘要翻译： 1.一种机械式心脏瓣膜假体（2），包括环形壳体（13），其中所述三个阀（14）围绕它们各自的轴线（15）枢转地安装，以在打开位置（14“ ）和闭合位置（14'）以使得轴（15）将每个阀（14）分成周边部分（20）和中心部分（21）的方式制成。轴（15）以这样的方式分隔阀（14），使得周边部分（20）组合地覆盖瓣膜假体（2）的通道（17）的大于由中心覆盖的区域阀门（14）的部分（21）。因此，通过通道（17）的中心部分和通过通道（17）的周边部分的大的周边流动获得大的中心流。这导致当血液流过心脏瓣膜假体（2）时出现小的速度梯度，从而降低血栓和溶血形成的风险。

34. 发明申请

WO1991002500A1 HEART VALVE PROSTHESIS 审中-公开
标题翻译：心脏瓣膜预防
公开(公告)号：WO1991002500A1
公开(公告)日：1991-03-07
申请号：PCT/SU1989000217
申请日：1989-08-18
申请人： EVDOKIMOV, Sergei Vasilievich , MELNIKOV, Alexandr Petrovich , KARTOSHKIN, Vyacheslav Mikhailovich , GORSHKOV, Jury Vladimirovich , PERIMOV, Jury Alexandrovich , POPOV, Leonid Leonidovich , UDALTSOV, Vladimir Fedorovich , SMYSHLYAEV, Leonid Ivanovich , KONSTANTINOV, Boris Alexeevich
IPC分类号： A61F02/24
CPC分类号： A61F2/2409 , A61F2/2406
摘要： A heart valve prosthesis has an annular frame (9) in which is mounted a disk-shaped closing element (10) with an excentrical axis (O-O') of rotation from the closed position to the open one and backward effected by means of a rotation means (11). The latter comprises two support pins (15) provided with cam surfaces (16) intended for rotation of the closing element (10) from its open position to the closed one, and a supporting part (21) which interacts with the closing element (10) in its closed position and is connnected to the frame (1) by means of crosspieces (25). Each of the crosspieces (25) has another supporting part (26) interacting with the closing element (10) in its closed position. The vectors (R21, R26) of reaction forces arising on the supporting parts (21 and 26) are of the same direction which is opposite to the vector of the blood flow head resultant force (F14) applied at the mass centre (23). The fulcrum of the reaction forces (R21 and R26) is situated in one and the same plane and counterbalances the flow head resultant force (F14).
摘要翻译：心脏瓣膜假体具有环形框架（9），其中安装有从闭合位置到打开位置的旋转的外侧轴线（O-O'）的盘形闭合元件（10），并且通过旋转装置（11）。后者包括设置有用于使闭合元件（10）从其打开位置旋转到闭合元件的凸轮表面（16）的两个支撑销（15），以及与闭合元件（10）相互作用的支撑部分（21））处于其关闭位置，并且通过横档（25）连接到框架（1）。每个挡条（25）具有在闭合位置与关闭元件（10）相互作用的另一个支撑部分（26）。在支撑部件（21和26）上产生的反作用力的矢量（R21，R26）与在质心中心（23）施加的血流头合力（F14）的矢量相反方向。反作用力（R21和R26）的支点位于同一平面上，并平衡流动头合力（F14）。

35. 发明申请

WO1989004154A1 ARTIFICIAL CARDIAC VALVE 审中-公开
标题翻译：人工心脏瓣膜
公开(公告)号：WO1989004154A1
公开(公告)日：1989-05-18
申请号：PCT/FR1988000558
申请日：1988-11-14
申请人： E.R.A.C.C. ETUDES, RECHERCHES ET APPLICATIONS EN ... , COUETIL, Jean-Paul
发明人： E.R.A.C.C. ETUDES, RECHERCHES ET APPLICATIONS EN ...
IPC分类号： A61F02/24
CPC分类号： A61F2/2409 , A61F2/2406
摘要： An artificial cardiac valve made of biocompatible material comprises an annular element (1) and a flap (2) pivotally lodged inside said element (1) and possessing linking elements for cooperating with guiding and restraining means provided on the internal side wall (4) of the annular element (1). The flap (2) consists of a disc folded along an axis XX' parallel to one of its diameters through an angle alpha between 0 and 30 DEG in such a way that the opening of the valve is effectued in two consecutive phases. The first phase corresponds to a rotation of the flap (2) about the contact and hinging point A between the rear part (3) of the flap (2) and the lower edge of the side wall of said element until said linking elements abut against the guiding and restraining means. The second phase corresponds to a rotation about an axis ZZ' parallel to the axis XX' until the rear part (3) of the flap (2) is parallel to the axis YY' of the element (1).
摘要翻译：由生物相容材料制成的人造心脏瓣膜包括环形元件（1）和枢转地装在所述元件（1）内的翼片（2），并且具有连接元件，用于与设置在内侧壁（4）上的引导和限制装置配合环形元件（1）。翼片（2）由沿着与其直径之一平行的轴线XX'折叠的圆盘组成，角度α在0和30度之间，使得阀门的开口在两个连续的阶段中起作用。第一阶段对应于翼片（2）围绕翼片（2）的后部（3）与所述元件的侧壁的下边缘之间的接触和铰接点A的旋转，直到所述连接元件抵靠指导和约束手段。第二相对应于平行于轴线XX'的轴线ZZ'的旋转，直到翼片（2）的后部（3）平行于元件（1）的轴线YY'为止。

36. 发明申请

WO1989000033A1 HEART VALVE WITH DISC OCCLUDER 审中-公开
标题翻译：带有碟片的心瓣膜
公开(公告)号：WO1989000033A1
公开(公告)日：1989-01-12
申请号：PCT/US1988001971
申请日：1988-06-15
申请人： PACIFIC BIOMEDICAL HOLDINGS, LTD. , MARTIN, Richard, L.
发明人： PACIFIC BIOMEDICAL HOLDINGS, LTD.
IPC分类号： A61F02/24
CPC分类号： A61F2/2406
摘要： A heart valve prosthesis (10) which is suited for replacement of the aortic valve or mitral heart valve or any of the four valves in the heart. The invention includes a ring body portion (30) having a fluid flow bore (32) with an elliptical inner wall through which blood flows controlled by a disc occluder (44) supported between proximal and distal support struts (50, 52) having their ends attached to the metallic ring and coinciding with the curvature of the disc. The disc has a thickened outer edge (42) so that the disc allows blood flow through the opening in the ring by rotation and translation of the disc occluder, from a closed position in sealing engagement (35) around the ring body, to an open position wherein the thickened edge of the disc occluder (44) serves as a travel stop for translational movement of the occluder during operation.

37. 发明申请

WO1998018411A1 MITRAL VALVE RECONSTRUCTION RING 审中-公开
标题翻译： MITRALKLAPPENREKONSTRUKTIONSRING
公开(公告)号：WO1998018411A1
公开(公告)日：1998-05-07
申请号：PCT/DE1997002501
申请日：1997-10-24
申请人： MAHMOODI, Mehrdad
IPC分类号： A61F02/24
CPC分类号： A61F2/2454 , A61F2/2445
摘要： A mitral valve reconstruction ring consisting of two curved hoops (10, 12) and two connecting struts (14, 16). The struts (14, 16) are made out of a material which enables them to be bent at right angles, thereby reducing their length.
摘要翻译：由两个弧形托架（10，12）和两个撑杆这些互连的Mitralklappenrekonstruktionsring（14，16），所述支柱（14，16）由它是支柱（14,16）实现压接的缩短的材料允许。

38. 发明申请

WO1998006357A1 MECHANICAL PROSTHETIC VALVE, AND METHODS OF ITS CONSTRUCTION AND OPERATION 审中-公开
标题翻译：机械式前置阀及其构造和运行方法
公开(公告)号：WO1998006357A1
公开(公告)日：1998-02-19
申请号：PCT/US1997012909
申请日：1997-07-23
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , CARPENTIER, Alain , GUO, George, X. , SCHRECK, Stefan, G.
IPC分类号： A61F02/24
CPC分类号： A61F2/2403
摘要： A prosthetic mechanical valve includes a base portion defining a through blood flow pathway closed by at least a pair of valve leaflets. The valve leaflets are pivotally carried by the base portion and movable in response to dynamic blood fluid pressures between a first position at which the leaflets close blood flow through the pathway and a second open position allowing blood flow in the pathway. A pair of confronting magnets are carried one to each of the pair of valve leaflets and attract one another. The magnetic forces of attraction between the pair of magnets impart a biasing torque to the valve leaflets which tends to synchronize pivotal movements of the leaflets, cushions their sealing contact, quiets valve operation, and biases the leaflets toward a third partially open position. As a result, under conditions of nearly balanced blood fluid pressures across the pair of valve leaflets they anticipatorily open toward their third position to improve pumping effectiveness. Also, at about the end of a blood pumping stroke, the valve leaflets anticipatorily close from their fully open position toward the third position to reduce regurgitation flow and quiet the valve.
摘要翻译：假体机械阀包括基部，其限定通过至少一对瓣膜小叶封闭的通过血流通道。所述瓣叶由所述基部枢转地支承并响应于第一位置和第二打开位置之间的动态血液流体压力移动，所述第一位置在所述第一位置与所述通道之间血液流动的第二打开位置。一对面对的磁体被一对携带在一对瓣叶中并相互吸引。一对磁体之间的吸引磁力对阀门小叶施加偏置力矩，从而使叶片的枢轴运动趋于同步，缓冲它们的密封接触，阀门操作，并将传单偏向第三部分打开位置。因此，在一对瓣膜单张的血液流体压力几乎平衡的条件下，他们预期朝着第三个位置开放，以提高泵送效率。此外，在血液抽吸冲程结束时，瓣膜小叶预期从其完全打开位置朝向第三位置关闭，以减少反流并使瓣膜静止。

39. 发明申请

WO1997046177A1 EXPANSIBLE BIOPROSTHETIC VALVE STENT 审中-公开
标题翻译：可膨胀生物阀门
公开(公告)号：WO1997046177A1
公开(公告)日：1997-12-11
申请号：PCT/CA1997000374
申请日：1997-05-30
申请人： THE UNIVERSITY OF WESTERN ONTARIO , WAN, Wan-Kei , DUNCAN, Anthony , CAMPBELL, Gordon , BOUGHNER, Derek
发明人： THE UNIVERSITY OF WESTERN ONTARIO
IPC分类号： A61F02/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2415 , A61L27/52 , A61L31/145
摘要： A bioprosthetic valve stent fabricated from a hydrogel, wherein the hydrogel, when hydrated, has (a) a strain value at ultimate tensile stress (UTS) greater than the maximum strain occurring in a human aortic root under physiological conditions; (b) an elastic modulus similar to that of the aortic root; and (c) a relaxation rate similar to that of the aortic root.
摘要翻译：一种由水凝胶制造的生物假体瓣膜支架，其中当水合时，水凝胶具有（a）在极大拉伸应力（UTS）下的应变值大于在生理条件下在人主动脉根部中发生的最大应变; （b）类似于主动脉根的弹性模量; 和（c）类似于主动脉根的松弛率。

40. 发明申请

WO1997024082A1 HEART VALVE REPLACEMENT USING FLEXIBLE TUBES 审中-公开
标题翻译：使用柔性管更换心脏瓣膜
公开(公告)号：WO1997024082A1
公开(公告)日：1997-07-10
申请号：PCT/US1995016872
申请日：1995-12-28
申请人： COX, James, L.
IPC分类号： A61F02/24
CPC分类号： A61F2/0095 , A61F2/2412 , A61L27/3604 , A61L27/3629 , A61L27/3645 , A61L27/3683 , A61L27/507 , A61L2430/20
摘要： This invention comprises a method of using tubular material (200) to replace a heart valve (118, 120, 162) during cardiac surgery. To create a replacement atrioventricular (mitral or tricuspid) valve (120, 160), the tube inlet is sutured to a valve annulus (121, 162) from which the native leaflets have been removed, and the tube outlet is sutured to papillary muscles (126, 128, 170) in the ventricle (112, 152). To create a semilunar (aortic or pulmonary) valve (118), the tube inlet is sutured to an annulus from which the native cusps have been removed, and the tube is either "tacked" at three points distally inside the artery, or sutured longitudinally along three lines; this allows the flaps of tissue between the three fixation points at the valve outlet to function as movable cusps. These approaches generate flow patterns that closely duplicate the flow patterns of native valves. A preferred tubular material (200) comprises submucosal tissue from the small intestine; this can be taken from the same patient who is undergoing the cardiac operation, to reduce antigenicity. Animal or cadaver intestinal tissue can also be used if properly treated, or a biocompatible synthetic tubular material can be used. This invention also discloses a properly treated intestinal tissue segment or synthetic tubular segment (500) suitable for implantation as a replacement heart valve, enclosed in a sealed sterile package (510).
摘要翻译：本发明包括在心脏手术期间使用管状材料（200）来替换心脏瓣膜（118,120,162）的方法。为了创建替换房室（二尖瓣或三尖瓣）阀（120,160），将管入口缝合到已经被去除天然小叶的瓣膜环（121,162），并将管出口缝合到乳头肌（（112,152）中。为了创建一个半月（主动脉或肺动脉）阀门（118），将管道入口缝合到已经被去除天然尖头的环形区域，并且将管子在动脉内部的远端的三个点处“粘住”，或纵向缝合沿三条线这允许在阀出口处的三个固定点之间的组织瓣可用作可移动的尖头。这些方法产生与本机阀的流动模式密切相反的流动模式。优选的管状材料（200）包括来自小肠的粘膜下组织; 这可以从正在进行心脏手术的同一患者中获取，以降低抗原性。动物或尸体肠组织也可以使用，如果适当处理，或生物相容的合成管状材料可以使用。本发明还公开了一种适当处理的肠组织段或合适的管状段（500），其适于作为置换心脏瓣膜植入，封闭在密封的无菌包装（510）中。

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