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1. 发明申请

WO1998006357A1 MECHANICAL PROSTHETIC VALVE, AND METHODS OF ITS CONSTRUCTION AND OPERATION 审中-公开
标题翻译：机械式前置阀及其构造和运行方法
公开(公告)号：WO1998006357A1
公开(公告)日：1998-02-19
申请号：PCT/US1997012909
申请日：1997-07-23
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , CARPENTIER, Alain , GUO, George, X. , SCHRECK, Stefan, G.
IPC分类号： A61F02/24
CPC分类号： A61F2/2403
摘要： A prosthetic mechanical valve includes a base portion defining a through blood flow pathway closed by at least a pair of valve leaflets. The valve leaflets are pivotally carried by the base portion and movable in response to dynamic blood fluid pressures between a first position at which the leaflets close blood flow through the pathway and a second open position allowing blood flow in the pathway. A pair of confronting magnets are carried one to each of the pair of valve leaflets and attract one another. The magnetic forces of attraction between the pair of magnets impart a biasing torque to the valve leaflets which tends to synchronize pivotal movements of the leaflets, cushions their sealing contact, quiets valve operation, and biases the leaflets toward a third partially open position. As a result, under conditions of nearly balanced blood fluid pressures across the pair of valve leaflets they anticipatorily open toward their third position to improve pumping effectiveness. Also, at about the end of a blood pumping stroke, the valve leaflets anticipatorily close from their fully open position toward the third position to reduce regurgitation flow and quiet the valve.
摘要翻译：假体机械阀包括基部，其限定通过至少一对瓣膜小叶封闭的通过血流通道。所述瓣叶由所述基部枢转地支承并响应于第一位置和第二打开位置之间的动态血液流体压力移动，所述第一位置在所述第一位置与所述通道之间血液流动的第二打开位置。一对面对的磁体被一对携带在一对瓣叶中并相互吸引。一对磁体之间的吸引磁力对阀门小叶施加偏置力矩，从而使叶片的枢轴运动趋于同步，缓冲它们的密封接触，阀门操作，并将传单偏向第三部分打开位置。因此，在一对瓣膜单张的血液流体压力几乎平衡的条件下，他们预期朝着第三个位置开放，以提高泵送效率。此外，在血液抽吸冲程结束时，瓣膜小叶预期从其完全打开位置朝向第三位置关闭，以减少反流并使瓣膜静止。

2. 发明公开

EP0988069A1 TREATING BIOLOGICAL TISSUE TO MITIGATE CALCIFICATION 失效
标题翻译：生物组织用于减少钙化治疗
公开(公告)号：EP0988069A1
公开(公告)日：2000-03-29
申请号：EP98923456.2
申请日：1998-05-18
申请人： BAXTER INTERNATIONAL INC.
发明人： CARPENTIER, Sophie , CARPENTIER, Alain, F. , QUINTERO, Lillian, J. , PACKHAM, Victor, S. , WANG, Jong, H. , SCHRECK, Stefan, G.
IPC分类号： A61L27/00
CPC分类号： A61L27/3691 , A61L27/3625 , A61L27/3683 , A61L27/3687 , A61L2400/02 , Y10S623/915
摘要： A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with a treatment solution, inducing relative tissue/solution movement, and heating the solution. The relative movement may be induced by shaking a container in which the tissue is immersed in the treatment solution, or by stirring the solution within the container. The movement may also be induced by flowing a treatment solution past the tissue to be treated. The tissue may be free to move in the treatment container, or may be restrained from gross movements. The flow may be part of a circulation system having a reservoir, with a heater being provided to heat the treatment solution in the reservoir. Alternatively, a treatment apparatus, including a fluid circulation system if desired, may be enclosed in an incubator. The tissue may be mounted in a planar configuration generally parallel to the direction of fluid flow. A flow column having a plurality of sections divided by perforated baffles may be used to treat multiple tissues at once.

3. 发明公开

EP0923353A1 MECHANICAL PROSTHETIC VALVE, AND METHODS OF ITS CONSTRUCTION AND OPERATION 失效
标题翻译：带磁铁心脏机械瓣膜
公开(公告)号：EP0923353A1
公开(公告)日：1999-06-23
申请号：EP97934267.0
申请日：1997-07-23
申请人： BAXTER INTERNATIONAL INC.
发明人： CARPENTIER, Alain , GUO, George, X. , SCHRECK, Stefan, G.
IPC分类号： A61M1 , A61F2
CPC分类号： A61F2/2403
摘要： A prosthetic mechanical valve includes a base portion defining a through blood flow pathway closed by at least a pair of valve leaflets. The valve leaflets are pivotally carried by the base portion and movable in response to dynamic blood fluid pressures between a first position at which the leaflets close blood flow through the pathway and a second open position allowing blood flow in the pathway. A pair of confronting magnets are carried one to each of the pair of valve leaflets and attract one another. The magnetic forces of attraction between the pair of magnets impart a biasing torque to the valve leaflets which tends to synchronize pivotal movements of the leaflets, cushions their sealing contact, quiets valve operation, and biases the leaflets toward a third partially open position. As a result, under conditions of nearly balanced blood fluid pressures across the pair of valve leaflets they anticipatorily open toward their third position to improve pumping effectiveness. Also, at about the end of a blood pumping stroke, the valve leaflets anticipatorily close from their fully open position toward the third position to reduce regurgitation flow and quiet the valve.

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