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31. 发明授权

US08961789B2 Systems and methods for performing hemodialysis 有权
标题翻译：用于进行血液透析的系统和方法
公开(公告)号：US08961789B2
公开(公告)日：2015-02-24
申请号：US12338052
申请日：2008-12-18
申请人： Randolph H. Watkins , Steven J. Wurgler , Shincy Maliekkal , Sujatha Karoor , Katrina Smith
发明人： Randolph H. Watkins , Steven J. Wurgler , Shincy Maliekkal , Sujatha Karoor , Katrina Smith
IPC分类号： B01D63/00 , C02F1/44 , A61M1/34 , B01D63/16 , B01D65/08 , A61M1/26
CPC分类号： A61M1/1623 , A61M1/26 , A61M1/265 , A61M1/3472 , A61M1/3479 , B01D63/16 , B01D65/08 , B01D2315/02 , B01D2321/2033
摘要： Systems and methods for performing hemodialysis to remove metabolic waste from the blood of a patient are disclosed. The systems and methods preferably comprise at least one blood processing apparatus that receives whole blood from a patient. Cellular blood components are removed from the whole blood by hemofiltration, to provide filtered plasma comprising metabolic waste that is substantially reduced of blood cells. The cellular blood components may be returned to the patient. The filtered plasma comprising waste may be removed from the blood processing apparatus through a waste path for further processing in a separate apparatus, or in the same apparatus in a second stage processing procedure to remove metabolic waste components and excess water from the plasma by hemodialysis. At least one of the hemofiltration and hemodialysis processing apparatus comprises a Taylor vortex-enhanced separation apparatus.
摘要翻译：公开了用于进行血液透析以从患者的血液中除去代谢废物的系统和方法。该系统和方法优选地包括从患者接收全血的至少一个血液处理装置。通过血液滤过从全血中除去细胞血液成分，以提供包含基本上减少血细胞的代谢废物的过滤血浆。细胞血液成分可以返回给患者。包含废物的过滤等离子体可以通过废物路径从血液处理设备中除去，以便在单独的设备中进行进一步处理，或者在第二阶段处理过程中的相同装置中，通过血液透析从血浆中除去代谢废物成分和过量的水。血液透析和血液透析处理装置中的至少一个包括泰勒涡旋增强分离装置。

32. 发明授权

US08734382B2 Intracorporeal gas exchange devices, systems and methods 有权
标题翻译：体内气体交换装置，系统和方法
公开(公告)号：US08734382B2
公开(公告)日：2014-05-27
申请号：US12865958
申请日：2009-02-06
申请人： Brian J. Frankowski , William J. Federspiel , Kevin M. Mihelc , Samuel C. Lieber
发明人： Brian J. Frankowski , William J. Federspiel , Kevin M. Mihelc , Samuel C. Lieber
IPC分类号： A61M37/00 , A61M1/00
CPC分类号： A61M37/00 , A61M1/1678 , A61M1/26 , A61M1/262 , A61M5/14 , A61M2005/006 , A61M2005/1403 , A61M2025/0031 , A61M2025/0057 , B01D63/02 , B01D2313/025 , B01D2313/105 , B01D2313/125 , B01D2313/20
摘要： A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adapted to permit diffusion of a gas between an intracorporeal fluid and an interior of the hollow fibers. The plurality of hollow fibers is positioned radially outward from the agitation mechanisms. A blood contacting medical system includes at least one seal, and a purge system via which a flushing fluid is introduced under pressure over a blood-side face of the at least one seal and caused to flow through a space on the blood-side face of the at least one seal. The system can further include a rotatable member. The space on the blood-side face of the at least one seal can be in fluid connection with an annular space adjacent to a rotating element operatively connected to the rotatable member.
摘要翻译：用于体内气体交换的系统包括柔性可旋转的轴; 多个轴向间隔开的搅拌机构，其位于可旋转的轴上，使得可旋转的轴可在轴向间隔开的搅拌机构之间弯曲; 多个中空透气纤维，其适于允许气体在体内流体和中空纤维的内部之间扩散。多个中空纤维从搅拌机构径向向外定位。血液接触医疗系统包括至少一个密封件和净化系统，通过该清洗系统，冲洗流体在压力下被引导到至少一个密封件的血液侧面上并且流过血液侧面上的空间所述至少一个密封件。该系统还可包括可旋转构件。所述至少一个密封件的血液侧面上的空间可以与与可旋转构件可操作地连接的旋转元件相邻的环形空间流体连接。

33. 发明申请

US20100331767A1 INTRACORPOREAL GAS EXCHANGE DEVICES, SYSTEMS AND METHODS 有权
标题翻译：内部气体交换装置，系统和方法
公开(公告)号：US20100331767A1
公开(公告)日：2010-12-30
申请号：US12865958
申请日：2009-02-06
申请人： Brian J. Frankowski , William J. Federspiel , Kevin M. Mihelc , Samuel C. Lieber
发明人： Brian J. Frankowski , William J. Federspiel , Kevin M. Mihelc , Samuel C. Lieber
IPC分类号： A61M37/00
CPC分类号： A61M37/00 , A61M1/1678 , A61M1/26 , A61M1/262 , A61M5/14 , A61M2005/006 , A61M2005/1403 , A61M2025/0031 , A61M2025/0057 , B01D63/02 , B01D2313/025 , B01D2313/105 , B01D2313/125 , B01D2313/20
摘要： A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between intracorporeal fluid and an interior of the hollow fibers. The plurality of hollow fibers is positioned radially outward from the agitation mechanisms. A blood contacting medical system includes at least one seal, and a purge system via which a flushing fluid is introduced under pressure over a blood-side face of the seal and caused to flow through a space on the blood side of the seal. The system can further include a rotatable member. The space on the blood side of the seal can be in fluid connection with an annular space adjacent to a rotating element operatively connected to the rotatable member.
摘要翻译：用于体内气体交换的系统包括柔性可旋转的轴; 多个轴向间隔开的搅拌机构，其位于可旋转的轴上，使得可旋转的轴可在轴向间隔开的搅拌机构之间弯曲; 多个中空透气纤维，其适于允许气体在体内流体和中空纤维内部之间扩散。多个中空纤维从搅拌机构径向向外定位。血液接触医疗系统包括至少一个密封件和清洗系统，通过该清洗系统，冲洗流体在压力下在密封件的血液侧面上被引入并且流过密封件的血液侧上的空间。该系统还可包括可旋转构件。密封件的血液侧的空间可以与与可旋转构件可操作地连接的旋转元件相邻的环形空间流体连接。

34. 发明授权

US07717871B2 System and method for site specific therapy 有权
标题翻译：场地特异性治疗的系统和方法
公开(公告)号：US07717871B2
公开(公告)日：2010-05-18
申请号：US10395573
申请日：2003-03-24
申请人： Rick Mathew Odland
发明人： Rick Mathew Odland
IPC分类号： A61M5/00 , A61M1/00 , A61M37/00 , A61B5/05
CPC分类号： A61M1/1678 , A61M1/26 , A61M2025/0042 , A61M2025/0057 , A61M2210/0693
摘要： A system, including catheter apparatus, and related method for performing site specific therapy. The catheter apparatus can include one or more semipermeable microcatheters for use in performing site specific microdialysis. The system and method are particularly suited for use in addressing cerebral edema by affecting the osmolar relationship between fluids making up the brain tissue. Also disclosed is an apparatus having a delivery/recovery mechanism in the form of a pump reservoir and one or more catheters in the form of semipermeable microcatheters, for use in delivering and/or recovering fluid to and/or from a tissue site or for performing tissue engineering outside of the body. The apparatus can be used in a method to perform site specific microtherapy, including for the treatment of avascular necrosis, compartment syndrome, cerebral edema, and to improve skin flap survival in the course of reconstructive surgery.
摘要翻译：一种包括导管装置的系统，以及用于进行现场特异性治疗的相关方法。导管装置可以包括一个或多个半透膜微导管，用于进行位点特异性微透析。该系统和方法特别适用于通过影响构成脑组织的液体之间的渗透压关系来解决脑水肿。还公开了一种具有泵储存器形式的输送/回收机构和一种或多种半透明微导管形式的导管的装置，用于将流体递送和/或从组织部位或/或从组织部位回收或用于执行组织工程以外的身体。该装置可用于进行位点特异性微疗法的方法，包括用于治疗无血管坏死，室综合征，脑水肿，以及在重建手术过程中改善皮瓣存活。

35. 发明授权

US07497944B2 Blood component processing system, apparatus, and method 有权
标题翻译：血液成分处理系统，装置和方法
公开(公告)号：US07497944B2
公开(公告)日：2009-03-03
申请号：US11727550
申请日：2007-03-27
申请人： Niclas Högberg , Emanuel Hällgren , Peter Pihlstedt , Brian M. Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin, III
发明人： Niclas Högberg , Emanuel Hällgren , Peter Pihlstedt , Brian M. Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin, III
IPC分类号： B01D21/30 , B04B5/02 , B04B5/04
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/26 , A61M1/262 , A61M1/3633 , A61M1/3639 , A61M1/3641 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045 , B04B2005/0478 , B04B2013/006
摘要： A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.
摘要翻译：与血液成分的处理有关的系统和方法。血液成分的处理可能涉及血液成分的离心分离和/或过滤。在一些实例中，至少一些血液成分在室中离心分离，然后通过与离心机转子一起旋转的过滤器过滤，其中过滤器位于比转筒更靠近转动轴的位置。过滤器可以包括被配置为过滤白细胞，血小板和/或红细胞的多孔过滤介质。一些示例包括感测泵送的血液成分的压力的压力传感器。感测到的压力可以与控制血液制品的泵送和/或与确定与血液制品相关联的界面的位置的结合一起使用。感测压力的其他用途也是可能的。

36. 发明申请

US20070255505A1 Blood component processing system, apparatus, and method 有权
标题翻译：血液成分处理系统，装置和方法
公开(公告)号：US20070255505A1
公开(公告)日：2007-11-01
申请号：US11727550
申请日：2007-03-27
申请人： Niclas Hogberg , Emanuel Hallgren , Peter Pihlstedt , Brian Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin
发明人： Niclas Hogberg , Emanuel Hallgren , Peter Pihlstedt , Brian Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin
IPC分类号： G01N33/48 , B01D29/88
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/26 , A61M1/262 , A61M1/3633 , A61M1/3639 , A61M1/3641 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045 , B04B2005/0478 , B04B2013/006
摘要： A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.
摘要翻译：与血液成分的处理有关的系统和方法。血液成分的处理可能涉及血液成分的离心分离和/或过滤。在一些实例中，至少一些血液成分在室中离心分离，然后通过与离心机转子一起旋转的过滤器过滤，其中过滤器位于离转子更靠近转动轴的位置。过滤器可以包括被配置为过滤白细胞，血小板和/或红细胞的多孔过滤介质。一些示例包括感测泵送的血液成分的压力的压力传感器。感测到的压力可以与控制血液制品的泵送和/或与确定与血液制品相关联的界面的位置的结合一起使用。感测压力的其他用途也是可能的。

37. 发明申请

US20020183677A1 Apparatus for enhanced plasmapheresis and methods thereof 失效
标题翻译：用于增强血浆置换术的装置及其方法
公开(公告)号：US20020183677A1
公开(公告)日：2002-12-05
申请号：US10195814
申请日：2002-07-15
发明人： Yu-An Chang , Daniel Duff , Hosheng Tu
IPC分类号： A61M037/00 , C02F001/44
CPC分类号： A61M1/3496 , A61M1/26 , A61M1/262 , A61M1/3693 , B01D63/16
摘要： An apparatus and methods for enhanced plasmapheresis comprising a filter membrane under an orbital motion or movement that has optimal local shear forces and maximum plasma flow output. The methods for biological separation and therapies comprise platelet collection, viral particle removal, cell washing and processing for stem cell selection, bone marrow purging, red blood cell collection, auto-transfusion, auto-immune disease treatment, selective macro-molecule removal, toxin removal, LDL removal, extracorporeal plasma delipidation, and the like.
摘要翻译：一种用于增强血浆置换术的装置和方法，包括在轨道运动或运动下具有最佳局部剪切力和最大血浆流量输出的滤膜。生物分离和治疗的方法包括血小板收集，病毒颗粒去除，细胞洗涤和干细胞选择的处理，骨髓清除，红细胞收集，自动输血，自身免疫疾病治疗，选择性大分子去除，毒素去除，LDL去除，体外血浆脱脂等。

38. 发明授权

US06387323B1 Integrated blood oxygenator and pump system having active blood oxygenator 失效
标题翻译：具有活动性血液充氧器的综合血液充氧器和泵系统
公开(公告)号：US06387323B1
公开(公告)日：2002-05-14
申请号：US09079863
申请日：1998-05-15
申请人： Thomas A. Afzal , Ronald G. Williams
发明人： Thomas A. Afzal , Ronald G. Williams
IPC分类号： A61M114
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1029 , A61M1/26 , A61M1/262 , A61M1/267 , A61M2206/16
摘要： An integrated blood oxygenation and pump system suitable for use in a sterile field having a low priming volume is provided in which a blood oxygenator portion of the system includes an active element, separate from the pump, that disrupts the development of laminar flow and stagnation zones in the fiber bundle employed for gas exchange. The integrated system enables the pump and oxygenator to be used independently of one another or be rapidly reconfigured to provide both pumping action and blood oxygenation.
摘要翻译：提供了适用于具有低起动体积的无菌领域的综合血氧和泵系统，其中系统的血液充氧器部分包括与泵分离的有源元件，其破坏层流和停滞区的发展在用于气体交换的纤维束中。集成系统使得泵和氧合器彼此独立地使用或被快速重新配置以提供泵送作用和血氧合作用。

39. 发明授权

US06348162B1 Starting dialysate composition for use as an initial dialysate in hemo dialysis 有权
标题翻译：启动透析液组合物，用作血液透析中的初始透析液
公开(公告)号：US06348162B1
公开(公告)日：2002-02-19
申请号：US09541956
申请日：2000-04-03
申请人： Stephen R. Ash
发明人： Stephen R. Ash
IPC分类号： C01B316
CPC分类号： A61M1/3679 , A61M1/16 , A61M1/1649 , A61M1/1696 , A61M1/26 , A61M1/34 , A61M1/3403 , A61M1/3486 , A61M1/3493 , A61M1/3607 , A61M1/369 , A61M2205/3331 , A61M2205/3368 , A61M2205/3379 , A61M2205/366
摘要： An apparatus for use in whole body hypothermia includes a dialyzer having a blood side and a dialysate side separated by one or more dialysis membranes. A blood pump associated with the a blood circuit established on the blood side circulates blood through the dialyzer at high rates advantageous for hyperthermia treatments. A bypass is included whereby circulated blood can bypass the dialyzer. The bypass aids in preventing blood-side tensioning of dialyzer membranes thereby allowing proper membrane movement to assist in mixing a sorbent suspension circulated on the dialysate side of the dialyzer. A sorbent suspension composition for use as a dialysate in hemodialysis, especially when performed in conjunction with whole body hyperthermia, includes water, a surface adsorptive agent such as charcoal, a cation exchanger, and precipitated calcium phosphate. The precipitated calcium phosphate serves as a reservoir for calcium and phosphate ions to assist in controlling patient blood chemistries.
摘要翻译：用于全身低温的装置包括具有血液侧的透析器和由一个或多个透析膜分离的透析液侧。与建立在血液侧的血液回路相关联的血液泵以高速率通过透析器以有利于高热治疗的方式循环血液。包括旁路，循环血液可以绕过透析器。旁路有助于防止透析器膜的血液侧张力，从而允许适当的膜运动以帮助混合在透析器的透析液侧上循环的吸附剂悬浮液。用作血液透析中透析液的吸附剂悬浮液组合物，特别是与全身热疗相结合时，包括水，表面吸附剂如木炭，阳离子交换剂和沉淀的磷酸钙。沉淀的磷酸钙用作钙和磷酸根离子的储存器，以帮助控制患者的血液化学物质。

40. 发明授权

US6156007A Apparatus for whole-body hyperthermia 失效
标题翻译：全身热疗仪
公开(公告)号：US6156007A
公开(公告)日：2000-12-05
申请号：US126372
申请日：1995-01-26
申请人： Stephen R. Ash
发明人： Stephen R. Ash
IPC分类号： A61M1/16 , A61M1/26 , A61M1/34 , A61M1/36 , A61M1/00
CPC分类号： A61M1/3679 , A61M1/1649 , A61M1/3486 , A61M1/3493 , A61M1/369 , A61M1/16 , A61M1/1696 , A61M1/26 , A61M2205/366
摘要： An apparatus for use in whole body hypothermia includes a dialyzer having a blood side and a dialysate side separated by one or more dialysis membranes. A blood pump associated with the a blood circuit established on the blood side circulates blood through the dialyzer at high rates advantageous for hyperthermia treatments. A bypass is included whereby circulated blood can bypass the dialyzer. The bypass aids in preventing blood-side tensioning of dialyzer membranes thereby allowing proper membrane movement to assist in mixing a sorbent suspension circulated on the dialysate side of the dialyzer. A sorbent suspension composition for use as a dialysate in hemodialysis, especially when performed in conjunction with whole body hyperthermia, includes water, a surface adsorptive agent such as charcoal, a cation exchanger, and precipitated calcium phosphate. The precipitated calcium phosphate serves as a reservoir for calcium and phosphate ions to assist in controlling patient blood chemistries.
摘要翻译：用于全身低温的装置包括具有血液侧的透析器和由一个或多个透析膜分离的透析液侧。与建立在血液侧的血液回路相关联的血液泵以高速率通过透析器以有利于高热治疗的方式循环血液。包括旁路，循环血液可以绕过透析器。旁路有助于防止透析器膜的血液侧张力，从而允许适当的膜运动以帮助混合在透析器的透析液侧上循环的吸附剂悬浮液。用作血液透析中透析液的吸附剂悬浮液组合物，特别是与全身热疗相结合时，包括水，表面吸附剂如木炭，阳离子交换剂和沉淀的磷酸钙。沉淀的磷酸钙用作钙和磷酸根离子的储存器，以帮助控制患者的血液化学物质。

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