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1. 发明授权

US09254279B2 Nitric oxide scavengers 有权
公开(公告)号：US09254279B2
公开(公告)日：2016-02-09
申请号：US10844202
申请日：2004-05-12
申请人： Sujatha Karoor , Ton That Hai , Cong Jiang , Paul Sanders , Cliff Holmes
发明人： Sujatha Karoor , Ton That Hai , Cong Jiang , Paul Sanders , Cliff Holmes
IPC分类号： A61K31/4164 , A61K31/353 , A61K31/4178 , A61K31/4439
CPC分类号： A61K31/4164 , A61K31/353 , A61K31/4178 , A61K31/4439 , A61K31/714 , A61K45/06
摘要： Therapeutic compositions capable of removing excess nitric oxide are provided. The therapeutic compositions include nitronyl nitroxide monoradicals, B12 derivatives, flavonoid derivatives, the like and combinations thereof. The therapeutic compositions can be utilized in a number of suitable applications, such as to prevent or treat intradialytic hypotension during dialysis.

2. 发明申请

US20130213891A1 METHOD AND COMPOSITION FOR REMOVING UREMIC TOXINS IN DIALYSIS PROCESSES 有权
标题翻译：在脱水过程中去除尿毒素的方法和组合物
公开(公告)号：US20130213891A1
公开(公告)日：2013-08-22
申请号：US13745388
申请日：2013-01-18
申请人： Sujatha Karoor
发明人： Sujatha Karoor
IPC分类号： A61M1/14 , A61M1/28
CPC分类号： A61M1/3687 , A61M1/14 , A61M1/1694 , A61M1/1696 , A61M1/267 , A61M1/28 , A61M1/284 , A61M1/287 , A61M1/3679 , A61M2209/088 , B01J20/0292 , B01J20/06 , B01J20/20 , B01J20/24 , B01J20/28052 , B01J2220/62
摘要： A dialysis system comprising: a sorbent cartridge in fluid communication with at least one of a patient or a dialyzer, the sorbent cartridge including a housing having a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; a storage container in fluid communication with the sorbent cartridge; a pump in fluid communication sorbent cartridge and the storage container; and a control unit in operable communication with the pump, wherein the control unit is programmed to cause the pump to pump a dialysis fluid to flow (i) in a first direction through the sorbent cartridge, wherein the zirconium phosphate layer is contacted by the dialysis fluid before the at least one of the urease layer, zirconium oxide layer or carbon layer and (ii) in a second direction, reverse from the first direction, through the sorbent cartridge wherein the at least one of the urease layer, zirconium oxide layer or carbon layer is contacted by the dialysis fluid before the zirconium phosphate layer.
摘要翻译：一种透析系统，包括：与患者或透析器中的至少一个流体连通的吸附剂盒，所述吸着剂盒包括具有磷酸锆层的壳体，其后是脲酶层，氧化锆层或碳层; 与吸附剂盒流体连通的储存容器; 流体连通吸附剂盒中的泵和储存容器; 以及与所述泵可操作地连通的控制单元，其中所述控制单元被编程为使所述泵泵送透析流体沿着第一方向流过所述吸附剂筒，其中所述磷酸锆层与所述透析接触在尿素酶层，氧化锆层或碳层中的至少一个之前的流体和（ii）沿与第一方向相反的第二方向通过吸附剂盒，其中脲酶层，氧化锆层或在磷酸锆层之前，碳层与透析液接触。

3. 发明授权

US08357113B2 Systems and methods for performing peritoneal dialysis 有权
公开(公告)号：US08357113B2
公开(公告)日：2013-01-22
申请号：US12562730
申请日：2009-09-18
申请人： Robert W. Childers , David S. Brown , Ramesh Wariar , Sujatha Karoor , Shahid Din , Leo Martis , Cody Buckmann , Paul Soltys
发明人： Robert W. Childers , David S. Brown , Ramesh Wariar , Sujatha Karoor , Shahid Din , Leo Martis , Cody Buckmann , Paul Soltys
IPC分类号： A61M1/00
CPC分类号： A61M1/1696 , A61M1/1656 , A61M1/1658 , A61M1/166 , A61M1/28 , A61M1/284 , A61M1/285 , A61M1/287 , A61M1/288 , A61M2202/0413 , A61M2205/12 , A61M2205/3306 , A61M2205/3327
摘要： A regenerative peritoneal dialysis system includes a dialysis fluid loop; a filter located in the dialysis fluid loop, a first portion of the dialysis fluid sent to the filter rejected by the filter and returned upstream of the filter, a second portion of the dialysis fluid sent to the filter forming permeate, the permeate being rich in urea; and a urea removing apparatus located in the dialysis fluid loop downstream from the filter to receive the permeate and absorb urea from the permeate.

4. 发明申请

US20090218288A1 METHOD AND COMPOSITION FOR REMOVING UREMIC TOXINS IN DIALYSIS PROCESSES 有权
标题翻译：在脱水过程中去除尿毒素的方法和组合物
公开(公告)号：US20090218288A1
公开(公告)日：2009-09-03
申请号：US12465214
申请日：2009-05-13
申请人： Sujatha Karoor , Brian Donovan , Ton That Hai , Mari Katada , Luis Lu , Leo Martis , Stavroula Morti , Salim Mujais , Paul J. Sanders , Paul J. Soltys , Rahul Tandon
发明人： Sujatha Karoor , Brian Donovan , Ton That Hai , Mari Katada , Luis Lu , Leo Martis , Stavroula Morti , Salim Mujais , Paul J. Sanders , Paul J. Soltys , Rahul Tandon
IPC分类号： B01D61/26 , B01D15/00 , B01D39/06 , B01J8/00 , B01D61/30
CPC分类号： A61M1/1696 , A61M1/284 , A61M1/287 , B01D15/00 , B01J20/0211 , B01J20/0292 , B01J20/06 , B01J20/20 , B01J20/22 , B01J20/28052 , B01J39/10 , B01J39/12 , B01J41/10
摘要： Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.
摘要翻译：提供了提供透析治疗的方法和装置。该装置包括含有磷酸锆，氧化锆和脲酶的树脂床。

5. 发明申请

US20090098215A1 DIALYSIS SOLUTIONS CONTAINING PYROPHOSPHATES 有权
标题翻译：包含磷酸盐的透析溶液
公开(公告)号：US20090098215A1
公开(公告)日：2009-04-16
申请号：US11871018
申请日：2007-10-11
申请人： Bruce L. Riser , Paul Zieske , Sujatha Karoor , Himanshu D. Patel
发明人： Bruce L. Riser , Paul Zieske , Sujatha Karoor , Himanshu D. Patel
IPC分类号： A61K33/42 , A61P7/08
CPC分类号： A61K33/42 , A61L2/0011 , A61L2/0017 , A61L2/0023 , A61M1/1672 , A61M1/1674 , A61M1/287
摘要： Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.
摘要翻译：提供了包含焦磷酸盐的透析溶液以及制备和使用透析溶液的方法。在一个实施方案中，本公开提供了包含稳定和治疗有效量的焦磷酸盐的透析溶液。透析溶液可以例如使用高压釜，蒸汽，高压，紫外线，过滤或其组合的技术进行灭菌。透析溶液可以是浓缩物的形式。

6. 发明授权

US08491517B2 Method and composition for removing uremic toxins in dialysis processes 有权
公开(公告)号：US08491517B2
公开(公告)日：2013-07-23
申请号：US13281675
申请日：2011-10-26
申请人： Sujatha Karoor , Brian Donovan , Ton That Hai , Mari Katada , Luis Lu , Leo Martis , Stavroula Morti , Salim Mujais , Paul J. Sanders , Paul J. Soltys , Rahul Tandon
发明人： Sujatha Karoor , Brian Donovan , Ton That Hai , Mari Katada , Luis Lu , Leo Martis , Stavroula Morti , Salim Mujais , Paul J. Sanders , Paul J. Soltys , Rahul Tandon
IPC分类号： A61M37/00
CPC分类号： A61M1/1696 , A61M1/284 , A61M1/287 , B01D15/00 , B01J20/0211 , B01J20/0292 , B01J20/06 , B01J20/20 , B01J20/22 , B01J20/28052 , B01J39/10 , B01J39/12 , B01J41/10
摘要： Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.

7. 发明申请

US20120238525A1 PERITONEAL DIALYSIS SOLUTIONS COMPRISING GLUCOSE POLYMERS 有权
标题翻译：包含葡萄糖聚合物的PERITONEAL DIALYSIS SOLUTIONS
公开(公告)号：US20120238525A1
公开(公告)日：2012-09-20
申请号：US13419701
申请日：2012-03-14
申请人： John Kenneth Leypoldt , Clifford J. Holmes , Sujatha Karoor , Catherine M. Hoff , Leo Martis , Rahul Tandon
发明人： John Kenneth Leypoldt , Clifford J. Holmes , Sujatha Karoor , Catherine M. Hoff , Leo Martis , Rahul Tandon
IPC分类号： A61K31/715 , A61P13/12 , A61K31/718
CPC分类号： A61K31/717 , A61K31/716 , A61K31/718 , C08L3/02
摘要： Peritoneal dialysis solutions including a glucose polymer and methods of using the dialysis solutions are disclosed herein. In a general embodiment, the peritoneal dialysis solution includes a glucose polymer in an amount to provide an increased ultrafiltration fluid volume for a given amount of carbohydrate absorbed compared to conventional dialysis solutions containing icodextrin as the active pharmaceutical ingredient. The increased ultrafiltration fluid volume for a given amount of carbohydrate absorbed is obtained by providing specific combinations of weight-average molecular weight, polydispersity index and concentration of the glucose polymer in the dialysis solution.
摘要翻译：本文公开了包括葡萄糖聚合物的腹膜透析溶液和使用透析溶液的方法。在一般实施方案中，腹膜透析溶液包含葡萄糖聚合物，其含量与给定量的碳水化合物相比提供了增加的超滤流体体积，与常规含有作为活性药物成分的伊曲诺白蛋白的透析溶液相比。通过提供透析溶液中葡萄糖聚合物的重均分子量，多分散指数和浓度的特定组合，可以获得给定量的碳水化合物吸收增加的超滤液体积。

8. 发明申请

US20110303590A1 WEIGHT/SENSOR-CONTROLLED SORBENT SYSTEM FOR HEMODIALYSIS 有权
标题翻译：重量/传感器控制的血液分析系统
公开(公告)号：US20110303590A1
公开(公告)日：2011-12-15
申请号：US13213707
申请日：2011-08-19
申请人： Robert W. Childers , David S. Brown , Ramesh Wariar , Sujatha Karoor , Shahid Din , Leo Martis , Cody Buchmann , Paul Soltys
发明人： Robert W. Childers , David S. Brown , Ramesh Wariar , Sujatha Karoor , Shahid Din , Leo Martis , Cody Buchmann , Paul Soltys
IPC分类号： B01D61/26 , B01D61/34
CPC分类号： A61M1/1696 , A61M1/1656 , A61M1/1658 , A61M1/166 , A61M1/28 , A61M1/284 , A61M1/285 , A61M1/287 , A61M1/288 , A61M2202/0413 , A61M2205/12 , A61M2205/3306 , A61M2205/3327
摘要： A hemodialysis system including (i) a dialyzer; (ii) a blood circuit including a blood pump in fluid communication with the dialyzer; (iii) a dialysate circuit including a dialysate circulation pump in fluid communication with the dialyzer, the dialysate circuit further including a sorbent cartridge for cleaning used dialysate; (iv) a container holding an initial supply of dialysate; (v) a container pump in fluid communication with the dialysate circuit and the container; (vi) a supply of concentrate; and (vii) an electronic weight balance positioned and arranged to weigh the supply of concentrate.
摘要翻译：一种血液透析系统，包括（i）透析器; （ii）包括与所述透析器流体连通的血液泵的血液回路; （iii）透析液回路，其包括与所述透析器流体连通的透析液循环泵，所述透析液回路还包括用于清洗使用过的透析液的吸附剂盒; （iv）容纳初始供应透析液的容器; （v）与透析液回路和容器流体连通的容器泵; （vi）精矿供应; 和（vii）定位和布置成对浓缩物供应进行称重的电子重量平衡。

9. 发明申请

US20100119618A1 DIALYSIS SOLUTIONS CONTAINING PYROPHOSPHATES 有权
标题翻译：包含磷酸盐的透析溶液
公开(公告)号：US20100119618A1
公开(公告)日：2010-05-13
申请号：US12687536
申请日：2010-01-14
申请人： Bruce L. Riser , Paul Zieske , Sujatha Karoor , Himanshu D. Patel
发明人： Bruce L. Riser , Paul Zieske , Sujatha Karoor , Himanshu D. Patel
IPC分类号： A61K33/42
CPC分类号： A61K33/42 , A61L2/0011 , A61L2/0017 , A61L2/0023 , A61M1/1672 , A61M1/1674 , A61M1/287
摘要： Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.
摘要翻译：提供了包含焦磷酸盐的透析溶液以及制备和使用透析溶液的方法。在一个实施方案中，本公开提供了包含稳定和治疗有效量的焦磷酸盐的透析溶液。透析溶液可以例如使用高压釜，蒸汽，高压，紫外线，过滤或其组合的技术进行灭菌。透析溶液可以是浓缩物的形式。

10. 发明申请

US20090314707A1 METHOD AND COMPOSITION FOR REMOVING UREMIC TOXINS IN DIALYSIS PROCESSES 审中-公开
公开(公告)号：US20090314707A1
公开(公告)日：2009-12-24
申请号：US12474517
申请日：2009-05-29
申请人： Sujatha Karoor , Brian Donovan , Ton That Hai , Mari Katada , Luis Lu , Leo Martis , Stavroula Morti , Salim Mujais , Paul J. Sanders , Paul J. Soltys , Rahul Tandon
发明人： Sujatha Karoor , Brian Donovan , Ton That Hai , Mari Katada , Luis Lu , Leo Martis , Stavroula Morti , Salim Mujais , Paul J. Sanders , Paul J. Soltys , Rahul Tandon
IPC分类号： B01D27/08
CPC分类号： A61M1/1696 , A61M1/284 , A61M1/287 , B01D15/00 , B01J20/0211 , B01J20/0292 , B01J20/06 , B01J20/20 , B01J20/22 , B01J20/28052 , B01J39/10 , B01J39/12 , B01J41/10
摘要： Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.

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