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31. 发明专利

JP2007244699A Iontophoresis apparatus 审中-公开
标题翻译： IOPOPHORESIS设备
公开(公告)号：JP2007244699A
公开(公告)日：2007-09-27
申请号：JP2006073476
申请日：2006-03-16
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： KOSHIBA NOBUHARU , YAMAUCHI MITSUGU , WATANABE YURIKO , SAKANOUE NORIKO , MORI EMI
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus which gives medicinal ions with high efficiency or at a high speed, or to provide an iontophoresis apparatus which is excellent in terms of the safety and keeps an adhesiveness and a conductivity between a non-working side electrode structure and a living skin easily in an excellent manner.
SOLUTION: In the iontophoresis apparatus equipped with a first electrolyte retaining part 14 for retaining an electrolysis solution, a first ion-exchange membrane 15 of a first polarity placed on the underside of the first electrolyte retaining part, and a first electrode for applying a voltage of the first polarity to the first electrolyte retaining part; a first skin contact membrane 16 made of vinylon is disposed on the underside of the first ion-exchange membrane.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种离子电渗疗法，其以高效率或高速度给药药物离子，或者提供一种离子电渗疗法，其在安全性方面优异，并且保持非粘合性之间的粘合性和导电性工作侧电极结构和活体皮肤。解决方案：在配备有用于保持电解溶液的第一电解质保留部分14的离子电渗仪中，放置在第一电解质保持部分的下侧上的第一极性的第一离子交换膜15和第一电极将第一极性的电压施加到第一电解质保留部分; 由维纶制成的第一皮肤接触膜16设置在第一离子交换膜的下侧。版权所有（C）2007，JPO＆INPIT

32. 发明专利

JP2007244551A Iontophoresis apparatus 审中-公开
标题翻译： IOPOPHORESIS设备
公开(公告)号：JP2007244551A
公开(公告)日：2007-09-27
申请号：JP2006070445
申请日：2006-03-15
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： KOSHIBA NOBUHARU , HAYAKAWA YOSHITSUNE , MAEKAWA YUKINORI , AWANO JUNJIRO
IPC分类号： A61N1/30 , C23C30/00
摘要： PROBLEM TO BE SOLVED: To enhance performance of an iontophoresis apparatus equipped with an electrode structure having a polarizable electrode by improving an electric conductivity from a power source to the polarizable electrode.
SOLUTION: In the iontophoresis apparatus equipped with the electrode structure having a power collecting body 12 formed by coating a conductive coating material containing conductive powder and the polarizable electrode 13 which is disposed on the front side of the power collecting body and is electrified by the power collecting body, the iontophoresis apparatus having the power collecting body to which metal plating M1, M2 having a specific resistance smaller than the conductive powder is applied is opened. The metal plating M1, M2 is applied to the surface of the conductive powder P or is applied to the surface on the front side of the power collecting body 12. Gold is used for the metal plating.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：通过提高从电源到可极化电极的导电性，来提高配备有具有可极化电极的电极结构的离子电渗装置的性能。解决方案：在具有电极结构的离子电渗装置中，该电极结构具有通过涂布含有导电粉末的导电性涂料形成的集电体12和设置在集电体前侧的带电极的电极13，通过集电体，打开具有电力电阻小于导电性粉末的金属电镀M1，M2的集电体的离子电渗疗装置。将金属电镀M1，M2施加到导电粉末P的表面，或者施加到集电体12的前侧的表面。金用于金属电镀。版权所有（C）2007，JPO＆INPIT

33. 发明专利

JP2007229228A Release liner 审中-公开
标题翻译：释放内衬
公开(公告)号：JP2007229228A
公开(公告)日：2007-09-13
申请号：JP2006054858
申请日：2006-03-01
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： HORIOKA ATSUSHI , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , SHIBATA TSUTOMU
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To provide a release liner for preventing drug diffusion or the like in an iontophoresis device, which can be easily pulled out transversely when being used.
SOLUTION: The release liner 36 placed, for instance, between a second ion-selective membrane 26 in an active electrode structure 20 of the iontophoresis device 10 and a chemical keeping part 32, or between an electrolytic solution keeping part 24 and the chemical keeping part 32, in contact with them for separating the layers before use is mutually detachably connected to at least two of a small-area part and a large-area part of different areas, and can be gradually pulled out by detaching at least the large-area part from the other parts.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于在离子电渗疗法装置中防止药物扩散等的剥离衬垫，其可以在使用时容易地横向拉出。解决方案：将离子电渗装置10的有源电极结构20中的第二离子选择性膜26和药剂保持部32之间或电解液保持部24与电解液保持部24之间的放电衬垫36 化学保存部32与使用前分离层的接触部可以相互可拆卸地连接到不同区域的小区域部分和大面积部分中的至少两个，并且可以通过分开至少大面积部分从其他部分。版权所有（C）2007，JPO＆INPIT

34. 发明专利

JP2007229208A Iontophoresis apparatus and its manufacturing method 有权
标题翻译： IOPOPHORESIS设备及其制造方法
公开(公告)号：JP2007229208A
公开(公告)日：2007-09-13
申请号：JP2006054516
申请日：2006-03-01
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： HAYAKAWA YOSHITSUNE , MITSUGUCHI KAZUMA , KOSHIBA NOBUHARU
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0436 , A61N1/0448
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus capable of suppressing the variation of the pH value of medical solution when the medical solution dissolved with salt of medical substance and acid is retained in contact with a polarizable electrode.
SOLUTION: This iontophoresis apparatus is provided with an electrode structure retaining the medical solution dissolved with the salt of a first medical substance and acid, the electrode structure has the polarizable electrode 13 coming into contact with the medical solution, and the polarizable electrode 13 used is adsorbed with a second medical substance being same kind to the first medical solution. Preferably, this manufacturing method of the iontophoresis apparatus includes a first process of allowing the polarizable electrode to adsorb the second medical substance and a second process being executed after the first process and bringing the polarizable electrode in contact with the medical solution.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够抑制药物溶液与医药物质和酸溶解的溶液与可极化电极接触时能够抑制药液的pH值变化的离子电渗疗法装置。该离子电渗疗法装置具有保持与第一药物和酸的盐溶解的药液的电极结构，电极结构具有与药液接触的极化电极13和极化电极 13所吸收的第一药液与第一药物相同。优选地，离子电渗疗法装置的制造方法包括使可极化电极吸附第二药物的第一工序和在第一工序之后进行的第二工序，使可极化电极与药液接触。版权所有（C）2007，JPO＆INPIT

35. 发明专利

JP2007167581A Iontophoresis apparatus 审中-公开
标题翻译： IOPOPHORESIS设备
公开(公告)号：JP2007167581A
公开(公告)日：2007-07-05
申请号：JP2005373139
申请日：2005-12-26
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： AKIYAMA HIDEO , NAKAYAMA HATOO , MATSUMURA TAKEHIKO
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To immediately percutaneously administer medicine without any special preparation when urgently administering the medicine.
SOLUTION: This iontophoresis apparatus 10 is provided with an apparatus body 50 percutaneously administering the ionized medicine by iontophoresis, and clothes 400 to be worn on a living body; and the apparatus body 50 is attached to the inside of the clothes 400. This apparatus is further provided with a separator 51 for isolating the medicine retained to the apparatus body 50 from the outside, and preferably the medicine is percutaneously administered by removing the separator 51 from the apparatus body 50.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：立即施药时，立即经皮给药，无需特别准备。该离子电渗疗法装置10设置有通过离子电渗法经皮施用电离药物的装置体50和要穿在生物体上的衣物400; 将装置主体50安装在衣物400的内部。该装置还具备用于将保存在装置主体50上的药物与外部隔离的隔膜51，优选通过除去隔膜51经皮给药（C）2007，JPO＆INPIT

36. 发明专利

JP2007159640A Packaging article for iontophoresis apparatus 有权
标题翻译：包装物品用于IOPOPHORESIS设备
公开(公告)号：JP2007159640A
公开(公告)日：2007-06-28
申请号：JP2005356431
申请日：2005-12-09
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： NAKAYAMA HATOO , MATSUMURA TAKEHIKO , SHIBATA TSUTOMU
IPC分类号： A61N1/30 , B65D77/00
CPC分类号： B65D75/58 , A61N1/303
摘要： PROBLEM TO BE SOLVED: To prevent a reduction of a medical solution due to volatilization of a medication or a solvent in which the medication is dissolved and corrosion in a power source section due to the medication evaporated by the volatilization.
SOLUTION: A packaging article 15 for an iontophoresis apparatus is equipped with an iontophoresis apparatus 10 having a main body 50 of a device for transdermally administering the ionized medication by iontophoresis and a joint 70 which extends from the main body 50 and connects to the main body 50 and the power source section 60 supplying power to the main body 50, a packaging member 80 for packaging the main body 50 and a part of the joint 70 in an air-tight manner by welding at least a part of the packaging member 80 to the joint 70, and a cutting guiding part 400 for guiding a cutting line of the packaging member 80 so that the part of the packaging member 80 which is welded to the joint 70 remains on the joint 70 when the packaging member 80 is opened.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了防止药物溶解挥发或由于药物挥发挥发而导致电源部分腐蚀，药物溶解的药液的减少。解决方案：用于离子电渗仪的包装物15配备有离子电渗疗法装置10，该离子电渗疗法装置10具有通过离子电渗疗法对经离子化药物进行经皮施用的装置的主体50以及从主体50延伸并连接到主体50和向主体50供电的动力源部分60，用于通过焊接至少一部分包装来将主体50和接头70的一部分以气密方式包装的包装部件80 构件80到接头70，以及切割引导部400，用于引导包装构件80的切割线，使得当包装构件80是包装构件80时，焊接到接头70的包装构件80的一部分保留在接头70上打开。版权所有（C）2007，JPO＆INPIT

37. 发明专利

JP2007097686A Iontophoresis device and operation side electrode structure unit 审中-公开
标题翻译：电子设备和操作侧电极结构单元
公开(公告)号：JP2007097686A
公开(公告)日：2007-04-19
申请号：JP2005288692
申请日：2005-09-30
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： AKIYAMA HIDEO , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30 , A61N1/04
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis device for dosing medical ions to a living body, capable of dosing medicaments to the living body avoiding hair, etc. SOLUTION: The iontophoresis device 10 for dosing medical ions to the living body comprises a first electrode member 210 electrically connected to a terminal 62 having the same electric polarity as the medical ions in a power supply 60, an operation side electrode structure 200 with a medicament holder part 240 disposed inside an electric field made by the first electrode member 210 for holding medicaments, and a non-operation side electrode structure 300 electrically connected to a terminal 64 with the electric polarity different from the medical ions in the power supply 60. The medicament holder part 240 has a plurality of comb-like projections with medicaments held inside, projecting from the first electrode member 210 side to an object for dosing when medicaments are dosed. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种离子电渗疗法装置，用于将生物体的药物离子计量给药，能够将生物体内的药物给予避免毛发等。解决方案：用于将药物离子给药给药的离子电渗疗法装置10 活体包括电连接到具有与电源60中的医用离子相同的电极性的端子62的第一电极构件210，具有设置在第一电极的电场内部的药剂保持部240的操作侧电极结构200 用于保持药物的电极部件210以及电连接到端子64的非操作侧电极结构300，其电极性与电源60中的医用离子不同。药剂保持部240具有多个梳状突起药物保持在内部，从第一电极部件210侧突出到用于给药药剂时的给药对象。版权所有（C）2007，JPO＆INPIT

38. 发明专利

JP2007097641A Electrode structure for iontophoresis used to administer drug enclosed in liposome and iontophoresis device making use of the same 审中-公开
标题翻译：用于用脂质体包裹的管理药物的静电结构的电极结构和使用其的异源装置
公开(公告)号：JP2007097641A
公开(公告)日：2007-04-19
申请号：JP2005288167
申请日：2005-09-30
申请人： Hokkaido Univ , Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社 , 国立大学法人北海道大学
发明人： AKIYAMA HIDEO , KOGURE KENTARO , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30 , A61N1/04
摘要： PROBLEM TO BE SOLVED: To provide an electrode structure for iontophoresis which enables iontophoresis administration of drugs even those administered without ionization or those insoluble or hardly soluble in water and confers disirable functions in drug delivery to such drugs or drugs administered after ionization. SOLUTION: The electrode structure for iontophoresis holds a drug enclosed in ionic liposomes. The electrode structure at least comprises an electrode connected to a power source having the same polarity as the ionic liposomes held within the electrode structure, an electrolyte holding section arranged adjacent to the electrode for impregnating and holding an electrolyte, an ion exchange membrane arranged adjacent to the electrolyte holding section for selecting ions having a polarity opposite to the ionic liposomes, a drug solution holding section arranged adjacent to the ion exchange membrane for impregnating and holding the ionic liposomes, and an ion exchange membrane for selecting ions having the same polarity as the ionic liposomes. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于离子电渗疗法的电极结构，其即使是没有电离的药物也能够进行离子电渗治疗，或者不溶于或几乎不溶于水的药物的离子电渗给药，并且在药物递送中赋予药物或电离后施用的药物的令人不快的功能。解决方案：用于离子电渗疗法的电极结构保持封闭在离子脂质体中的药物。电极结构至少包括连接到具有与保持在电极结构内的离子脂质体相同极性的电源的电极，与电极相邻设置的用于浸渍和保持电解质的电解质保持部分，邻近设置的离子交换膜用于选择具有与离子脂质体相反的极性的离子的电解质保持部分，与用于浸渍和保持离子性脂质体的离子交换膜相邻设置的药物溶液保持部分，以及用于选择具有相同极性的离子的离子交换膜离子脂质体。版权所有（C）2007，JPO＆INPIT

39. 发明专利

JP2007089911A PERCUTANEOUS INTRODUCTION METHOD FOR siRNA 审中-公开
标题翻译：用于siRNA的PERCUTANEOUS引言方法
公开(公告)号：JP2007089911A
公开(公告)日：2007-04-12
申请号：JP2005285427
申请日：2005-09-29
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： KAWAKAMI HIROYOSHI , AKIYAMA HIDEO , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30 , A61K48/00 , A61N1/04 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To percutaneously introduce a siRNA (small interfering RNA) to an introduction part without imposing a large load on a patient concerning a method for allowing the siRNA to electrically penetrate skin. SOLUTION: The chemical holding part 240 of an iontophoresis apparatus 10 holds the siRNA dissociated into ions. The siRNA held in the chemical holding part 240 are allowed to electrically penetrate the skin by energizing the iontophoresis apparatus 10 and the skin of a living body. An ion-exchange membrane may be used in the iontophoresis apparatus 10. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了经皮地将siRNA（小干扰RNA）引入引入部分，而不会对患者施加大的负荷，涉及允许siRNA电穿透皮肤的方法。解决方案：离子电渗疗法装置10的化学保持部分240保持被离解成离子的siRNA。通过使离子电渗透装置10和生物体的皮肤通电，使被保持在化学保持部240中的siRNA能够电穿透皮肤。离子电渗装置10中可以使用离子交换膜。（C）2007，JPO＆INPIT

40. 发明专利

JP2007054531A Iontophoresis apparatus 审中-公开
标题翻译： IOPOPHORESIS设备
公开(公告)号：JP2007054531A
公开(公告)日：2007-03-08
申请号：JP2005246442
申请日：2005-08-26
申请人： Transcutaneous Technologies Inc , トランスキュー・テクノロジーズ株式会社
发明人： AKIYAMA HIDEO , NAKAYAMA HATOO , MATSUMURA TAKEHIKO , MATSUMURA AKIHIKO
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To provide an iontophoresis apparatus having a disinfecting function.
SOLUTION: This iontophoresis apparatus comprises an acting electrode structure body 120A to be used for administering ionized medicine through iontophoresis, a non-acting electrode structure body, and a direct current power unit 112 to be connected with the acting electrode structure body 120A and the non-acting electrode structure body whose respective polarity is different from each other. Each top surface of the acting electrode structure body 120A and the non-acting electrode structure body can be closely put on the skin or other interfaces of a living body, at least either one of which is provided with a disinfectant holder 142A on its outer side surface.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供具有消毒功能的离子电渗疗法装置。解决方案：该离子电渗疗法装置包括用于通过离子电渗法施用电离药物的作用电极结构体120A，非作用电极结构体和与作用电极结构体120A连接的直流电力单元112 以及各极性不同的非作用电极结构体。作用电极结构体120A和非作用电极结构体的上表面可以紧密地放置在活体的皮肤或其他界面上，其中至少任一个在其外侧设置有消毒剂保持器142A 表面。版权所有（C）2007，JPO＆INPIT

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