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31. 发明申请

US20080032931A1 ACTIVATABLE CLOSTRIDIAL TOXINS 审中-公开
公开(公告)号：US20080032931A1
公开(公告)日：2008-02-07
申请号：US11834068
申请日：2007-08-06
申请人： Lance Steward , Joseph Francis , Ester Fernandez-Salas , Marcella Gilmore , Shengwen Li , J. Dolly , Kei Aoki
发明人： Lance Steward , Joseph Francis , Ester Fernandez-Salas , Marcella Gilmore , Shengwen Li , J. Dolly , Kei Aoki
IPC分类号： A61K38/22 , A61P43/00 , C07H21/00 , C07K14/575 , C12P21/02
CPC分类号： C12N9/52 , C07K1/22 , C07K14/33 , C07K14/68 , C07K14/695 , C07K2319/03 , C07K2319/035 , C07K2319/50
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.

32. 发明申请

US20080032318A1 FRET PROTEASE ASSAYS FOR CLOSTRIDIAL TOXINS 审中-公开
公开(公告)号：US20080032318A1
公开(公告)日：2008-02-07
申请号：US11780872
申请日：2007-07-20
申请人： Lance Steward , Ester Fernandez-Salas , Kei Aoki
发明人： Lance Steward , Ester Fernandez-Salas , Kei Aoki
IPC分类号： G01N33/569 , C07K14/33 , C12Q1/04
CPC分类号： C12Q1/37 , C07K14/001 , C07K14/435 , G01N33/56911 , G01N2333/33
摘要： The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence that includes a cleavage site, where the cleavage site intervenes between the donor fluorophore and the acceptor and where, under the appropriate conditions, resonance energy transfer is exhibited between the donor fluorophore and the acceptor.

33. 发明申请

US20050276820A1 Leucine-based motif and Clostridial neurotoxins 有权
标题翻译：亮氨酸为主题和梭菌神经毒素
公开(公告)号：US20050276820A1
公开(公告)日：2005-12-15
申请号：US11039268
申请日：2005-01-19
申请人： Lance Steward , Todd Herrington , Kei Aoki
发明人： Lance Steward , Todd Herrington , Kei Aoki
IPC分类号： C12N15/09 , A61K38/00 , A61P1/00 , A61P5/00 , A61P21/00 , A61P25/00 , A61P25/04 , A61P27/02 , A61P29/02 , A61P37/00 , C07K14/33 , A61K39/08
CPC分类号： C07K14/33 , A61K38/00 , Y10S530/825
摘要： Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, preferably the biological half-life, of the modified neurotoxin relative to an identical neurotoxin without the structural modification. The structural modification includes addition or deletion of a leucine-based motif or parts thereof. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat biological disorders include treating autonomic disorders, neuromuscular disorders or pains.
摘要翻译：包含神经毒素的改性神经毒素包括结构修饰，其中所述结构修饰改变了修饰神经毒素相对于相同神经毒素的生物学持续性，优选生物半衰期而没有结构修饰。结构修饰包括加入或缺失基于亮氨酸的基序或其部分。在一个实施方案中，制备修饰的神经毒素的方法包括使用重组技术。在另一个实施方案中，使用经修饰的神经毒素治疗生物学障碍的方法包括治疗自主神经障碍，神经肌肉疾病或疼痛。

34. 发明授权

US06180251B2 Flame-retardant polyester resin composition 有权
标题翻译：阻燃聚酯树脂组合物
公开(公告)号：US06180251B2
公开(公告)日：2001-01-30
申请号：US09533382
申请日：2000-03-22
申请人： Hiroyuki Kanai , Kei Aoki , Toru Katsumata
发明人： Hiroyuki Kanai , Kei Aoki , Toru Katsumata
IPC分类号： B32B1504
CPC分类号： C09K21/14 , C08K5/12 , C08L67/02 , C08L67/025 , C08L75/04 , C08L77/00 , C09K21/00 , Y10T428/31678 , Y10T428/31786 , C08L51/00 , C08L2666/14
摘要： A thermoplastic resin having such a sufficient heat shock resistance that it is unbroken by common temperature changes and also exhibiting an excellent flame resistance when applied to an insert molded article, which is obtained by blending a thermoplastic polyester resin (A) with 1-25% by weight to the total amount of the composition of an impact resistance giving agent (B), 1-50% by weight to the total amount of the composition of an inorganic filler (C), 1-25% by weight to the total amount of the composition of a flame retardant (D) and 0.1-10% by weight to the total amount of the composition of an aromatic polyvalent carboxylate (E).
摘要翻译：一种热塑性树脂具有足够的耐热冲击性，使其不受常温变化的破坏，并且当应用于嵌入成型制品时也表现出优异的阻燃性，其通过将热塑性聚酯树脂（A）与1-25％（B）的组合物的总量相对于无机填充剂（C）的组合物的总量为1-50重量％，相对于总量为1-25重量％的阻燃剂（D）的组成和0.1-10重量％的组合物的芳族多价羧酸酯（E）的总量。

35. 发明授权

US6054606A Method for preparing malonate group-containing acrylate monomers 失效
标题翻译：制备丙二酸酯基丙烯酸酯单体的方法
公开(公告)号：US6054606A
公开(公告)日：2000-04-25
申请号：US861015
申请日：1997-05-21
申请人： Takashi Irie , Kei Aoki
发明人： Takashi Irie , Kei Aoki
IPC分类号： C07C69/54 , C07C69/34 , C07C69/52
CPC分类号： C07C69/54
摘要： A malonate group-containing acrylate monomer is produced by a transesterification reaction of dialkyl malonate with a hydroxyalkyl (meth)acrylate or a polyalkylene glycol mono(meth)acrylate. The malonate group-containing acrylate monomer finds use in the production of an acrylic polymer capable of crosslinking through a Michael reaction with an .alpha., .beta.-unsaturated carbonyl compound or resin.
摘要翻译：通过丙二酸二烷基酯与（甲基）丙烯酸羟烷基酯或聚亚烷基二醇单（甲基）丙烯酸酯的酯交换反应制备含丙二酸酯基团的丙烯酸酯单体。含丙二酸酯基团的丙烯酸酯单体用于制备能够通过与α，β-不饱和羰基化合物或树脂的迈克尔反应交联的丙烯酸类聚合物。

36. 发明授权

US5827928A One-component, thermosetting resin composition for coating use 失效
标题翻译：用于涂料的单组分热固性树脂组合物
公开(公告)号：US5827928A
公开(公告)日：1998-10-27
申请号：US630630
申请日：1996-04-11
申请人： Hideo Morimoto , Takashi Irie , Kei Aoki , Haruhiko Sawada
发明人： Hideo Morimoto , Takashi Irie , Kei Aoki , Haruhiko Sawada
IPC分类号： B05D1/36 , B05D7/24 , C08F290/06 , C08F290/14 , C09D4/00 , C09D4/02 , C09D7/12 , C09D133/04 , C09D175/14 , C08F20/00 , C08F20/52
CPC分类号： C08F290/06 , C08F290/14
摘要： A one-component, thermosetting resin composition curable through a Michael reaction between (a) a component having a plurality of .alpha., .beta.-unsaturated carbonyl groups and (b) a component having a plurality of activated methylene of activated methyne groups is disclosed. The curing reaction is catalyzed with a quaternary ammonium, quaternary phosphonium or tertiary sulfonium salt in the presence of a five-membered cyclic carbonate compound independently added to the composition or covalently attached to either component (a) or component (b).
摘要翻译：公开了通过（a）具有多个α，β-不饱和羰基的组分和（b）具有多个活化的甲炔基的活化亚甲基的组分之间的迈克尔反应可固化的单组分热固性树脂组合物。在五元环状碳酸酯化合物存在下，季铵，季鏻或叔锍盐催化固化反应，该五元环状碳酸酯化合物独立地加入到组合物中或共价连接到组分（a）或组分（b）上。

37. 发明授权

US5326827A Heat-curable resin composition containing acrylic polymer having alicyclic epoxide functions 失效
标题翻译：含有脂环式环氧官能团的丙烯酸类聚合物的热固性树脂组合物
公开(公告)号：US5326827A
公开(公告)日：1994-07-05
申请号：US139076
申请日：1993-10-21
申请人： Kei Aoki , Shinji Nakano , Nobuaki Tomita
发明人： Kei Aoki , Shinji Nakano , Nobuaki Tomita
IPC分类号： C08K5/36 , C08F8/00 , C08F20/32 , C08G59/32 , C08G59/68 , C08K5/55 , C08K5/59 , C08L33/04 , C08L33/14 , C08L63/00 , C09D133/04 , C09D133/06 , C09D133/14 , C09J133/04 , C09J133/14
CPC分类号： C08F8/00 , C08G59/3209 , C08G59/68 , C09D133/068 , C08L63/00
摘要： A curable resin composition comprising (a) an acrylic polymer having a plurality of alicyclic epoxide functions, and (b) an amount effective to initiate the curing reaction of the acrylic polymer (a) upon heating of a heat-latent cation polymerization initiator. The composition finds its uses in coating compositions, sealants, potting and casting compositions.
摘要翻译：一种可固化树脂组合物，其包含（a）具有多个脂环族环氧官能团的丙烯酸类聚合物，和（b）在热潜阳离子聚合引发剂加热时有效引发丙烯酸类聚合物（a）的固化反应的量。该组合物可用于涂料组合物，密封剂，灌封和浇铸组合物中。

38. 发明授权

US07641833B2 Method for producing a pellet from a fiber-filled resin composition and injection-molded products thereof 失效
标题翻译：从纤维填充树脂组合物及其注射成型体制造颗粒的方法
公开(公告)号：US07641833B2
公开(公告)日：2010-01-05
申请号：US10594679
申请日：2005-04-12
申请人： Kei Aoki , Masayuki Sakai , Kazufumi Watanabe
发明人： Kei Aoki , Masayuki Sakai , Kazufumi Watanabe
IPC分类号： B29C47/60 , B29B7/24
CPC分类号： B29B9/14 , B29B7/90 , B29C47/1081 , B29C47/6025 , B29C47/6031 , B29C47/6037 , B29C47/6056 , B29C2947/9218 , B29C2947/92704
摘要： An object of the present invention is to economically produce a resin composition pellet with the degradation of resin suppressed, by using an ordinary extruder, the resin composition pellet being filled with a desired filling amount of a uniformly compounded fibrous filler, and having a required weight average fiber length, in particular, to produce a resin composition pellet used for a socket of a planar socket pin in which the pitch interval of a lattice area of a semiconductor device is 2.0 mm or less, the thickness of the lattice area is 0.5 mm or less, and the height of the socket is 5.0 mm or less. To achieve the object, in supplying 80 to 55% by weight of resin and 20 to 45% by weight of the fibrous filler with a weight average fiber length of 1 mm or more to an extruder to produce a resin composition pellet in which a weight average fiber length of a fibrous filler is 180 to 360 μm, a part of an amount (x) of the resin is supplied through a main feed port of the extruder, and the fibrous filler and a remaining amount (1−x) of the resin are supplied through a side-feed port so that x/(1−x) becomes 50/50 to 10/90% by weight.
摘要翻译：本发明的目的是通过使用普通的挤出机经济地生产树脂降解降解的树脂组合物颗粒，所述树脂组合物颗粒填充有所需的填充量的均匀复合的纤维填料并具有所需的重量平均纤维长度，特别是为了制造用于平面插座销的插座的树脂组合物颗粒，其中半导体器件的晶格面积的间距间隔为2.0mm或更小，晶格面积的厚度为0.5mm 以下，插座的高度为5.0mm以下。为了达到上述目的，向挤出机中供给80〜55重量％的树脂和20〜45重量％的重均纤维长度为1mm以上的纤维填料，制成树脂组合物颗粒，其中重量纤维填料的平均纤维长度为180〜360μm，树脂的量（x）的一部分通过挤出机的主供料口供给，纤维填料的剩余量（1-x）树脂通过侧进料口供给，使得x /（1-x）成为50/50至10/90重量％。

39. 发明申请

US20080038756A1 FRET PROTEASE ASSAYS FOR CLOSTRIDIAL TOXINS 审中-公开
标题翻译：用于封闭性毒素的FRET蛋白质测定
公开(公告)号：US20080038756A1
公开(公告)日：2008-02-14
申请号：US11780925
申请日：2007-07-20
申请人： Lance Steward , Ester Fernandez-Salas , Kei Aoki
发明人： Lance Steward , Ester Fernandez-Salas , Kei Aoki
IPC分类号： G01N33/569 , C07K14/33 , C12Q1/04
CPC分类号： C12Q1/37 , C07K14/001 , C07K14/435 , G01N33/56911 , G01N2333/33
摘要： The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence that includes a cleavage site, where the cleavage site intervenes between the donor fluorophore and the acceptor and where, under the appropriate conditions, resonance energy transfer is exhibited between the donor fluorophore and the acceptor.
摘要翻译：本发明提供了可用于测定任何梭菌毒素（包括所有血清型的肉毒毒素）以及破伤风毒素的蛋白酶活性的梭菌毒素底物。本发明的梭菌毒素底物含有供体荧光团; 具有与供体荧光团的发射光谱重叠的吸收光谱的受体; 和梭菌毒素识别序列，其包括切割位点，其中切割位点插入供体荧光团和受体之间，并且在适当条件下，在供体荧光团和受体之间显示共振能量转移。

40. 发明申请

US20070275477A1 Assays of Molecular or Subcellular Interactivity Using Depolarization After Resonance Transfer Energy (DARET) 有权
标题翻译：共振转移能（DARET）后去极化分子或亚细胞相互作用的分析
公开(公告)号：US20070275477A1
公开(公告)日：2007-11-29
申请号：US11548411
申请日：2006-10-11
申请人： Marcella Gilmore , Dudley Williams , Lance Steward , Kei Aoki
发明人： Marcella Gilmore , Dudley Williams , Lance Steward , Kei Aoki
IPC分类号： G01N21/76 , G01N33/68
CPC分类号： G01N33/542
摘要： The present invention provides a method of determining the proximity, or changes in the proximity of two or more molecular features labeled with fluorophores able to undergo DARET. In preferred embodiments the change in proximity of molecular features in a sample is correlated with changes in the fluorescence polarization of the sample, and may be monitored in real time.
摘要翻译：本发明提供了一种确定两个或多个分子特征的邻近性的变化或方法，所述分子特征用能够进行DARET的荧光团标记。在优选实施例中，样品中分子特征的接近度的变化与样品的荧光偏振的变化相关，并且可以实时监测。

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