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31. 发明申请

US20120216157A1 ROUTING ANALYSIS WITH DOUBLE PATTERN LITHOGRAPHY 有权
标题翻译：路由分析与双模式图
公开(公告)号：US20120216157A1
公开(公告)日：2012-08-23
申请号：US13400411
申请日：2012-02-20
申请人： Jianfeng Luo , Gang Chen
发明人： Jianfeng Luo , Gang Chen
IPC分类号： G06F17/50
CPC分类号： G06F17/5077
摘要： Graph analysis for double pattern lithography is described. Layout shapes are decomposed into rectangles and a vertex is provided for each rectangle. Double pattern spacing conflicts are determined and shown as edges for the graph analysis. Odd cycles are used to identify double pattern lithography violations. Cycles can be completed with the addition of edges between vertices where stitches have been included in the layout. Edges between touching shapes do not count toward the odd count in the cycles. Fixes are included by increasing space or by rerouting. A portion of the layout can be incrementally changed and a local update of the graph analysis performed. Correct by construction layout is implemented by avoiding certain odd cycle prone layout routings.
摘要翻译：描述了双模式光刻的图形分析。布局形状分解为矩形，并为每个矩形提供一个顶点。确定双重图案间距冲突，并将其显示为图形分析的边。奇数周期用于识别双重图案光刻违规。可以通过在布局中包含针迹的顶点之间添加边缘来完成循环。触摸形状之间的边缘不计入循环中的奇数。通过增加空间或重新路由来增加修复。布局的一部分可以递增地改变，并且执行图分析的本地更新。通过施工布局进行校正是通过避免某些奇怪的周期倾向布局布线来实现的。

32. 发明授权

US08192741B2 Method of treating rheumatoid arthritis with an anti-IL-6R antibody 有权
标题翻译：用抗IL-6R抗体治疗类风湿性关节炎的方法
公开(公告)号：US08192741B2
公开(公告)日：2012-06-05
申请号：US13286261
申请日：2011-11-01
申请人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , A61K31/4706 , A61K31/519 , A61K31/655 , A61K38/191 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S514/885 , A61K2300/00
摘要： The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
摘要翻译：本发明提供使用特异性结合人白细胞介素-6受体（hIL-6R）的完全人抗体或其抗原结合片段预防或治疗类风湿性关节炎的方法。本发明的方法可以包括施用第二治疗剂，例如非甾体抗炎药（NSAID），糖皮质激素，疾病缓解性抗风湿药（DMARD）中的一种或多种，或 TNF-α拮抗剂，T细胞阻断剂，抗CD20抗体，IL-1，JAK或IL-17拮抗剂或其任何组合。

33. 发明申请

US20120128958A1 SILICA AEROGELS AND THEIR PREPARATION 有权
标题翻译：二氧化硅航空及其制备
公开(公告)号：US20120128958A1
公开(公告)日：2012-05-24
申请号：US13206087
申请日：2011-08-09
申请人： Taofang Zeng , Yanjia Zuo , Gang Chen
发明人： Taofang Zeng , Yanjia Zuo , Gang Chen
IPC分类号： C01B33/14
CPC分类号： C01B33/14 , C01B33/1585 , C01P2006/16 , C04B14/064
摘要： Silica aerogels with improved properties are disclosed together with methods for synthesizing such aerogels. The improved properties include lower thermal conductivity (better insulating capacity), lower acoustic velocity, lower dielectric constant and improved ductility. Greater tunability of the refractive index can also be achieved. The silica aerogels are prepared by a sol-gel processing method that provides better control of the formation of aerogel structures. Generally speaking, the improvements arise from control of the synthesis to create a morphology of primary clusters and diverse-sized secondary clusters of dense silica aerogels separated by less densely packed regions. By providing a broader range of secondary clusters and/or pore sizes and loose connectivity between clusters, reductions can be achieved in thermal conductivity and flexural modulus.
摘要翻译：公开了具有改进性能的二氧化硅气凝胶以及合成这种气凝胶的方法。改进的性能包括较低的热导率（更好的绝缘能力），更低的声速，更低的介电常数和更好的延展性。也可以实现更高的折射率的可调性。二氧化硅气凝胶通过溶胶 - 凝胶加工方法制备，可以更好地控制气凝胶结构的形成。一般来说，改进是由合成的控制产生的，以形成一个初级团簇的形态和由密度较小的区域分开的致密二氧化硅气凝胶的不同大小的二级团簇。通过提供更广泛的次级簇和/或孔径和簇之间的松散连通性，可以在热导率和挠曲模量方面实现降低。

34. 发明授权

US08099416B2 Generalized language independent index storage system and searching method 有权
标题翻译：广义语言独立索引存储系统和搜索方法
公开(公告)号：US08099416B2
公开(公告)日：2012-01-17
申请号：US12107943
申请日：2008-04-23
申请人： Weigen Qiu , Gang Chen , ShiQiang Wei
发明人： Weigen Qiu , Gang Chen , ShiQiang Wei
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/3064
摘要： The invention may be embodied as a system having and/or a method utilizing a searchable database of index information. Each index in the database may have (a) at least one descriptor, which matches an entry that a user might provide in order to identify an item, (b) a first pointer which identifies a location of the item, and (c) a second pointer which identifies a location of information that may be helpful to the user in deciding whether to request retrieval of the item. The first pointers of one index may be the same as first pointers in a different index. The second pointer may identify a general class to which an item belongs.
摘要翻译：本发明可以体现为具有使用索引信息的可搜索数据库的方法和/或方法。数据库中的每个索引可以具有（a）与用户可能提供的用于识别项目的条目匹配的至少一个描述符，（b）识别该项目的位置的第一指针，以及（c）第二指针，其标识可能有助于用户决定是否请求检索项目的信息的位置。一个索引的第一个指针可以与不同索引中的第一个指针相同。第二个指针可以标识项目所属的一般类。

35. 发明申请

US20120003697A1 HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR 有权
标题翻译：人类IL-6受体的高亲和力抗体
公开(公告)号：US20120003697A1
公开(公告)日：2012-01-05
申请号：US13230081
申请日：2011-09-12
申请人： Sean STEVENS , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Sean STEVENS , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： C12P21/00 , C12N1/21 , C12N5/10 , C07H21/00 , C12N15/63
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
摘要翻译：提供了以约500pM以下的KD结合人IL-6受体（hIL-6R）的人抗体或抗原结合片段，并且以200pM以下的IC 50阻断IL-6活性。在优选的实施方案中，抗体抗体或抗原结合片段以相对于其结合猴IL-6R至少高2倍的亲和力结合hIL-6R。

36. 发明申请

US20110290882A1 QR CODE DETECTION 审中-公开
标题翻译： QR码检测
公开(公告)号：US20110290882A1
公开(公告)日：2011-12-01
申请号：US12790125
申请日：2010-05-28
申请人： Zhiwei Gu , Matthew R. Scott , Gang Chen , Jonathan Y. Tien
发明人： Zhiwei Gu , Matthew R. Scott , Gang Chen , Jonathan Y. Tien
IPC分类号： G06K7/10
CPC分类号： G06K7/1456
摘要： One or more techniques and/or systems are disclosed for detecting a quick response (QR) code. An area of an image comprising a QR code is localized by combining pixel dynamic scale (DS), black-cell ratio (BR), and edge intensity sum (EIS) criteria determination to identify the QR code. A pattern for the QR code is detected, comprising determining if a position detection pattern (PDP) is located in respective grid areas of a first grid that comprises the QR code, and identifying an alignment pattern (AP), if present. To identify the AP, an AP region is estimated using the PDPs, and a center area of the AP is found by examining respective areas of a second grid comprising the estimated AP region.
摘要翻译：公开了用于检测快速响应（QR）代码的一个或多个技术和/或系统。包括QR码的图像的区域通过组合像素动态尺度（DS），黑色单元比（BR）和边缘强度和（EIS）标准确定来识别QR码来定位。检测QR码的图案，包括确定位置检测图案（PDP）是否位于包括QR码的第一格栅的相应网格区域中，以及如果存在则识别对准图案（AP）。为了识别AP，使用PDP估计AP区域，并且通过检查包括估计的AP区域的第二网格的相应区域来找到AP的中心区域。

37. 发明授权

US07987442B2 Fault dictionaries for integrated circuit yield and quality analysis methods and systems 有权
标题翻译：集成电路产品和质量分析方法和系统的故障字典
公开(公告)号：US07987442B2
公开(公告)日：2011-07-26
申请号：US11221394
申请日：2005-09-06
申请人： Janusz Rajski , Gang Chen , Martin Keim , Nagesh Tamarapalli , Manish Sharma , Huaxing Tang
发明人： Janusz Rajski , Gang Chen , Martin Keim , Nagesh Tamarapalli , Manish Sharma , Huaxing Tang
IPC分类号： G06F17/50 , G06F9/455 , G06F11/00
CPC分类号： G06F11/2273 , G01R31/01 , G01R31/2846 , G01R31/2853 , G01R31/2894 , G01R31/31704 , G01R31/31835
摘要： Methods, apparatus, and systems for testing, analyzing, and improving integrated circuit yield and quality are disclosed herein. For example, in one exemplary embodiment, one or more fault dictionaries are generated for identifying one or more defect candidates from corresponding observation point combinations. In this exemplary method, the observation point combinations indicate the observation points of a circuit-under-test that captured faulty test values upon application of a respective test pattern. Further, the one or more fault dictionaries in one embodiment are generated by: (a) for a first defect candidate, storing one or more first indicators indicative of test patterns detecting the first defect candidate, and (b) for a second defect candidate, storing at least a second indicator indicative of the test patterns that detect the second defect candidate, the second indicator comprising a bit mask that indicates which of the test patterns detecting the first defect candidate also detect the second defect candidate.
摘要翻译：本文公开了用于测试，分析和提高集成电路产量和质量的方法，装置和系统。例如，在一个示例性实施例中，生成用于从相应的观察点组合识别一个或多个缺陷候选的一个或多个故障字典。在该示例性方法中，观察点组合表示在应用相应测试图案时捕获故障测试值的被测电路的观察点。此外，一个实施例中的一个或多个故障字典通过以下方式产生：（a）对于第一缺陷候选，存储指示检测第一缺陷候选的测试图案的一个或多个第一指示符，以及（b）对于第二缺陷候选，存储指示检测第二缺陷候选的测试图案的至少第二指示符，第二指示符包括指示检测第一缺陷候选的哪个测试图案还检测第二缺陷候选的位掩码。

38. 发明申请

US20110140033A1 GRAPHITE MICROFLUIDS 有权
标题翻译：石墨微流控
公开(公告)号：US20110140033A1
公开(公告)日：2011-06-16
申请号：US12638135
申请日：2009-12-15
申请人： Gang Chen , Ruiting Zheng , Jinwei Gao
发明人： Gang Chen , Ruiting Zheng , Jinwei Gao
IPC分类号： C09K5/00
CPC分类号： C09K5/10 , C01B32/20 , Y10S977/778 , Y10S977/779 , Y10S977/783 , Y10S977/784 , Y10S977/786 , Y10S977/788
摘要： Fluids comprising graphite particles and related methods are generally described. In some embodiments, “microfluids” are described. Generally, the microfluids can comprise a fluid and a plurality of graphite particles with microscale dimensions.
摘要翻译：通常描述包含石墨颗粒的流体和相关方法。在一些实施方案中，描述了“微流体”。通常，微流体可以包含流体和具有微尺寸的多个石墨颗粒。

39. 发明授权

US07943121B2 IL-1β binding antibodies and fragments thereof 有权
标题翻译： IL-1和bgr 结合抗体及其片段
公开(公告)号：US07943121B2
公开(公告)日：2011-05-17
申请号：US12464381
申请日：2009-05-12
申请人： Linda Masat , Mary Haak-Frendscho , Arnold H. Horwitz , Gang Chen , Marina Roell
发明人： Linda Masat , Mary Haak-Frendscho , Arnold H. Horwitz , Gang Chen , Marina Roell
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/245 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92 , Y10S514/885
摘要： An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1β binding polypeptide. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.
摘要翻译： IL-1和bgr 结合抗体或IL-1和bgr; 包含SEQ ID NO：2的氨基酸序列的结合片段，以及相关的核酸，载体，细胞和组合物，以及其用于治疗或预防疾病的方法，以及制备亲和力成熟的IL的方法 -1＆bgr 结合多肽。 IL-1和bgr 结合抗体或IL-1和bgr; 提供其结合片段，其具有期望的亲和力和效力。

40. 发明申请

US20110055033A1 PAYMENT WORKFLOW EXTENSIBILITY FOR POINT-OF-SALE APPLICATIONS 有权
标题翻译：支付点销售应用的支付工作流程可扩展性
公开(公告)号：US20110055033A1
公开(公告)日：2011-03-03
申请号：US12548435
申请日：2009-08-27
申请人： Gang Chen , Balaji Balasubramanian , Dmitry V. Belikov , Himanshu Lal
发明人： Gang Chen , Balaji Balasubramanian , Dmitry V. Belikov , Himanshu Lal
IPC分类号： G06Q20/00
CPC分类号： G06Q20/40 , G06Q20/20 , G06Q20/206 , G07G1/14
摘要： Architecture that employs a software development kit and an add-in model to collect payment data and communicate with payment processors in a point-of-sale (POS) application to meet new requirements in new markets. Data gathered from an add-in and from the POS application can be combined and then communicated to the payment processor. The payment method can be determined and payment processing routed to different payment processors based on data and schema of data collected is also described. An add-in can also programmatically obtain information from the POS application information about a transaction and authorize a payment. A payment collecting/processing API is the interface between the POS application tender logic and payment collecting/processing logic and defines how a payment collecting/processing add-in interacts with the POS application.
摘要翻译：架构采用软件开发工具包和附加模型来收集支付数据并与销售点（POS）应用程序中的支付处理器进行通信，以满足新市场的新需求。从加载项和POS应用程序收集的数据可以组合，然后传送到支付处理器。还描述了支付方法，并且还描述了基于收集的数据和模式的支付处理路由到不同支付处理器。加载项还可以以编程方式从POS应用程序获取关于交易的信息并授权付款。付款收集/处理API是POS应用程序招标逻辑和支付收集/处理逻辑之间的接口，并定义了付款收集/处理加载项如何与POS应用程序交互。

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