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31. 发明授权

US06363277B1 Cardiac rhythm management system with differential sensing channel 有权
标题翻译：具有差分感应通道的心律管理系统
公开(公告)号：US06363277B1
公开(公告)日：2002-03-26
申请号：US09378403
申请日：1999-08-20
申请人： Michael W. Dooley , Ronald Balczewski , William J. Linder
发明人： Michael W. Dooley , Ronald Balczewski , William J. Linder
IPC分类号： A61N136
CPC分类号： H03M1/0682 , A61N1/3704 , H03M1/46
摘要： A differential discrete-time signal processing channel differentially processes cardiac signals in an implantable cardiac rhythm management device. Such signal processing effectively uses downsampling to uses lower bias currents, thereby saving power and prolonging the life of the implanted device, and also reduces clock feedthrough, provides a wider dynamic range and better rejection of power supply noise. The device includes a continuous-time buffer, a decimator/averager and/or other filter and/or amplifier circuits, and an analog-to-digital converter, each configured for processing differential signals. The device also includes an operational transconductance amplifier (OTA), for the discrete-time differential signal processing. The OTA provides, among other things, an output common mode adjustment circuit and an offset compensation circuit.
摘要翻译：差分离散时间信号处理通道差异地处理可植入心律管理装置中的心脏信号。这种信号处理有效地使用下采样来使用较低的偏置电流，从而节省功率并延长植入器件的寿命，并且还减少时钟馈通，提供更宽的动态范围和更好地抑制电源噪声。该装置包括连续时间缓冲器，抽取器/平均器和/或其他滤波器和/或放大器电路以及模数转换器，每个被配置用于处理差分信号。器件还包括用于离散时间差分信号处理的运算跨导放大器（OTA）。 OTA除其他外还提供输出共模调整电路和偏移补偿电路。

32. 发明授权

US6151524A Apparatus and method for treating ventricular tachyarrhythmias 有权
公开(公告)号：US6151524A
公开(公告)日：2000-11-21
申请号：US376245
申请日：1999-08-18
申请人： David B. Krig , James O. Gilkerson , Robert D. Dreher , Jan D. Wald , William J. Linder , William L. Zimmer
发明人： David B. Krig , James O. Gilkerson , Robert D. Dreher , Jan D. Wald , William J. Linder , William L. Zimmer
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3962 , A61N1/395
摘要： A system and method for selectively treating a ventricular tachycardia based on sensed atrial and ventricular intervals from the patient's heart. A detection window of the ten most recent atrial and ventricular intervals are analyzed for the occurrence of either tachycardia or fibrillation. When a majority of the sensed intervals are satisfied, the apparatus starts a duration time interval. Ventricular intervals and atrial intervals are compare, ventricular interval greater than the atrial interval by a bias factor the system delivers tachycardia therapy to the heart. Alternatively, the method withholds tachycardia therapy to the heart when the atrial rate is classified as atrial fibrillation and the ventricular response is unstable.

33. 发明授权

US5690683A After potential removal in cardiac rhythm management device 失效
标题翻译：心脏节律管理装置中潜在去除后
公开(公告)号：US5690683A
公开(公告)日：1997-11-25
申请号：US492199
申请日：1995-06-19
申请人： Paul A. Haefner , Mark A. Stockburger , William J. Linder
发明人： Paul A. Haefner , Mark A. Stockburger , William J. Linder
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/3704 , Y10S128/901
摘要： An apparatus effectively removes after potential occurring after a electrical pulse is delivered in a cardiac rhythm management system such as a pacemaker system or cardioverter/defibrillator system having an electrode used for both sensing electrical activity of the heart and carrying the electrical pulse to the heart and a sense amplifier for detecting the electrical activity from the electrode. The apparatus includes a lowpass filter coupled to the electrode to filter the sensed electrical activity. A highpass filter is coupled between the lowpass filter and the sense amplifier to further filter the electrical activity passed from the lowpass filter. Equilibrium circuitry is included to allow passive filter components of the lowpass filter and the highpass filter to return to an equilibrium state following delivery of the electrical pulse.
摘要翻译：一种装置在电脉冲在诸如起搏器系统或心脏转复器/除颤器系统的心律管理系统中传递之后有效地消除，所述心脏起搏器系统或心脏转复器/除颤器系统具有用于感测心脏的电活动并将心电的脉搏传送到心脏的电极，用于检测来自电极的电活动的读出放大器。该装置包括耦合到电极的低通滤波器以滤波感测的电活动。低通滤波器耦合在低通滤波器和读出放大器之间，以进一步滤除从低通滤波器传递的电活动。包括平衡电路，以允许低通滤波器的无源滤波器组件和高通滤波器在电脉冲传递后恢复平衡状态。

34. 发明授权

US4728931A Charge redistribution capacitance detection apparatus 失效
标题翻译：电荷再分配电容检测装置
公开(公告)号：US4728931A
公开(公告)日：1988-03-01
申请号：US890215
申请日：1986-07-25
申请人： William J. Linder , James D. Reinke
发明人： William J. Linder , James D. Reinke
IPC分类号： G01R27/26 , H03K5/24 , H03K17/96 , G06F3/02
CPC分类号： H03K17/9622 , G01R27/2605 , H03K5/249 , H03K2017/9613 , Y10T307/766
摘要： A charge redistribution capacitance detector is disclosed for detecting whether the capacitance of a variable capacitor is smaller or larger than that of a reference capacitor. First plates of the variable and reference capacitors are connected to a sense node, and a switching device responsive to a clock signal periodically impresses a reference voltage on the sense node during one phase of the clock signal and allows the sense node to electrically float during the alternate phase of the clock signal. Second plates of the sense and reference capacitors are alternately charged and discharged by equal voltage differences in opposite senses during successive clock phases. The voltage on the first plates of the capacitors changes in a sense dependent on the relative capacitance values of the capacitors and is compared with the reference voltage by a comparator which produces a corresponding detector output.
摘要翻译：公开了一种用于检测可变电容器的电容是否小于或大于参考电容器的电荷再分配电容检测器。可变参考电容器的第一板连接到感测节点，并且响应于时钟信号的开关装置在时钟信号的一个相位期间周期性地在感测节点上施加参考电压，并允许感测节点在时钟信号的交替相位。感测和参考电容器的第二板在连续的时钟相位期间以相反的感测相等的电压差交替地充电和放电。电容器的第一板上的电压在某种意义上根据电容器的相对电容值而改变，并且通过产生相应检测器输出的比较器与参考电压进行比较。

35. 发明授权

US4503340A CMOS Window detector with hysteresis 失效
标题翻译：具有滞后的CMOS窗口检测器
公开(公告)号：US4503340A
公开(公告)日：1985-03-05
申请号：US418512
申请日：1982-09-16
申请人： William J. Linder
发明人： William J. Linder
IPC分类号： H03K3/3565 , H03K5/153
CPC分类号： H03K3/3565
摘要： A CMOS window detector provides an output signal which indicates the relationship of an input signal to a voltage "window" as a function of the previous output signal. The window detector includes first and second current source circuits and first and second inverter circuits. A bias current is established in each current source circuit as a function of a different reference voltage. The first and second inverter circuits each include a current mirror field effect transistor (FET) and a current control FET connected in a series current path. The current mirror FET of each inverter circuit is connected to its respective current source circuit and establishes a current in the inverter current path equal in magnitude to its respective bias current. The input signal is applied to the gates of the current control FETs. Each current control FET changes conductivity state when the input signal reaches the reference voltage level used to establish the respective inverter current flow. Each reference voltage therefore represents a window voltage level. The difference in window voltage levels defines the voltage window. An output circuit formed by a CMOS NAND-latch is connected to the first and second inverter circuits and provides the output signal which exhibits hysteresis with respect to the input signal.
摘要翻译： CMOS窗口检测器提供输出信号，其指示输入信号与作为先前输出信号的函数的电压“窗口”的关系。窗口检测器包括第一和第二电流源电路以及第一和第二反相器电路。在每个电流源电路中建立偏置电流作为不同参考电压的函数。第一和第二逆变器电路各自包括电流镜效应晶体管（FET）和连接在串联电流路径中的电流控制FET。每个逆变器电路的电流反射镜FET连接到其各自的电流源电路，并且在逆变器电流路径中建立与其相应的偏置电流大小相等的电流。输入信号被施加到电流控制FET的栅极。当输入信号达到用于建立相应逆变器电流的基准电压电平时，每个电流控制FET改变导电状态。因此，每个参考电压表示窗口电压电平。窗口电压电平的差异定义了电压窗口。由CMOS NAND锁存器形成的输出电路连接到第一和第二反相器电路，并提供相对于输入信号呈现迟滞的输出信号。

36. 发明授权

US08755886B2 Implantable device with bias for MRI 有权
标题翻译：具有偏心MRI的植入式装置
公开(公告)号：US08755886B2
公开(公告)日：2014-06-17
申请号：US12976862
申请日：2010-12-22
申请人： Nicholas J. Stessman , Michael J. Lyden , Thomas M. Bocek , William J. Linder , Joseph M. Bocek
发明人： Nicholas J. Stessman , Michael J. Lyden , Thomas M. Bocek , William J. Linder , Joseph M. Bocek
IPC分类号： A61N1/00 , A61B5/05
CPC分类号： A61N1/08 , A61N1/086 , A61N1/37 , A61N1/3718
摘要： An ambulatory or implantable device, such as a pacer, defibrillator, or other cardiac rhythm management device, can tolerate magnetic resonance imaging (MRI) or other noise without turning on an integrated circuit diode by selectively providing a bias voltage that can overcome an expected induced voltage resulting from the MRI or other noise.
摘要翻译：诸如起搏器，除颤器或其他心律管理装置的移动或可植入装置可以容忍磁共振成像（MRI）或其他噪声，而不通过选择性地提供可以克服预期诱导的偏置电压而导通集成电路二极管由MRI或其他噪音引起的电压。

37. 发明申请

US20130245718A1 SYSTEMS AND METHODS FOR MONITORING NEUROSTIMULATION DOSING 有权
标题翻译：用于监测神经调节剂量的系统和方法
公开(公告)号：US20130245718A1
公开(公告)日：2013-09-19
申请号：US13780903
申请日：2013-02-28
申请人： Doug M. Birkholz , Douglas J. Brandner , Douglas J. Gifford , David J. Ternes , William J. Linder
发明人： Doug M. Birkholz , Douglas J. Brandner , Douglas J. Gifford , David J. Ternes , William J. Linder
IPC分类号： A61N1/36
CPC分类号： A61N1/3727 , A61N1/3605 , A61N1/36082 , A61N1/36125 , A61N1/36142 , A61N1/36178 , A61N1/378
摘要： Various implantable device embodiments may comprise a neural stimulator configured to deliver a neurostimulation therapy with stimulation ON times and stimulation OFF times where a dose of the neurostimulation therapy is provided by a number of neurostimulation pulses over a period of time. The neural stimulator may be configured to monitor the dose of the delivered neurostimulation therapy against dosing parameters. The neural stimulator may be configured to declare a fault if the monitored dose does not favorably compare to a desired dose for the neurostimulation therapy, or may be configured to record data for the monitored dose of the delivered neurostimulation therapy, or may be configured to both record data for the monitored dose of the delivered neurostimulation therapy and declare a fault if the monitored dose does not favorably compare to a desired dose for the neurostimulation therapy.
摘要翻译：各种可植入装置实施例可以包括神经刺激器，所述神经刺激器被配置为在刺激ON次数和刺激OFF时间递送神经刺激疗法，其中神经刺激疗法的剂量在一段时间内由许多神经刺激脉冲提供。神经刺激器可以被配置为监测所输送的神经刺激疗法针对给药参数的剂量。如果所监测的剂量与用于神经刺激疗法的期望剂量不利地比较，则神经刺激器可以被配置为宣告故障，或者可被配置为记录所输送的神经刺激疗法的监测剂量的数据，或者可以被配置为两者记录所输送的神经刺激疗法的监测剂量的数据，并且如果所监测的剂量与用于神经刺激疗法的期望剂量不利地相比较，则声明故障。

38. 发明授权

US08509910B2 Telemetry during safety mode operation 有权
标题翻译：安全模式运行时的遥测
公开(公告)号：US08509910B2
公开(公告)日：2013-08-13
申请号：US12328454
申请日：2008-12-04
申请人： Conrad L. Sowder , Thomas J. Harris , Douglas J. Gifford , William J. Linder , Hiten J. Doshi , Scott R. Stubbs , Kenneth P. Hoyme
发明人： Conrad L. Sowder , Thomas J. Harris , Douglas J. Gifford , William J. Linder , Hiten J. Doshi , Scott R. Stubbs , Kenneth P. Hoyme
IPC分类号： A61N1/02
CPC分类号： A61N1/37252
摘要： This document discusses, among other things, an implantable device comprising a communication circuit configured to communicate with an external device, a logic circuit communicatively coupled to the communication circuit, and a processor, communicatively coupled to the logic circuit and the communication circuit. The processor is configured to communicate information with the external device, via the communication circuit and the logic circuit, using a set of communication messages. While in a device safety mode, the processor is held in an inactive state and the logic circuit is configured to communicate with the external device using a subset of the set of communication messages.
摘要翻译：本文件尤其涉及一种可植入装置，其包括被配置为与外部装置通信的通信电路，通信地耦合到通信电路的逻辑电路，以及通信地耦合到逻辑电路和通信电路的处理器。处理器被配置为使用一组通信消息通过通信电路和逻辑电路与外部设备通信信息。在处于设备安全模式时，处理器处于非活动状态，并且逻辑电路被配置为使用该组通信消息的子集与外部设备进行通信。

39. 发明授权

US08504149B2 System and method to deliver therapy in presence of another therapy 有权
公开(公告)号：US08504149B2
公开(公告)日：2013-08-06
申请号：US13397115
申请日：2012-02-15
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/05
CPC分类号： A61N1/37 , A61N1/36114 , A61N1/36125 , A61N1/362 , A61N1/36514 , A61N1/36564 , A61N1/36592 , A61N1/3987
摘要： Various aspects relate to a method. In various embodiments, a therapy of a first therapy type is delivered, and it is identified whether a therapy of a second therapy type is present to affect the therapy of the first therapy type. Delivery of the therapy is controlled based on the presence of the therapy of the second therapy type. Some embodiments deliver the therapy of the first type using one set of parameters in the presence of a therapy of a second type, and deliver the therapy of the first type using another set of parameters when the therapy of the second type is not present. In various embodiments, one of the therapy types includes a cardiac rhythm management therapy, and the other includes a neural stimulation therapy. Other aspects and embodiments are provided herein.

40. 发明授权

US08473049B2 Implantable neural stimulator with mode switching 有权
标题翻译：具有模式切换的植入型神经刺激器
公开(公告)号：US08473049B2
公开(公告)日：2013-06-25
申请号：US11137038
申请日：2005-05-25
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/00
CPC分类号： A61N1/36128 , A61M5/1723 , A61N1/3605 , A61N1/36053 , A61N1/36114 , A61N1/36135 , A61N1/3688
摘要： Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面涉及可植入装置。各种装置实施例包括至少一个端口，以连接至少一个引线，至少电极，刺激电路连接到至少一个端口，并且适于使用至少一个至少一个端口向至少一个神经刺激目标提供至少一个神经刺激治疗一个电极，连接到所述至少一个端口并适于提供感测信号的感测电路，以及连接到所述刺激电路以提供所述至少一个神经刺激治疗的控制器，以及所述感测电路以接收感测到的信号。响应于触发事件，控制器适于在至少两种模式之间切换。本文提供了其它方面和实施例。

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