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1. 发明授权

US06363277B1 Cardiac rhythm management system with differential sensing channel 有权
标题翻译：具有差分感应通道的心律管理系统
公开(公告)号：US06363277B1
公开(公告)日：2002-03-26
申请号：US09378403
申请日：1999-08-20
申请人： Michael W. Dooley , Ronald Balczewski , William J. Linder
发明人： Michael W. Dooley , Ronald Balczewski , William J. Linder
IPC分类号： A61N136
CPC分类号： H03M1/0682 , A61N1/3704 , H03M1/46
摘要： A differential discrete-time signal processing channel differentially processes cardiac signals in an implantable cardiac rhythm management device. Such signal processing effectively uses downsampling to uses lower bias currents, thereby saving power and prolonging the life of the implanted device, and also reduces clock feedthrough, provides a wider dynamic range and better rejection of power supply noise. The device includes a continuous-time buffer, a decimator/averager and/or other filter and/or amplifier circuits, and an analog-to-digital converter, each configured for processing differential signals. The device also includes an operational transconductance amplifier (OTA), for the discrete-time differential signal processing. The OTA provides, among other things, an output common mode adjustment circuit and an offset compensation circuit.
摘要翻译：差分离散时间信号处理通道差异地处理可植入心律管理装置中的心脏信号。这种信号处理有效地使用下采样来使用较低的偏置电流，从而节省功率并延长植入器件的寿命，并且还减少时钟馈通，提供更宽的动态范围和更好地抑制电源噪声。该装置包括连续时间缓冲器，抽取器/平均器和/或其他滤波器和/或放大器电路以及模数转换器，每个被配置用于处理差分信号。器件还包括用于离散时间差分信号处理的运算跨导放大器（OTA）。 OTA除其他外还提供输出共模调整电路和偏移补偿电路。

2. 发明授权

US06531907B2 Amplifier with common mode and offset correction 有权
标题翻译：具有共模和偏移校正的放大器
公开(公告)号：US06531907B2
公开(公告)日：2003-03-11
申请号：US09764557
申请日：2001-01-17
申请人： Michael W. Dooley , Ronald Balczewski , William J. Linder
发明人： Michael W. Dooley , Ronald Balczewski , William J. Linder
IPC分类号： H03L500
CPC分类号： H03M1/0682 , A61N1/3704 , H03M1/46
摘要： A differential discrete-time signal processing channel differentially processes cardiac signals in an implantable cardiac rhythm management device. Such signal processing effectively uses downsampling to uses lower bias currents, thereby saving power and prolonging the life of the implanted device, and also reduces clock feedthrough, provides a wider dynamic range and better rejection of power supply noise. The device includes a continuous-time buffer, a decimator/averager and/or other filter and/or amplifier circuits, and an analog-to-digital converter, each configured for processing differential signals. The device also includes an operational transconductance amplifier (OTA), for the discrete-time differential signal processing. The OTA provides, among other things, an output common mode adjustment circuit and an offset compensation circuit.
摘要翻译：差分离散时间信号处理通道差异地处理可植入心律管理装置中的心脏信号。这种信号处理有效地使用下采样来使用较低的偏置电流，从而节省功率并延长植入器件的寿命，并且还减少时钟馈通，提供更宽的动态范围和更好地抑制电源噪声。该装置包括连续时间缓冲器，抽取器/平均器和/或其他滤波器和/或放大器电路以及模数转换器，每个被配置用于处理差分信号。器件还包括用于离散时间差分信号处理的运算跨导放大器（OTA）。 OTA除其他外还提供输出共模调整电路和偏移补偿电路。

3. 发明授权

US5959371A Power management system for an implantable device 有权
公开(公告)号：US5959371A
公开(公告)日：1999-09-28
申请号：US190971
申请日：1998-11-12
申请人： Michael W. Dooley , Keith R. Maile , William J. Linder
发明人： Michael W. Dooley , Keith R. Maile , William J. Linder
IPC分类号： A61N1/37 , A61N1/378 , A61N1/39 , H01H35/00
CPC分类号： A61N1/378 , A61N1/3708 , A61N1/3937 , A61N1/3975 , A61N1/3981 , Y10T307/826 , Y10T307/839 , Y10T307/858
摘要： A power management system for an implantable device is disclosed. One application is an implantable cardioverter/defibrillator. Charging circuits for implantable cardioverter/defibrillators require relatively large currents from the power supply. The present power management system provides extended device operation and reduced charge cycle time. The present system monitors both current and voltage drawn from the power supply to prevent a loss of system voltage. Elective replacement indication is performed using charging information provided by the present power management system.

4. 发明授权

US06292050B1 Current and temperature compensated voltage reference having improved power supply rejection 有权
标题翻译：电流和温度补偿电压基准具有改进的电源抑制
公开(公告)号：US06292050B1
公开(公告)日：2001-09-18
申请号：US09260206
申请日：1999-03-01
申请人： Michael W. Dooley , Terrence L. Marshall , William J. Linder , Suneel Arora
发明人： Michael W. Dooley , Terrence L. Marshall , William J. Linder , Suneel Arora
IPC分类号： G05F110
CPC分类号： G05F3/245 , A61N1/3706
摘要： A current and temperature compensated voltage reference circuit uses a power supply voltage as low as 1.3 Volts. A folded-cascode amplifier measures the temperature dependent voltages provided by first and second bias circuits, each including two series-coupled diodes or diode-connected bipolar junction transistors (BJTs), and provides a resulting proportional to absolute temperature (PTAT) current through a cascode-protected output transistor. A voltage reference circuit uses a PTAT current through a resistor to create a PTAT voltage in series with a diode-voltage. The resistor value is adjusted until the sum of these voltages is equal to the bandgap voltage of silicon, providing a temperature compensated voltage reference. The reference circuit is suitable for use with an implantable cardiac rhythm management system having a battery that provides a power supply voltage varying approximately between 1.3 Volts and 3.25 Volts. Cascode-protected current mirrors further improve rejection of such variations in the power supply voltage.
摘要翻译：电流和温度补偿电压参考电路使用低至1.3伏的电源电压。折叠共源共栅放大器测量由第一和第二偏置电路提供的与温度相关的电压，每个电压包括两个串联耦合的二极管或二极管连接的双极结型晶体管（BJT），并提供与绝对温度（PTAT）电流成比例的结果共源共栅保护的输出晶体管。电压参考电路使用通过电阻器的PTAT电流来产生与二极管电压串联的PTAT电压。调整电阻值，直到这些电压之和等于硅的带隙电压，提供温度补偿电压基准。参考电路适用于具有电池的可植入心律管理系统，该电池提供约1.3伏至3.25伏变化的电源电压。串联保护的电流镜进一步改善了对电源电压的这种变化的抑制。

5. 发明授权

US5869970A Power management system for an implantable device 失效
公开(公告)号：US5869970A
公开(公告)日：1999-02-09
申请号：US550835
申请日：1995-10-31
申请人： William A. Palm , Lloyd A. Van Hofwegen , Jean-Cheui Hsung , Michael W. Dooley , Keith R. Maile , William J. Linder , David W. Kelly , Jeffrey Laackmann , Richard J. Wessels
发明人： William A. Palm , Lloyd A. Van Hofwegen , Jean-Cheui Hsung , Michael W. Dooley , Keith R. Maile , William J. Linder , David W. Kelly , Jeffrey Laackmann , Richard J. Wessels
IPC分类号： A61N1/37 , A61N1/378 , A61N1/39
CPC分类号： A61N1/378 , A61N1/3708 , A61N1/3937 , A61N1/3975 , A61N1/3981 , Y10T307/826 , Y10T307/839 , Y10T307/858
摘要： A power management system for an implantable device is disclosed. One application is an implantable cardioverter/defibrillator. Charging circuits for implantable cardioverter/defibrillators require relatively large currents from the power supply. The present power management system provides extended device operation and reduced charge cycle time. The present system monitors both current and voltage drawn from the power supply to prevent a loss of system voltage. Elective replacement indication is performed using charging information provided by the present power management system.

6. 发明授权

US08718771B2 Dynamic battery management in an implantable device 有权
标题翻译：植入式设备中的动态电池管理
公开(公告)号：US08718771B2
公开(公告)日：2014-05-06
申请号：US13287824
申请日：2011-11-02
申请人： Rajesh K. Gandhi , William J. Linder , Michael J. Lyden , Nicholas J. Stessman , Jonathan H. Kelly , James Kalgren
发明人： Rajesh K. Gandhi , William J. Linder , Michael J. Lyden , Nicholas J. Stessman , Jonathan H. Kelly , James Kalgren
IPC分类号： A61N1/00 , H02J7/04
CPC分类号： A61N1/378 , A61N1/3627 , A61N1/3708 , A61N1/3975
摘要： One aspect of this disclosure relates to a system for dynamic battery management in implantable medical devices. An embodiment of the system includes two or more devices for measuring battery capacity for an implantable medical device battery. The embodiment also includes a controller connected to the measuring devices. The controller is adapted to combine the measurements from the measuring devices using a weighted average to determine battery capacity consumed. According to various embodiments, at least one of the measuring devices includes a coulometer. At least one of the measuring devices includes a capacity-by-voltage device, according to an embodiment. The system further includes a display in communication with the controller in various embodiments. The display is adapted to provide a depiction of battery longevity in units of time remaining in the life of the implantable medical device battery, according to various embodiments. Other aspects and embodiments are provided herein.
摘要翻译：本公开的一个方面涉及用于可植入医疗装置中的动态电池管理的系统。该系统的实施例包括用于测量可植入医疗装置电池的电池容量的两个或更多个装置。该实施例还包括连接到测量装置的控制器。控制器适于使用加权平均值来组合来自测量装置的测量值，以确定消耗的电池容量。根据各种实施例，测量装置中的至少一个包括电量计。根据实施例，至少一个测量装置包括逐个电容装置。该系统还包括在各种实施例中与控制器通信的显示器。根据各种实施例，该显示器适于以可植入医疗装置电池的寿命中剩余的时间单位提供电池寿命的描绘。本文提供了其它方面和实施例。

7. 发明授权

US08428713B2 Implantable defibrillation output circuit 有权
标题翻译：可植入除颤输出电路
公开(公告)号：US08428713B2
公开(公告)日：2013-04-23
申请号：US13041970
申请日：2011-03-07
申请人： Keith R. Maile , William J. Linder
发明人： Keith R. Maile , William J. Linder
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3912
摘要： An implantable defibrillation circuit can include an output circuit. The output circuit can include a first switch configured to controllably connect a first supply node to a first output node, a second switch configured to controllably connect a second supply node to the first output node through a first rectifier, and the second switch can be configured to inhibit the first switch from connecting the first supply node to the first output node when the second supply node is connected to the first output node through the second switch. In an example, the first and second switches can include insulated gate bipolar transistors.
摘要翻译：可植入除颤电路可以包括输出电路。输出电路可以包括被配置为将第一供应节点可控地连接到第一输出节点的第一开关，被配置为通过第一整流器可控地将第二供电节点连接到第一输出节点的第二开关，并且第二开关可被配置当所述第二供应节点通过所述第二开关连接到所述第一输出节点时，禁止所述第一开关连接所述第一供应节点与所述第一输出节点。在一个示例中，第一和第二开关可以包括绝缘栅双极晶体管。

8. 发明授权

US08391972B2 Safety control system for implantable neural stimulator 有权
公开(公告)号：US08391972B2
公开(公告)日：2013-03-05
申请号：US13282325
申请日：2011-10-26
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/00
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/37
摘要： A neural stimulation system includes a safety control system that prevents delivery of neural stimulation pulses from causing potentially harmful effects. The neural stimulation pulses are delivered to one or more nerves to control the physiological functions regulated by the one or more nerves. Examples of such harmful effects include unintended effects in physiological functions associated with autonomic neural stimulation and nerve injuries caused by excessive delivery of the neural stimulation pulses.

9. 发明授权

US08364261B2 Cardiac pacemaker with pacing rate monitoring 有权
标题翻译：心脏起搏器，起搏速率监测
公开(公告)号：US08364261B2
公开(公告)日：2013-01-29
申请号：US12916881
申请日：2010-11-01
申请人： Scott Stubbs , Conrad L. Sowder , William J. Linder , Lynn S. Elliott , Kenneth P. Hoyme , Hiten J. Doshi
发明人： Scott Stubbs , Conrad L. Sowder , William J. Linder , Lynn S. Elliott , Kenneth P. Hoyme , Hiten J. Doshi
IPC分类号： A61N1/362
CPC分类号： A61N1/3706 , A61N1/3931
摘要： A pacing monitoring system is described for incorporation in an implantable pacemaker that monitors the pacing rate and/or cumulative pace count in order to protect a patient from excessive pacing. The system includes monitoring circuitry that is configured to operate in multiple monitoring zones, where each zone is adapted to prevent excessively high-rate pacing during a particular mode of device operation.
摘要翻译：描述了一种起搏监测系统，用于结合在可植入起搏器中，监测起搏速率和/或累积步速计数，以保护患者免受过度起搏。该系统包括被配置为在多个监测区域中操作的监测电路，其中每个区域适于在特定设备操作模式期间防止过高的速率起搏。

10. 发明授权

US08364259B2 High voltage capacitor route with integrated failure point 有权
标题翻译：具有集成故障点的高压电容器路由
公开(公告)号：US08364259B2
公开(公告)日：2013-01-29
申请号：US12952554
申请日：2010-11-23
申请人： William J. Linder , Ron A. Balczewski , Jacob M. Ludwig
发明人： William J. Linder , Ron A. Balczewski , Jacob M. Ludwig
IPC分类号： A61N1/39
CPC分类号： A61N1/3931 , A61N1/3956 , H01H85/0078 , H01H85/0095 , H01H85/046 , H01H85/463
摘要： An implantable medical device may have a circuit failure mode. The disclosed circuit may have an integrated failure point designed to fail prior to those portions of the circuit. The integrated failure point may include a narrowed portion of a high voltage lead and a grounded lead having a narrow gap separating the grounded lead from the narrowed portion of the high voltage lead. During a high stress fault condition the narrowed portion of the high voltage lead acts as a fuse, forming a vaporized cloud of metal, which shorts current in the high voltage lead across the narrow gap to the grounded lead, thus protecting the remaining portion of the circuit from the high stress condition.
摘要翻译：可植入医疗装置可具有电路故障模式。所公开的电路可以具有设计成在电路的那些部分之前故障的集成故障点。集成的故障点可以包括高压引线的窄部分和具有将接地引线与高压引线的变窄部分分开的窄间隙的接地引线。在高应力故障条件下，高压引线的变窄部分作为保险丝，形成蒸发的金属云，将高压引线上的电流短路到窄接地引线上，从而保护电路从高应力状态。

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