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31. 发明授权

US07419999B2 Gamma lactams as prostaglandin agonists and use thereof 失效
标题翻译： γ-内酰胺作为前列腺素激动剂及其用途
公开(公告)号：US07419999B2
公开(公告)日：2008-09-02
申请号：US10517626
申请日：2003-06-09
申请人： Gian Luca Araldi , Adulla P. Reddy , Zhong Zhao , Sean D. McKenna , Bagna Bao
发明人： Gian Luca Araldi , Adulla P. Reddy , Zhong Zhao , Sean D. McKenna , Bagna Bao
IPC分类号： A61K31/4015 , A61K31/5377 , C07D207/27 , C07D413/06
CPC分类号： C07D207/26 , C07D405/06 , C07D409/06
摘要： 1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, or gastric ulcer, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.
摘要翻译：提供了1,2-取代的5-吡咯烷酮化合物，以及使用或包含一种或多种这样的化合物的治疗方法和药物组合物。本发明的化合物可用于多种疗法，包括治疗或预防早产，痛经，哮喘，高血压，不育症或生育障碍，不期望的血液凝固，先兆子痫或子痫，嗜酸性粒细胞紊乱，性功能障碍，骨质疏松症和其他破坏性骨疾病或病症，肾功能障碍，免疫缺陷障碍，干眼症，鱼鳞病，眼内压升高，睡眠障碍或胃溃疡，炎症性疾病和与前列腺素家族化合物相关的其它疾病和病症。

32. 发明授权

US07410991B2 Pyrazolidinone compounds as ligands of the prostaglandin EP2 and/or EP4 receptors 失效
标题翻译：吡唑啉酮化合物作为前列腺素EP2和/或EP4受体的配体
公开(公告)号：US07410991B2
公开(公告)日：2008-08-12
申请号：US10492910
申请日：2002-10-23
申请人： Gian Luca Araldi , Yihua Liao , Adulla P. Reddy , Zhong Zhao
发明人： Gian Luca Araldi , Yihua Liao , Adulla P. Reddy , Zhong Zhao
IPC分类号： A61K31/4152
CPC分类号： A61K31/4152 , C07D231/08
摘要： The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin EP2 and/or EP4 receptors.
摘要翻译：本发明提供取代的吡唑烷酮化合物，以及使用或包含一种或多种这些化合物的治疗方法和药物组合物。本发明的化合物可用于多种疗法，包括治疗或预防早产，痛经，哮喘，高血压，不育症或生育障碍，不期望的血液凝固，先兆子痫或子痫，嗜酸性粒细胞紊乱，性功能障碍，骨质疏松症和其他破坏性骨疾病或病症，以及与前列腺素EP2和/或EP4受体相关的其它疾病和病症。

33. 发明申请

US20050288357A1 Gamma lactams as prostaglandin agonists and use thereof 失效
标题翻译： γ-内酰胺作为前列腺素激动剂及其用途
公开(公告)号：US20050288357A1
公开(公告)日：2005-12-29
申请号：US10517626
申请日：2003-06-09
申请人： Gian Araldi , Adulla Reddy , Zhong Zhao , Sean McKenna , Bagna Bao
发明人： Gian Araldi , Adulla Reddy , Zhong Zhao , Sean McKenna , Bagna Bao
IPC分类号： C07D207/27 , A61K31/4015 , A61K31/558 , A61K31/559 , A61P1/04 , A61P7/00 , A61P7/02 , A61P7/10 , A61P9/12 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/04 , A61P15/06 , A61P15/08 , A61P15/10 , A61P17/12 , A61P19/10 , A61P21/02 , A61P25/20 , A61P27/02 , A61P27/06 , A61P29/00 , A61P37/04 , A61P43/00 , C07D207/12 , C07D207/26 , C07D405/06 , C07D409/06
CPC分类号： C07D207/26 , C07D405/06 , C07D409/06
摘要： 1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, or gastric ulcer, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.
摘要翻译：提供了1,2-取代的5-吡咯烷酮化合物，以及使用或包含一种或多种这样的化合物的治疗方法和药物组合物。本发明的化合物可用于多种疗法，包括治疗或预防早产，痛经，哮喘，高血压，不育症或生育障碍，不期望的血液凝固，先兆子痫或子痫，嗜酸性粒细胞紊乱，性功能障碍，骨质疏松症和其他破坏性骨疾病或病症，肾功能障碍，免疫缺陷障碍，干眼症，鱼鳞病，眼内压升高，睡眠障碍或胃溃疡，炎症性疾病和与前列腺素家族化合物相关的其它疾病和病症。

34. 发明申请

US20050182236A1 Phosphorous-containing compounds with polymeric chains, and methods of making and using the same 失效
标题翻译：含聚合物链的含磷化合物及其制备和使用方法
公开(公告)号：US20050182236A1
公开(公告)日：2005-08-18
申请号：US10505529
申请日：2003-02-25
申请人： Keith Branham , Mahesh Chaubal , James English , Donna Hall , Zhong Zhao
发明人： Keith Branham , Mahesh Chaubal , James English , Donna Hall , Zhong Zhao
IPC分类号： A61K9/00 , A61K31/66 , A61K45/06 , A61K47/02 , A61K47/24 , A61K47/34 , C08G65/335 , C08G79/02 , C08L81/02
CPC分类号： A61K9/0024 , A61K31/66 , A61K45/06 , A61K47/02 , A61K47/24 , A61K47/34 , C08G65/335 , C08G79/02 , C08L81/02 , C08L2203/02 , A61K2300/00
摘要： The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
摘要翻译：本发明涉及具有聚合物链的新型含磷化合物及其制备和使用方法。一部分描述含有含聚合物链的含磷化合物和治疗剂的主题组合物及其制备和使用方法。某些主题组合物显示出反向热凝胶化。

35. 发明申请

US20050176800A1 Pyrrolidine derivatives as prostaglandin modulators 失效
标题翻译：吡咯烷衍生物作为前列腺素调节剂
公开(公告)号：US20050176800A1
公开(公告)日：2005-08-11
申请号：US10499346
申请日：2002-12-19
申请人： Yihua Liao , Zhong Zhao , Gian Araldi
发明人： Yihua Liao , Zhong Zhao , Gian Araldi
IPC分类号： A61K31/559 , A61K45/00 , A61P7/00 , A61P7/02 , A61P9/12 , A61P11/06 , A61P15/06 , A61P15/08 , A61P19/08 , A61P25/08 , A61P27/06 , A61P43/00 , C07D207/10 , C07D207/12 , C07D207/36 , C07D405/12 , A61K31/557 , C07D207/30
CPC分类号： C07D405/12 , C07D207/10 , C07D207/36
摘要： Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.
摘要翻译：提供了取代的吡咯烷化合物，以及使用或包含一种或多种这些化合物的治疗方法和药物组合物。本发明的化合物可用于多种疗法，包括治疗或预防早产，痛经，哮喘，高血压，不育症或生育障碍，不期望的血液凝固，先兆子痫或子痫，嗜酸性粒细胞紊乱，性功能障碍，骨质疏松症和其他破坏性骨疾病或病症，以及与前列腺素家族化合物相关的其它疾病和病症。在优选的方面，将取代的吡咯烷化合物与磷酸二酯酶抑制剂化合物配体施用于受试者。

36. 发明授权

US6028163A Solution polymerization of high molecular weight poly(phosphoesters) in toluene 失效
标题翻译：高分子量聚（磷酸酯）在甲苯中的溶液聚合
公开(公告)号：US6028163A
公开(公告)日：2000-02-22
申请号：US884382
申请日：1997-06-27
申请人： Zhong Zhao
发明人： Zhong Zhao
IPC分类号： C08G79/04 , C08G69/26
CPC分类号： C08G79/04
摘要： A process for making a high molecular weight poly(phosphoester) comprising the recurring monomeric units: ##STR1## wherein X is --O-- or --NR"--, where R" is H or alkyl; L is a divalent organic moiety, with the proviso that L cannot have the formula ##STR2## R' is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic, or heterocycloxy; and n is from about 25 to 2000,is described. The process comprises the steps of:(a) substantially dissolving p moles of a di-XH compound in a solvent comprising more than 75% toluene at a first temperature between about -75.degree. C. and 60.degree. C. to form a reaction mixture;(b) while maintaining the reaction mixture at the first temperature, adding q moles, where p.apprxeq.q, of a phosphorodihalo compound;(c) gradually increasing said first temperature at a rate of less than about 2.degree. C. per minute as necessary to achieve a second temperature between about 0.degree. C. and 110.degree. C., and mixing the reaction mixture at the second temperature to form the polymer of formula I; and(d) isolating the polymer of formula I.
摘要翻译：制备包含重复单体单元的高分子量聚（磷酸酯）的方法：其中X是-O-或-NR“ - ，其中R”是H或烷基; L是二价有机部分，条件是L不能具有式R'是H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; 并且n为约25〜2000。该方法包括以下步骤：（a）在约-75℃至60℃之间的第一温度下，将p摩尔的二-XH化合物基本上溶解在包含大于75％的甲苯的溶剂中以形成反应混合物 ; （b）在将反应混合物保持在第一温度的同时，加入q摩尔，其中p APPROX q为二卤代化合物; （c）根据需要以小于约2℃/分钟的速率逐渐增加所述第一温度以达到约0℃至110℃之间的第二温度，并将反应混合物在第二温度下混合至形成式I的聚合物; 和（d）分离式I的聚合物。

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