专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050288357A1 Gamma lactams as prostaglandin agonists and use thereof 失效
标题翻译： γ-内酰胺作为前列腺素激动剂及其用途
公开(公告)号：US20050288357A1
公开(公告)日：2005-12-29
申请号：US10517626
申请日：2003-06-09
申请人： Gian Araldi , Adulla Reddy , Zhong Zhao , Sean McKenna , Bagna Bao
发明人： Gian Araldi , Adulla Reddy , Zhong Zhao , Sean McKenna , Bagna Bao
IPC分类号： C07D207/27 , A61K31/4015 , A61K31/558 , A61K31/559 , A61P1/04 , A61P7/00 , A61P7/02 , A61P7/10 , A61P9/12 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/04 , A61P15/06 , A61P15/08 , A61P15/10 , A61P17/12 , A61P19/10 , A61P21/02 , A61P25/20 , A61P27/02 , A61P27/06 , A61P29/00 , A61P37/04 , A61P43/00 , C07D207/12 , C07D207/26 , C07D405/06 , C07D409/06
CPC分类号： C07D207/26 , C07D405/06 , C07D409/06
摘要： 1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, or gastric ulcer, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.
摘要翻译：提供了1,2-取代的5-吡咯烷酮化合物，以及使用或包含一种或多种这样的化合物的治疗方法和药物组合物。本发明的化合物可用于多种疗法，包括治疗或预防早产，痛经，哮喘，高血压，不育症或生育障碍，不期望的血液凝固，先兆子痫或子痫，嗜酸性粒细胞紊乱，性功能障碍，骨质疏松症和其他破坏性骨疾病或病症，肾功能障碍，免疫缺陷障碍，干眼症，鱼鳞病，眼内压升高，睡眠障碍或胃溃疡，炎症性疾病和与前列腺素家族化合物相关的其它疾病和病症。

2. 发明授权

US07419999B2 Gamma lactams as prostaglandin agonists and use thereof 失效
标题翻译： γ-内酰胺作为前列腺素激动剂及其用途
公开(公告)号：US07419999B2
公开(公告)日：2008-09-02
申请号：US10517626
申请日：2003-06-09
申请人： Gian Luca Araldi , Adulla P. Reddy , Zhong Zhao , Sean D. McKenna , Bagna Bao
发明人： Gian Luca Araldi , Adulla P. Reddy , Zhong Zhao , Sean D. McKenna , Bagna Bao
IPC分类号： A61K31/4015 , A61K31/5377 , C07D207/27 , C07D413/06
CPC分类号： C07D207/26 , C07D405/06 , C07D409/06
摘要： 1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, or gastric ulcer, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.
摘要翻译：提供了1,2-取代的5-吡咯烷酮化合物，以及使用或包含一种或多种这样的化合物的治疗方法和药物组合物。本发明的化合物可用于多种疗法，包括治疗或预防早产，痛经，哮喘，高血压，不育症或生育障碍，不期望的血液凝固，先兆子痫或子痫，嗜酸性粒细胞紊乱，性功能障碍，骨质疏松症和其他破坏性骨疾病或病症，肾功能障碍，免疫缺陷障碍，干眼症，鱼鳞病，眼内压升高，睡眠障碍或胃溃疡，炎症性疾病和与前列腺素家族化合物相关的其它疾病和病症。

3. 发明申请

US20060194865A1 G-lactam derivatives as prostaglandin agonists 失效
标题翻译：内酰胺衍生物作为前列腺素激动剂
公开(公告)号：US20060194865A1
公开(公告)日：2006-08-31
申请号：US10547676
申请日：2004-03-02
申请人： Gian Araldi , Srinivasa Karra , Zhong Zhao , Nadia Brugger
发明人： Gian Araldi , Srinivasa Karra , Zhong Zhao , Nadia Brugger
IPC分类号： A61K31/558 , C07D403/02 , C07D207/24
CPC分类号： C07D207/267 , C07D401/06 , C07D405/06 , C07D409/06
摘要： The present invention relates γ-lactam derivatives, in particular for use as medicaments, as well as pharmaceutical formulations containing such γ-lactam derivatives. Said γ-lactam derivatives are useful in the treatment and/or prevention of asthma, hypertension, osteoporosis, sexual dysfunction and fertility disorders.
摘要翻译：本发明涉及特别用作药物的γ-内酰胺衍生物，以及含有γ-内酰胺衍生物的药物制剂。所述γ-内酰胺衍生物可用于治疗和/或预防哮喘，高血压，骨质疏松症，性功能障碍和生育障碍。

4. 发明申请

US20050176800A1 Pyrrolidine derivatives as prostaglandin modulators 失效
标题翻译：吡咯烷衍生物作为前列腺素调节剂
公开(公告)号：US20050176800A1
公开(公告)日：2005-08-11
申请号：US10499346
申请日：2002-12-19
申请人： Yihua Liao , Zhong Zhao , Gian Araldi
发明人： Yihua Liao , Zhong Zhao , Gian Araldi
IPC分类号： A61K31/559 , A61K45/00 , A61P7/00 , A61P7/02 , A61P9/12 , A61P11/06 , A61P15/06 , A61P15/08 , A61P19/08 , A61P25/08 , A61P27/06 , A61P43/00 , C07D207/10 , C07D207/12 , C07D207/36 , C07D405/12 , A61K31/557 , C07D207/30
CPC分类号： C07D405/12 , C07D207/10 , C07D207/36
摘要： Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.
摘要翻译：提供了取代的吡咯烷化合物，以及使用或包含一种或多种这些化合物的治疗方法和药物组合物。本发明的化合物可用于多种疗法，包括治疗或预防早产，痛经，哮喘，高血压，不育症或生育障碍，不期望的血液凝固，先兆子痫或子痫，嗜酸性粒细胞紊乱，性功能障碍，骨质疏松症和其他破坏性骨疾病或病症，以及与前列腺素家族化合物相关的其它疾病和病症。在优选的方面，将取代的吡咯烷化合物与磷酸二酯酶抑制剂化合物配体施用于受试者。

5. 发明授权

US08288398B2 Antiproliferative pyrimidyl, fused pyrimidyl and pyrimidyl hydrazones 失效
标题翻译：抗增殖性嘧啶基，稠合嘧啶基和嘧啶基腙
公开(公告)号：US08288398B2
公开(公告)日：2012-10-16
申请号：US12096110
申请日：2006-12-08
申请人： Brian Healey , Zhong Zhao , Amanda Sutton , Matthias Schwarz
发明人： Brian Healey , Zhong Zhao , Amanda Sutton , Matthias Schwarz
IPC分类号： A01N43/54 , A61K31/517
CPC分类号： C07D239/94 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D413/04
摘要： The present invention is related to a novel series of pyrimidyl or fused pyrimidyl hydrazones. Compounds of Formula (I) wherein A is selected from the group consisting of Formulas (A1), (A2), (A3), (A4), (A5) are useful for the treatment and/or prevention of a proliferative disease.
摘要翻译：本发明涉及新的一系列嘧啶基或稠合的嘧啶基腙。其中A选自式（A1），（A2），（A3），（A4），（A5）的式（I）化合物可用于治疗和/或预防增殖性疾病。

6. 发明授权

US07674875B2 Phosphorus-containing compounds with polymeric chains, and methods of making and using the same 失效
标题翻译：具有聚合物链的含磷化合物及其制备和使用方法
公开(公告)号：US07674875B2
公开(公告)日：2010-03-09
申请号：US12355359
申请日：2009-01-16
申请人： Keith Branham , Mahesh V. Chaubal , James P. English , Donna Hall , Zhong Zhao
发明人： Keith Branham , Mahesh V. Chaubal , James P. English , Donna Hall , Zhong Zhao
IPC分类号： C08G79/02 , C08G79/04 , C08G79/00
CPC分类号： A61K9/0024 , A61K31/66 , A61K45/06 , A61K47/02 , A61K47/24 , A61K47/34 , C08G65/335 , C08G79/02 , C08L81/02 , C08L2203/02 , A61K2300/00
摘要： The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
摘要翻译：本发明涉及具有聚合物链的新型含磷化合物及其制备和使用方法。一部分描述含有含聚合物链的含磷化合物和治疗剂的主题组合物及其制备和使用方法。某些主题组合物显示出反向热凝胶化。

7. 发明申请

US20090247778A1 Phosphorus-Containing Compounds with Polymeric Chains, and Methods of Making and Using the Same 失效
标题翻译：含聚合链的含磷化合物及其制备和使用方法
公开(公告)号：US20090247778A1
公开(公告)日：2009-10-01
申请号：US12355359
申请日：2009-01-16
申请人： Keith Branham , Mahesh V. Chaubal , James P. English , Donna Hall , Zhong Zhao
发明人： Keith Branham , Mahesh V. Chaubal , James P. English , Donna Hall , Zhong Zhao
IPC分类号： C07F9/06
CPC分类号： A61K9/0024 , A61K31/66 , A61K45/06 , A61K47/02 , A61K47/24 , A61K47/34 , C08G65/335 , C08G79/02 , C08L81/02 , C08L2203/02 , A61K2300/00
摘要： The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
摘要翻译：本发明涉及具有聚合物链的新型含磷化合物及其制备和使用方法。一部分描述含有含聚合物链的含磷化合物和治疗剂的主题组合物及其制备和使用方法。某些主题组合物显示出反向热凝胶化。

8. 发明授权

US06322797B1 Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same 失效
标题翻译：可生物降解的对苯二甲酸酯聚酯 - 聚（磷酸酯）聚合物，组合物，制品及其制备和使用方法
公开(公告)号：US06322797B1
公开(公告)日：2001-11-27
申请号：US09053648
申请日：1998-04-02
申请人： Hai-Quan Mao , Kam W. Leong , Wenbin Dang , Hungnan Lo , Zhong Zhao , David P. Nowotnik , James P. English
发明人： Hai-Quan Mao , Kam W. Leong , Wenbin Dang , Hungnan Lo , Zhong Zhao , David P. Nowotnik , James P. English
IPC分类号： C08G7902
CPC分类号： C08G63/6926 , A61K9/1647 , A61L17/12 , A61L26/0019 , A61L27/18 , Y10T428/2938 , Y10T442/3545 , C08L85/02
摘要： Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; R′ is an aliphatic, aromatic or heterocyclic residue; x is ≧1; and n is 0-5,000, wherein the biodegradable polymer is biocompatible before and upon biodegradation. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.
摘要翻译：描述了可生物降解的对苯二甲酸酯聚合物，其包含式I所示的重复单体单元：其中R是二价有机部分; R'是脂族，芳族或杂环残基; x是> = 1; andn为0-5,000，其中生物可降解聚合物在生物降解之前和之后是生物相容的。用于制备聚合物的方法，含有聚合物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及可控制的方法还使用聚合物释放生物活性物质。

9. 发明申请

US20080234346A1 PYRAZALIDINONE COMPOUNDS AS LIGANDS OF THE PROSTAGLANDIN EP2 AND/OR EP4 RECEPTORS 失效
标题翻译：作为PROSTAGLANDIN EP2和/或EP4受体的配体的吡唑烷酮化合物
公开(公告)号：US20080234346A1
公开(公告)日：2008-09-25
申请号：US12120408
申请日：2008-05-14
申请人： Gian Luca ARALDI , Yihua Liao , Adulla P. Reddy , Zhong Zhao
发明人： Gian Luca ARALDI , Yihua Liao , Adulla P. Reddy , Zhong Zhao
IPC分类号： A61K31/4152 , C07D231/04 , A61P15/00 , A61P11/00 , A61P7/00
CPC分类号： A61K31/4152 , C07D231/08
摘要： The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin EP2 and/or EP4 receptors.
摘要翻译：本发明提供取代的吡唑烷酮化合物，以及使用或包含一种或多种这些化合物的治疗方法和药物组合物。本发明的化合物可用于多种疗法，包括治疗或预防早产，痛经，哮喘，高血压，不育症或生育障碍，不期望的血液凝固，先兆子痫或子痫，嗜酸性粒细胞紊乱，性功能障碍，骨质疏松症和其他破坏性骨疾病或病症，以及与前列腺素EP2和/或EP4受体相关的其它疾病和病症。

10. 发明授权

US07335680B2 Pyrrolidine derivatives as prostaglandin modulators 失效
标题翻译：吡咯烷衍生物作为前列腺素调节剂
公开(公告)号：US07335680B2
公开(公告)日：2008-02-26
申请号：US10499346
申请日：2002-12-19
申请人： Yihua Liao , Zhong Zhao , Gian Luca Araldi
发明人： Yihua Liao , Zhong Zhao , Gian Luca Araldi
IPC分类号： A61K31/40 , C07D207/10 , C07D207/08
CPC分类号： C07D405/12 , C07D207/10 , C07D207/36
摘要： Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.
摘要翻译：提供了取代的吡咯烷化合物，以及使用或包含一种或多种这些化合物的治疗方法和药物组合物。本发明的化合物可用于多种疗法，包括治疗或预防早产，痛经，哮喘，高血压，不育症或生育障碍，不期望的血液凝固，先兆子痫或子痫，嗜酸性粒细胞紊乱，性功能障碍，骨质疏松症和其他破坏性骨疾病或病症，以及与前列腺素家族化合物相关的其它疾病和病症。在优选的方面，将取代的吡咯烷化合物与磷酸二酯酶抑制剂化合物配体施用于受试者。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式