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    • 31. 发明申请
    • Piperazine compounds and medicinal use thereof
    • 哌嗪类化合物及其医药用途
    • US20060167014A1
    • 2006-07-27
    • US11298980
    • 2005-12-12
    • Kunitomo AdachiYoshiyuki AokiTokushi HananoHiroshi MorimotoMasao Hisadome
    • Kunitomo AdachiYoshiyuki AokiTokushi HananoHiroshi MorimotoMasao Hisadome
    • A61K31/495C07D241/04
    • C07D239/42C07C2601/02C07D213/74C07D233/88C07D239/47C07D239/48C07D239/50C07D239/52C07D239/545C07D277/42C07D295/135
    • The present invention relates to a piperazine compound of the formula wherein R1 and R2 are each hydrogen, halogen, lower alkyl, lower alkoxy, amino, substituted amino, nitro, hydroxy or cyano, R3, R4 and R5 are each hydrogen, halogen, lower alkyl, lower alkoxy, nitro, amino, substituted amino or hydroxy, R6 and R7 are each hydrogen, lower alkyl, lower alkyl substituted by halogen, aralkyl, acyl or lower acyl substituted by halogen, R8 and R9 are each hydrogen or lower alkyl, Y is lower alkylene and the like, and ring A is phenyl, pyrimidyl, thiazolyl, pyridyl, pyrazyl or imidazolyl, a pharmaceutically acceptable salt thereof and pharmaceutical agents containing these compounds. The compound of the present invention has superior TNF-α production inhibitory effect and/or IL-10 production promoting effect, and, since it is free of or shows only strikingly reduced expression of an effect on the central nervous system, the compound is useful as a highly safe and superior TNF-α production inhibitor an/or IL-10 production promoter and is useful as an agent for the prophylaxis or treatment of various diseases caused by abnormal TNF-α production, diseases curable with IL-10, such as chronic inflammatory diseases, acute inflammatory diseases, inflammatory diseases due to infection, autoimmune diseases, allergic diseases, and TNF-α mediated diseases.
    • 本发明涉及下式的哌嗪化合物其中R 1和R 2各自为氢,卤素,低级烷基,低级烷氧基,氨基,取代的氨基,硝基, 羟基或氰基,R 3,R 4和R 5各自为氢,卤素,低级烷基,低级烷氧基,硝基,氨基,取代的 氨基或羟基,R 6和R 7各自为氢,低级烷基,被卤素取代的低级烷基,芳烷基,酰基或被卤素取代的低级酰基, 8和R 9各自为氢或低级烷基,Y为低级亚烷基等,环A为苯基,嘧啶基,噻唑基,吡啶基,吡唑基或咪唑基,其药学上可接受的盐 和含有这些化合物的药剂。 本发明的化合物具有优异的TNF-α产生抑制作用和/或IL-10产生促进作用,并且由于其没有或显示出仅显着降低对中枢神经系统的作用的表达,所以该化合物是有用的 作为高度安全和优越的TNF-α产生抑制剂和/或IL-10产生促进剂,并且可用作预防或治疗由异常TNF-α产生引起的各种疾病的药剂,可用IL-10固化的疾病,例如 慢性炎性疾病,急性炎性疾病,感染引起的炎性疾病,自身免疫疾病,过敏性疾病和TNF-α介导的疾病。
    • 33. 发明授权
    • Image forming apparatus
    • 图像形成装置
    • US06760562B2
    • 2004-07-06
    • US10463140
    • 2003-06-16
    • Satoshi NishidaHiroaki MihoShigetaka KurosuHiroshi MorimotoMasashi Saito
    • Satoshi NishidaHiroaki MihoShigetaka KurosuHiroshi MorimotoMasashi Saito
    • G03G1516
    • G03G15/75G03G15/1685G03G2215/0119
    • This invention relates to an image forming apparatus. The image forming apparatus includes a primary transfer means for bringing one surface of an intermediate transfer body and/or transfer medium into contact with a photosensitive body surface and pressing the surface against the photosensitive body surface to transfer a toner image formed on the photosensitive body surface onto one surface of the intermediate transfer body and/or transfer medium. When a time of passage through the contact transfer area between the photosensitive body and the intermediate transfer body and/or transfer medium in the process of transferring the toner image from the photosensitive body onto the intermediate transfer body and/or transfer medium is T, T1, or T2 sec, the contact angle of the photosensitive body with respect to pure water applied to the photosensitive body surface after a lapse of T, T1, or T2 sec since application of the pure water is larger than that of the intermediate transfer body and/or transfer medium with respect to the pure water after a lapse of the T, T1, or T2 sec.
    • 本发明涉及一种图像形成装置。 图像形成装置包括用于使中间转印体和/或转印介质的一个表面与感光体表面接触并将表面压靠在感光体表面上的一次转印装置,以转印形成在感光体表面上的调色剂图像 在中间转印体和/或转印介质的一个表面上。 在将调色剂图像从感光体转印到中间转印体和/或转印介质上的过程中,当通过感光体和中间转印体和/或转印介质之间的接触转移区域的时间是T,T1 或T2秒,由于施加纯水后经过T,T1或T2秒后感光体相对于施加到感光体表面的纯水的接触角大于中间转印体的接触角,并且 /或在经过T,T1或T2秒之后相对于纯水的转印介质。