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31. 发明授权

US06702839B1 Method of controlling body temperature while reducing shivering 有权
标题翻译：减少发抖的方法来控制体温
公开(公告)号：US06702839B1
公开(公告)日：2004-03-09
申请号：US10137741
申请日：2002-05-02
申请人： Michael W. Dae , Timothy R. Machold , Wade A. Keller
发明人： Michael W. Dae , Timothy R. Machold , Wade A. Keller
IPC分类号： A61F700
CPC分类号： A61M25/00 , A61B2017/00084 , A61F7/123 , A61F2007/0056 , A61F2007/0295 , A61F2007/126 , A61M2205/36
摘要： A method and apparatus for lowering the body temperature of a patient while reducing shivering by using a heat exchange device in combination with an &agr;2-adrenoreceptor agonist, a non-opiod analgesic monoamine uptake inhibitor or neuropeptide that temporarily reduces shivering. The devices disclosed include a catheter having a heat exchange balloon thereon with heat exchange fluid circulating through the interior of the balloon. The heat exchange balloon is placed in the vasculature of a patient, and heat exchange fluid at a temperature other than the temperature of the blood in the vasculature is circulated through the interior of the balloon to add or remove heat from the blood of the patient. Various &agr;2-adrenoreceptor agonist &agr;2-adrenoreceptor agonists, non-opiod analgesic monoamine uptake inhibitors and neuropeptides are disclosed including dexmedetomidine, nefopam, neurotensin and anticonvulsant medications and pharmaceutically acceptable salts thereof. A control system for the control of the patient's temperature is disclosed for controlling the patient's temperature in conjunction with administering the &agr;2-adrenoreceptor agonist, non-opiod analgesic monoamine uptake inhibitor or neuropeptide.
摘要翻译：一种用于降低患者体温的方法和装置，同时通过使用热交换装置与α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂或神经肽暂时减轻发抖相结合来减轻发抖。所公开的装置包括具有热交换球囊的导管，其中热交换流体循环通过气囊的内部。将热交换球放置在患者的脉管系统中，并且在脉管系统中除血液温度以外的温度下的热交换流体循环通过气囊的内部以从患者的血液中添加或除去热量。公开了各种α2-肾上腺素受体激动剂α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂和神经肽，包括右美托咪定，奈福泮，神经降压素和抗惊厥药物及其药学上可接受的盐。公开了用于控制患者体温的控制系统，用于与施用α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂或神经肽一起控制患者的温度。

32. 发明授权

US06655386B1 Transluminal method for bypassing arterial obstructions 有权
标题翻译：用于旁路动脉阻塞物的方法
公开(公告)号：US06655386B1
公开(公告)日：2003-12-02
申请号：US09639963
申请日：2000-08-16
申请人： Joshua Makower , J. Christopher Flaherty , Timothy R. Machold , Jason Brian Whitt , Philip Christopher Evard , Patrick Edward Macaulay , John Thomas Garibotto , Claude A. Vidal , Russell J. Redmond , Thomas Banks
发明人： Joshua Makower , J. Christopher Flaherty , Timothy R. Machold , Jason Brian Whitt , Philip Christopher Evard , Patrick Edward Macaulay , John Thomas Garibotto , Claude A. Vidal , Russell J. Redmond , Thomas Banks
IPC分类号： A61B1900
CPC分类号： A61B1/3137 , A61B17/00234 , A61B17/00491 , A61B17/0057 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/320725 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/00331 , A61B2017/00504 , A61B2017/00637 , A61B2017/00668 , A61B2017/0641 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22038 , A61B2017/22077 , A61B2017/22095 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00404 , A61B2018/00869 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61M2025/0076 , A61M2025/0096 , A61M2025/018 , A61M2025/1052
摘要： Methods, devices, and systems for a) revascularization and/or b) performing other medical procedures at vascular or non-vascular intracorporeal locations within a mammalian body. The methods generally comprise the formation of at least one extravascular passageway from a blood vessel to a vascular or non-vascular target location. In the revascularization methods the extravascular passageway is utilized for blood flow. In the medical procedure methods the extravascular passageway is utilized as a conduit for accessing or performing procedures at the vascular or non-vascular target location. Also disclosed are catheter devices and systems which are useable to form the extravascular passageways of the invention, as well as apparatus for modifying, maintaining and/or closing such extravascular passageways.
摘要翻译：方法，装置和系统，用于a）血管重建和/或b）在哺乳动物体内的血管或非血管体内位置执行其他医学程序。所述方法通常包括从血管到血管或非血管目标位置形成至少一个血管内通道。在血运重建方法中，血管外通路用于血流。在医疗程序方法中，血管外通路被用作在血管或非血管目标位置处进入或执行手术的导管。还公开了可用于形成本发明的血管外通道的导管装置和系统，以及用于修改，维持和/或关闭这种血管外通道的装置。

33. 发明授权

US06491707B2 Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures 有权
标题翻译：用于闭合，形成附着物和/或形成管腔解剖结构中的吻合接头的翻译方法和装置
公开(公告)号：US06491707B2
公开(公告)日：2002-12-10
申请号：US09908337
申请日：2001-07-18
申请人： Joshua Makower , J. Christopher Flaherty , Timothy R. Machold , John Thomas Garibotto , Jason Brian Whitt
发明人： Joshua Makower , J. Christopher Flaherty , Timothy R. Machold , John Thomas Garibotto , Jason Brian Whitt
IPC分类号： A61B1704
CPC分类号： A61B17/11 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/06 , A61B17/064 , A61B17/12 , A61B17/12013 , A61B2017/00292 , A61B2017/00557 , A61B2017/00946 , A61B2017/0409 , A61B2017/0419 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/06047 , A61B2017/1107 , A61B2017/1135 , A61B2017/1139
摘要： Methods and apparatus for passing attachment apparatus or connector material into or through the wall of a luminal anatomical structure for the purpose of, closing the lumen of the anatomical structure, forming an anastomotic junction between separate anatomical structures or between approximated segments of the same anatomical structure, and/or attaching an article, or other apparatus to the wall of the anatomical structure.
摘要翻译：用于将附着装置或连接器材料通过管腔解剖结构的壁或通过管腔解剖结构的壁的方法和装置，用于封闭解剖结构的内腔，在分离的解剖结构之间或相同解剖结构的近似段之间形成吻合结，和/或将物品或其他装置附接到解剖结构的壁上。

34. 发明授权

US06325067B1 Methods and systems for performing thoracoscopic coronary bypass and other procedures 失效
标题翻译：执行胸腔镜冠状动脉搭桥及其他手术的方法和系统
公开(公告)号：US06325067B1
公开(公告)日：2001-12-04
申请号：US09482306
申请日：2000-01-12
申请人： Wesley D. Sterman , Lawrence C. Siegel , Patricia E. Curtis , John H. Stevens , William S. Peters , Timothy R. Machold
发明人： Wesley D. Sterman , Lawrence C. Siegel , Patricia E. Curtis , John H. Stevens , William S. Peters , Timothy R. Machold
IPC分类号： A61B1900
CPC分类号： A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/064 , A61B17/068 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B17/29 , A61B17/2909 , A61B17/30 , A61B17/3403 , A61B18/1442 , A61B18/1492 , A61B90/50 , A61B2017/00053 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2017/00637 , A61B2017/00663 , A61B2017/00867 , A61B2017/00907 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/306 , A61B2017/3405 , A61B2017/3427 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00982 , A61B2090/064 , A61F2/2427 , A61M25/0032 , A61M25/1011 , A61M39/0247 , A61M2025/0003 , A61M2025/0031 , A61M2025/028 , A61M2025/1052 , A61M2039/0258 , A61M2039/0273 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , A61M2230/005
摘要： A method for closed-chest cardiac surgical intervention relies on viewing the cardiac region through a thoracoscope or other viewing scope and endovascularly partitioning the patient's arterial system at a location within the ascending aorta. The cardiopulmonary bypass and cardioplegia can be induced, and a variety of surgical procedures performed on the stopped heart using percutaneously introduced tools. The method of the present invention will be particularly suitable for forming coronary artery bypass grafts, where an arterial blood source is created using least invasive surgical techniques, and the arterial source is connected to a target location within a coronary artery while the patient is under cardiopulmonary bypass and cardioplegia
摘要翻译：闭胸心脏外科手术的方法依赖于通过胸腔镜或其他观察范围观察心脏区域，并在升主动脉内的位置血管内划分病人的动脉系统。可以诱发心肺分流术和心脏停跳症，并使用经皮引入的工具对停止的心脏进行各种手术程序。本发明的方法将特别适用于形成冠状动脉旁路移植物，其中使用最少侵入性手术技术产生动脉血源，并且当患者处于心肺时，动脉源连接到冠状动脉内的目标位置旁路和心麻痹

35. 发明授权

US5961481A Systems for coronary bypass procedures 失效
标题翻译：冠状动脉搭桥手术系统
公开(公告)号：US5961481A
公开(公告)日：1999-10-05
申请号：US559613
申请日：1996-03-12
申请人： Wesley D. Sterman , Lawrence C. Siegel , Patricia E. Curtis , John H. Stevens , Timothy R. Machold
发明人： Wesley D. Sterman , Lawrence C. Siegel , Patricia E. Curtis , John H. Stevens , Timothy R. Machold
IPC分类号： A61B1/00 , A61B17/00 , A61B17/02 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/068 , A61B17/12 , A61B17/122 , A61B17/128 , A61B17/28 , A61B17/30 , A61B17/34 , A61B18/14 , A61B19/00 , A61F2/24 , A61F2/958 , A61M1/00 , A61M25/00 , A61M37/00
CPC分类号： A61M39/0247 , A61B17/00234 , A61B17/0218 , A61B17/0469 , A61B17/06061 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B18/1442 , A61B18/1492 , A61B90/50 , A61F2/2427 , A61B17/0057 , A61B17/0467 , A61B17/064 , A61B17/068 , A61B17/12013 , A61B17/29 , A61B17/2909 , A61B17/30 , A61B17/3403 , A61B2017/00243 , A61B2017/00247 , A61B2017/00637 , A61B2017/00663 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/306 , A61B2017/3405 , A61B2017/3427 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2090/064 , A61M2025/0003 , A61M2025/028 , A61M2039/0273 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , A61M25/1011
摘要： A method for closed-chest cardiac surgical intervention relies on viewing the cardiac region through a thoracoscope or other viewing scope and endovascularly partitioning the patient's arterial system at a location within the ascending aorta. The cardiopulmonary bypass and cardioplegia can be induced, and a variety of surgical procedures performed on the stopped heart using percutaneously introduced tools. The method of the present invention will be particularly suitable for forming coronary artery bypass grafts, where an arterial blood source is created using least invasive surgical techniques, and the arterial source is connected to a target location within a coronary artery while the patient is under cardiopulmonary bypass and cardioplegia.
摘要翻译：闭胸心脏外科手术的方法依赖于通过胸腔镜或其他观察范围观察心脏区域，并在升主动脉内的位置血管内划分病人的动脉系统。可以诱发心肺分流术和心脏停跳症，并使用经皮引入的工具对停止的心脏进行各种手术程序。本发明的方法将特别适用于形成冠状动脉旁路移植物，其中使用最少侵入性手术技术产生动脉血源，并且当患者处于心肺时，动脉源连接到冠状动脉内的目标位置旁路和心麻痹。

36. 发明授权

US5868702A System for cardiac procedures 失效
标题翻译：心脏手术系统
公开(公告)号：US5868702A
公开(公告)日：1999-02-09
申请号：US819455
申请日：1997-03-17
申请人： John H. Stevens , Wesley D. Sterman , Hanson S. Gifford, III , Timothy R. Machold
发明人： John H. Stevens , Wesley D. Sterman , Hanson S. Gifford, III , Timothy R. Machold
IPC分类号： A61B17/00 , A61B17/28 , A61B17/32 , A61F2/24 , A61F2/958 , A61M1/36 , A61M25/00 , A61M25/01 , A61M25/06 , A61M29/02 , A61M31/00
CPC分类号： A61F2/2427 , A61B17/29 , A61F2/2433 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/0147 , A61M25/0152 , A61M25/0662 , A61M25/10 , A61B17/320016 , A61B2017/00243 , A61B2018/00232 , A61B2018/00261 , A61F2/2436 , A61M2025/0031 , A61M2025/0078 , A61M2025/015 , A61M2025/0161 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2025/1095 , A61M2205/11 , A61M2205/366 , A61M2210/125 , A61M2210/127 , A61M25/0032 , A61M25/0125 , A61M25/1002
摘要： A system for accessing a patient's cardiac anatomy which includes an endovascular aortic partitioning device that separates the coronary arteries and the heart from the rest of the patient's arterial system. The endovascular device for partitioning a patient's ascending aorta comprises a flexible shaft having a distal end, a proximal end, and a first inner lumen therebetween with an opening at the distal end. The shaft may have a preshaped distal portion with a curvature generally corresponding to the curvature of the patient's aortic arch. An expandable means, e.g., a balloon, is disposed near the distal end of the shaft proximal to the opening in the first inner lumen for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles, while the patient is supported by cardiopulmonary bypass. The endovascular aortic partitioning device may be coupled to an arterial bypass cannula for delivering oxygenated blood to the patient's arterial system. The heart muscle or myocardium is paralyzed by the retrograde delivery of a cardioplegic fluid to the myocardium through patient's coronary sinus and coronary veins, or by antegrade delivery of cardioplegic fluid through a lumen in the endovascular aortic partitioning device to infuse cardioplegic fluid into the coronary arteries. The pulmonary trunk may be vented by withdrawing liquid from the trunk through an inner lumen of an elongated catheter. The cardiac accessing system is particularly suitable for removing the aortic valve and replacing the removed valve with a prosthetic valve.
摘要翻译：一种用于访问患者心脏解剖结构的系统，其包括将冠状动脉和心脏与患者动脉系统的其余部分分离的血管内主动脉分配装置。用于分隔患者升主动脉的血管内装置包括具有远端，近端和其间的第一内腔的柔性轴，在远端具有开口。轴可以具有预先形成的远端部分，其曲率通常对应于患者主动脉弓的曲率。一个可膨胀的装置，例如气球，靠近靠近第一内腔内的开口的轴的远端设置，用于闭塞上升主动脉，从而阻止基本上所有的血流通过其中进行多个心动周期，而患者由体外循环支持。血管内主动脉分配装置可以联接到动脉旁路套管，用于将氧合血液输送到患者的动脉系统。通过患者的冠状窦和冠状静脉逆行递送心脏停搏液到心肌，或者通过血管内主动脉分配装置的内腔顺序递送心脏停跳液，将心肌或心肌瘫痪，将心脏停搏液注入冠状动脉。可以通过从细长的导管的内腔中抽出液体来排出肺动脉干。心脏存取系统特别适用于去除主动脉瓣并用假体瓣替换去除的瓣膜。

37. 发明授权

US5263963A Expandable cage catheter for repairing a damaged blood vessel 失效
标题翻译：用于修复受损血管的可扩展的笼导管
公开(公告)号：US5263963A
公开(公告)日：1993-11-23
申请号：US682190
申请日：1991-04-08
申请人： Michi E. Garrison , Timothy R. Machold
发明人： Michi E. Garrison , Timothy R. Machold
IPC分类号： A61B19/00 , A61F2/00 , A61F2/06 , A61F2/84 , A61M25/04 , A61M29/00 , A61M29/02
CPC分类号： A61F2/95 , A61M25/04 , A61M29/02 , A61B90/39 , A61F2250/0059 , A61F2250/0098 , A61M2025/0063 , A61M2025/0183 , A61M2025/107
摘要： A vascular catheter having an expandable cage mounted on the distal end of a tubular member which is radially expanded and contracted by means of a control wire which is secured to the distal end of the expandable cage. The control wire extends through a first inner lumen within the tubular member which extends along essentially the entire length thereof. A second inner lumen is provided in the distal portion of the tubular member which has a proximal port at least 15 but not more than 60 cm from the distal end of the catheter and a distal port which opens into the interior of the expandable cage. A guidewire or a low-profile steerable catheter is slidably disposed within the second lumen and a tubular member such as a slightly expanded coil through the expandable cage interior to facilitate the rapid exchange of the catheter. The catheter assembly is particularly adapted to hold open a blood vessel after a vascular procedure therein such as an angioplasty.
摘要翻译：一种血管导管，其具有安装在管状构件的远端上的可膨胀笼，其通过固定到可膨胀笼的远端的控制线径向膨胀和收缩。控制线延伸穿过管状构件内的基本上整个长度延伸的第一内腔。第二内腔设置在管状构件的远端部分中，其具有距离导管的远端至少15个但不超过60cm的近端口以及通向可扩张笼的内部的远端口。引导线或低轮廓可导向导管可滑动地设置在第二腔内，以及管状构件，例如通过可膨胀笼内部的略微膨胀的线圈，以促进导管的快速更换。导管组件特别适用于在其中的血管手术（例如血管成形术）之后保持打开血管。

38. 发明授权

US5002560A Expandable cage catheter with a rotatable guide 失效
标题翻译：具有可旋转导轨的可扩展笼式导管
公开(公告)号：US5002560A
公开(公告)日：1991-03-26
申请号：US404818
申请日：1989-09-08
申请人： Timothy R. Machold , Michi E. Garrison
发明人： Timothy R. Machold , Michi E. Garrison
IPC分类号： A61M25/04 , A61F2/00 , A61F2/90 , A61M29/02
CPC分类号： A61F2/95 , A61F2/90 , A61M29/02 , A61F2002/9517 , A61F2250/0059 , A61F2250/0098
摘要： A steerable vascular catheter having an expandable cage mounted on the distal end of a tubular member which is radially expanded and contracted by means of a guidewire which is disposed within an inner lumen in the tubular member and secured to the distal end of the expandable cage. A helical coil is disposed about the secured to a distal portion of the guidewire which extends out the distal end of the expandable cage facilitate steering the catheter through the patient's coronary anatomy. The catheter assembly is particularly adapted to hold open a blood vessel after a vascular procedure therein such as an angioplasty.

39. 发明授权

US4940062A Guiding member with deflectable tip 失效
标题翻译：引导构件具有偏转尖端
公开(公告)号：US4940062A
公开(公告)日：1990-07-10
申请号：US199099
申请日：1988-05-26
申请人： Hilary J. Hampton , John W. Gaiser , Charles S. Taylor , Timothy R. Machold
发明人： Hilary J. Hampton , John W. Gaiser , Charles S. Taylor , Timothy R. Machold
IPC分类号： A61M25/01 , A61B17/22 , A61M25/09
CPC分类号： A61M25/09033 , A61B2017/22001 , A61M2025/09175 , A61M2025/1079
摘要： The invention is directed to a guiding member for vascular catheters, particularly dilatation catheters for angioplasty procedures having a deflectable tip. The guiding member generally includes an elongated core wire having a tapered distal portion, a coil encasing at least part of the tapered distal portion of a core wire. The coil has an expanded section, and a reference member disposed therein which is secured to the coil proximally and distally of the expanded coil section. The core wire is secured to the coil at a location distally of the expanded section but proximally to the distal tip of the coil. Relative axial movement between the core wire and the coil causes expansion or contraction of the expanded coil section which results in tip deflection.

40. 发明授权

US09056004B2 Methods and apparatus for treating or deterring injuries to or disorders of the brain or spinal cord of a subject 有权
标题翻译：用于治疗或阻止受试者的脑或脊髓损伤或障碍的方法和装置
公开(公告)号：US09056004B2
公开(公告)日：2015-06-16
申请号：US13182805
申请日：2011-07-14
申请人： Robert Ginsburg , Timothy R. Machold , Michael T. Dineen
发明人： Robert Ginsburg , Timothy R. Machold , Michael T. Dineen
IPC分类号： A61F7/00 , A61F7/12 , A61M25/00 , A61B18/00 , A61B18/08 , A61B18/24 , A61B17/00 , A61B17/22 , A61F7/10 , A61M25/10
CPC分类号： A61F7/12 , A61B18/00 , A61B18/082 , A61B18/245 , A61B2017/00084 , A61B2017/22051 , A61B2018/00095 , A61F7/007 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0056 , A61F2007/0086 , A61F2007/0093 , A61F2007/0095 , A61F2007/0096 , A61F2007/126 , A61M25/00 , A61M25/1011 , A61M2025/0078 , A61M2025/1072 , A61M2025/1086 , A61M2205/366 , A61M2206/10 , A61M2230/50
摘要： Methods and apparatus for treating or deterring injuries to or disorders of the brain or spinal cord of a subject. A heat exchange catheter device is inserted into the subject's body and used to cause heating or cooling the subject's cerebrospinal fluid. In some embodiments, the heat exchanger may be positioned within the subject's vasculature so as to heat or cool the flowing blood, thereby resulting in heating or cooling of the cerebrobpinal fluid.
摘要翻译：用于治疗或阻止受试者的脑或脊髓损伤或障碍的方法和装置。将热交换导管装置插入受试者的身体并用于引起受试者脑脊液的加热或冷却。在一些实施例中，热交换器可以被定位在受试者的脉管系统内，以便加热或冷却流动的血液，从而导致脑部液体的加热或冷却。

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