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    • 39. 发明授权
    • Avermectins and avermectin monosacharides substituted in the 4′-and 4″ position having pesticidal properties
    • 在具有杀虫性的4'和4“位置取代的阿维菌素和阿维菌素单糖苷
    • US07704961B2
    • 2010-04-27
    • US10568715
    • 2004-08-27
    • Fiona Murphy KessabiThomas PitternaPeter MaienfischJérôme CassayreLaura QuarantaPierre JungOttmar Franz Hueter
    • Fiona Murphy KessabiThomas PitternaPeter MaienfischJérôme CassayreLaura QuarantaPierre JungOttmar Franz Hueter
    • A61K31/70A61K31/7028C07H17/08
    • A01N43/90C07H19/01
    • Described is a compound of the formula (I) wherein the bond between carbon atoms 22 and 23 is a single or double bond; m is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; and either (A) R2 is —N(R3)R4, and (1) X is 0, wherein R3 is, for instance, hydrogen, unsubstituted or mono- to pentasubstituted C1-C12alkyl, and R4 is, for instance, mono- to pentasubstituted C1-C12alkyl, unsubstituted or mono- to pentasubstituted C3-C12cycloalkyl; or (2) X is S, wherein R3 is, for instance, hydrogen, unsubstituted or mono- to pentasubstituted C1-C12alkyl, and R4 is, for instance, hydrogen, unsubstituted or mono- to pentasubstituted C1-C12alkyl; or (3) X is 0 or S, wherein R3 and R4 together are, for instance, a three- to seven membered alkylene or a four- to seven-membered alkenylene bridge; or (B) R2 is OR5, X is 0 or S, wherein R5 is, for instance, C1-C12alkyl, mono- to pentasubstituted C1-C12alkyl; or, if appropriate, an E/Z isomer, E/Z isomer mixture and/or tautomer thereof, in each case in free form or in salt form; such a compound demonstrates pesticidal activity.
    • 描述了式(I)的化合物,其中碳原子22和23之间的键是单键或双键; m为0或1; R1是C1-C12烷基,C3-C8环烷基或C2-C12链烯基; (A)R 2是-N(R 3)R 4,和(1)X是0,其中R 3是例如氢,未被取代的或单取代到五取代的C 1 -C 12烷基,R 4是例如, 至五取代的C 1 -C 12烷基,未取代的或一至五取代的C 3 -C 12环烷基; 或(2)X为S,其中R 3为例如氢,未取代或单价至五价取代的C 1 -C 12烷基,R 4为例如氢,未取代或单价至五价取代的C 1 -C 12烷基; 或(3)X为0或S,其中R3和R4一起为例如三至七元亚烷基或四至七元亚烯基桥; 或(B)R 2是OR 5,X是0或S,其中R 5是例如C 1 -C 12烷基,一至五取代的C 1 -C 12烷基; 或者如果合适的话,E / Z异构体,E / Z异构体混合物和/或其互变异构体在每种情况下都是游离形式或盐形式; 这种化合物显示出杀虫活性。
    • 40. 发明授权
    • Avermectin and avermectin monosaccharide derivatives substituted in the 4″-or 4′-position having pesticidal properties
    • 在4“ - 或4”位取代的具有杀虫性的阿维菌素和阿维菌素单糖衍生物
    • US07678740B2
    • 2010-03-16
    • US10543637
    • 2004-01-30
    • Thomas PitternaFiona Murphy KessabiPeter MaienfischJerome CassayreLaura QuarantaPierre Jung
    • Thomas PitternaFiona Murphy KessabiPeter MaienfischJerome CassayreLaura QuarantaPierre Jung
    • A01N25/26A01N43/02A01N43/04C07H17/08
    • A01N43/90C07H17/08
    • What is described are a compound of the formula (I) Wherein U is —N(R2)OR3 or —N+(O−)═C(RE)RZ); n is 0 or 1; X—Y is —CH═CH— or —CH2—CH2—; R1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; R2 and R3 are, for example; independently from each other, —Q, —C(═O)—Z—Q or —CN; RZ and RE are, independently from each other, —Q, —C(═O)—Z—Q or —CN; or RZ and RE together are a three- to seven membered alkylene or alkenylene bridge, which is unsubstituted or mono- to tri-substituted; Z is a bond, O or —NR4—; Q is H, C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, C3-C12-Cycloalkyl, C5-C12-cycloalkenyl, aryl, or heterocyclyl, which are unsubstituted or mono- to pentasubstituted; R4 is for example H, C1-C8alkyl, hydroxy-C1-C8alkyl, C3-C8cycloalkyl or C2-C8alkenyl; or, if appropriate, an E/Z isomer, E/Z isomer mixture and/or tautomer thereof; a process for preparing these compounds, their isomers and tautomers and the use of these compounds, their isomers and tautomers; pesticidal compositions whose active compound is selected from these compounds and their tautomers; intermediates for the preparation of the said compounds of the formula (I), methods for the preparation of the compounds of the formula (I), and a method for controlling pests using these compositions.
    • 描述的是式(I)的化合物,其中U是-N(R 2)OR 3或-N +(O-)= C(RE)R Z); n为0或1; X-Y是-CH = CH-或-CH 2 -CH 2 - ; R1是C1-C12烷基,C3-C8环烷基或C2-C12链烯基; R2和R3例如是: 独立地为-Q,-C(= O)-Z-Q或-CN; RZ和RE彼此独立地为-Q,-C(= O)-Z-Q或-CN; 或RZ和RE一起是三至七元的亚烷基或亚烯基桥,其是未取代的或一至三取代的; Z是O或-NR4-键; Q是未被取代或被一取代或五取代的H,C 1 -C 12烷基,C 2 -C 12烯基,C 2 -C 12炔基,C 3 -C 12环烷基,C 5 -C 12 - 环烯基,芳基或杂环基, R4是例如H,C1-C8烷基,羟基-C1-C8烷基,C3-C8环烷基或C2-C8链烯基; 或者,如果合适的话,E / Z异构体,E / Z异构体混合物和/或其互变异构体; 制备这些化合物,其异构体和互变异构体的方法以及这些化合物,其异构体和互变异构体的用途; 活性化合物选自这些化合物及其互变异构体的杀虫组合物; 用于制备所述式(I)化合物的中间体,式(I)化合物的制备方法和使用这些组合物来控制害虫的方法。