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31. 发明授权

US07678820B2 Hetero compound 有权
标题翻译：杂环化合物
公开(公告)号：US07678820B2
公开(公告)日：2010-03-16
申请号：US12244102
申请日：2008-10-02
申请人： Hironori Harada , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
发明人： Hironori Harada , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： C07D413/04 , C07D417/04 , C07D471/04
摘要： To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity. Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.
摘要翻译：为了提供具有优异的S1P1激动剂活性的器官，骨髓或组织，自身免疫疾病等的移植中的预防和/或治疗剂的有效成分的有用化合物。由于本发明的化合物具有S1P1激动剂活性，因此可用作治疗或预防由不利淋巴细胞浸润引起的疾病的活性成分，例如自体免疫疾病例如器官移植中的移植排斥反应骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化症，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺病，哮喘，特应性皮炎炎症性肠病，动脉粥样硬化，缺血再灌注损伤或炎性疾病，以及由细胞如癌症和白血病的异常生长或积累引起的疾病。

32. 发明申请

US20060270678A1 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US20060270678A1
公开(公告)日：2006-11-30
申请号：US11500293
申请日：2006-08-08
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： A61K31/503 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病。

33. 发明授权

US07459451B2 Pyrazolopyridine derivatives 失效
标题翻译：吡唑并吡啶衍生物
公开(公告)号：US07459451B2
公开(公告)日：2008-12-02
申请号：US11171320
申请日：2005-07-01
申请人： Yoshito Abe , Kazuhiko Ohne , Kentaro Sato , Makoto Inoue , Mitsuaki Okumura
发明人： Yoshito Abe , Kazuhiko Ohne , Kentaro Sato , Makoto Inoue , Mitsuaki Okumura
IPC分类号： A61K31/535 , A61K31/44 , A01N43/42 , C07D413/00 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 4如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE- IV或TNF-α介导的疾病。

34. 发明授权

US07317009B2 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US07317009B2
公开(公告)日：2008-01-08
申请号：US11500293
申请日：2006-08-08
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病

35. 发明申请

US20070247530A1 Interpolation Method for Captured Color Image Data 失效
标题翻译：捕获的彩色图像数据的插值方法
公开(公告)号：US20070247530A1
公开(公告)日：2007-10-25
申请号：US11661709
申请日：2005-07-29
申请人： Yoshihisa Takahasi , Hisakazu Kikuchi , Shogo Muramatsu , Yoshito Abe , Naoki Mizutani
发明人： Yoshihisa Takahasi , Hisakazu Kikuchi , Shogo Muramatsu , Yoshito Abe , Naoki Mizutani
IPC分类号： H04N9/73 , G06T3/40 , H04N9/04
CPC分类号： G06T3/4015 , H04N1/648 , H04N9/045
摘要： To achieve more appropriate interpolation of a missing pixel, an image is input to a processing section for interpolation. The interpolation is applied utilizing image data of pixels located around the pixel to be interpolated. Specifically, correlations between the image data of the pixels to be interpolated, and pixel data in a horizontal direction, vertical direction, and diagonal direction, are compared to one another; pixel data having stronger correlation is used for the interpolation. Correlation between the image data of the pixels to be interpolated and which direction is strong is determined, so that different weighting for interpolation is used accordingly.
摘要翻译：为了实现对缺失像素的更合适的插值，将图像输入到用于插值的处理部分。使用位于要内插的像素周围的像素的图像数据来应用插值。具体而言，将要内插的像素的图像数据与水平方向，垂直方向和对角线方向上的像素数据之间的相关性相互比较; 使用具有较强相关性的像素数据进行插值。确定要插值的像素的图像数据和哪个方向是强的相关性，使得相应地使用用于插值的不同加权。

36. 发明授权

US07153854B2 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US07153854B2
公开(公告)日：2006-12-26
申请号：US10747079
申请日：2003-12-30
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病

37. 发明申请

US20050075342A1 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US20050075342A1
公开(公告)日：2005-04-07
申请号：US10747079
申请日：2003-12-30
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： A61P31/00 , C07D487/04 , A61K31/503
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 4如说明书中所定义，它们作为药物的用途，其制备和用途用于治疗PDE-IV或TNF-α介导的疾病。

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