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31. 发明专利

JPH0933521A METHOD AND MEDICAMENT FOR INSPECTING INFLAMMATORY DISEASE 失效
公开(公告)号：JPH0933521A
公开(公告)日：1997-02-07
申请号：JP20743595
申请日：1995-07-21
申请人： TOAGOSEI CO LTD
发明人： MITSUYAMA KEIICHI , TANIGAWA KYUICHI , HANATANI MITSUYA , KONDO SHINICHI , OMORI IWAO , MATSUO KATSUHIKO
IPC分类号： G01N33/50 , A61K39/395 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To realize an effective inspection for inflammatory disease by measuring the quantity of VPF(Vascular Penetration Factor) in serum using labeled immunoassay. SOLUTION: A method for predicting the presence of an inflammatory disease, e.g. uncerative colitis, clonal disease or other inflammatory diseases, especially a method employing a monoclonal antibody or polyclonal antibody for VPF, can be carried out easily without requiring any special facility or experience. It is especially useful for mass health examination where a large quantity of specimens are examined at once. Furthermore, since a significant difference appears in the quantity of VPF in serum between the active interval and inactive interval of uncerative colitis or clonal disease, the inventive method is useful for diagnosing the active interval of both diseases, deciding the effect of treatment, and monitoring after operation.

32. 发明专利

JPH099995A MEASUREMENT OF CLOT FORMING TENDENCY OF BLOOD 失效
公开(公告)号：JPH099995A
公开(公告)日：1997-01-14
申请号：JP16768295
申请日：1995-07-03
申请人： TOAGOSEI CO LTD
发明人： TANAKA YOICHI , MATSUO KATSUHIKO
IPC分类号： G01N33/49 , C12Q1/28 , C12Q1/37 , C12Q1/56
摘要： PROBLEM TO BE SOLVED: To measure a clot forming tendency(CFT) of blood useful for diagnosis, etc., of thrombosis by measuring the total fibrinolytic activities in a sample derived from the blood. SOLUTION: The activities or fibrinolytic activities of a protein participating in fibrinolysis (a tissue plasminogen activating factor, a plasminogen activating factor inhibitor 1, etc.) in a sample derived from blood (preferably the blood in a pseudocoagulated state) are measured. The fibrinolytic activities in the sample derived from the blood and the CFT are regarded as having a positive correlation and the CFT can simply be measured from the measurement of the fibrinolytic activities.

33. 发明专利

JPH08228774A STABILIZATION OF PEROXIDASE OR PEROXIDASE-LABELED ANTIBODY 失效
公开(公告)号：JPH08228774A
公开(公告)日：1996-09-10
申请号：JP6333995
申请日：1995-02-27
申请人： TOAGOSEI CO LTD
发明人： NAOE TOMOKO , FUJITA JINJI , MATSUO KATSUHIKO
IPC分类号： G01N33/531 , C07K16/00 , C07K16/40 , C12N9/96 , G01N33/543
摘要： PURPOSE: To stabilize a peroxidase (-labeled antibody) useful as a diagnostic, esp. lyophilized products thereof so as to be storable, by combined use of bovine serum albumin, p-hydroxyphenylacetic acid and lactose etc., as stabilizers. CONSTITUTION: Bovine serum albumin, p-hydroxyphenylacetic acid and lactose or dextran are used as stabilizers in combination with a peroxidase or peroxidase-labeled antibody, and the resultant mixture is dissolved in an aqueous solution containing sodium chloride, disodium hydrogenphosphate, potassium chloride or potassium dihydrogenphosphate; the resultant aqueous solution is filled at a depth of

34. 发明专利

JPH08169898A PEPTIDE AND MONOCLONAL ANTIBODY 失效
公开(公告)号：JPH08169898A
公开(公告)日：1996-07-02
申请号：JP16284195
申请日：1995-06-06
申请人： TOAGOSEI CO LTD
发明人： HANATANI MITSUYA , KONDO SHINICHI , OKAMOTO MASAJI , ASANO MAKOTO , MATSUMOTO TOMOE , MATSUO KATSUHIKO , OMORI IWAO
IPC分类号： G01N33/577 , A61K38/00 , A61K39/395 , A61P35/00 , C07K7/06 , C07K16/00 , C07K16/18 , C07K19/00
摘要： PURPOSE: To obtain a new peptide, comprising a partial peptide of a human vascular permeability factor having a specific amino acid sequence and useful as an antigen for preparing a monoclonal antibody against the vascular permeability factor, a biochemical reagent and a diagnostic agent, a therapeutic agent, etc., for cancer, etc. CONSTITUTION: This new peptide has at least one of amino acid sequences represented by formula I or II, comprises a partial peptide of a human vascular permeability factor and is useful as an antigen for preparing a monoclonal antibody against the vascular permeability factor, a biochemical reagent or a diagnostic agent, a therapeutic agent, etc., for cancer or other diseases and its new monoclonal antibody is capable of recognizing the peptide. The peptide is prepared from a cDNA of a human vascular permeability factor gene by using a DNA capable of coding an amino acid sequence having strong actions on a vascular endothelial cell according to the gene manipulation. A mouse is immunized with the resultant peptide as an immunogen and a cell of a spleen is fused with a cell of a myeloma and the resultant hybridoma is cloned and cultured to afford a new human vascular permeability factor monoclonal antibody.

35. 发明专利

JP2013014446A Method for producing silicon tetrachloride 有权
标题翻译：生产硅酮四氯化铝的方法
公开(公告)号：JP2013014446A
公开(公告)日：2013-01-24
申请号：JP2011146440
申请日：2011-06-30
申请人： Toagosei Co Ltd , 東亞合成株式会社
发明人： NIWA MASAO , TO SHINRIN , MATSUO KATSUHIKO , SUZUKI HIROSHI
IPC分类号： C01B33/107
摘要： PROBLEM TO BE SOLVED: To provide a method by which high purity silicon tetrachloride can be inexpensively produced using, as a raw material, decomposition residue obtained by heat treatment, chemical or biological treatment or the like of silica-containing plants.SOLUTION: Metallic silicon of 1.0-4.8 mm in nominal dimension of a JIS standard sieve is added to decomposition residue having a carbon to silica mass ratio of 0.2-2.0 obtained by heating silica-containing plants in an amount of 10-40 pts.mass relative to 100 pts.mass of silica in the decomposition residue and chlorination reaction is performed, whereby silicon tetrachloride can be produced with a high silica reaction rate without requiring excess energy supply from the outside.
摘要翻译：要解决的问题提供一种通过以二氧化硅的植物的热处理，化学或生物处理等获得的分解残渣作为原料廉价生产高纯度四氯化硅的方法。解决方案：将JIS标准筛的标称尺寸为1.0-4.8mm的金属硅添加到碳二氧化硅质量比为0.2-2.0的分解残余物中，所述分解残余物通过加热10-40℃的含二氧化硅的植物而获得 pts.mass相对于分解残渣中的100ppm二氧化硅进行氯化反应，由此可以以高的二氧化硅反应速率制备四氯化硅，而不需要从外部提供过量的能量。版权所有（C）2013，JPO＆INPIT

36. 发明专利

JP2011007623A Medicine and method for examination of brain infarction and clinical condition of the same 有权
标题翻译：用于检查脑部感染及其临床病症的药物和方法
公开(公告)号：JP2011007623A
公开(公告)日：2011-01-13
申请号：JP2009151279
申请日：2009-06-25
申请人： Kagawa Univ , Toagosei Co Ltd , 国立大学法人香川大学 , 東亞合成株式会社
发明人： MATSUO KATSUHIKO , HOSOMI NAOHISA
IPC分类号： G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a medicine and method for examination of a brain infarction and its clinical condition which enable an anticipation and a prediction of a pathogenesis of the brain infarction.SOLUTION: The medicine and method for examination of the brain infarction and its clinical condition are characterized by measuring the quantity of an antibody against a Prevotella intermedia within a specimen of a test subject, and also are characterized by measuring the quantity of the antibody against the Prevotella intermedia within the specimen of the test subject. Preferably, the antibody is Immunogulobulins (an IgG antibody, an IgA antibody and an IgM antibody) or the IgG antibody.
摘要翻译：要解决的问题：提供脑梗塞检查的药物和方法及其临床状况，其能够预测和预测脑梗死的发病机理。解决方案：脑梗死及其检测方法临床状况的特征在于测量在受检对象的标本内的针对中间型Prevotella的抗体的量，并且其特征还在于测试受试者标本内的针对中间型Prevotella的抗体的量。优选地，抗体是免疫球蛋白（IgG抗体，IgA抗体和IgM抗体）或IgG抗体。

37. 发明专利

JP2001074732A METHOD FOR MEASURING UGF IN URINE 失效
公开(公告)号：JP2001074732A
公开(公告)日：2001-03-23
申请号：JP24707499
申请日：1999-09-01
申请人： TOAGOSEI CO LTD
发明人： NAOE TOMOKO , MATSUO KATSUHIKO
IPC分类号： G01N33/493 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To stably and accurately measure UGF(urinary gonadotropin fragment) even after storage by measuring the UGF in urine without separating a settlement being generated when fusing a urine specimen being frozen and stored. SOLUTION: UGF is partially insoluble in urine that has been fused by freezing and storing. When the UGF is to be measured, a settlement is dissolved uniformly, and liquid is sampled and measured. For dissolving the settlement uniformly, a dilute solution being used when measuring the UGF such as the dilute solution containing protein that does not affect the reaction system of an inorganic salt buffer solution near pH 7 at a concentration for indicating at least a constant conductivity (approximately 60 ms/cm or higher), bovine serum albumin, and the like, and further solution containing a salt with pH 7 for indicating the equivalent conductivity for dissolving the settlement, thus stably measuring a specimen that has been frozen and stored at least for two months.

38. 发明专利

JP2000290298A MONOCLONAL ANTIBODY WHICH REACTS WITH ADENOVIRUS AND DETECTION OF ADENOVIRUS THEREWITH 失效
公开(公告)号：JP2000290298A
公开(公告)日：2000-10-17
申请号：JP9847499
申请日：1999-04-06
申请人： TOAGOSEI CO LTD
发明人： NAOE TOMOKO , MATSUO KATSUHIKO , AZUMA TAKACHIKA , IMAI YUMI , ITO NORIHIKO , ONO SHIGEAKI , AOKI KOKI
IPC分类号： C12P21/08 , C07K16/08 , C12N5/10 , G01N33/569 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a monoclonal antibody which highly sensitively reacts not only with serum type adenoviruses, especially prototype adenoviruses, but also with clinically separated strains. SOLUTION: This monoclonal antibody reacts with adenoviruses of serium types 1, 3, 4, 5, 6, 7, 8, 11, 19, and 37, especially commonly exhibits high reactivity with all the adenovirus of serium types 3, 4, 8, 19, and 37, and does not react with viruses except the adenoviruses. The monoclonal antibody is preferably produced from a hybridoma which is obtained by fusing a mouse myeloma cell with the splenic cell of a mouse immunized with the mixture of the 3, 4, 8, 19 and 37 type adenoviruses.

39. 发明专利

JP2000241426A INSPECTING METHOD FOR SUB NASAL CAVITY INFLAMMATION, AND INSPECTING CHEMICAL 失效
公开(公告)号：JP2000241426A
公开(公告)日：2000-09-08
申请号：JP3906299
申请日：1999-02-17
申请人： TOAGOSEI CO LTD
发明人： MATSUO KATSUHIKO , MATSUBARA ISAMU , MATSUNE AKIYUKI , KURONO YUICHI
IPC分类号： A61B10/00 , G01N33/487 , G01N33/50 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To identify a chronic sub nasal cavity inflammation patient by measuring an blood vessel inner skin cell growth factor/blood vessel permeable factor(VPF) concentration in human mucus. SOLUTION: The inspection is based on a close relation between a chronic sub nasal cavity inflammation client and VPF concentration in mucus corrected with albumin, namely a relation where the VPF in mucus corrected with albumin of the chronic sub nasal cavity inflammation patient is significantly lower than VPF in mucus corrected with albumin of a healthy person, and additionally a close relation between an allergic coryda patient having sub nasal cavity inflammation and an allergic coryda patient having no sub nasal cavity inflammation, and VPF concentration in mucus, namely a relation where the VPF concentration in mucus of the allergic coryda patient having sub nasal cavity inflammation is significantly lower than the VPF concentration in mucus of the allergic coryda patient having no sub nasal cavity inflammation. The inspection of existence of sub nasal cavity inflammation can be inspected by measuring the VPF concentration in mucus, and the VPF concentration in mucus and albumin concentration in mucus.

40. 发明专利

JP2000169390A MEDICINE FOR TREATING OR PREVENTING NEPHRITIS 失效
公开(公告)号：JP2000169390A
公开(公告)日：2000-06-20
申请号：JP36611498
申请日：1998-12-08
申请人： TOAGOSEI CO LTD , KITAMOTO YASUNORI
发明人： KITAMOTO YASUNORI , TOMITA KIMIO , MATSUO KATSUHIKO
IPC分类号： A61K38/22 , A61K31/00 , A61P13/00 , A61P13/12
摘要： PROBLEM TO BE SOLVED: To prepare a medicine for treating or preventing nephritis capable of preventing the onset of nephritis such as minimal change group intraductal proliferative nephritis, crescentic gametocyte forming one, glomerulosclerosis or the like by including a neovascular inducer as an active ingredient. SOLUTION: This medicine for treating or preventing nephritis includes a neovascular inducer (preferably an endothelial cell growth factor and/or a vascular permeability factor) as an active ingredient. The medicine may be dosed by oral administration including sublingual administration or by parenteral administration including subcutaneous injection, intramuscular one, intravascular one, intravenous drip or the like. It is preferable that the daily dose is 0.5-100 mg/(kg body weight) divided in one or few portions per day in the case of a baby.

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