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1. 发明专利

JP2003146956A NEW QUATERNARY AMMONIUM SALT AND METHOD FOR PRODUCING THE SAME 审中-公开
公开(公告)号：JP2003146956A
公开(公告)日：2003-05-21
申请号：JP2001349345
申请日：2001-11-14
申请人： TOAGOSEI CO LTD
发明人： SHIBATA SHIGEYUKI , KANO MUNEAKI , TANAKA YOICHI , NAGATA TOSHIYUKI , KOMA HIROKI
IPC分类号： A61K8/30 , A01N33/12 , A01N37/10 , A01N37/20 , A01N37/44 , A01N47/28 , A61K8/40 , A61K31/14 , A61K31/166 , A61K31/222 , A61K31/325 , A61P27/02 , A61P31/04 , A61P31/10 , C07C213/02 , C07C217/16 , C07C219/14 , C07C227/08 , C07C229/12 , C07C231/14 , C07C233/78 , C07C273/18 , C07C275/24 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide an antimicrobial agent exhibiting high antimicrobial activity and wide antimicrobial spectrum and having high safety to human bodies. SOLUTION: This new quaternary ammonium salt compound is represented by formula (1) [wherein R1 is a 3-20C alkyl group; R2 is a 3-20C alkyl group; R3 is a 1-2C alkyl group; A is CONR13 , NR13 CO, COO, OOC, O, NR13 COO or NR13 CONR13 ; R13 is hydrogen atom or a 1-4C alkyl group; L is 0 or 1; k is an integer of 1 to 4; X is an inorganic or organic anion and n is the valence of the anion X and the product of n with m is 2].

2. 发明专利

JP2003146953A NEW QUATERNARY AMMONIUM SALT COMPOUND, METHOD FOR PRODUCING THE SAME AND ANTIMICROBIAL AGENT CONTAINING THE SAME COMPOUND 审中-公开
公开(公告)号：JP2003146953A
公开(公告)日：2003-05-21
申请号：JP2001348635
申请日：2001-11-14
申请人： TOAGOSEI CO LTD
发明人： SHIBATA SHIGEYUKI , KANO MUNEAKI , TANAKA YOICHI , NAGATA TOSHIYUKI , KOMA HIROKI
IPC分类号： A61K8/30 , A01N33/12 , A01N37/12 , A01N37/20 , A01N47/20 , A61K8/40 , A61K31/166 , A61K31/216 , A61K31/27 , A61P27/04 , A61P31/02 , A61P31/04 , C07C213/02 , C07C217/10 , C07C219/14 , C07C231/12 , C07C233/78 , C07C269/06 , C07C271/28 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide an antimicrobial agent exhibiting high antimicrobial activity and wide antimicrobial spectrum and having high safety to human bodies. SOLUTION: This new quaternary ammonium salt compound is represented by formula (1) [wherein R1 is a 3-20C alkyl group; R2 is a 1-20C alkyl group; R3 is a 1-20C alkyl group; A is CONR13 , NR13 CO, COO, OOC, O, NR13 COO or NR13 CONR13 ; R13 is hydrogen atom or a 1-4C alkyl group; B is phenylene or a group represented by formula (2) or formula (3); L is 0 or 1; k is an integer of 1 to 4; X is an inorganic or organic anion and n is the valence of the anion X and the product of n with m is 2].

3. 发明专利

JP2000329760A METHOD FOR MEASURING PROTEIN IN STOOL 失效
公开(公告)号：JP2000329760A
公开(公告)日：2000-11-30
申请号：JP13840799
申请日：1999-05-19
申请人： TOAGOSEI CO LTD
发明人： NAITO AKIHIRO , MATSUBARA ISAMU , TANAKA YOICHI , MATSUO KATSUHIKO
IPC分类号： G01N33/48 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To eliminate an erroneous answer brought about when a protein in a stool is measured and to obtain a correct inspection result by adding a protein except a protein to be measured or a protein decomposing enzyme inhibitor to a specimen or measuring the protein after heating the specimen. SOLUTION: A protein of an object to be inspected or a protein decomposing enzyme inhibitor is added to a stool or a stool extract to be inspected for the presence or absence of the protein to be inspected, that is, a specimen. Or, the specimen is heated. As the protein to be added, an α-macroglobulin or a BSA(Bovine Serum Albumin) is used, as the inhibitor, a p-AEBSF [4-(2- aminoethyl)benzenesulfonyl-fluoride] or the like is used. In the case of the protein, adding amounts of them to the specimen, the stool are 0.1 μg to 10 mg per 1 mg of the stool and 1 μg to 10 mg per 1 mg of the stool in the case of the inhibitor, and suitably selected in response to the state of the stool, the type of the protein to be inspected and the type of an additive.

4. 发明专利

JP2010085244A Aqueous reagent for heightening sensitivity of antigen of periodontal disease pathogenic bacteria in immunoassay 审中-公开
标题翻译：用于免疫测定的周围疾病病原菌抗原抗原敏感性的水性试剂
公开(公告)号：JP2010085244A
公开(公告)日：2010-04-15
申请号：JP2008254653
申请日：2008-09-30
申请人： Toagosei Co Ltd , 東亞合成株式会社
发明人： NAOE TOMOKO , TANAKA YOICHI , MATSUO KATSUHIKO , NIWA MIKIO
IPC分类号： G01N33/531 , G01N33/569
摘要： PROBLEM TO BE SOLVED: To provide an aqueous reagent for heightening sensitivity of antigen measurement of periodontal disease pathogenic bacteria in enzyme immunoassay [Enzyme-Linked Immuno-sorbent Assay (ELISA)] having lower cost and quantitativeness, which is used most widely or frequently in a field of research or diagnosis in immunoassay.
SOLUTION: An antigen of periodontal disease pathogenic bacteria can be measured with high sensitivity by using this aqueous reagent containing a buffer agent and a water-soluble surfactant.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于提高牙周病病原体抗原测量的灵敏度的水性试剂，其酶联免疫吸附测定（酶联免疫吸附测定法（ELISA））具有较低的成本和定量性，其被广泛使用或经常在免疫测定中的研究或诊断领域。解决方案：通过使用含有缓冲剂和水溶性表面活性剂的水性试剂，可以高灵敏度地测量牙周病病原菌的抗原。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2004026722A New quaternary ammonium salt, method for producing the same, and antibacterial agent comprising the salt 审中-公开
公开(公告)号：JP2004026722A
公开(公告)日：2004-01-29
申请号：JP2002185708
申请日：2002-06-26
申请人： Hiroki Koma , Toagosei Co Ltd , 東亞合成株式会社 , 高麗寛紀
发明人： SHIBATA SHIGEYUKI , KANO MUNEAKI , TANAKA YOICHI , NAGATA TOSHIYUKI , KOMA HIROKI
IPC分类号： A61K9/08 , A01N33/12 , A61K8/30 , A61K8/40 , A61K47/18 , A61P27/04 , C07C209/12 , C07C211/63 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain an antibacterial agent, antifungal agent or antiseptic having high antimicrobial activity and a wide antimicrobial spectrum and highly safe to human health.
SOLUTION: A new quaternary ammonium salt as the antimicrobial agent is represented by formula(1)( wherein, R
1 , R
2 and R
3 are each a 1-16C alkyl, the total number of the carbon atoms in R
1 , R
2 and R
3 being ≥10; X
n- is an inorganic or organic anionic group; (n) is the valence of the anionic group : X
n- , and is 1 or 2; (m) is 2 when (n) is 1, and is 1 when (n) is 2 ).
COPYRIGHT: (C)2004,JPO

6. 发明专利

JPH08313522A METHOD FOR MEASURING VASCULAR PERMEABILITY FACTOR 失效
公开(公告)号：JPH08313522A
公开(公告)日：1996-11-29
申请号：JP14127195
申请日：1995-05-16
申请人： TOAGOSEI CO LTD
发明人： HANATANI MITSUYA , TANAKA YOICHI , MATSUO KATSUHIKO , KONDO SHINICHI , OMORI IWAO
IPC分类号： G01N33/53
摘要： PURPOSE: To accurately measure the amount of VPF(vascular permeability factor) by using the chemiluminescence as a detection method of enzyme immunity measurement using anti-VPF polyclonal antibody. CONSTITUTION: Anti-VPF polyclonal antibody (5μg/ml) is poured into each hole of 96-hole plate, is left stand for one night at approximately 4 deg.C, is washed in phosphoric acid buffering physiological salt solution containing 0.1% bovine serum albumin(BSA), and is blocked for approximately one hour in 1% BSA- containing buffer solution. The serum of a healthy person which is diluted approximately ten times by sodium phosphate buffer solution containing 1% BSA is added and is left stand for approximately one hour. It is washed with tris buffer solution, alkali phosphatase labeled antibody VPF polyclonal antibody is added to react for approximately one hour, and is washed with tris buffer liquid. For example, Lumi-Phos 530 which is diluted by approximately five times in a buffer solution is added into it, and the entire part is left stand for approximately 30 minutes at approximately 37 deg.C. After that, by measuring luminous intensity, a small amount of VPF in the humor derived from a human can be measured.

7. 发明专利

JP2004224734A New quaternary ammonium salt compound 审中-公开
公开(公告)号：JP2004224734A
公开(公告)日：2004-08-12
申请号：JP2003015160
申请日：2003-01-23
申请人： Toagosei Co Ltd , 東亞合成株式会社
发明人： NAGATA TOSHIYUKI , SHIBATA SHIGEYUKI , TANAKA YOICHI , KOMA HIROKI
IPC分类号： A61P31/02 , A01N33/12 , A61K31/14 , A61P31/04 , A61P31/10 , C07C209/12 , C07C211/63 , C07C213/00 , C07C215/14
摘要： PROBLEM TO BE SOLVED: To provide an antibacterial agent exhibiting high antibacterial activity and a wide antibacterial spectrum scarcely contributing to bacteria's acquiring resistance even after long-term repeated use, and having high antibacterial activity on strains that have acquired resistance to existing antibacterial agents.
SOLUTION: The antibacterial agent comprises a quaternary ammonium salt compound of the formula(1)( wherein, R
1 is a 4-20C alkyl; R
2 is a hydroxy-functional 1-4C alkyl; R
3 is a 1-4C alkyl or hydroxy-functional 1-4C alkyl; R
4 is a 6-20C alkyl; R
5 and R
6 are each a 1-4C alkyl or hydroxy-functional 1-4C alkyl; X
n- us an inorganic or organic anionic group; and n is the valence of the anionic group X
n- ). A method for producing the compound is also provided. Disinfectants, preservatives or antifungal agents each comprising the compound are also provided.
COPYRIGHT: (C)2004,JPO&NCIPI

8. 发明专利

JP2003146952A NEW QUATERNARY AMMONIUM SALT COMPOUND AND METHOD FOR PRODUCING THE SAME 审中-公开
公开(公告)号：JP2003146952A
公开(公告)日：2003-05-21
申请号：JP2001349149
申请日：2001-11-14
申请人： TOAGOSEI CO LTD
发明人： SHIBATA SHIGEYUKI , KANO MUNEAKI , TANAKA YOICHI , NAGATA TOSHIYUKI , KOMA HIROKI
IPC分类号： A61K9/08 , A01N33/12 , A01N37/12 , A01N47/20 , A01N47/30 , A61K8/00 , A61K8/30 , A61K8/40 , A61K31/14 , A61K31/166 , A61K31/17 , A61K31/235 , A61K31/27 , A61P27/02 , A61P31/02 , A61P31/04 , A61P31/10 , A61Q11/00 , C07C217/06 , C07C219/04 , C07C229/12 , C07C269/02 , C07C271/28 , C07C273/18 , C07C275/40 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide an antimicrobial agent exhibiting high antimicrobial activity and wide antimicrobial spectrum and having high safety to human bodies. SOLUTION: This new quaternary ammonium salt compound is represented by formula (1) [wherein R1 is a 3-20C alkyl group; R2 is a 1-20C alkyl group; R3 is a 1-20C alkyl group; A is CONR13 , NR13 CO, COO, OOC, O, NR13 COO or NR13 CONR13 ; R13 is hydrogen atom or a 1-4C alkyl group; L is 0 or 1; k is an integer of 1 to 4; X is an inorganic or organic anion and n is the valence of the anion X and the product of n with m is 2].

9. 发明专利

JP2001252085A ANTI-SENSE NUCLEIC ACID COMPOUND 失效
公开(公告)号：JP2001252085A
公开(公告)日：2001-09-18
申请号：JP2000072741
申请日：2000-03-15
申请人： TOAGOSEI CO LTD
发明人： MATSUDA YOKO , TANAKA YOICHI , TAKEUCHI HIROAKI , UCHIDA KIYOSHI
IPC分类号： C12N15/09 , A61K31/711 , A61K48/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide an anti-sense nucleic acid compound which has restraining or inhibitory action on the expression of the receptor of 1 type (FGFR1) to a fibroblast growth factor(FGF) shouldering the roles of the propagation stimulation of various kinds of cells starting with fibroblast, the cell differentiation control of cells in a hemocyte system and/or a skeletal muscle system, and the protrusion elongation and/or survival maintenance of nerve cells. SOLUTION: This nucleic acid compound is represented by the following base sequence: TTGGGTTT.

10. 发明专利

JPH099995A MEASUREMENT OF CLOT FORMING TENDENCY OF BLOOD 失效
公开(公告)号：JPH099995A
公开(公告)日：1997-01-14
申请号：JP16768295
申请日：1995-07-03
申请人： TOAGOSEI CO LTD
发明人： TANAKA YOICHI , MATSUO KATSUHIKO
IPC分类号： G01N33/49 , C12Q1/28 , C12Q1/37 , C12Q1/56
摘要： PROBLEM TO BE SOLVED: To measure a clot forming tendency(CFT) of blood useful for diagnosis, etc., of thrombosis by measuring the total fibrinolytic activities in a sample derived from the blood. SOLUTION: The activities or fibrinolytic activities of a protein participating in fibrinolysis (a tissue plasminogen activating factor, a plasminogen activating factor inhibitor 1, etc.) in a sample derived from blood (preferably the blood in a pseudocoagulated state) are measured. The fibrinolytic activities in the sample derived from the blood and the CFT are regarded as having a positive correlation and the CFT can simply be measured from the measurement of the fibrinolytic activities.

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