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31. 发明授权

US08244337B2 Method and implantable medical device for classifying sensor signals 有权
标题翻译：用于分类传感器信号的方法和可植入医疗装置
公开(公告)号：US08244337B2
公开(公告)日：2012-08-14
申请号：US12280505
申请日：2006-02-28
申请人： Nils Holmström , Malin Öhlander
发明人： Nils Holmström , Malin Öhlander
IPC分类号： A61B5/04
CPC分类号： A61N1/3627 , A61B5/0402 , A61B5/7264 , A61N1/36514 , A61N1/3702
摘要： In a method and an apparatus for creating hemodynamic sensor signal templates using an implantable medical device connectable to a patient heart activity of the patient is sensed in order to identify a paste or sensed sequence of events of a heart cycle. Hemodynamic sensor signals for consecutive heart cycles are sensed and the sensed hemodynamic sensor signals for consecutive heart cycles are stored. The sensed sensor signals are classified dependent on at least one predetermined heart event sequence condition. A template may be created using the classified sensor signals.
摘要翻译：在用于创建血液动力学传感器信号模板的方法和装置中，使用可植入的医疗装置来感测患者的心脏活动，以识别患者心脏周期的糊状物或感测的事件序列。感测连续心脏循环的血液动力学传感器信号，并存储感测到的连续心脏循环的血液动力学传感器信号。感测的传感器信号根据至少一个预定的心脏事件序列条件进行分类。可以使用分类的传感器信号来创建模板。

32. 发明授权

US07146208B2 Systolic function monitoring utilizing slope of measured impedance 有权
标题翻译：使用测量阻抗斜率的收缩功能监测
公开(公告)号：US07146208B2
公开(公告)日：2006-12-05
申请号：US10396958
申请日：2003-03-25
申请人： Nils Holmström , Anna Norlin , Kenneth Dahlberg , Martin Obel
发明人： Nils Holmström , Anna Norlin , Kenneth Dahlberg , Martin Obel
IPC分类号： A61B5/053 , A61N1/365
CPC分类号： A61B5/0535 , A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A heart monitoring device has a control circuit, the control circuit being adapted to be electrically connected to electrode surfaces arranged at two different positions of the heart. The control circuit derives an impedance value indicative of the impedance between the electrode surfaces. Furthermore, the control circuit is arranged to determine and monitor a relationship between a positive rate of change and a negative rate of change of the impedance value. The device can, in particular, be used to detect and treat a systolic dysfunction of a heart.
摘要翻译：心脏监测装置具有控制电路，所述控制电路适于电连接到布置在心脏两个不同位置处的电极表面。控制电路导出指示电极表面之间的阻抗的阻抗值。此外，控制电路被布置成确定和监测正的变化率和阻抗值的负的变化率之间的关系。该装置特别可用于检测和治疗心脏的收缩功能障碍。

33. 发明申请

US20100121400A1 IMPLANTABLE CARDIAC DEVICE AND METHOD FOR MONITORING THE STATUS OF A CARDIOVASCULAR DISEASE 有权
标题翻译：可注射的心脏装置和监测心血管疾病状态的方法
公开(公告)号：US20100121400A1
公开(公告)日：2010-05-13
申请号：US12528653
申请日：2007-03-23
申请人： Nils Holmström , Malin Öhlander , Kjell Norén , Andreas Blomqvist , Karin Ljungström
发明人： Nils Holmström , Malin Öhlander , Kjell Norén , Andreas Blomqvist , Karin Ljungström
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/0215 , A61B5/02405 , A61B5/053 , A61B5/4035 , A61B5/4836 , A61B5/7257 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： An implantable cardiac device has a heart stimulator for electrically stimulating the heart of a patient, detector that measures a physiologic parameter that is affected by the status of a cardiovascular disease associated with sympathetic activation, a signal processor that determines at least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the measured parameter, and analyzer that automatically analyzes the determined Mayer wave component in relation to a predetermined reference value to determine the status of the cardiovascular disease. The detector is a cardio-mechanical parameter detector that measures, as said physiologic parameter, a mechanical change in at least one of the four chambers of the heart. In a corresponding method for monitoring the status of a cardiovascular disease associated with sympathetic activation of a patient having an implantable electric heart stimulator a physiologic parameter affected by the cardiac disease is measured. At least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the parameter is determined, and the wave component is analyzed in relation to a predetermined reference value to determine the status of the cardiovascular disease. A mechanical change in at least one of the four chambers of the heart is measured as the physiologic parameter.
摘要翻译：可植入心脏装置具有用于电刺激患者心脏的心脏刺激器，所述心脏刺激器测量受到与交感神经激活相关的心血管疾病状态影响的生理参数的检测器，信号处理器确定低频 LF，以及在测量参数中的非常低频VLF，Mayer波分量，以及分析仪，其自动分析与预定参考值相关的确定的Mayer波分量，以确定心血管疾病的状态。检测器是心机械参数检测器，其作为所述生理参数测量心脏的四个腔室中的至少一个中的机械变化。在用于监测与具有可植入电心脏刺激器的患者的交感神经激活相关的心血管疾病的状态的相应方法中，测量受心脏病影响的生理参数。确定参数中的低频，低频和极低频VLF，迈耶波分量中的至少一个，并且相对于预定参考值分析波分量以确定心血管疾病的状态。心脏的四个腔室中的至少一个的机械变化被测量为生理参数。

34. 发明授权

US07569020B2 Method for extracting timing parameters using a cardio-mechanical sensor 有权
标题翻译：使用心机械传感器提取定时参数的方法
公开(公告)号：US07569020B2
公开(公告)日：2009-08-04
申请号：US11455518
申请日：2006-06-19
申请人： Kjell Norén , Nils Holmström
发明人： Kjell Norén , Nils Holmström
IPC分类号： A61B5/026
CPC分类号： A61B5/02416 , A61B5/0031 , A61B5/0452 , A61B5/083 , A61B5/1116 , A61B5/686 , A61B5/7239 , A61N1/36514 , A61N1/36578
摘要： In a method and apparatus for measuring the ejection fraction in a mammalian heart, the opening and closing of a heart valve is sensed with an implanted sensor, and a pre-ejection period is measured as a function of the sensed opening and closing of the heart valve. The ventricular ejection time also is measured, and the ejection fraction is determined as a function of the measured pre-ejection period and the ejection time.
摘要翻译：在用于测量哺乳动物心脏中的射血分数的方法和装置中，用植入的传感器感测心脏瓣膜的打开和关闭，并且根据检测到的心脏的开启和关闭来测量预喷射周期阀。也测量心室射血时间，并且将射血分数确定为所测量的预喷射时间和喷射时间的函数。

35. 发明授权

US06447670B1 Method and apparatus for compensating for drift in potential of a reference electrode in electrochemical measurements 失效
标题翻译：用于补偿电化学测量中参考电极电位漂移的方法和装置
公开(公告)号：US06447670B1
公开(公告)日：2002-09-10
申请号：US09530295
申请日：2000-07-11
申请人： Nils Holmström
发明人： Nils Holmström
IPC分类号： G01N2726
CPC分类号： G01N27/4163 , A61N1/36557 , G01N33/4925
摘要： In a method and an apparatus for measuring a concentration of at least one dissolved chemical entity in a liquid medium, employing a counter electrode, a working electrode and a reference electrode immersed in the liquid medium, at least one measurement potential is applied to the working electrode relative to the reference electrode, corresponding to a measurement voltage during at least a part of a measurement period, thereby causing the dissolved chemical entity to participate in an electrochemical reaction at the working electrode, the chemical reaction resulting in a measurement evoked current. Compensation for potential drift at the reference electrode is achieved by comparing the measurement evoked current with a predetermined value, and decreasing or increasing the measurement voltage by an incremental value, in a negative or a positive incremental step, so that the measurement current approaches a predetermined value. After each increment, a new comparison is made and the next increment is determined dependent on that most recent comparison.
摘要翻译：在液体介质中测量至少一个溶解化学物质的浓度的方法和装置中，使用浸在液体介质中的对电极，工作电极和参比电极，至少一个测量电位施加到工作电极相对于参考电极，对应于在测量周期的至少一部分期间的测量电压，从而使溶解的化学实体参与在工作电极处的电化学反应，导致测量诱发电流的化学反应。通过将测量诱发电流与预定值进行比较，以及在负增量或正增量步长中将测量电压减小或增加增量值来实现对参考电极的电位漂移的补偿，使得测量电流接近预定的值。在每个增量之后，进行新的比较，并根据最近的比较确定下一个增量。

36. 发明授权

US06188931B1 Electrode lead with temporary increased stiffness during ingrowth 失效
标题翻译：电极导线在向内生长期间具有临时增加的刚度
公开(公告)号：US06188931B1
公开(公告)日：2001-02-13
申请号：US09319403
申请日：1999-07-26
申请人： Nils Holmström , Martin Obel
发明人： Nils Holmström , Martin Obel
IPC分类号： A61N105
CPC分类号： A61N1/056
摘要： An implantable lead for an implantable active device, such as a pacemaker, has at least two electrodes, and a proximal end adapted for electrical and mechanical connection to the active device and a distal end opposite the proximal end. A ventricular electrode is carried at the distal end of the lead for sensing and/or electrical interaction with the ventricle, and an atrial electrode is carried on the lead for sensing and/or electrical interaction with the atrium, the atrial electrode being disposed between the proximal end and the ventricular electrode. The lead at its distal end has a first part with a first predetermined length, which is between 9 and 13 cm, and which exhibits a first stiffness. Adjacent to this first part is a second part, having a second predetermined length, which exceeds 15 cm, and which exhibits a second stiffness. The first stiffness of the first part provides the overall lead with a stiffness so as to force the atrial electrode in contact with the atrial wall when the lead is implanted. The second stiffness is greater then the first stiffness. The lead has a transition point between the first part and the second part, disposed at the proximal end of the second part.
摘要翻译：用于可植入有源装置（例如起搏器）的可植入导线具有至少两个电极，以及适于与主动装置电连接和机械连接的近端以及与近端相对的远端。在电极的远端承载心室电极，用于与心室的感应和/或电相互作用，并且心房电极承载在引线上，用于与心房的感应和/或电相互作用，心房电极设置在心室近端和心室电极。其远端处的引线具有第一部分，其具有第一预定长度，其在9和13cm之间，并且其具有第一刚度。与第一部分相邻的是第二部分，具有超过15cm的第二预定长度，并且具有第二刚度。第一部分的第一刚度提供了具有刚度的整体引线，以便当植入引线时迫使心房电极与心房壁接触。第二刚度大于第一刚度。引线在第一部分和第二部分之间具有设置在第二部分的近端处的转变点。

37. 发明授权

US08135455B2 System and method for monitoring synchrony between chambers of a heart by volume measurements and analysis 有权
标题翻译：通过体积测量和分析来监测心脏室之间的同步的系统和方法
公开(公告)号：US08135455B2
公开(公告)日：2012-03-13
申请号：US11916463
申请日：2005-06-16
申请人： Nils Holmström
发明人： Nils Holmström
IPC分类号： A61B5/04
CPC分类号： A61N1/36521 , A61B5/029 , A61B5/0295 , A61N1/3627 , A61N1/3682 , A61N1/3702
摘要： An implantable heart monitoring system includes a housing configured for implantation in a subject, at least one sensor member implanted relative to the heart of the subject to detect an electrical signal related to cardiac activity of the heart, a control circuit in the housing, and a memory accessible by the control circuit. The control circuit, from said electrical signal, derives a first value related to the volume of a first part of the heart and derives a second value related to the volume of a second part of the heart, and monitors variation of said first value over time in at least a substantial portion of a heart cycle, and monitors variation of said second value over time in said substantial portion of said heart cycle, and stores in the memory information representing the monitoring of said first and second values that represents a relationship between the first and second values in the substantial portion of the heart cycle and variation of the relationship in the substantial portion of the heart cycle.
摘要翻译：可植入心脏监测系统包括构造成用于植入对象的壳体，相对于对象的心脏植入的至少一个传感器构件，以检测与心脏的心脏活动相关的电信号，壳体中的控制电路和存储器可由控制电路访问。来自所述电信号的控制电路导出与心脏的第一部分的体积相关的第一值，并且导出与心脏的第二部分的体积相关的第二值，并且监视所述第一值随时间的变化在心脏周期的至少大部分中，并且监视所述心脏周期的所述实质部分中随时间推移的所述第二值的变化，并且存储在表示所述第一和第二值的监视的存储器信息中，所述第一和第二值表示在心脏周期的实质部分中的第一和第二值以及心脏周期的实质部分中关系的变化。

38. 发明授权

US08133187B2 Implantable medical device with heart condition detection 有权
标题翻译：具有心脏状态检测的可植入医疗器械
公开(公告)号：US08133187B2
公开(公告)日：2012-03-13
申请号：US12095216
申请日：2005-12-16
申请人： Nils Holmström , Kjell Noren
发明人： Nils Holmström , Kjell Noren
IPC分类号： A61B5/0255
CPC分类号： A61B7/00 , A61B7/04 , A61N1/36514 , A61N1/36578
摘要： A method for detecting a condition of a heart of a patient using an implantable medical device, including the steps of sensing acoustic signals indicative of heart sounds of the heart of the patient; extracting signals corresponding to a first heart sound (S1) and a second heart sound (S2) from sensed signals; calculating an energy value corresponding to a signal corresponding to the first heart sound (S1) and an energy value corresponding to the second heart sound (S2); calculating a relation between the energy value corresponding to the first heart sound and the energy value corresponding to the second heart sound for successive cardiac cycles; and using at least one relation to detect the condition or a change of the condition. A medical device for determining the posture of a patient and a computer readable medium encoded with instructions are used to perform the inventive method.
摘要翻译：一种用于使用可植入医疗装置检测患者心脏状态的方法，包括以下步骤：感测指示患者心脏的心脏声音的声学信号; 从感测信号中提取对应于第一心音（S1）和第二心音（S2）的信号; 计算对应于对应于第一心音（S1）的信号的能量值和对应于第二心音（S2）的能量值; 计算对应于第一心音的能量值与对应于第二心音的能量值之间的关系，用于连续的心动周期; 并使用至少一个关系来检测条件或条件的变化。用于确定患者姿势的医疗装置和用指令编码的计算机可读介质用于执行本发明的方法。

39. 发明申请

US20100113961A1 MEDICAL DEVICE FOR DETERMINING THE POSTURE OF PATIENT 有权
标题翻译：用于确定患者症状的医疗装置
公开(公告)号：US20100113961A1
公开(公告)日：2010-05-06
申请号：US11993254
申请日：2005-06-29
申请人： Malin Öhlander , Nils Holmström , Kjell Norén
发明人： Malin Öhlander , Nils Holmström , Kjell Norén
IPC分类号： A61B5/053
CPC分类号： G06F19/34 , A61B5/0031 , A61B5/01 , A61B5/029 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/4561 , A61B5/686
摘要： The present invention relates to a method for determining the posture of a patient. The method comprises the steps of: initiating (50, 52) a patient posture determining session by performing an electrical bio-impedance measurement session in at least one of a number of different electrode configurations in order to measure an impedance value for the at least one configuration; obtaining reference impedance values (54) stored in advance for the at least one configuration and for at least one potential posture of the patient; comparing (54) the measured impedance value for the at least one configuration with corresponding stored reference impedance values for at least one potential posture of the patient; and determining (56) the present posture of the patient by using results from the comparison between measured impedance values and the stored reference impedance values. Furthermore, the invention relates to a medical device for determining the posture of a patient and a computer readable medium comprising instructions for bringing a computer to perform the inventive method.
摘要翻译：本发明涉及一种用于确定患者姿势的方法。该方法包括以下步骤：通过在多个不同电极配置中的至少一个中执行电生物阻抗测量会话来启动（50,52）患者姿势确定会话，以便测量至少一个组态; 获得针对所述至少一个配置和所述患者的至少一个潜在姿势预先存储的参考阻抗值（54）; 将所述至少一个配置的测量阻抗值与所述患者的至少一个潜在姿势的对应存储的参考阻抗值进行比较（54）; 以及通过使用测量的阻抗值与所存储的参考阻抗值之间的比较的结果来确定（56）患者的当前姿势。此外，本发明涉及一种用于确定患者姿势的医疗装置和包括用于使计算机执行本发明的方法的指令的计算机可读介质。

40. 发明授权

US07397166B1 Electroactive polymer-actuated peristaltic pump and medical lead incorporating such a pump 失效
标题翻译：电动聚合物致动的蠕动泵和包含这种泵的医用引线
公开(公告)号：US07397166B1
公开(公告)日：2008-07-08
申请号：US11404268
申请日：2006-04-12
申请人： Kevin L. Morgan , Anne M. Shelchuk , Jeffery D. Snell , Nils Holmström , John R. Helland
发明人： Kevin L. Morgan , Anne M. Shelchuk , Jeffery D. Snell , Nils Holmström , John R. Helland
IPC分类号： H01L41/08
CPC分类号： F04B43/1223 , A61M5/14228 , A61M2205/0283 , F04B43/095 , F04B43/12 , Y10S310/80
摘要： A peristaltic pump for conveying a fluid comprises a flexible tube having an outer surface and a lumen for carrying the fluid such as a therapeutic agent. The tube has a length defined by opposed ends of the tube, the outer surface of the body carrying a plurality of longitudinally spaced-apart electroactive polymer actuators. The plurality of actuators are adapted to be responsive to electrical signals for energizing the actuators sequentially along the length of the tube to move a lumen pinch-off along the length of the tube to thereby convey the fluid from one end of the tube to the other end by means of a peristaltic pumping action. The peristaltic pump may be incorporated into a medical lead, such as an endocardial pacing lead, carrying at least one electrode.
摘要翻译：用于输送流体的蠕动泵包括具有用于承载诸如治疗剂的流体的外表面和内腔的柔性管。管具有由管的相对端限定的长度，本体的外表面承载多个纵向间隔开的电活性聚合物致动器。多个致动器适于响应于电信号，以沿着管的长度依次致动致动器，以沿着管的长度移动管腔夹紧，从而将流体从管的一端传送到另一端通过蠕动泵送动作结束。蠕动泵可以并入到携带至少一个电极的医疗引线（例如心内膜起搏引线）中。

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