专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US4104372A 1-N-(.alpha.-hydroxy-.omega.-aminoalkanoyl) derivatives of 3'-deoxykanamycin A and the production thereof 失效
标题翻译： 3 {40-脱氧卡那霉素A的1-N - （{60-羟基 - {107-氨基烷酰基）衍生物及其制备
公开(公告)号：US4104372A
公开(公告)日：1978-08-01
申请号：US678560
申请日：1976-04-20
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya
IPC分类号： C07H15/234 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , B01J23/00 , B01J25/00 , C07B61/00 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/234 , Y02P20/55
摘要： 1-N-(.alpha.-hydroxy-.omega.-aminoalkanoyl)-derivatives of 3'-deoxykanamycin A or 6'-N-methyl-3'-deoxykanamycin A are provided as new and useful compounds which are active against gram-negative and gram-positive bacteria, including drug-resistant strains of these bacteria. Examples of these compounds include 1-N-((SR)-.beta.-amino-.alpha.-hydroxypropionyl)-3'-deoxykanamycin A, 1-N-((S)-.gamma.-amino-.alpha.-hydroxybutyryl)-3'-deoxykanamycin A, 1-N-((S)-.delta.-amino-.alpha.-hydroxyvaleryl)-3'-deoxykanamycin A and 1-N-((S)-.gamma.-amino-.alpha.-hydroxybutyryl)-6'-N-methyl-3'-deoxykanamycin A. The compounds may be prepared by selective acylation of the 1-amino group of 3'-deoxykanamycin A or 6'-N-methyl-3'-deoxykanamycin A with a corresponding .alpha.-hydroxy-.omega.-amino-alkanoic acid.
摘要翻译：提供3'-脱氧卡那霉素A或6'-N-甲基-3'-脱氧卡那霉素A的1-N-（α-羟基 - ω-氨基烷酰基）衍生物作为对革兰氏阴性和革兰氏阴性菌具有活性的新的有用化合物阳性细菌，包括这些细菌的耐药菌株。这些化合物的实例包括1-N - （（SR）-β-氨基-α-羟基丙酰基）-3'-脱氧卡那霉素A，1-N - （（S）-γ-氨基-α-羟基丁酰基）脱氧卡那霉素A，1-N - （（S）-δ-氨基-α-羟基戊酰基）-3'-脱氧卡那霉素A和1 -N（（S）-γ-氨基-α-羟基丁酰基）-6'-N- 甲基-3'-脱氧卡那霉素A.该化合物可以通过将3-脱氧卡那霉素A或6'- N-甲基-3'-脱氧卡那霉素A的1-氨基选择性酰化与相应的α-羟基 - 氨基 - 链烷酸。

32. 发明授权

US4065616A Processes for production of a 1-N-(.alpha.-hydroxy-.PHI.-amino alkanoyl)-3-deoxy-5-O-pentafuranosyl neamine and new compounds produced by the same processes 失效
标题翻译：制备1-N - （{60-羟基 - {101-氨基烷酰基）-3-脱氧-5-O-五氢呋喃糖基新胺的方法和通过相同方法生产的新化合物
公开(公告)号：US4065616A
公开(公告)日：1977-12-27
申请号：US710949
申请日：1976-08-02
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Isamu Watanabe
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Isamu Watanabe
IPC分类号： B01J23/00 , B01J25/00 , C07B61/00 , C07H15/224 , C07H15/23 , C07H15/22
CPC分类号： C07H15/224 , C07H15/23
摘要： This invention relates to new processes for the production of a 1-N-(.alpha.-hydroxy-.omega.-aminoalkanoyl)-3'-deoxy-5-O-pentofuranosylneamine, including 3'-deoxybutirosins A and B, as a semi-synthetic antibiotic. This invention further relates to new and useful semi-synthetic antibiotics which are produced by the above new processes.
摘要翻译：本发明涉及用于制备1-N-（α-羟基 - ω-氨基烷酰基）-3'-脱氧-5-O-呋喃鸟糖苷的新方法，包括3'-脱氧胆红素A和B作为半合成抗生素。本发明还涉及通过上述新方法生产的新的和有用的半合成抗生素。

33. 发明授权

US4169939A Processes for the production of 3',4'-dideoxykanamycin B 失效
标题翻译：生产3'，4'-二羟甲基氨基甲酸B的方法
公开(公告)号：US4169939A
公开(公告)日：1979-10-02
申请号：US851019
申请日：1977-11-14
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya
IPC分类号： C07H15/234 , C07H15/236 , C07H15/22
CPC分类号： C07H15/234 , Y02P20/55
摘要： A clinically valuable antibiotic, 3',4'-dideoxykanamycin B is now produced by a reduced number of consecutive steps in an improved overall yield by new processes starting from kanamycin B via intermediate derivatives of kanamycin B in which all the five amino groups are protected with an unsubstituted or substituted benzyloxycarbonyl group and possibly the 2"-hydroxyl group may be protected with a lower alkylsufonyl, arylsulfonyl or aralkylsulfonyl group.

34. 发明授权

US4156078A Process for the synthesis of 3',4'-dideoxykanamycin B and products 失效
标题翻译：合成3 {40,4（40-脱氧卡那霉素B和产物）的方法
公开(公告)号：US4156078A
公开(公告)日：1979-05-22
申请号：US745015
申请日：1976-11-26
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya
IPC分类号： C07H15/234 , B01J23/00 , B01J25/00 , C07B61/00 , C07H15/236 , C07H15/22
CPC分类号： C07H15/234 , Y02P20/55
摘要： A useful antibiotic, 3',4'-dideoxykanamycin B can be prepared in shortened steps and in an improved overall yield by a new process starting from kanamycin B via new intermediate derivatives of kanamycin B in which all the amino groups and possibly the 2"-hydroxyl group are protected with sulfonyl-type protecting groups selected from lower alkyl-, aryl- and aralkyl-sulfonyl groups.
摘要翻译：一种有用的抗生素，3'，4'-双脱氧卡那霉素B可以通过新的卡那霉素B通过卡那霉素B的新中间体衍生物从卡那霉素B开始的新方法以缩短的步骤和总产率提高，其中所有氨基和可能的2' ' - 羟基被选自低级烷基 - ，芳基 - 和芳烷基 - 磺酰基的磺酰基型保护基保护。

35. 发明授权

US4357466A Processes for the production of 3'-deoxykanamycin A and intermediates 失效
标题翻译：制备3'-脱氧卡那霉素A和中间体的方法
公开(公告)号：US4357466A
公开(公告)日：1982-11-02
申请号：US198612
申请日：1980-10-20
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Tomo Jikihara
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Tomo Jikihara
IPC分类号： C07H15/234 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/234
摘要： 3'-Deoxykanamycin A useful as antibacterial agent is produced from a protected kanamycin A derivative either by a process comprising imidazolylthiocarbonylation of the 3'- and 2"-hydroxyl groups of 4",6"-O-cyclohexylidene-4'-0:6'-N-carbonyl-5,2'-O-isopropylidene-1,3,3"-tri-N-tosylkanamycin A, preferential removal of the 3'-imidazolylthiocarbonyloxy group with tributyltin hydride for the 3'-deoxygenation, followed by removal of the 2"-O-imidazolylthiocarbonyl group with aqueous ammonia, removal of the N-tosyl groups with alkali or alkaline earth metal in liquid ammonia, hydrolytic fission of the 4',6'-cyclic carbamate ring and concurrent removal of the 5,2'-O-isopropylidene group and 4",6"-O-cyclohexylidene group, or by a process comprising selective acetylation of the 2"-hydroxyl group of said protected kanamycin A derivative with acetyl chloride in pyridine, trifluoromethanesulfonylation of the 3'-hydroxyl group, followed by concurrent removal of the 3'-trifluoromethanesulfonyloxy group and N-tosyl groups with alkali metal in liquid ammonia, removal of the 2"-O-acetyl group concurrently with hydrolytic fission of 4',6'-cyclic carbamate, and hydrolytic removal of the 5,2'-O-isopropylidene and 4",6"-O-cyclohexylidene groups.
摘要翻译：可用作抗菌剂的3'-脱氧卡那霉素A由受保护的卡那霉素A衍生物制备，其通过包含4'，6“-O-亚环己基-4'的3'和2” - 羟基的咪唑基硫代羰基化的方法制备， -0：6'-N-羰基-5,2'-O-异亚丙基-1,3,3“ - 三-N-甲苯磺酰基卡那霉素A，优选用三丁基氢化锡将3'-咪唑硫基羰基氧基除去3' 脱氧，然后用氨水除去2“-O-咪唑基硫代羰基，在液氨中用碱金属或碱土金属除去N-甲苯磺酰基，4'，6'-环状氨基甲酸酯环的水解裂变并且同时去除5,2'-O-异亚丙基和4“，6”-O-亚环己基，或通过包括将所述受保护的卡那霉素A衍生物的2'-羟基选择性乙酰化的方法与吡啶中的乙酰氯，3'-羟基的三氟甲磺酰化，然后同时除去3'-三氟甲磺酸氧基和N-甲苯磺酰基与液氨中的碱金属反应，与4'，6'-环状氨基甲酸酯的水解裂解同时除去2'-乙酰基，并除去5,2'-O 异亚丙基和4“，6”-O-亚环己基。

36. 发明授权

US4547492A 1-N-(.omega.-Amino-.alpha.-hydroxyalkanoyl-2',3'-dideoxykanamycin A and pharmaceutical composition containing same 失效
标题翻译： 1-N-（ω-氨基-α-羟基烷酰基-2'，3'-二脱氧卡那霉素A和含有它们的药物组合物
公开(公告)号：US4547492A
公开(公告)日：1985-10-15
申请号：US639392
申请日：1984-08-10
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Toshio Yoneta , Shunzo Fukatsu
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Toshio Yoneta , Shunzo Fukatsu
IPC分类号： C07H15/234 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/234 , Y02P20/55
摘要： 1-N-(L-3-amino-2-hydroxypropionyl)-2',-3'-dideoxykanamycin A and 1-N-(L-4-amino-2-hydroxybutyryl)-2',3'-dideoxykanamycin A are now provided which each is a new compound useful as antibacterial agent. The new compounds each is produced by acylating the 1-amino group of 2',3'-dideoxykanamycin A with L-3-amino-2-hydroxypropionic or L-4-amino-2-hydroxybutyric acid.
摘要翻译： 1-N-（L-3-氨基-2-羟基丙酰基）-2'，-3'-二脱氧卡那霉素A和1-N-（L-4-氨基-2-羟基丁酰基）-2'，3'-二脱氧卡那霉素A 现在提供它们各自是可用作抗菌剂的新化合物。新化合物各自通过用L-3-氨基-2-羟基丙酸或L-4-氨基-2-羟基丁酸酰化2'，3'-二脱氧卡那霉素A的1-氨基而产生。

37. 发明授权

US4438109A Tylosin derivatives 失效
标题翻译：泰乐菌素衍生物
公开(公告)号：US4438109A
公开(公告)日：1984-03-20
申请号：US285747
申请日：1981-07-22
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Akihiro Tanaka
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Akihiro Tanaka
IPC分类号： C07H17/08 , A61K31/70
CPC分类号： C07H17/08
摘要： Tylosin derivatives shown by the general formula ##STR1## wherein R represents a hydrogen atom or a hydroxyl group; R.sub.1 represents a halogen atom, a hydroxyl group, a tetrahydrofuranyloxy group, a tetrahydropyranyloxy group, a tetrahydrothiofuranyloxy group, a tetrahydrothiopyranyloxy group, an alkanoyloxy group, an arylcarbonyloxy group, an aralkylcarbonyloxy group, a lower alkylthiomethyloxy group, a heterocyclic thio group which may have a substituent, a mono- or di- lower alkylamino lower alkylthio group or a group of ##STR2## (wherein R.sub.4 represents a hydroxyl group or an alkanoyloxy group); R.sub.2 represents a hydrogen atom, a hydroxyl group, or an alkanoyloxy group; R.sub.3 represents a hydroxyl group or an alkanoyloxy group; and represents a single bond or a double bond, but represents a double bond when R.sub.2 is a hydrogen atom.These compounds are useful as antibiotics.
摘要翻译：由通式表示的泰乐菌素衍生物，其中R表示氢原子或羟基; R 1表示卤素原子，羟基，四氢呋喃氧基，四氢吡喃氧基，四氢噻喃氧基，四氢噻喃氧基，烷酰氧基，芳基羰基氧基，芳烷基羰基氧基，低级烷基硫代甲氧基，可具有的杂环硫基取代基，单 - 或二 - 低级烷基氨基低级烷硫基或一组（其中R 4表示羟基或烷酰氧基）。 R2表示氢原子，羟基或烷酰氧基; R3表示羟基或烷酰氧基; 并且表示单键或双键，但当R 2为氢原子时，表示双键。这些化合物可用作抗生素。

38. 发明授权

US4298727A 3',4'-Dideoxykanamycin A and 1-N-(S)-.alpha.-hydroxy-.omega.-aminoalkanoyl) derivatives thereof 失效
标题翻译： 3'，4'-双脱氧卡那霉素A和1-N-（S）-α-羟基-ω-氨基烷酰基）衍生物
公开(公告)号：US4298727A
公开(公告)日：1981-11-03
申请号：US114779
申请日：1980-01-23
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Tomo Jikahara , Toshiaki Miyake
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Tomo Jikahara , Toshiaki Miyake
IPC分类号： C07H15/234 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , C07H15/22
CPC分类号： C07H15/234 , Y02P20/55
摘要： 3',4'-Dideoxy derivative and 1-N-((S)-.alpha.-hydroxy-.omega.-aminoalkanoyl)-3',4'-dideoxy derivative of kanamycin A are now synthetized from kanamycin A and show a wider and/or higher antibacterial activity than the parent kanamycin A so that they are useful in therapeutic treatment of infections by gram-negative and gram-positive bacteria, including drug-resistant strains thereof. The production of these new derivatives may be made by preparing a protected kanamycin A derivative having its 3'- and 4'-hydroxyl groups unprotected and having its all or substantially all other functional groups protected from the initial material, kanamycin A, sulfonylating the 3'- and 4'-hydroxyl groups, removing the 3'- and 4'-sulfonyloxy groups from the resulting 3',4'-di-sulfonic acid ester product to give a 3'-eno-kanamycin A derivative, hydrogenating the 3'-eno-kanamycin A derivative to saturate the 3',4'-unsaturated bond and to yield a protected 3',4'-dideoxykanamycin A product, followed by removal of the remainiing protective groups, and optionally further followed by 1-N-acylation of the 1-amino group of the resulting 3',4'-dideoxykanamycin A with an (S)-.alpha.-hydroxy-.omega.-aminoalkanoic acid or its reactive equivalent.
摘要翻译：卡那霉素A的3'，4'-二脱氧衍生物和1-N - （（S）-α-羟基-ω-氨基烷酰基）-3'，4'-二脱氧衍生物现在从卡那霉素A合成并显示出更宽和/ 或更高的抗菌活性，使得它们可用于革兰氏阴性和革兰氏阳性细菌（包括其耐药菌株）的感染的治疗性治疗。这些新衍生物的生产可以通过制备其未被保护的3'和4'-羟基的保护的卡那霉素A衍生物和其全部或基本上所有其它保护起始材料的卡那霉素A的其他官能团来制备，磺酰化3 '和4'-羟基，从所得的3'，4'-二磺酸酯产物中除去3'-和4'-磺酰氧基，得到3'-烯 - 卡那霉素A衍生物，将3 ' - 卡那霉素A衍生物使3'，4'-不饱和键饱和并产生受保护的3'，4'-二脱氧卡那霉素A产物，然后除去剩余的保护基，并且任选地进一步加入1-N 所得的3'，4'-二脱氧卡那霉素A的1-氨基酸与（S）-α-羟基-ω-氨基链烷酸或其反应性等同物的酰基化。

39. 发明授权

US07425756B2 Semiconductor device and electronic device 有权
标题翻译：半导体器件和电子器件
公开(公告)号：US07425756B2
公开(公告)日：2008-09-16
申请号：US10512459
申请日：2003-04-28
申请人： Tadatoshi Danno , Tsutomu Tsuchiya
发明人： Tadatoshi Danno , Tsutomu Tsuchiya
IPC分类号： H01L23/495 , H01L21/00 , H01R9/00
CPC分类号： H01L24/32 , H01L21/561 , H01L23/3107 , H01L23/49503 , H01L23/49548 , H01L23/50 , H01L23/66 , H01L24/45 , H01L24/48 , H01L24/49 , H01L24/73 , H01L24/85 , H01L24/97 , H01L2223/6611 , H01L2224/05554 , H01L2224/27013 , H01L2224/29007 , H01L2224/32013 , H01L2224/32014 , H01L2224/32245 , H01L2224/45015 , H01L2224/45144 , H01L2224/48011 , H01L2224/48091 , H01L2224/48095 , H01L2224/48247 , H01L2224/48253 , H01L2224/48257 , H01L2224/484 , H01L2224/48599 , H01L2224/4911 , H01L2224/49171 , H01L2224/73265 , H01L2224/85 , H01L2224/92 , H01L2224/92247 , H01L2224/97 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01014 , H01L2924/01015 , H01L2924/01019 , H01L2924/01023 , H01L2924/01029 , H01L2924/01033 , H01L2924/01039 , H01L2924/01046 , H01L2924/01047 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/01087 , H01L2924/014 , H01L2924/10162 , H01L2924/10253 , H01L2924/12036 , H01L2924/1306 , H01L2924/13091 , H01L2924/14 , H01L2924/15747 , H01L2924/181 , H01L2924/19041 , H01L2924/19043 , H01L2924/19107 , H01L2924/20752 , H01L2924/30105 , H01L2924/30107 , H01L2924/3011 , H01L2924/3025 , H01L2924/351 , H03F3/189 , H01L2924/20645 , H01L2224/83 , H01L2224/78 , H01L2924/00012 , H01L2924/00 , H01L2224/85399 , H01L2224/05599
摘要： This invention provides a high frequency power module which is incorporated into a mobile phone and which incorporates high frequency portion analogue signal processing ICs including low noise amplifiers which amplify an extremely weak signal therein. A semiconductor device includes a sealing body which is made of insulation resin, a plurality of leads which are provided inside and outside the sealing body, a tab which is provided inside the sealing body and has a semiconductor element fixing region and a wire connection region on a main surface thereof, a semiconductor element which is fixed to the semiconductor element fixing region and includes electrode terminals on an exposed main surface, conductive wires which connect electrode terminals of the semiconductor element and the leads, and conductive wires which connect electrode terminals of the semiconductor element and the wire connecting region of the tab. In such a semiconductor device, a circuit formed in the semiconductor element in a monolithic manner is comprised of a plurality of circuit parts and, in a specified circuit part (a low noise amplifier) which forms a portion of the circuit parts, all grounding electrode terminals out of electrode terminals of the semiconductor element are not connected to the tab through wires but are connected with the leads through wires.
摘要翻译：本发明提供一种并入移动电话中的高频功率模块，其包括高频部分模拟信号处理IC，包括放大其中极弱信号的低噪声放大器。一种半导体器件，包括由绝缘树脂制成的密封体，设置在密封体的内部和外部的多个引线，设置在密封体内部并具有半导体元件固定区域和导线连接区域的突片其主表面，固定到半导体元件固定区并且在暴露的主表面上包括电极端子的半导体元件，连接半导体元件的电极端子和引线的导线以及连接半导体元件的电极端子的导线半导体元件和引线连接区域。在这种半导体装置中，以单片方式形成在半导体元件中的电路由多个电路部分构成，并且在形成电路部分的一部分的规定电路部分（低噪声放大器）中，所有接地极半导体元件的电极端子之外的端子不通过导线连接到突片，而是通过导线与引线连接。

40. 外观设计

USD524840S1 Video camera 失效
公开(公告)号：USD524840S1
公开(公告)日：2006-07-11
申请号：US29210746
申请日：2004-08-06
申请人： Tsutomu Tsuchiya
设计人： Tsutomu Tsuchiya

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式