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31. 发明申请

US20090149382A1 Modulation of lipid rafts 有权
标题翻译：脂筏的调制
公开(公告)号：US20090149382A1
公开(公告)日：2009-06-11
申请号：US12289390
申请日：2008-10-27
申请人： Hans-Arne Hansson , Stefan Lange
发明人： Hans-Arne Hansson , Stefan Lange
IPC分类号： A61K38/16 , A61P9/00 , A61P11/00 , A61P3/00 , A61P17/02 , A61P35/00
CPC分类号： A61K38/1709 , A61K38/08
摘要： The present invention relates to the use of an antisecretory protein, derivative, homologue, and/or fragment thereof, having equivalent activity, and/or a pharmaceutically active salt thereof, for the manufacture of a pharmaceutical composition and/or a medical food for the treatment and/or prevention of dysfunction, e.g. abnormal function, hypo- or hyper-function of lipid rafts, receptors and/or caveolae. A dysfunction of lipid rafts, receptors and/or caveolae may be caused by or be a cause of a variety of other conditions, which are also encompassed by the present invention, such as vascular, and lung dysfunctions, and/or endocrine disorders, e.g. diabetes and related disorders. Furthermore, the invention relates to a method for the treatment and/or prevention of dysfunction of lipid rafts and/or caveolae in a mammal in need thereof.
摘要翻译：本发明涉及具有相同活性的抗分泌蛋白，其衍生物，同系物和/或其片段，和/或其药学活性盐在制备药物组合物和/或用于治疗和/或预防功能障碍，例如异常功能，脂筏，受体和/或穴状病毒的低功能或超功能。脂质筏，受体和/或穴状窝蛋白的功能障碍可能是由本发明也包括在内的多种其它病症的原因引起的，例如血管和肺功能障碍，和/或内分泌紊乱，例如内分泌障碍。糖尿病和相关疾病。此外，本发明涉及在有需要的哺乳动物中治疗和/或预防脂筏和/或小窝病的功能障碍的方法。

32. 发明授权

US09234132B2 Conversion LED with high color rendition index 有权
标题翻译：转换LED具有高色彩再现指数
公开(公告)号：US09234132B2
公开(公告)日：2016-01-12
申请号：US13391197
申请日：2010-08-11
申请人： Frank Baumann , Norbert Boenisch , Tim Fiedler , Frank Jermann , Stefan Lange , Reiner Windisch
发明人： Frank Baumann , Norbert Boenisch , Tim Fiedler , Frank Jermann , Stefan Lange , Reiner Windisch
IPC分类号： C09K11/08 , C09K11/77 , C04B35/581 , C04B35/584 , H01L33/50
CPC分类号： H01L33/504 , C04B35/581 , C04B35/584 , C04B2235/3224 , C04B2235/3281 , C04B2235/3852 , C04B2235/444 , C04B2235/445 , C04B2235/446 , C09K11/0883 , C09K11/7728 , C09K11/7774 , H01L2224/32245 , H01L2224/48091 , H01L2224/48247 , H01L2224/73265 , H01L2924/00014 , H01L2924/00
摘要： A conversion LED comprising a chip which emits primary radiation and a luminescent substance-containing layer which is on the chip or positioned so that it intercepts the primary radiation emitted from the chip and which converts at least some of the primary radiation of the chip into secondary radiation, wherein a first luminescent substance of the A3B5O12:Ce garnet type which emits yellow green and a second luminescent substance of the MAlSiN3:Eu calsine type which emits orange red is used, wherein the peak wavelength of the primary radiation lies in the 435 to 455 nm range, the first luminescent substance being a garnet having essentially the cation A=75 to 100% Lu, remainder Y and a Ce content of 1.5 to 2.9%, where B=10 to 40% Ga, remainder Al, while the second luminescent substance is of the basic MAlSiN3:Eu type where M is Ca alone or at least 80%, in particular at least 90%, preferably at least 95% Ca and the remainder of M may be Sr, Ba, Mg, Li or Cu, in each case alone or in combination, wherein some of the Al up to 20%, preferably at most 5%, can be replaced by B, and wherein N can be partially replaced by O, F, Cl, alone or in combination.
摘要翻译：一种转换LED，包括发射初级辐射的芯片和位于芯片上或定位成使其截取从芯片发射的主要辐射并将芯片的至少一些主要辐射转换成次级的发光物质的层的发光物质层辐射，其中使用发射黄绿色的A3B5O12：Ce石榴石型的第一发光物质和发出橙色红色的MA1SiN3：Eu钙质型的第二发光物质，其中主辐射的峰值波长在435〜 455nm范围内，第一发光物质是基本上具有阳离子A = 75〜100％Lu，余量Y和Ce含量为1.5〜2.9％的石榴石，其中B = 10〜40％Ga，余量为Al，而第二发光物质是基本的MAlSiN 3：Eu型，其中M是单独的Ca或至少80％，特别是至少90％，优选至少95％的Ca，其余的M可以是Sr，Ba，Mg，Li或Cu ，在每种情况下，单独或在c 其中一些至多20％，优选至多5％的Al可以被B代替，并且其中N可以单独或组合地部分地被O，F，Cl部分替代。

33. 发明授权

US09220750B2 Use of antisecretory factors (AF) for optimizing cellular uptake 有权
标题翻译：使用抗分泌因子（AF）来优化细胞摄取
公开(公告)号：US09220750B2
公开(公告)日：2015-12-29
申请号：US13148878
申请日：2010-02-11
申请人： Eva Jennische , Stefan Lange , Hans-Arne Hansson
发明人： Eva Jennische , Stefan Lange , Hans-Arne Hansson
IPC分类号： A61K38/17 , A61K51/00 , C07K14/47 , A61P31/00 , G01N33/567 , A61K45/06
CPC分类号： A61K38/1709 , A61K45/06 , G01N2333/91215
摘要： The present invention relates to the use of an antisecretory factor (AF) protein, peptide, derivative, homologue, and/or fragment thereof, having equivalent functional activity, and/or a pharmaceutically active salt thereof, for optimizing delivery and cellular uptake of a pharmaceutical substance and/or formulation, or a gene delivery. Typically, said pharmaceutical substance and/or formulation comprises an anticancer drug, radiation therapy, an antibiotic substance, an antiviral substance or a drug targeting posttraumatic injury, neurodegeneration, a parasite, or an inflammatory condition.
摘要翻译：本发明涉及具有相同功能活性的抗分泌因子（AF）蛋白，肽，衍生物，同系物和/或其片段，和/或其药物活性盐的用途，用于优化递送和细胞摄取药物和/或制剂，或基因递送。通常，所述药物和/或制剂包含抗癌药物，放射治疗剂，抗生素物质，抗病毒物质或靶向创伤后损伤的药物，神经变性，寄生虫或炎性病症。

34. 发明申请

US20120146079A1 Conversion LED with High Color Rendition Index 有权
标题翻译：具有高色彩转换指数的转换LED
公开(公告)号：US20120146079A1
公开(公告)日：2012-06-14
申请号：US13391197
申请日：2010-08-11
申请人： Frank Baumann , Norbert Boenisch , Tim Fiedler , Frank Jermann , Stefan Lange , Reiner Windisch
发明人： Frank Baumann , Norbert Boenisch , Tim Fiedler , Frank Jermann , Stefan Lange , Reiner Windisch
IPC分类号： H01L33/50
CPC分类号： H01L33/504 , C04B35/581 , C04B35/584 , C04B2235/3224 , C04B2235/3281 , C04B2235/3852 , C04B2235/444 , C04B2235/445 , C04B2235/446 , C09K11/0883 , C09K11/7728 , C09K11/7774 , H01L2224/32245 , H01L2224/48091 , H01L2224/48247 , H01L2224/73265 , H01L2924/00014 , H01L2924/00
摘要： A conversion LED comprising a chip which emits primary radiation and, positioned upstream of the chip, a luminescent substance-containing layer which converts at least some of the primary radiation of the chip into secondary radiation, wherein a first yellow-green emitting luminescent substance of the A3B5O12:Ce garnet type and a second orange-red emitting luminescent substance of the MAlSiN3:Eu calsine type is used, wherein the peak wavelength of the primary radiation lies in the 435 to 455 nm range, the first luminescent substance being a garnet having essentially the cation A=Lu or Lu in combination with Y, and B simultaneously having fractions of Al and Ga, while the second luminescent substance is of the basic MAlSiN3:Eu type containing Ca as M with a fraction of at least 80%, in particular at least 90%, preferably at least 95%, where M is Ca alone or predominantly Ca and the remainder of M may be Sr, Ba, Mg, Li or Cu, in each case alone or in combination, and wherein some of the Al up to 20%, preferably at most 5%, can be replaced by B, O, F, Cl, alone or in combination.
摘要翻译：一种转换LED，包括发射初级辐射的芯片，并且位于芯片上游的含有发光物质的层，其将芯片的至少一些初级辐射转换成次级辐射，其中第一个黄绿色发光的发光物质使用A3B5O12：Ce石榴石型和MA1SiN3：Eu钙酸型的第二橙红色发光发光物质，其中初级辐射的峰值波长在435〜455nm范围内，第一发光物质是具有基本上阳离子A = Lu或Lu与Y组合，并且B同时具有Al和Ga的分数，而第二发光物质是含有Ca为M的基本MAISiN 3：Eu型，其分数至少为80％特别是至少90％，优选至少95％，其中M单独或主要是Ca，其余的M可以是Sr，Ba，Mg，Li或Cu，在每种情况下单独或组合，并且其中一些 Al至多20％，优选至多5％，可单独或组合用B，O，F，Cl代替。

35. 发明申请

US20090185982A1 Approach to the treatment of compartment syndrome 有权
标题翻译：方法治疗隔室综合征
公开(公告)号：US20090185982A1
公开(公告)日：2009-07-23
申请号：US12289389
申请日：2008-10-27
申请人： Hans-Arne Hansson , Stefan Lange , Eva Jennische , Tomas Bergstrom
发明人： Hans-Arne Hansson , Stefan Lange , Eva Jennische , Tomas Bergstrom
IPC分类号： A61K9/12 , A61K38/08 , A61K38/10 , A61K38/16
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of an antisecretory protein or a derivative, homologue, and/or fragment thereof, having antisecretory activity, and/or a pharmaceutically active salt thereof, for the manufacture of a pharmaceutical composition and/or a medical food for the treatment and/or prevention of compartment syndrome. A compartment syndrome may be caused by or a cause of a variety of other conditions which are also encompassed by the present invention, such as viral and bacterial infections. Furthermore, the invention relates to a method for the treatment and/or prevention of compartment syndrome in a mammal in need thereof.
摘要翻译：本发明涉及具有抗分泌活性的抗分泌蛋白或其衍生物，同系物和/或其片段，和/或其药物活性盐在制备药物组合物和/或医疗食品中的用途隔室综合征的治疗和/或预防。隔室综合征可能是由本发明也包括的各种其他病症引起的原因或原因，例如病毒和细菌感染。此外，本发明涉及在有需要的哺乳动物中治疗和/或预防隔室综合征的方法。

36. 发明授权

US07229817B2 Recombinant porcine liver esterases, their use and a method for the production thereof 有权
标题翻译：重组猪肝酯酶，其用途及其制备方法
公开(公告)号：US07229817B2
公开(公告)日：2007-06-12
申请号：US10450156
申请日：2001-12-06
申请人： Uwe Bornscheuer , Anna Musidlowska , Claudia Schmidt-Dannert , Stefan Lange
发明人： Uwe Bornscheuer , Anna Musidlowska , Claudia Schmidt-Dannert , Stefan Lange
IPC分类号： C12N9/18 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/18
摘要： The invention relates to biotechnologically expressible, enzymically active recombinant porcine liver esterases, to a biotechnological method for the preparation thereof and to the use thereof in organic synthesis. The monomeric subunits of recombinant porcine liver esterase are truncated at their C-terminal end, compared with naturally occurring porcine liver esterase subunits. Moreover, it has proved to be an additional advantage to truncate the N-terminal end as well.
摘要翻译：本发明涉及生物技术可表达的酶活性重组猪肝酯酶，涉及其制备的生物技术方法及其在有机合成中的用途。与天然存在的猪肝酯酶亚单位相比，重组猪肝酯酶的单体亚基在C末端截短。此外，已经证明也是截断N末端的另外的优点。

37. 发明授权

US6075294A Locking system, particularly for motor vehicles 有权
标题翻译：锁定系统，特别是机动车辆
公开(公告)号：US6075294A
公开(公告)日：2000-06-13
申请号：US171790
申请日：1998-10-26
申请人： Andreas Van den Boom , Stefan Lange
发明人： Andreas Van den Boom , Stefan Lange
IPC分类号： E05B49/00 , E05B17/22 , E05B81/78 , E05B85/16 , G07C9/00 , B60R25/00
CPC分类号： E05B81/78 , G07C9/00309 , E05B81/77 , E05B85/16 , G07C2009/00793 , G07C2209/65
摘要： In a locking system, used for instance on a vehicle, a switch or sensor initiates the interrogation of a data storage medium via a control unit to check for access authorization. If access authorization is given, the control unit releases the locks of the locking system automatically. To improve user convenience regarding the system release, at least one capacitance sensor in at least one door grip is provided. At least one first electrode of the sensor is situated in the inner shell of the door grip and a second electrode is placed in the door area opposite the grip. By applying antipole voltage to both electrodes, an electrical field is generated between the two electrodes. When a hand, which acts as a dielectric, approaches the grip, a change in the cumulative dielectric state between the two electrodes occurs. Such a change is recognized by the capacitance sensor and transformed into an electric pulse which initiates in the electrical control unit interrogation of the data storage medium. The data storage medium then sends its data to the on-board electrical control unit which compares the data received with the data stored and releases the locks of the vehicle doors if the data match.
摘要翻译： PCT No.PCT / EP97 / 01890 Sec。 371日期：1998年10月26日 102（e）1998年10月26日PCT PCT 1997年4月16日PCT公布。出版物WO97 / 41322 日期1997年11月6日在例如在车辆上使用的锁定系统中，开关或传感器通过控制单元启动询问数据存储介质以检查访问授权。如果给出访问授权，则控制单元自动释放锁定系统的锁定。为了提高关于系统释放的用户便利性，提供至少一个门把手中的至少一个电容传感器。传感器的至少一个第一电极位于门把手的内壳中，并且第二电极被放置在与把手相对的门区域中。通过向两个电极施加反极电压，在两个电极之间产生电场。当作为电介质的手接近手柄时，发生两个电极之间的累积介电状态的变化。这种变化由电容传感器识别并变换成在电子控制单元询问数据存储介质时启动的电脉冲。然后，数据存储介质将其数据发送到车载电气控制单元，该单元比较接收到的数据与所存储的数据，并且如果数据匹配则释放车门的锁。

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