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1. 发明申请

US20090185982A1 Approach to the treatment of compartment syndrome 有权
标题翻译：方法治疗隔室综合征
公开(公告)号：US20090185982A1
公开(公告)日：2009-07-23
申请号：US12289389
申请日：2008-10-27
申请人： Hans-Arne Hansson , Stefan Lange , Eva Jennische , Tomas Bergstrom
发明人： Hans-Arne Hansson , Stefan Lange , Eva Jennische , Tomas Bergstrom
IPC分类号： A61K9/12 , A61K38/08 , A61K38/10 , A61K38/16
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of an antisecretory protein or a derivative, homologue, and/or fragment thereof, having antisecretory activity, and/or a pharmaceutically active salt thereof, for the manufacture of a pharmaceutical composition and/or a medical food for the treatment and/or prevention of compartment syndrome. A compartment syndrome may be caused by or a cause of a variety of other conditions which are also encompassed by the present invention, such as viral and bacterial infections. Furthermore, the invention relates to a method for the treatment and/or prevention of compartment syndrome in a mammal in need thereof.
摘要翻译：本发明涉及具有抗分泌活性的抗分泌蛋白或其衍生物，同系物和/或其片段，和/或其药物活性盐在制备药物组合物和/或医疗食品中的用途隔室综合征的治疗和/或预防。隔室综合征可能是由本发明也包括的各种其他病症引起的原因或原因，例如病毒和细菌感染。此外，本发明涉及在有需要的哺乳动物中治疗和/或预防隔室综合征的方法。

2. 发明申请

US20120093716A1 USE OF ANTISECRETORY FACTORS (AF) FOR OPTIMIZING CELLULAR UPTAKE 有权
标题翻译：使用抗真菌因子（AF）优化细胞摄取
公开(公告)号：US20120093716A1
公开(公告)日：2012-04-19
申请号：US13148878
申请日：2010-02-11
申请人： Eva Jennische , Stefan Lange , Hans-Arne Hansson
发明人： Eva Jennische , Stefan Lange , Hans-Arne Hansson
IPC分类号： A61K38/17 , G01N33/567 , A61K51/00 , C40B30/00 , A61P25/00 , A61P35/00 , A61P31/12 , A61P31/00 , A61P29/00 , A61P33/00 , C07K14/47 , C12Q1/48
CPC分类号： A61K38/1709 , A61K45/06 , G01N2333/91215
摘要： The present invention relates to the use of an antisecretory factor (AF) protein, peptide, derivative, homologue, and/or fragment thereof, having equivalent functional activity, and/or a pharmaceutically active salt thereof, for optimizing delivery and cellular uptake of a pharmaceutical substance and/or formulation, or a gene delivery. Typically, said pharmaceutical substance and/or formulation comprises an anticancer drug, radiation therapy, an antibiotic substance, an antiviral substance or a drug targeting posttraumatic injury, neurodegeneration, a parasite, or an inflammatory condition.
摘要翻译：本发明涉及具有相同功能活性的抗分泌因子（AF）蛋白，肽，衍生物，同系物和/或其片段，和/或其药物活性盐的用途，用于优化递送和细胞摄取药物和/或制剂，或基因递送。通常，所述药物和/或制剂包含抗癌药物，放射治疗剂，抗生素物质，抗病毒物质或靶向创伤后损伤的药物，神经变性，寄生虫或炎性病症。

3. 发明授权

US09000125B2 Approach to treat intraocular hypertension 有权
公开(公告)号：US09000125B2
公开(公告)日：2015-04-07
申请号：US13469838
申请日：2012-05-11
申请人： Hans-Arne Hansson , Stefan Lange , Eva Jennische
发明人： Hans-Arne Hansson , Stefan Lange , Eva Jennische
IPC分类号： C07K7/06 , A61K38/17
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of antisecretory factors, such as antisecretory proteins, homologues, derivatives and/or fragments thereof having antisecretory activity, for the manufacture of a pharmaceutical composition for use in the treatment and/or prevention of intraocular hypertension. The invention thus relates to the use of pharmaceutical compositions comprising antisecretory factors in the treatment and/or prevention of intraocular hypertension, which is preferably characterized by hampered outflow of body fluid resulting in elevated pressure in the eye. The invention provides for a novel approach for treating and/or preventing such a condition turning the intraocular pressure to an acceptable level, optionally 21 mm Hg, or less.

4. 发明授权

US08207296B2 Approach to treat intraocular hypertension 有权
标题翻译：治疗眼内高血压的方法
公开(公告)号：US08207296B2
公开(公告)日：2012-06-26
申请号：US12289388
申请日：2008-10-27
申请人： Hans-Arne Hansson , Stefan Lange , Eva Jennische
发明人： Hans-Arne Hansson , Stefan Lange , Eva Jennische
IPC分类号： C07K7/06
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of antisecretory factors, such as antisecretory proteins, homologues, derivatives and/or fragments thereof having antisecretory activity, for the manufacture of a pharmaceutical composition for use in the treatment and/or prevention of intraocular hypertension. The invention thus relates to the use of pharmaceutical compositions comprising antisecretory factors in the treatment and/or prevention of intraocular hypertension, which is preferably characterized by hampered outflow of body fluid resulting in elevated pressure in the eye. The invention provides for a novel approach for treating and/or preventing such a condition turning the intraocular pressure to an acceptable level, optionally 21 mm Hg, or less.
摘要翻译：本发明涉及具有抗分泌活性的抗分泌蛋白，同系物，衍生物和/或片段等抗分泌因子在制备用于治疗和/或预防眼内高血压的药物组合物中的应用。因此，本发明涉及包含抗分泌因子的药物组合物在治疗和/或预防眼内高血压中的用途，其优点在于体内流体受阻的流出，导致眼压升高。本发明提供了一种用于治疗和/或预防这种将眼内压转换成可接受水平（可选地为21mm Hg或更小）的病症的新方法。

5. 发明申请

US20090162296A1 Approach to treat intraocular hypertension 有权
标题翻译：治疗眼内高血压的方法
公开(公告)号：US20090162296A1
公开(公告)日：2009-06-25
申请号：US12289388
申请日：2008-10-27
申请人： Hans-Arne Hansson , Stefan Lange , Eva Jennische
发明人： Hans-Arne Hansson , Stefan Lange , Eva Jennische
IPC分类号： A61K9/12 , A61K38/08 , A61K38/10 , A61K38/17 , C07K7/06
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of antisecretory factors, such as antisecretory proteins, homologues, derivatives and/or fragments thereof having antisecretory activity, for the manufacture of a pharmaceutical composition for use in the treatment and/or prevention of intraocular hypertension. The invention thus relates to the use of pharmaceutical compositions comprising antisecretory factors in the treatment and/or prevention of intraocular hypertension, which is preferably characterized by hampered outflow of body fluid resulting in elevated pressure in the eye. The invention provides for a novel approach for treating and/or preventing such a condition turning the intraocular pressure to an acceptable level, optionally 21 mm Hg, or less.
摘要翻译：本发明涉及具有抗分泌活性的抗分泌蛋白，同系物，衍生物和/或片段等抗分泌因子在制备用于治疗和/或预防眼内高血压的药物组合物中的应用。因此，本发明涉及包含抗分泌因子的药物组合物在治疗和/或预防眼内高血压中的用途，其优点在于体内流体受阻的流出，导致眼压升高。本发明提供了一种用于治疗和/或预防这种将眼内压转换成可接受水平（可选地为21mm Hg或更小）的病症的新方法。

6. 发明授权

US09220750B2 Use of antisecretory factors (AF) for optimizing cellular uptake 有权
标题翻译：使用抗分泌因子（AF）来优化细胞摄取
公开(公告)号：US09220750B2
公开(公告)日：2015-12-29
申请号：US13148878
申请日：2010-02-11
申请人： Eva Jennische , Stefan Lange , Hans-Arne Hansson
发明人： Eva Jennische , Stefan Lange , Hans-Arne Hansson
IPC分类号： A61K38/17 , A61K51/00 , C07K14/47 , A61P31/00 , G01N33/567 , A61K45/06
CPC分类号： A61K38/1709 , A61K45/06 , G01N2333/91215
摘要： The present invention relates to the use of an antisecretory factor (AF) protein, peptide, derivative, homologue, and/or fragment thereof, having equivalent functional activity, and/or a pharmaceutically active salt thereof, for optimizing delivery and cellular uptake of a pharmaceutical substance and/or formulation, or a gene delivery. Typically, said pharmaceutical substance and/or formulation comprises an anticancer drug, radiation therapy, an antibiotic substance, an antiviral substance or a drug targeting posttraumatic injury, neurodegeneration, a parasite, or an inflammatory condition.
摘要翻译：本发明涉及具有相同功能活性的抗分泌因子（AF）蛋白，肽，衍生物，同系物和/或其片段，和/或其药物活性盐的用途，用于优化递送和细胞摄取药物和/或制剂，或基因递送。通常，所述药物和/或制剂包含抗癌药物，放射治疗剂，抗生素物质，抗病毒物质或靶向创伤后损伤的药物，神经变性，寄生虫或炎性病症。

7. 发明申请

US20070009575A1 Novel use of antisecretory factor 审中-公开
标题翻译：小说使用抗分泌因子
公开(公告)号：US20070009575A1
公开(公告)日：2007-01-11
申请号：US10573601
申请日：2004-09-24
申请人： Hans-Arne Hansson , Eva Jennische , Stefan Lange , Ivar Lonnroth , Peter Eriksson , Anders Persson
发明人： Hans-Arne Hansson , Eva Jennische , Stefan Lange , Ivar Lonnroth , Peter Eriksson , Anders Persson
IPC分类号： A61K38/17 , A61K38/10 , A61K38/08 , A61K47/00
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of an antisecretory protein or homologues thereof having the same properties, or certain fragments thereof in the manufacture of a medicament or a medical food for inducing improved rescue of injured or diseased nervous tissue, proliferation, apoptosis, differentiation and/or migration of an embryonic stem cell, adult stem cell, progenitor cell and/or a cell derived from a stem cell or progenitor cell, for treating a condition characterized by or associated with loss and/or gain of cells. In a preferred embodiment, the condition is a neurotrauma or a condition or disease of the CNS and/or PNS and/or ANS, for example, Alzheimer's disease.
摘要翻译：本发明涉及具有相同性质的抗分泌蛋白或其同系物或其某些片段在制备药物或医疗食品中的用途，用于诱导损伤或患病神经组织的改善的拯救，增殖，凋亡，分化和 /或胚胎干细胞，成体干细胞，祖细胞和/或衍生自干细胞或祖细胞的细胞的迁移，用于治疗由细胞的损失和/或增益表征或相关的病症。在优选的实施方案中，该病症是CNS和/或PNS和/或ANS的神经损伤或病症或疾病，例如阿尔茨海默氏病。

8. 发明授权

US08748367B2 Use of antisecretory factor 有权
标题翻译：使用防分解因子
公开(公告)号：US08748367B2
公开(公告)日：2014-06-10
申请号：US12659142
申请日：2010-02-26
申请人： Hans-Arne Hansson , Eva Jennische , Stefan Lange , Ivar Lönnroth , Peter Eriksson , Anders Persson
发明人： Hans-Arne Hansson , Eva Jennische , Stefan Lange , Ivar Lönnroth , Peter Eriksson , Anders Persson
IPC分类号： A61K38/00 , A61P25/00 , A61K38/02 , A61K35/30 , C07K5/00 , C07K14/00
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of an antisecretory protein or homologues thereof having the same properties, or certain fragments thereof in the manufacture of a medicament or a medical food for inducing improved rescue of injured or diseased nervous tissue, proliferation, apoptosis, differentiation and/or migration of an embryonic stem cell, adult stem cell, progenitor cell and/or a cell derived from a stem cell or progenitor cell, for treating a condition characterized by or associated with loss and/or gain of cells. In a preferred embodiment, the condition is a neurotrauma or a condition or disease of the CNS and/or PNS and/or ANS, for example, Alzheimer's disease.
摘要翻译：本发明涉及具有相同性质的抗分泌蛋白或其同系物或其某些片段在制备药物或医疗食品中的用途，用于诱导损伤或患病神经组织的改善的拯救，增殖，凋亡，分化和 /或胚胎干细胞，成体干细胞，祖细胞和/或衍生自干细胞或祖细胞的细胞的迁移，用于治疗由细胞的损失和/或增益表征或相关的病症。在优选的实施方案中，该病症是CNS和/或PNS和/或ANS的神经损伤或病症或疾病，例如阿尔茨海默氏病。

9. 发明授权

US08389468B2 Approach to the treatment of compartment syndrome 有权
公开(公告)号：US08389468B2
公开(公告)日：2013-03-05
申请号：US13025702
申请日：2011-02-11
申请人： Hans-Arne Hansson , Stefan Lange , Eva Jennische , Tomas Bergström
发明人： Hans-Arne Hansson , Stefan Lange , Eva Jennische , Tomas Bergström
IPC分类号： A61K38/16 , A61K38/08 , A61K38/00
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of an antisecretory protein or a derivative, homologue, and/or fragment thereof, having antisecretory activity, and/or a pharmaceutically active salt thereof, for the manufacture of a pharmaceutical composition and/or a medical food for the treatment and/or prevention of compartment syndrome. A compartment syndrome may be caused by or a cause of a variety of other conditions which are also encompassed by the present invention, such as viral and bacterial infections. Furthermore, the invention relates to a method for the treatment and/or prevention of compartment syndrome in a mammal in need thereof.

10. 发明授权

US08309513B2 Approach to the treatment of compartment syndrome 有权
标题翻译：方法治疗隔室综合征
公开(公告)号：US08309513B2
公开(公告)日：2012-11-13
申请号：US12289389
申请日：2008-10-27
申请人： Hans-Arne Hansson , Stefan Lange , Eva Jennische , Tomas Bergström
发明人： Hans-Arne Hansson , Stefan Lange , Eva Jennische , Tomas Bergström
IPC分类号： A61K38/16 , A61K38/08 , A61K38/00
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of an antisecretory protein or a derivative, homologue, and/or fragment thereof, having antisecretory activity, and/or a pharmaceutically active salt thereof, for the manufacture of a pharmaceutical composition and/or a medical food for the treatment and/or prevention of compartment syndrome. A compartment syndrome may be caused by or a cause of a variety of other conditions which are also encompassed by the present invention, such as viral and bacterial infections. Furthermore, the invention relates to a method for the treatment and/or prevention of compartment syndrome in a mammal in need thereof.
摘要翻译：本发明涉及具有抗分泌活性的抗分泌蛋白或其衍生物，同系物和/或其片段，和/或其药物活性盐在制备药物组合物和/或医疗食品中的用途隔室综合征的治疗和/或预防。隔室综合征可能是由本发明也包括的各种其他病症引起的原因或原因，例如病毒和细菌感染。此外，本发明涉及在有需要的哺乳动物中治疗和/或预防隔室综合征的方法。

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