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31. 发明授权

US06501775B2 Semiconductor laser driving circuit and semiconductor laser device 失效
标题翻译：半导体激光驱动电路和半导体激光器件
公开(公告)号：US06501775B2
公开(公告)日：2002-12-31
申请号：US09814719
申请日：2001-03-23
申请人： Toyoki Taguchi , Makoto Morimoto
发明人： Toyoki Taguchi , Makoto Morimoto
IPC分类号： H01S300
CPC分类号： H01S5/0683 , H01S5/042
摘要： There is provided an input circuit including a current/current conversion circuit and a current change-over circuit for converting an input control current into an inside control current; a control amplification circuit for amplifying a voltage corresponding to a difference current between an output current from the input circuit and a monitor current which is fed back from the photodetector for detecting a light output of the LD; an output circuit which is controlled with an output from the control amplification circuit; an offset compensation circuit for compensating for the offset generated between the input of the current/current conversion circuit and the output of the control amplification circuit, so that the offset is detected to compensate for the offset in the state in which the output of the control amplification circuit is cut off with the switch.
摘要翻译：提供一种输入电路，其包括用于将输入控制电流转换为内部控制电流的电流/电流转换电路和电流转换电路; 控制放大电路，用于放大对应于来自输入电路的输出电流之间的差电流的电压和从用于检测LD的光输出的光电检测器反馈的监视电流; 由控制放大电路的输出控制的输出电路; 偏移补偿电路，用于补偿在电流/电流转换电路的输入与控制放大电路的输出之间产生的偏移，从而检测偏移以补偿控制的输出状态的偏移放大电路用开关切断。

32. 发明授权

US06369688B1 Automatic gang switch having a heat ray sensor 失效
标题翻译：具有热射线传感器的自动组合开关
公开(公告)号：US06369688B1
公开(公告)日：2002-04-09
申请号：US09584139
申请日：2000-05-31
申请人： Tatsuya Abe , Masaharu Fukushima , Shiro Mori , Takahiro Yamanouchi , Hirotoshi Watanabe , Makoto Morimoto , Hideki Kawahara
发明人： Tatsuya Abe , Masaharu Fukushima , Shiro Mori , Takahiro Yamanouchi , Hirotoshi Watanabe , Makoto Morimoto , Hideki Kawahara
IPC分类号： H01H3732
CPC分类号： H05B37/0227 , H03K17/94 , Y02B20/44 , Y10T307/773
摘要： The automatic gang switch having a heat ray sensor is fixedly mounted on a mounting frame having a generally rectangular opening. The length of a housing of the switch is approximately two thirds of that of the generally rectangular opening of the mounting frame, while the width of the housing is approximately equal to that of the generally rectangular opening of the mounting frame. The switch includes a human body detecting section for detecting heat rays emitted from a human body and a circuit section. The circuit section includes a control circuit for generating a control signal to turn a load on for a predetermined operation holding time when the human body detecting section generates a detection signal, a load control circuit connected to a power source and the load in series for turning on or off power supply to the load depending on the control signal, an off-time power circuit connected in parallel with the load control circuit and having an input impedance with which the load is not driven when the load control circuit is off, the off-time power circuit supplying an electric power to the control circuit when the load control circuit is off, and an on-time power circuit for supplying the electric power to the control circuit when the load control circuit is on. The switch further includes a time setting section for setting an operation holding time and a mode setting section for changing over an operation mode of the control circuit.
摘要翻译：具有热射线传感器的自动组合开关固定地安装在具有大致矩形开口的安装框架上。开关的壳体的长度大约是安装框架的大致矩形开口的三分之二，而壳体的宽度大致等于安装框架的大致矩形开口的宽度。开关包括用于检测从人体发射的热射线的人体检测部和电路部。电路部分包括控制电路，用于当人体检测部分产生检测信号时，产生控制信号以使预定的操作保持时间变为负载，连接到电源的负载控制电路和用于转动的串联负载根据控制信号对负载进行通电或断电，与负载控制电路并联连接并具有当负载控制电路断开时不驱动负载的输入阻抗的断电时间电源电路，关断时间电源电路，当负载控制电路断开时向控制电路供电;以及接通电源电路，用于在负载控制电路接通时向控制电路供电。开关还包括用于设定操作保持时间的时间设定部分和用于切换控制电路的操作模式的模式设置部分。

33. 发明授权

US6027720A G-CSF conjugate 失效
标题翻译： G-CSF缀合物
公开(公告)号：US6027720A
公开(公告)日：2000-02-22
申请号：US274433
申请日：1994-07-13
申请人： Tetsuro Kuga , Hiromasa Miyaji , Moriyuki Sato , Masami Okabe , Makoto Morimoto , Seiga Itoh , Motoo Yamasaki , Yoshiharu Yokoo , Kazuo Yamaguchi , Hajime Yoshida , Yoshinori Komatsu
发明人： Tetsuro Kuga , Hiromasa Miyaji , Moriyuki Sato , Masami Okabe , Makoto Morimoto , Seiga Itoh , Motoo Yamasaki , Yoshiharu Yokoo , Kazuo Yamaguchi , Hajime Yoshida , Yoshinori Komatsu
IPC分类号： A61K38/00 , C07K1/107 , C07K1/113 , C07K1/12 , C07K14/535 , C07K16/24 , C07K17/06 , C12N15/70
CPC分类号： C07K1/113 , C07K1/1077 , C07K14/535 , C07K16/243 , C07K17/06 , C12N15/70 , A61K38/00 , Y10S530/82 , Y10S530/825 , Y10S930/145
摘要： Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.
摘要翻译：具有衍生自人粒细胞集落刺激因子多肽的氨基酸序列的氨基酸序列的新型hG-CSF多肽衍生物通过用不同氨基酸取代至少一个氨基酸和/或缺失至少一个氨基酸，重组体含有编码这些hG-CSF多肽衍生物中的任何一种的DNA片段插入片段的质粒，携带这种质粒之一的微生物，使用微生物生产hG-CSF多肽衍生物的方法，与hG-CSF多肽衍生物结合的单克隆抗体，以及公开了化学修饰的hG-CSF或其衍生物。

34. 发明授权

US5413997A Triphenylmethane derivatives 失效
标题翻译：三苯甲烷衍生物
公开(公告)号：US5413997A
公开(公告)日：1995-05-09
申请号：US7104
申请日：1993-01-21
申请人： Iwao Kinoshita , Daisuke Machii , Yasuo Onoda , Haruki Takai , Nobuo Kosaka , Katsuichi Shuto , Katsushige Gomi , Makoto Morimoto , Akio Ishii
发明人： Iwao Kinoshita , Daisuke Machii , Yasuo Onoda , Haruki Takai , Nobuo Kosaka , Katsuichi Shuto , Katsushige Gomi , Makoto Morimoto , Akio Ishii
IPC分类号： A61K31/09 , A61K31/135 , A61K31/165 , A61K31/365 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/47 , A61K31/472 , A61P3/00 , A61P9/00 , A61P19/10 , C07C217/58 , C07C217/60 , C07C233/11 , C07C233/25 , C07C233/26 , C07C233/29 , C07C233/60 , C07C233/65 , C07C233/75 , C07C235/44 , C07C235/46 , C07C235/54 , C07C235/56 , C07C235/64 , C07C237/32 , C07C237/40 , C07C323/42 , C07D207/09 , C07D211/58 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/06 , C07D217/04 , C07D221/20 , C07D223/20 , C07D225/08 , C07D277/20 , C07D277/44 , C07D277/46 , C07D277/82 , C07D295/096 , C07D295/10 , C07D295/112 , C07D295/13 , C07D295/135 , C07D295/192 , C07D295/205 , C07D307/00 , C07D311/00 , C07D333/20 , C07D333/38 , C07D401/04 , C07D413/04 , A01N43/00 , A01N33/02 , A01N43/40 , A01N43/62 , C07C43/21 , C07C211/45 , C07C229/42 , C07D215/28 , C07D215/36 , C07D215/38
CPC分类号： C07D213/75 , C07C217/58 , C07C217/60 , C07C233/25 , C07C233/26 , C07C233/29 , C07C233/60 , C07C233/75 , C07C235/44 , C07C235/56 , C07C235/64 , C07C237/40 , C07C323/42 , C07D211/58 , C07D213/74 , C07D215/06 , C07D217/04 , C07D221/20 , C07D225/08 , C07D277/46 , C07D277/82 , C07D295/096 , C07D295/112 , C07D295/13 , C07D295/135 , C07D295/192 , C07D295/205 , C07D307/00 , C07D333/20 , C07D333/38 , C07D413/04 , C07C2101/02 , C07C2101/08 , C07C2101/18 , C07C2102/08 , C07C2102/42 , C07C2103/18 , C07C2103/74
摘要： A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis.
摘要翻译：由以下通式表示的三苯甲烷衍生物：表现出骨吸收抑制作用，可用作治疗骨质疏松症的药物。

35. 发明授权

US5021423A Mitomycin derivatives and intermediates therefor 失效
标题翻译：丝裂霉素衍生物及其中间体
公开(公告)号：US5021423A
公开(公告)日：1991-06-04
申请号：US358272
申请日：1989-05-26
申请人： Yutaka Kanda , Hitoshi Arai , Masaji Kasai , Makoto Morimoto
发明人： Yutaka Kanda , Hitoshi Arai , Masaji Kasai , Makoto Morimoto
IPC分类号： A61K31/40 , A61P31/04 , A61P35/00 , C07D491/22
CPC分类号： C07D491/22
摘要： Mitomycin derivatives having the formula ##STR1## wherein X is acyl, lower alkyl, alkoxycarbonyl aryloxycarbonyl or aralkoxycarbonyl;Y is hydrogen or methyl;Z is hydrogen, methyl, acyl or allyloxycarbonyl;one of R.sub.1 and R.sub.2 represents carbamoyloxymethyl and the other represents hydrogen, or R.sub.1 and R.sub.2 together represent methylene, show antibacterial and antitumor activities.

36. 发明授权

US4791130A Mitomycin derivatives as antileukemia agents 失效
标题翻译：丝裂霉素衍生物作为抗白血病剂
公开(公告)号：US4791130A
公开(公告)日：1988-12-13
申请号：US38376
申请日：1987-04-15
申请人： Tokuyuki Kuroda , Koji Hisamura , Tohru Sugaya , Yutaka Ohsawa , Hideo Ueno , Makoto Morimoto , Tadashi Ashizawa
发明人： Tokuyuki Kuroda , Koji Hisamura , Tohru Sugaya , Yutaka Ohsawa , Hideo Ueno , Makoto Morimoto , Tadashi Ashizawa
IPC分类号： A61K31/40 , A61P35/00 , C07D487/14 , C07D487/04
CPC分类号： C07D487/14
摘要： Mitomycin derivatives having potent antitumour activity have the formula: ##STR1## wherein R represents lower alkyl, cycloalkyl or unsubstituted or substituted aralkyl;X represents hydrogen or carbamoyl;Y and Z each independently represents hydrogen or methyl;and represents an .alpha. or .beta. bond.
摘要翻译：具有有效抗肿瘤活性的丝裂霉素衍生物具有下式：其中R表示低级烷基，环烷基或未取代或取代的芳烷基; X表示氢或氨基甲酰基; Y和Z各自独立地表示氢或甲基; 并表示α或β键。

37. 发明授权

US4748251A 7-n-aminomethylenemitomycin derivative 失效
标题翻译： 7-氨基亚甲基霉素衍生物
公开(公告)号：US4748251A
公开(公告)日：1988-05-31
申请号：US824227
申请日：1986-01-30
申请人： Kunikatsu Shirahata , Motomichi Kono , Masaji Kasai , Makoto Morimoto , Tadashi Ashizawa
发明人： Kunikatsu Shirahata , Motomichi Kono , Masaji Kasai , Makoto Morimoto , Tadashi Ashizawa
IPC分类号： A61K31/40 , A61P35/00 , C07D487/14
CPC分类号： C07D487/14
摘要： Mitomycin derivatives represented by the formula (I): ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different, and represent a hydrogen atom or a lower alkyl group; R.sub.3 and R.sub.4 mean that when R.sub.3 is a hydrogen atom, R.sub.4 represents --CH.sub.2 OCONH.sub.2 or ##STR2## (wherein R.sub.1 and R.sub.2 have the same significances as defined above), or R.sub.3 and R.sub.4 are combined to form .dbd.CH.sub.2 ; Y and Z may be the same or different, and represent a hydrogen atom or a methyl group; represents .alpha.- or .beta.-bond, provided that Y represents a hydrogen atom when R.sub.4 takes .beta.-configuration, have an excellent anti-tumor activity.
摘要翻译：由式（I）表示的丝裂霉素衍生物：其中R 1和R 2可以相同或不同，表示氢原子或低级烷基; R 3和R 4表示当R 3是氢原子时，R 4表示-CH 2 OCONH 2或者其中R 1和R 2具有与上述相同的含义，或者R 3和R 4组合形成= CH 2; Y和Z可以相同或不同，表示氢原子或甲基; 表示α或β键，条件是当R 4为β-构型时，Y表示氢原子，具有优异的抗肿瘤活性。

38. 发明授权

US4650869A DX-52-1 compounds and process for preparing the same 失效
标题翻译： DX-52-1化合物及其制备方法
公开(公告)号：US4650869A
公开(公告)日：1987-03-17
申请号：US606902
申请日：1984-05-04
申请人： Tadashi Hirata , Shigeru Kobayashi , Keiichi Takahashi , Makoto Morimoto , Yuko Arai
发明人： Tadashi Hirata , Shigeru Kobayashi , Keiichi Takahashi , Makoto Morimoto , Yuko Arai
IPC分类号： A61K31/495 , A61P31/04 , A61P35/00 , C07D471/18 , C07D498/08 , C07D498/22 , C07D487/18
CPC分类号： C07D471/18 , C07D498/22
摘要： A compound represented by the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl group, X is a hydroxymethyl group and Y is a cyano group, and when R is a lower alkyl group, X and Y may combine to form --CH.sub.2 --O--, and salts thereof, process for preparing the same, and an anti-tumor composition containing the same, which is improved in stability in comparison with a starting compound DC-52.
摘要翻译：由下式表示的化合物：其中r是氢原子或低级烷基，X是羟甲基，Y是氰基，当R是低级烷基时，X和Y可以组合形成 -CH 2 -O-及其盐，其制备方法和含有该组合物的抗肿瘤组合物，与起始化合物DC-52相比，其稳定性提高。

39. 发明授权

US4618687A Cyclopentenone compound and process for production thereof 失效
标题翻译：环戊烯酮化合物及其生产方法
公开(公告)号：US4618687A
公开(公告)日：1986-10-21
申请号：US724549
申请日：1985-04-18
申请人： Tadashi Hirata , Hiromitsu Saito , Makoto Morimoto
发明人： Tadashi Hirata , Hiromitsu Saito , Makoto Morimoto
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/94
CPC分类号： C07D311/94
摘要： A cyclopentenone compound represented by the following formula: ##STR1## has an antitumor effect and can be produced from the antibiotic XK-213.
摘要翻译：由下式表示的环戊烯酮化合物：具有抗肿瘤作用，可由抗生素XK-213生产。

40. 发明授权

US5994518A Method of producing a polypeptide having human granulocyte colony stimulating factor activity 失效
标题翻译：制备具有人粒细胞集落刺激因子活性的多肽的方法
公开(公告)号：US5994518A
公开(公告)日：1999-11-30
申请号：US890640
申请日：1997-07-09
申请人： Tetsuro Kuga , Hiromasa Miyaji , Moriyuki Sato , Masami Okabe , Makoto Morimoto , Seiga Itoh , Motoo Yamasaki , Yoshiharu Yokoo , Kazuo Yamaguchi , Hajime Yoshida , Yoshinori Komatsu
发明人： Tetsuro Kuga , Hiromasa Miyaji , Moriyuki Sato , Masami Okabe , Makoto Morimoto , Seiga Itoh , Motoo Yamasaki , Yoshiharu Yokoo , Kazuo Yamaguchi , Hajime Yoshida , Yoshinori Komatsu
IPC分类号： A61K38/00 , C07K1/107 , C07K1/113 , C07K1/12 , C07K14/535 , C07K16/24 , C07K17/06 , C12N15/70
CPC分类号： C07K1/1077 , C07K1/113 , C07K14/535 , C07K16/243 , C07K17/06 , C12N15/70 , A61K38/00
摘要： Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.
摘要翻译：具有衍生自人粒细胞集落刺激因子多肽的氨基酸序列的氨基酸序列的新型hG-CSF多肽衍生物通过用不同氨基酸取代至少一个氨基酸和/或缺失至少一个氨基酸，重组体含有编码这些hG-CSF多肽衍生物中的任何一种的DNA片段插入片段的质粒，携带这种质粒之一的微生物，使用微生物生产hG-CSF多肽衍生物的方法，与hG-CSF多肽衍生物结合的单克隆抗体，以及公开了化学修饰的hG-CSF或其衍生物。

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