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31. 发明申请

WO2014164098A1 SAFELY INGESTIBLE BATTERIES 审中-公开
标题翻译：安全无铅电池
公开(公告)号：WO2014164098A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/020537
申请日：2014-03-05
申请人： BRIGHAM AND WOMEN'S HOSPITAL, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LAULICHT, Bryan , FREILICH, Janet , KARP, Jeffrey, M. , LANGER, Robert
发明人： LAULICHT, Bryan , FREILICH, Janet , KARP, Jeffrey, M. , LANGER, Robert
IPC分类号： H01M2/02
CPC分类号： H01M2/0222 , H01M2/025 , H01M2/0267 , H01M2/08 , H01M2/18 , H01M2/30 , H01M2/34 , H01M10/4235 , H01M2200/00 , H01M2220/00 , H01M2220/30
摘要： A battery for use in electronic devices and which is safely ingested into a body and a related method of making the battery. The battery includes an anode, a cathode and a quantum tunneling composite coating. The quantum tunneling composite coating covers at least a portion of at least one of the anode or the cathode and provides pressure sensitive conductive properties to the battery including a compressive stress threshold for conduction. The compressive stress threshold may be greater than a pre-determined applied stress in a digestive tract of the body in order to prevent harm if the battery is ingested. The battery may include a waterproof seal that extends between the quantum tunneling composite coating and a gasket separating the anode and cathode to inhibit the battery from short circuiting in a conductive fluid below the compressive stress threshold.
摘要翻译：一种用于电子设备并被安全地摄入身体的电池和相关的制造电池的方法。电池包括阳极，阴极和量子隧道复合涂层。量子隧道复合涂层覆盖阳极或阴极中的至少一个的至少一部分，并且为电池提供压敏导电性能，包括用于传导的压应力阈值。压缩应力阈值可能大于身体消化道中预先确定的施加应力，以防止电池摄入时的危害。电池可以包括在量子隧道复合涂层和分隔阳极和阴极的垫圈之间延伸的防水密封件，以阻止电池在低于压缩应力阈值的导电流体中短路。

32. 发明申请

WO2012150467A2 NOVEL POLYMERS WHICH RESIST BACTERIAL ATTACHMENT 审中-公开
标题翻译：新型聚合物，可抵抗细菌附着
公开(公告)号：WO2012150467A2
公开(公告)日：2012-11-08
申请号：PCT/GB2012/050987
申请日：2012-05-04
申请人： THE UNIVERSITY OF NOTTINGHAM , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , WILLIAMS, Paul , ALEXANDER, Morgan Russell , DAVIES, Martyn Christopher , LANGER, Robert , ANDERSON, Daniel Griffith
发明人： WILLIAMS, Paul , ALEXANDER, Morgan Russell , DAVIES, Martyn Christopher , LANGER, Robert , ANDERSON, Daniel Griffith
CPC分类号： A61L29/16 , A01N37/12 , A01N37/20 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F220/18 , C08F220/22 , C08F220/24 , C08F220/56 , C08F222/1006 , C08L33/08 , C08L33/10 , C08L33/26 , A01N25/10 , A01N25/34
摘要： The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H 2 C=CR'-C(=0)-0-] n , R (I) [H 2 C=CR'-C(=0)-NH-] n R (II) wherein n is 1, 2 or 3, R' is independently H or CH 3 , R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.
摘要翻译：本发明提供了抑制细菌附着于表面的方法，该方法包括由聚合物形成表面，或将聚合物施用于表面，其中聚合物是由（甲基）丙烯酸酯或（甲基）丙烯酰胺单体形成的均聚物或由一种或多种（甲基）丙烯酸酯或（甲基）丙烯酰胺单体形成的共聚物，其中（甲基）丙烯酸酯或（甲基）丙烯酰胺单体为式（I）或（II）：[H 2 C = CR'-C = 0）-0-] n，R（I）[H2C = CR'-C（= 0）-NH-] n R（II）其中n为1,2或3，R'独立地为H或CH3， R是总共2至24个碳原子的有机基团，其中有机基团包括脂族或芳族烃部分，并且其中有机基团不包括任何羟基。

33. 发明申请

WO2009067482A1 ADHESIVE ARTICLES 审中-公开
标题翻译：胶粘剂
公开(公告)号：WO2009067482A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/083980
申请日：2008-11-19
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KARP, Jeffrey , ALBORZ, Mahdavi , FERREIRA, Lino , CARTER, David , ZUMBUEHL, Andreas , BORENSTEIN, Jeffrey , CHAN, Edwin , BETTINGER, Christopher , LANGER, Robert
发明人： KARP, Jeffrey , ALBORZ, Mahdavi , FERREIRA, Lino , CARTER, David , ZUMBUEHL, Andreas , BORENSTEIN, Jeffrey , CHAN, Edwin , BETTINGER, Christopher , LANGER, Robert
IPC分类号： A61F2/02
CPC分类号： A61F2/0077 , A61F2002/30448 , A61F2013/00774 , A61F2220/0016 , A61F2220/005 , A61K9/0019 , A61L15/42 , A61L15/58 , A61L15/64 , A61L31/005 , A61L31/14 , A61L31/148 , B29C65/18 , B29C65/52 , B29C66/1122 , B31B70/81 , B31B2160/10 , C04B37/005
摘要： An adhesive article includes a biocompatible and at least partially biodegradable substrate having a surface; and a plurality of protrusions extending from the surface. The protrusions include a biocompatible and at least partially biodegradable material, and have an average height of less than approximately 1,000 micrometers.
摘要翻译：粘合剂制品包括具有表面的生物相容性和至少部分可生物降解的基材; 以及从表面延伸的多个突起。突起包括生物相容性和至少部分可生物降解的材料，并且具有小于约1,000微米的平均高度。

34. 发明申请

WO2008096194A1 METHOD OF FABRICATION OF HIGHLY HEAT DISSIPATIVE SUBSTRATES 审中-公开
标题翻译：高热耗散基板的制造方法
公开(公告)号：WO2008096194A1
公开(公告)日：2008-08-14
申请号：PCT/IB2007/000950
申请日：2007-02-08
申请人： S.O.I.TEC SILICON ON INSULATOR TECHNOLOGIES , KONONCHUK, Oleg , LETERTRE, Fabrice , LANGER, Robert
发明人： KONONCHUK, Oleg , LETERTRE, Fabrice , LANGER, Robert
IPC分类号： H01L21/762
CPC分类号： H01L21/76254
摘要： The invention relates to a method for fabricating a composite structure having heat dissipation properties greater than a bulk single crystal silicon structure having the same dimensions, the structure comprising a support substrate, a top layer and an oxide layer between the support substrate and the top layer, the method comprising the steps of: a) providing a top layer made of a crystalline material, b) bonding the top layer with a support substrate made of a polycrystalline material having high heat dissipation properties, such that an oxide layer is formed at the bonding interface, in order to obtain said structure, characterized in that it further comprises a heat treatment of the structure in an inert or reducing atmosphere at a predetermined temperature and a predetermined duration to increase the heat dissipation properties by dissolving at least a part of the oxide layer.
摘要翻译：本发明涉及一种制造具有大于具有相同尺寸的本体单晶硅结构的散热特性的复合结构的方法，该结构包括支撑基板和顶层之间的支撑基板，顶层和氧化物层所述方法包括以下步骤：a）提供由结晶材料制成的顶层，b）将顶层与由具有高散热性质的多晶材料制成的支撑衬底结合，使得氧化物层形成在接合界面，以获得所述结构，其特征在于，其还包括在预定温度和预定持续时间内在惰性或还原性气氛中对结构进行热处理，以通过将至少一部分氧化层。

35. 发明申请

WO2007022348A3 AMPLIFICATION OF CELL POLULATIONS FROM EMBRYONIC STEM CELLS 审中-公开
公开(公告)号：WO2007022348A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/032132
申请日：2006-08-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KARP, Jeffrey, J. , FERREIRA, Lino, S. , KHADEMHOSSEINI, Ali , LANGER, Robert
发明人： KARP, Jeffrey, J. , FERREIRA, Lino, S. , KHADEMHOSSEINI, Ali , LANGER, Robert
IPC分类号： C12N5/02
摘要： Culturing embryonic stem cells without the use of embryoid bodies leads to an increase in the frequency of predetermined cell types.

36. 发明申请

WO2004064737A3 THERAPEUTICS COMPOSITIONS 审中-公开
公开(公告)号：WO2004064737A3
公开(公告)日：2004-08-05
申请号：PCT/US2004/001193
申请日：2004-01-16
申请人： ALNYLAM PHARMACEUTICALS , WESTPHAL, Christoph , LANGER, Robert
发明人： WESTPHAL, Christoph , LANGER, Robert
IPC分类号： C12Q1/68
摘要： Therapeutic siRNA agents and methods of making and using are enclosed.

37. 发明申请

WO2010042866A1 NICOTINE IMMUNONANOTHERAPEUTICS 审中-公开
公开(公告)号：WO2010042866A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060236
申请日：2009-10-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , IANNACONE, Matteo , VON ANDRIAN, Ulrich , FAROKHZAD, Omid, C. , ALEXIS, Frank , BASTO, Pamela , SHI, Jinjun , MOSEMAN, Ashley , LANGER, Robert , TONTI, Elena
发明人： IANNACONE, Matteo , VON ANDRIAN, Ulrich , FAROKHZAD, Omid, C. , ALEXIS, Frank , BASTO, Pamela , SHI, Jinjun , MOSEMAN, Ashley , LANGER, Robert , TONTI, Elena
IPC分类号： A61K39/00
CPC分类号： A61K39/00
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof. For example, the present invention describes nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.
摘要翻译：本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。本发明提供包含具有多个尼古丁部分的免疫表面的纳米载体。本发明提供包含纳米载体的药物组合物。本发明提供了纳米载体及其药物组合物的设计，制造和使用方法。例如，本发明描述能够引发免疫应答和产生抗尼古丁抗体的纳米载体。

38. 发明申请

WO2008097609A2 METHODS AND DEVICES FOR SENSING TISSUES AND TISSUE COMPARTMENTS 审中-公开
标题翻译：用于感测组织和组织间隔的方法和设备
公开(公告)号：WO2008097609A2
公开(公告)日：2008-08-14
申请号：PCT/US2008/001622
申请日：2008-02-07
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SLOCUM, Alexander , BASSETT, Erik , KARP, Jeffrey, M. , LANGER, Robert , FAROKHZAD, Omid, C.
发明人： SLOCUM, Alexander , BASSETT, Erik , KARP, Jeffrey, M. , LANGER, Robert , FAROKHZAD, Omid, C.
IPC分类号： A61M25/00 , A61M5/00
CPC分类号： A61M5/3287 , A61B17/3401 , A61B2090/064
摘要： An apparatus provides feedback regarding the material in which tip of the apparatus is located as the tip is advanced into matter of varying resistances. The apparatus responds to a change in pressure, force, or other parameter such that when the tip reaches matter of a certain resistance, a change in the parameter is sensed. The apparatus provides a driving force to a penetrating medical device, such as a needle, when the apparatus tip encounters material of high resistance. When the apparatus tip encounters a low resistance material, no further driving force is applied to the apparatus. An inner core may be advanced into the low resistance material for deployment of a gas or a liquid as desired.
摘要翻译：当装置尖端前进到不同电阻的物质中时，装置提供关于装置的尖端位于其中的材料的反馈。该设备响应于压力，力或其他参数的变化，使得当尖端达到某个电阻的物质时，感测参数的变化。当装置尖端遇到高阻力材料时，该装置向刺穿的医疗装置（例如针）提供驱动力。当装置尖端遇到低电阻材料时，不会对装置施加进一步的驱动力。根据需要，内芯可以被推进到低电阻材料中用于气体或液体的展开。

39. 发明申请

WO2006078725A1 SOFT POLYLACTIDES 审中-公开
标题翻译：软聚酯
公开(公告)号：WO2006078725A1
公开(公告)日：2006-07-27
申请号：PCT/US2006/001748
申请日：2006-01-19
申请人： DOMB, Abraham , LANGER, Robert
发明人： LANGER, Robert
IPC分类号： C08G63/00
CPC分类号： A61K9/0024 , A61K9/0019 , A61K47/34 , C08G63/06
摘要： Biodegradable polymeric compositions that are liquids or pastes at temperatures below 370C are described. Immersion of the compositions in aqueous medium, such as body fluids, increases the viscosity of the composition resulting in the formation of a semisolid material. The polymeric material is a hydroxyalkanoic acid polyester derived from the copolymerization of at least one unsaturated hydroxy fatty acid copolymerized with hydroxyalkanoic acids of 2-6 carbons.
摘要翻译：描述了在低于370℃的温度下是液体或糊状物的可生物降解的聚合物组合物。组合物在水性介质（例如体液）中的浸渍增加了组合物的粘度，从而形成半固体材料。聚合物材料是由至少一种与2-6个碳原子的羟基链烷酸共聚的不饱和羟基脂肪酸的共聚得到的羟基链烷酸聚酯。

40. 发明申请

WO2005089123A2 THERAPEUTIC ANTI-CANCER DNA 审中-公开
标题翻译：治疗性抗癌DNA
公开(公告)号：WO2005089123A2
公开(公告)日：2005-09-29
申请号：PCT/US2005/007001
申请日：2005-03-04
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LANKENAU INSTITUTE FOR MEDICAL RESEARCH , ANDERSON, Daniel, Griffith , LANGER, Robert , SAWICKI, Janet , PENG, Weidan
发明人： ANDERSON, Daniel, Griffith , LANGER, Robert , SAWICKI, Janet , PENG, Weidan
IPC分类号： A61K48/00 , C07H21/04 , C12N15/85 , C12N15/861 , C12N15/88
CPC分类号： C12N15/88 , A61K48/0058 , C12N15/86 , C12N2710/10343 , C12N2800/30 , C12N2830/008 , C12N2830/15
摘要： Aspects of the invention relate to nucleic acids molecules that are useful for specifically destroying selected cells, tissues, or organs. Aspects of the invention are useful for treating diseases (e.g., cancer) that affect cells, tissues, or organs.
摘要翻译：本发明的方面涉及可用于特异性破坏选定细胞，组织或器官的核酸分子。本发明的方面可用于治疗影响细胞，组织或器官的疾病（例如癌症）。

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