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31. 发明授权

US09150832B2 Cell training for local field stimulation 有权
标题翻译：局部场刺激的细胞训练
公开(公告)号：US09150832B2
公开(公告)日：2015-10-06
申请号：US11745620
申请日：2007-05-08
申请人： Bruce KenKnight , Steven D. Girouard
发明人： Bruce KenKnight , Steven D. Girouard
IPC分类号： C12N13/00 , A61N1/362 , C12N5/077 , A61K35/12 , A61M37/00 , A61B17/34 , A61B17/00 , A61B18/00 , A61N1/32
CPC分类号： C12N5/0657 , A61B17/3468 , A61B2017/00247 , A61B2017/00256 , A61B2018/00392 , A61K35/12 , A61M37/0069 , A61N1/326 , A61N1/362
摘要： A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial node spontaneously depolarize predominantly due to the slow depolarization of transmembrane potential. The present system may provide sino-atrial cells with a local field stimulation that while not eliciting an action potential may nonetheless alter local transmembrane potential. Such alteration of transmembrane potential may permit an increase or decrease in a rate of depolarization, and hence modify heart rate.
摘要翻译：提供了一种用于刺激一个或多个细胞的系统，其中所述刺激是次阈值的并且可以改变所述一个或多个细胞的跨膜电位。对于一些细胞群体，可能影响跨膜电位以获得治疗益处。由于跨膜电位缓慢去极化，中心节点的细胞主要去极化。本发明的系统可以为中心细胞提供局部场刺激，尽管不引起动作电位也可能改变局部跨膜电位。跨膜电位的这种改变可以允许去极化率的增加或减少，从而改变心率。

32. 发明授权

US08224443B2 Method for controlling pacemaker therapy 有权
标题翻译：控制起搏器治疗的方法
公开(公告)号：US08224443B2
公开(公告)日：2012-07-17
申请号：US11745823
申请日：2007-05-08
申请人： Bruce KenKnight , Steven D. Girouard
发明人： Bruce KenKnight , Steven D. Girouard
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61B5/0468 , A61N1/36514 , A61N1/36592 , A61N1/3688 , A61N1/3702
摘要： The present invention includes a method for controlling pacemaker therapy in a patient with an implanted biological pacemaker. The method may include pacing a heart at a predetermined rate using an electronic pacemaker and configuring the pacemaker to periodically enter a biological pacemaker weaning mode. The weaning mode may include ceasing pacing for at least a predetermined length of time and monitoring the heart to detect electrical depolarizations of a ventricle of the heart during the predetermined length of time. The weaning mode may further include determining the length of time between the cessation of pacing and the detected electrical depolarization and determining if the length of time between the cessation of pacing and the detected electrical depolarization is less than a maximum predetermined interval. The pacemaker therapy may be withheld as long as the length of time is less than the maximum predetermined interval. Further, if the length of time exceeds a maximum interval, the pacemaker will exit the weaning mode.
摘要翻译：本发明包括一种用植入式生物起搏器控制患者起搏器治疗的方法。该方法可以包括使用电子起搏器以预定速率起搏心脏并且配置起搏器周期性地进入生物起搏器断奶模式。断奶模式可以包括停止至少预定时间长度的起搏并监测心脏以在预定时间长度内检测心脏心室的电去极化。断奶模式还可以包括确定停止起搏和检测到的电去极化之间的时间长度，并确定停止起搏和检测到的电去极化之间的时间长度是否小于最大预定间隔。只要时间长度小于最大预定间隔，就可以禁止起搏器治疗。此外，如果时间长度超过最大间隔，则起搏器将退出断奶模式。

33. 发明申请

US20070150013A1 METHOD AND SYSTEM FOR SETTING CARDIAC RESYNCHRONIZATION THERAPY PARAMETERS 有权
标题翻译：用于设置心脏再生治疗参数的方法和系统
公开(公告)号：US20070150013A1
公开(公告)日：2007-06-28
申请号：US11681244
申请日：2007-03-02
申请人： Jiang Ding , Yinghong Yu , Bruce KenKnight
发明人： Jiang Ding , Yinghong Yu , Bruce KenKnight
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.
摘要翻译：提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。

34. 发明申请

US20060089679A1 Method and apparatus for determining changes in heart failure status 有权
公开(公告)号：US20060089679A1
公开(公告)日：2006-04-27
申请号：US11299876
申请日：2005-12-12
申请人： Qingsheng Zhu , Julio Spinelli , Bruce KenKnight , Jay Warren
发明人： Qingsheng Zhu , Julio Spinelli , Bruce KenKnight , Jay Warren
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36585
摘要： A method for operating a cardiac rhythm management device in which a clinical state vector is computed as a combination of a plurality of parameters related to a patient's heart failure status and compared to a previously computed clinical state vector to determine a clinical trajectory indicative of changes in the patient's heart failure status. Such detected changes in status can be used both as a clinical tool to evaluate treatment and to automatically adjust the operation of the device.

35. 发明申请

US20050261741A1 Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权
标题翻译：通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗
公开(公告)号：US20050261741A1
公开(公告)日：2005-11-24
申请号：US10850341
申请日：2004-05-20
申请人： Imad Libbus , Bruce KenKnight , Julia Moffitt , Yatheendhar Manicka
发明人： Imad Libbus , Bruce KenKnight , Julia Moffitt , Yatheendhar Manicka
IPC分类号： A61N1/36 , A61N1/362 , A61N1/18
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译：公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

36. 发明申请

US20050137633A1 Pacing method and device for preserving native conduction system 失效
标题翻译：起搏方法和保存天然传导系统的装置
公开(公告)号：US20050137633A1
公开(公告)日：2005-06-23
申请号：US10744952
申请日：2003-12-22
申请人： Rodney Salo , Bruce KenKnight , Joseph Pastore , Steven Girouard
发明人： Rodney Salo , Bruce KenKnight , Joseph Pastore , Steven Girouard
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/3684
摘要： An implantable device for delivering cardiac pacing therapy in order to improve cardiac function is programmed to allow some amount of intrinsic activity to occur without otherwise the disturbing the pacing algorithm used to deliver therapy. Intrinsic cardiac cycles utilize the heart's native conduction system and thus serve to prevent the atrophy which may otherwise result from continuous pacing.
摘要翻译：用于递送心脏起搏治疗以改善心脏功能的可植入装置被编程为允许发生一定量的内在活动，而无需另外打扰用于递送治疗的起搏算法。内在心脏周期利用心脏的天然传导系统，从而用于预防由连续起搏引起的萎缩。

37. 发明授权

US06666862B2 Radio frequency ablation system and method linking energy delivery with fluid flow 有权
公开(公告)号：US06666862B2
公开(公告)日：2003-12-23
申请号：US09797435
申请日：2001-03-01
申请人： Mudit K. Jain , Milton M. Morris , Bruce KenKnight
发明人： Mudit K. Jain , Milton M. Morris , Bruce KenKnight
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B18/16 , A61B2018/0016 , A61B2018/00351 , A61B2018/00577 , A61B2018/00654 , A61B2018/00714 , A61B2018/00726 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00839 , A61B2018/00863 , A61B2018/124 , A61B2018/1253 , A61B2018/1273 , A61B2018/1286 , A61B2018/1467 , A61B2090/065
摘要： Information indicative of the flow rate of fluid through a biological organ is provided to a processor. Using this information the processor assesses whether the fluid-flow rate is high or low and controls a generator such that the generator provides energy to an electrode positioned within the organ to effect tissue ablation. Energy of a first level is provided during periods of high fluid-flow and energy of a second level, less than the first level, during periods of low fluid-flow. The flow rate information may be provided by an electrocardiograph (ECG) device or a flow sensor. A temperature sensor provides temperature signals to the processor indicative of the electrode temperature. The processor further controls the generator based on the electrode temperature to maintain the temperature at or near a target temperature and below a maximum threshold temperature.

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