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31. 发明授权

US5300527A Alkylamino-and alkylamino alkyl diarylketones 失效
标题翻译：烷基氨基和烷基氨基烷基二芳基酮
公开(公告)号：US5300527A
公开(公告)日：1994-04-05
申请号：US960336
申请日：1992-10-13
申请人： R. Richard L. Hamer , Brian Freed , Richard C. Allen
发明人： R. Richard L. Hamer , Brian Freed , Richard C. Allen
IPC分类号： C07C45/00 , C07C45/45 , C07C49/233 , C07C49/80 , C07C217/86 , C07C225/16 , C07C225/22 , A61K31/135
CPC分类号： C07C225/22 , C07C217/86 , C07C225/16 , C07C45/004 , C07C45/455 , C07C49/233 , C07C49/80
摘要： This invention relates to alkylamino and alkyl amino alkyl diarylketones of the formula ##STR1## where Ar is aryl of the formula ##STR2## where V is hydrogen, halogen, loweralkyl, loweralkoxy, CF.sub.3, NO.sub.2 and u is an integer of 1 to 3; X and Y are independently CH.sub.2 --, --CF.sub.2 -- or --CHF--; Z and W are independently --CH.sub.2 --, --O--, --CHOH--, or --CHF--; m, n, p, q and t are integers which are independently 0 or 1; R.sub.1 is H or loweralkyl; R.sub.2 and R.sub.3 are loweralkyl; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic agents and as agents for alleviating various memory dysfunctions, characterized by a decreased cholinergic function, such as Alzheimer's disease.
摘要翻译：本发明涉及式IMA的烷基氨基和烷基氨基烷基二芳基酮，其中Ar是下式的芳基：其中V是氢，卤素，低级烷基，低级烷氧基，CF 3，NO 2，u是1至3的整数; X和Y独立地是CH 2 - ， - CF 2 - 或-CHF-; Z和W独立地是-CH 2 - ， - O - ， - CHOH-或-CHF-; m，n，p，q和t分别是0或1的整数; R1是H或低级烷基; R2和R3是低级烷基; 和其药学上可接受的酸加成盐，并且在适用的情况下为其几何和旋光异构体及其外消旋混合物。本发明的化合物显示出作为镇痛剂的用途，并且作为减轻各种记忆功能障碍的药剂，其特征在于胆碱能功能降低，如阿尔茨海默病。

32. 发明授权

US5264575A Process of preparing 2,6-methano-1,3-benzodiazocine compounds 失效
标题翻译：制备2,6-亚甲基-1,3-苯并二氮辛腈的方法
公开(公告)号：US5264575A
公开(公告)日：1993-11-23
申请号：US901638
申请日：1992-06-19
申请人： Richard C. Allen , Marc N. Agnew , David M. Fink
发明人： Richard C. Allen , Marc N. Agnew , David M. Fink
IPC分类号： C07D471/08 , C07D221/02
CPC分类号： C07D471/08
摘要： Novel 2,6-methano-1,3-benzodiazocines, intermediates, processes for the preparation thereof, and methods for alleviating pain and for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease, utilizing compounds or compositions thereof are disclosed.
摘要翻译：新颖的2,6-亚甲基-1,3-苯并二氮杂环丁烷，中间体，其制备方法，利用化合物或组合物，减轻疼痛和减轻胆碱能功能降低的各种记忆障碍功能如阿尔茨海默病的方法，披露

33. 发明授权

US5177111A Alkylamino- and alkylamino alkyl diarylketones and pharmaceutical compositions thereof 失效
标题翻译：烷基氨基和烷基氨基烷基二芳基酮及其药物组合物
公开(公告)号：US5177111A
公开(公告)日：1993-01-05
申请号：US643631
申请日：1991-01-22
申请人： R. Richard L. Hamer , Brian Freed , Richard C. Allen
发明人： R. Richard L. Hamer , Brian Freed , Richard C. Allen
IPC分类号： C07C45/00 , C07C45/45 , C07C49/233 , C07C49/80 , C07C217/86 , C07C225/16 , C07C225/22
CPC分类号： C07C225/22 , C07C217/86 , C07C225/16 , C07C45/004 , C07C45/455 , C07C49/233 , C07C49/80
摘要： This invention relates to alkylamino and alkyl amino alkyl diarylketones of the formula ##STR1## where Ar is aryl of the formula ##STR2## where V is hydrogen, halogen, loweralkyl, loweralkoxy, CF.sub.3, NO.sub.2 and u is an integer of 1 to 3; X and Y are independently CH.sub.2 --, --CF.sub.2 -- or --CHF--; Z and W are independently --CH.sub.2 --, --O--, --CHOH--, or --CHF--; m, n, p, q and t are integers which are independently 0 or 1, R.sub.1 is H or loweralkyl; R.sub.2 and R.sub.3 are loweralkyl; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic agents and as agents for alleviating various memory dysfunctions, characterized by a decreased cholinergic function, such as Alzheimer's disease.
摘要翻译：本发明涉及式IMA的烷基氨基和烷基氨基烷基二芳基酮，其中Ar是下式的芳基：其中V是氢，卤素，低级烷基，低级烷氧基，CF 3，NO 2，u是1至3的整数; X和Y独立地是CH 2 + 13，-CF 2 - 或-CHF-; Z和W独立地是-CH 2 - ， - O - ， - CHOH-或-CHF-; m，n，p，q和t分别为0或1，R1为H或低级烷基的整数; R2和R3是低级烷基; 和其药学上可接受的酸加成盐，并且在适用的情况下为其几何和旋光异构体及其外消旋混合物。本发明的化合物显示出作为镇痛剂的用途，并且作为减轻各种记忆功能障碍的药剂，其特征在于胆碱能功能降低，如阿尔茨海默病。

34. 发明授权

US5097033A 2,6-methano-1,3-benzodiazocine compounds 失效
标题翻译： 2,6-亚甲基-1,3-苯并二氮辛啶化合物
公开(公告)号：US5097033A
公开(公告)日：1992-03-17
申请号：US638933
申请日：1991-01-09
申请人： Richard C. Allen , Marc N. Agnew , David M. Fink
发明人： Richard C. Allen , Marc N. Agnew , David M. Fink
IPC分类号： C07D471/08
CPC分类号： C07D471/08
摘要： Novel 2,6-methano-1,3-benzodiazocines, intermediates, processes for the preparation thereof, and methods for alleviating pain and for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease, utilizing compounds or compositions thereof are disclosed.
摘要翻译：新颖的2,6-亚甲基-1,3-苯并二氮杂环丁烷，中间体，其制备方法，利用化合物或组合物，减轻疼痛和减轻胆碱能功能降低的各种记忆障碍功能如阿尔茨海默病的方法，披露

35. 发明授权

US4908361A Tetrahydroisoquino(2,1-C)(1,3)benzodiazepines 失效
标题翻译：四氢异喹啉（2,1-C）（1,3）苯并二氮杂
公开(公告)号：US4908361A
公开(公告)日：1990-03-13
申请号：US344799
申请日：1989-04-28
申请人： Lawrence L. Martin , Richard C. Allen
发明人： Lawrence L. Martin , Richard C. Allen
IPC分类号： C07D217/18 , A61K31/55 , A61P25/28 , C07D217/20 , C07D471/04
CPC分类号： C07D471/04
摘要： Novel Tetrahydroisoquino[2,1-c][1,3]benzodiazepines are disclosed having the formula ##STR1## where X and Y are each independently hydrogen, halogen, loweralkyl, loweralkoxy or --CF.sub.3, and R is hydrogen or loweralkyl, and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility in enhancing memory.

36. 发明授权

US4518713A Analgesic substituted-1-aminoalkylamino-4-aryloxypiperidines 失效
标题翻译：止痛性取代的-1-氨基烷基氨基-4-芳氧基哌啶
公开(公告)号：US4518713A
公开(公告)日：1985-05-21
申请号：US600265
申请日：1984-04-13
申请人： Raymond W. Kosley, Jr. , Richard C. Allen
发明人： Raymond W. Kosley, Jr. , Richard C. Allen
IPC分类号： A61K31/443 , A61K31/445 , A61P25/04 , C07D211/46 , C07D317/00 , C07D317/28 , C07D405/12
CPC分类号： C07D405/12 , C07D211/46 , C07D317/28
摘要： There are described analgesic substituted-1-aminoalkylamino-4-aryloxypiperidines of the formula ##STR1## where X is hydrogen, loweralkyl, CF.sub.3, acetyl or halogen; n is 1 or 2; R.sub.1 is H.sub.2 or oxygen; R.sub.2 is H, loweralkyl or benzyl; and R.sub.3 is oxygen or --OCH.sub.2 CH.sub.2 O--, which are useful as analgesic agents and intermediate compounds therefor.
摘要翻译：描述了式为“IMAGE”的镇痛取代的-1-氨基烷基氨基-4-芳氧基哌啶，其中X是氢，低级烷基，CF 3，乙酰基或卤素; n为1或2; R1是H2或氧; R2是H，低级烷基或苄基; 并且R 3为氧或-OCH 2 CH 2 O-，其可用作止痛剂及其中间体化合物。

37. 发明授权

US4425342A 1-(Substituted) piperazine-4-benzenesulfinamides, compositions and method of use 失效
标题翻译： 1-（取代）哌嗪-4-苯亚磺酰胺，组合物和使用方法
公开(公告)号：US4425342A
公开(公告)日：1984-01-10
申请号：US24930
申请日：1979-03-29
申请人： Richard C. Allen , Solomon S. Klioze
发明人： Richard C. Allen , Solomon S. Klioze
IPC分类号： A61K31/495 , A61P9/12 , C07D213/74 , C07D295/26 , C07D295/00 , C07D401/12
CPC分类号： C07D213/74 , C07D295/26
摘要： Benzenesulfinamides of the formula ##STR1## wherein R is pyridyl, phenyl or phenyl substituted by halogen, loweralkyl, loweralkoxy or trifluoromethyl and the pharmaceutically acceptable acid addition salts thereof are useful blood pressure reducing agents.
摘要翻译：其中R是吡啶基，苯基或被卤素，低级烷基，低级烷氧基或三氟甲基取代的苯基的苯甲酰胺和其药学上可接受的酸加成盐是有用的减压剂。

38. 发明授权

US4193207A Method for veneer drying 失效
标题翻译：贴面干燥方法
公开(公告)号：US4193207A
公开(公告)日：1980-03-18
申请号：US888457
申请日：1978-03-20
申请人： Richard C. Allen , Darrell E. Pierson
发明人： Richard C. Allen , Darrell E. Pierson
IPC分类号： F26B3/20 , F26B15/04 , F26B25/00
CPC分类号： F26B15/04 , F26B25/004 , F26B3/20
摘要： A heated metal plate drying system for drying either green veneer or partially dried veneer can have a plurality of modular hot presses mounted on a frame. At a loading station, individual sheets of veneer to be dried or redried are fed into a hot press, and at an unloading station the dried veneer sheets are unloaded from the system. Within each individual modular hot press, a direct contact drying process occurs that functions to reduce the moisture content of a veneer sheet down to the desired uniform level such as within a range of from 1 to 10%. The drying process accepts veneer of different species, thickness, and beginning moisture contents and the controlled process variables include contact time, temperature and pressure.Each individual modular press can be multi-opening and has the ability to open and close on command. Specially designed heated metal plates are part of each press and each plate has substantially parallel grooves on at least one surface. The modular presses are mounted on the frame such that they may be tilted at the unloading station to facilitate unloading of the dried veneer sheets.
摘要翻译：用于干燥绿色薄板或部分干燥的单板的加热金属板干燥系统可以具有安装在框架上的多个模块化热压机。在装载站处，将要干燥或重新干燥的各个薄板单元送入热压机中，并且在卸载站处，干燥的单板从系统中卸载。在每个单独的模块化热压机中，发生直接接触干燥过程，其功能是将单板的水分含量降低到所需的均匀水平，例如在1至10％的范围内。干燥过程接受不同种类，厚度和起始含水量的胶合板，受控过程变量包括接触时间，温度和压力。每个单独的模块化印刷机可以是多开的，并具有打开和关闭命令的能力。特别设计的加热金属板是每个压机的一部分，每个板在至少一个表面上具有基本平行的凹槽。模块式压力机安装在框架上，使得它们可以在卸载站处倾斜以便于干燥的单板的卸载。

39. 发明授权

US4160781A 4-Benzyloxy-3-(chlorocarbonyl)-phenylacetyl chloride 失效
标题翻译： 4-苄氧基-3-（氯羰基） - 苯基乙酰氯
公开(公告)号：US4160781A
公开(公告)日：1979-07-10
申请号：US939263
申请日：1978-09-05
申请人： Arthur R. McFadden , Richard C. Allen , Thomas B. K. Lee
发明人： Arthur R. McFadden , Richard C. Allen , Thomas B. K. Lee
IPC分类号： A61K31/335 , A61P25/04 , A61P29/00 , C07D295/185 , C07D313/12 , C07C63/00
CPC分类号： C07D295/185 , C07D313/12
摘要： A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
摘要翻译：描述了制备6,11-二氢-11-氧代二苯并[b，e]氧杂七环素-2-乙酸的方法和中间体。酸具有抗炎和镇痛作用。

40. 发明授权

US07406239B2 Optical elements containing a polymer fiber weave 失效
标题翻译：含有聚合物纤维编织的光学元件
公开(公告)号：US07406239B2
公开(公告)日：2008-07-29
申请号：US11068590
申请日：2005-02-28
申请人： Andrew J. Ouderkirk , Richard C. Allen , Olester Benson, Jr. , James C. Breister , Yeun-Jong Chou , Patrick R. Fleming , William J. Kopecky , Diane North , Roger J. Stumo , Kristin L. Thunhorst , Bruce B. Wilson , Harold E. Rude
发明人： Andrew J. Ouderkirk , Richard C. Allen , Olester Benson, Jr. , James C. Breister , Yeun-Jong Chou , Patrick R. Fleming , William J. Kopecky , Diane North , Roger J. Stumo , Kristin L. Thunhorst , Bruce B. Wilson , Harold E. Rude
IPC分类号： G02B6/10 , G02B6/02
CPC分类号： G02B6/001 , B82Y20/00 , G02B1/04 , G02B5/3008 , G02B5/3033 , G02B5/3083 , G02B6/0051 , G02B6/0053 , G02B6/04 , G02B6/105 , Y10T428/2933 , Y10T428/2967 , Y10T428/2973 , Y10T442/20 , Y10T442/30 , Y10T442/3065
摘要： A polarizer is formed with an arrangement of polymer fibers substantially parallel within a polymer matrix. The polymer fibers are formed of at least first and second polymer materials. At least one of the polymer matrix and the first and second polymer materials is birefringent, and provides a birefringent interface with the adjacent material. Light is reflected and/or scattered at the birefringent interfaces with sensitivity to the polarization of the light. In some embodiments, the polymer fibers are formed as composite fibers, having a plurality of scattering polymer fibers disposed within a filler to form the composite fiber. In other embodiments, the polymer fiber is a multilayered polymer fiber. The polymer fibers may be arranged within the polymer matrix as part of a fiber weave.
摘要翻译：偏振器由基本上平行于聚合物基质内的聚合物纤维的排列形成。聚合物纤维由至少第一和第二聚合物材料形成。聚合物基质和第一和第二聚合物材料中的至少一种是双折射的，并提供与相邻材料的双折射界面。光在双折射界面反射和/或散射，对光的偏振具有敏感性。在一些实施方案中，聚合物纤维形成为复合纤维，其具有布置在填料内以形成复合纤维的多个散射聚合物纤维。在其它实施方案中，聚合物纤维是多层聚合物纤维。聚合物纤维可以作为纤维编织的一部分布置在聚合物基质内。

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