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31. 发明授权

US6068829A Method of identifying molecules that home to a selected organ in vivo 失效
标题翻译：在体内鉴定归属于所选器官的分子的方法
公开(公告)号：US6068829A
公开(公告)日：2000-05-30
申请号：US862855
申请日：1997-06-23
申请人： Erkki Ruoslahti , Renata Pasqualini
发明人： Erkki Ruoslahti , Renata Pasqualini
IPC分类号： A61K39/395 , A61K49/00 , C12Q1/68 , C12Q1/70 , G01N33/53
CPC分类号： A61K49/0008 , C12Q1/6883
摘要： The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.
摘要翻译：本发明提供用于体内淘选文库以鉴定特定归属于所选器官的分子的方法。

32. 发明授权

US5994501A Tetrapeptide 失效
公开(公告)号：US5994501A
公开(公告)日：1999-11-30
申请号：US58540
申请日：1998-04-10
申请人： Erkki Ruoslahti , Michael Pierschbacher
发明人： Erkki Ruoslahti , Michael Pierschbacher
IPC分类号： A61K38/00 , A61K38/07 , A61K38/08 , A61L27/22 , C07K14/78 , C12N11/08 , C07K5/00 , C07K17/02
CPC分类号： C07K14/78 , A61K38/07 , A61K38/08 , A61L27/227 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same cell-attachment activity as fibronectin and the peptide X-Arg-Gly-Asp-Ser-Y, wherein X and Y, having said activity are disclosed.

33. 发明授权

US10179801B2 Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides 有权
公开(公告)号：US10179801B2
公开(公告)日：2019-01-15
申请号：US13594194
申请日：2012-08-24
申请人： Erkki Ruoslahti , Tambet Teesalu , Kazuki Sugahara , Lise Roth
发明人： Erkki Ruoslahti , Tambet Teesalu , Kazuki Sugahara , Lise Roth
IPC分类号： C07K7/06 , A61K31/337 , C07K7/08 , C07K14/47 , A61K38/08 , A61K45/06 , A61K47/62 , A61K47/69
摘要： Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences, such as truncated LyP-1 peptides, that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.

34. 发明授权

US08815804B2 Methods and compositions related to targeting tumors and wounds 有权
标题翻译：与靶向肿瘤和创伤相关的方法和组合
公开(公告)号：US08815804B2
公开(公告)日：2014-08-26
申请号：US12162751
申请日：2007-02-05
申请人： Erkki Ruoslahti , Jan Pilch
发明人： Erkki Ruoslahti , Jan Pilch
IPC分类号： C07K7/00 , C07K7/06 , C07K7/64 , C07K14/47 , A61K38/08 , A61K38/12 , A61K38/16 , A61K38/17 , A61K51/08 , A61K49/00 , A61K49/08 , A61K49/14 , A61K47/48
CPC分类号： A61K49/0056 , A61K38/08 , A61K38/10 , A61K38/12 , A61K38/16 , A61K38/17 , A61K47/64 , A61K49/0043 , A61K49/085 , A61K49/14 , C07K7/06 , C07K7/64 , C07K14/00 , C07K2319/00 , C07K2319/01 , C07K2319/035
摘要： Disclosed are compositions and methods useful for targeting tumors, sites of injury and blood clots. The compositions and methods are based on peptide sequences that selectively bind to and home to tumors, sites of injury and blood clots in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tumors, sites of injury and blood clots.
摘要翻译：公开了用于靶向肿瘤，损伤部位和血块的组合物和方法。组合物和方法基于肽序列，其选择性地结合和归属于动物的肿瘤，损伤部位和血块。所公开的靶向对于将治疗和可检测的药物递送到肿瘤，损伤部位和血块是有用的。

35. 发明授权

US08017326B2 Methods of modulating cell death based on the Bit-1/AES regulatory pathway 失效
标题翻译：基于Bit-1 / AES调节途径调节细胞死亡的方法
公开(公告)号：US08017326B2
公开(公告)日：2011-09-13
申请号：US12135068
申请日：2008-06-06
申请人： Yiwen Jan , Michelle Matter , Jih-Tung Pai , Erkki Ruoslahti
发明人： Yiwen Jan , Michelle Matter , Jih-Tung Pai , Erkki Ruoslahti
IPC分类号： C12Q1/68
CPC分类号： G01N33/6896 , G01N33/57496 , G01N2500/02
摘要： The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1 polypeptide, or active fragment thereof, and an AES polypeptide, or active fragment thereof, with an agent under conditions that allow the Bit1 polypeptide or active fragment thereof to associate with the AES polypeptide or active fragment thereof; and detecting an altered association of the Bit1 polypeptide or active fragment thereof and the AES polypeptide or active fragment thereof, where an altered association indicates that the agent is an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. Such an effective agent can modulate apoptosis and can be a useful therapeutic agent.
摘要翻译：本发明提供了鉴定改变Bit1多肽与AES多肽的缔合的有效试剂的方法。该方法通过使Bit1多肽或其活性片段和AES多肽或其活性片段与允许Bit1多肽或其活性片段与AES多肽或其活性片段缔合的条件与试剂接触来实施; 并检测Bit1多肽或其活性片段和AES多肽或其活性片段的改变的关联，其中改变的缔合表明该试剂是改变Bit1多肽与AES多肽的缔合的有效试剂。这种有效的药剂可以调节细胞凋亡并且可以是有用的治疗剂。

36. 发明申请

US20090246133A1 METHODS AND COMPOSITIONS RELATED TO INTERNALIZING RGD PEPTIDES 有权
标题翻译：与内在RGD肽相关的方法和组合物
公开(公告)号：US20090246133A1
公开(公告)日：2009-10-01
申请号：US12355672
申请日：2009-01-16
申请人： Erkki Ruoslahti , Tambet Teesalu , Kazuki Sugahara
发明人： Erkki Ruoslahti , Tambet Teesalu , Kazuki Sugahara
IPC分类号： A61K47/42 , C07K7/00 , C07K7/64 , A61K51/08 , A61P35/00 , A61P27/00 , A61P17/00
CPC分类号： C07K7/06 , A61K47/64 , A61K49/0002 , A61K49/0043 , A61K49/0056 , A61K49/0082 , A61K51/082 , C07K5/081 , C07K5/1013 , C07K5/1019 , C07K7/64
摘要： Disclosed are compositions and methods useful for targeting tissue undergoing angiogenesis or to cells or tissue expressing αv integrins. The compositions and methods are based on peptide sequences that selectively bind to and home to tissue undergoing angiogenesis or to cells or tissue expressing αv integrins in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tissue experiencing angiogenesis or to cells or tissue expressing αv integrins.
摘要翻译：公开了用于靶向经历血管生成的组织或用于表达alphav整合素的细胞或组织的组合物和方法。组合物和方法基于选择性结合并经历血管发生的组织的肽序列或表达动物中表达α1整合素的细胞或组织。所公开的靶向对于将经治疗和可检测的药物递送到经历血管生成的组织或表达alphav整合素的细胞或组织是有用的。

37. 发明授权

US07488792B2 Collagen-binding molecules that selectively home to tumor vasculature and methods of using same 有权
标题翻译：选择性地置于肿瘤血管系统的胶原结合分子及其使用方法
公开(公告)号：US07488792B2
公开(公告)日：2009-02-10
申请号：US10648813
申请日：2003-08-25
申请人： Erkki Ruoslahti , Markus Essler , Darren M. Brown
发明人： Erkki Ruoslahti , Markus Essler , Darren M. Brown
IPC分类号： C07K5/00 , C07K7/06
CPC分类号： C07K7/06
摘要： The present invention provides a conjugate containing a therapeutic agent linked to a homing molecule that selectively homes to tumor vasculature and selectively binds collagen such as non-helical collagen or collagen IV. In one embodiment, the conjugate contains a homing peptide or peptidomimetic that includes the amino acid sequence CREKA (SEQ ID NO: 1) or a conservative variant or peptidomimetic thereof.
摘要翻译：本发明提供了含有与归巢分子连接的治疗剂的缀合物，其选择性地置于肿瘤脉管系统并选择性地结合胶原如非螺旋胶原或胶原IV。在一个实施方案中，缀合物含有归巢肽或肽模拟物，其包含氨基酸序列CREKA（SEQ ID NO：1）或其保守变体或肽模拟物。

38. 发明申请

US20090036349A1 Methods and Compositions Related to Targeting Wounds, Regenerating Tissue, and Tumors 有权
标题翻译：靶向伤口，再生组织和肿瘤相关的方法和组成
公开(公告)号：US20090036349A1
公开(公告)日：2009-02-05
申请号：US11951819
申请日：2007-12-06
申请人： Erkki Ruoslahti , Tero Jarvinen
发明人： Erkki Ruoslahti , Tero Jarvinen
IPC分类号： A61K38/00 , C07K7/00 , A61P31/00 , C07K14/00
CPC分类号： C07K7/06 , A61K38/00
摘要： Disclosed are compositions and methods useful for targeting regenerating tissue, wounds, and tumors. The compositions and methods are based on peptide sequences that selectively bind to and home to regenerating tissue, wound sites, and tumors in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to regenerating tissue, wound sites, and tumors in animals.
摘要翻译：公开了用于靶向再生组织，伤口和肿瘤的组合物和方法。组合物和方法基于肽序列，其选择性地结合并在家中在动物中再生组织，伤口部位和肿瘤。所公开的靶向对于递送治疗和可检测的药剂以在动物中再生组织，伤口部位和肿瘤是有用的。

39. 发明申请

US20090022711A1 METHODS OF MODULATING CELL DEATH BASED ON THE BIT-1/AES REGULATORY PATHWAY 失效
标题翻译：基于BIT-1 / AES法规路径调节细胞死亡的方法
公开(公告)号：US20090022711A1
公开(公告)日：2009-01-22
申请号：US12135068
申请日：2008-06-06
申请人： Yiwen Jan , Michelle Matter , Jih-tung Pai , Erkki Ruoslahti
发明人： Yiwen Jan , Michelle Matter , Jih-tung Pai , Erkki Ruoslahti
IPC分类号： A61K39/395 , C12Q1/68 , A61K31/711 , A61P25/00 , A61K38/02
CPC分类号： G01N33/6896 , G01N33/57496 , G01N2500/02
摘要： The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1 polypeptide, or active fragment thereof, and an AES polypeptide, or active fragment thereof, with an agent under conditions that allow the Bit1 polypeptide or active fragment thereof to associate with the AES polypeptide or active fragment thereof; and detecting an altered association of the Bit1 polypeptide or active fragment thereof and the AES polypeptide or active fragment thereof, where an altered association indicates that the agent is an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. Such an effective agent can modulate apoptosis and can be a useful therapeutic agent.
摘要翻译：本发明提供了鉴定改变Bit1多肽与AES多肽的缔合的有效试剂的方法。该方法通过使Bit1多肽或其活性片段和AES多肽或其活性片段与允许Bit1多肽或其活性片段与AES多肽或其活性片段缔合的条件与试剂接触来实施; 并检测Bit1多肽或其活性片段和AES多肽或其活性片段的改变的关联，其中改变的缔合表明该试剂是改变Bit1多肽与AES多肽的缔合的有效试剂。这种有效的药剂可以调节细胞凋亡并且可以是有用的治疗剂。

40. 发明授权

US07341710B2 Method of identifying molecules that home to a selected organ in vivo 失效
标题翻译：在体内鉴定归属于所选器官的分子的方法
公开(公告)号：US07341710B2
公开(公告)日：2008-03-11
申请号：US10943372
申请日：2004-09-17
申请人： Erkki Ruoslahti , Renata Pasqualini
发明人： Erkki Ruoslahti , Renata Pasqualini
IPC分类号： A61K49/00 , C12Q1/68 , A61K38/00 , A61K38/02 , C07K2/00 , C07K1/02
CPC分类号： A61K49/0008 , C12Q1/6883
摘要： The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.
摘要翻译：本发明提供用于体内淘选文库以鉴定特定归属于所选器官的分子的方法。

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