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1. 发明授权

US06306365B1 Method of identifying molecules that home to a selected organ in vivo 失效
标题翻译：在体内鉴定归属于所选器官的分子的方法
公开(公告)号：US06306365B1
公开(公告)日：2001-10-23
申请号：US09227906
申请日：1999-01-08
申请人： Erkki Ruoslahti , Renata Pasqualini
发明人： Erkki Ruoslahti , Renata Pasqualini
IPC分类号： A61K4900
CPC分类号： A61K49/0008 , C12Q1/6883
摘要： The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.
摘要翻译：本发明提供用于体内淘选文库以鉴定特定归属于所选器官的分子的方法。

2. 发明授权

US06174687B1 Methods of identifying lung homing molecules using membrane dipeptidase 失效
标题翻译：使用膜二肽酶鉴定肺归巢分子的方法
公开(公告)号：US06174687B1
公开(公告)日：2001-01-16
申请号：US09258754
申请日：1999-02-26
申请人： Daniel Rajotte , Renata Pasqualini , Erkki Ruoslahti
发明人： Daniel Rajotte , Renata Pasqualini , Erkki Ruoslahti
IPC分类号： G01N3353
CPC分类号： C07K7/06 , A61K31/195 , A61K38/00 , A61K47/6425 , C07K7/08 , G01N33/566 , G01N33/6884
摘要： The present invention provides a method of identifying a membrane dipeptidase (MDP)-binding homing molecule that selectively homes to lung endothelium. The method includes the steps of contacting MDP with one or more molecules; and determining specific binding of a molecule to the MDP, where the presence of specific binding identifies the molecule as a MDP-binding homing molecule that selectively homes to lung endothelium. Such MDP-binding homing molecules can be linked to a moiety and, when administered to a subject as a conjugate, can selectively direct the moiety to lung endothelium in the subject.
摘要翻译：本发明提供了鉴定选择性地适应于肺内皮的膜二肽酶（MDP）结合归巢分子的方法。该方法包括使MDP与一种或多种分子接触的步骤; 并确定分子与MDP的特异性结合，其中特异性结合物的存在将该分子鉴定为选择性地置于肺内皮的MDP结合归巢分子。这种MDP结合的归巢分子可以连接到部分上，并且当作为结合物施用于受试者时，可以选择性地将该部分导向受试者的肺内皮。

3. 发明授权

US6068829A Method of identifying molecules that home to a selected organ in vivo 失效
标题翻译：在体内鉴定归属于所选器官的分子的方法
公开(公告)号：US6068829A
公开(公告)日：2000-05-30
申请号：US862855
申请日：1997-06-23
申请人： Erkki Ruoslahti , Renata Pasqualini
发明人： Erkki Ruoslahti , Renata Pasqualini
IPC分类号： A61K39/395 , A61K49/00 , C12Q1/68 , C12Q1/70 , G01N33/53
CPC分类号： A61K49/0008 , C12Q1/6883
摘要： The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.
摘要翻译：本发明提供用于体内淘选文库以鉴定特定归属于所选器官的分子的方法。

4. 发明授权

US07341710B2 Method of identifying molecules that home to a selected organ in vivo 失效
标题翻译：在体内鉴定归属于所选器官的分子的方法
公开(公告)号：US07341710B2
公开(公告)日：2008-03-11
申请号：US10943372
申请日：2004-09-17
申请人： Erkki Ruoslahti , Renata Pasqualini
发明人： Erkki Ruoslahti , Renata Pasqualini
IPC分类号： A61K49/00 , C12Q1/68 , A61K38/00 , A61K38/02 , C07K2/00 , C07K1/02
CPC分类号： A61K49/0008 , C12Q1/6883
摘要： The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.
摘要翻译：本发明提供用于体内淘选文库以鉴定特定归属于所选器官的分子的方法。

5. 发明申请

US20050074812A1 Molecules that home to various selected organs or tissues 失效
公开(公告)号：US20050074812A1
公开(公告)日：2005-04-07
申请号：US10607595
申请日：2003-06-27
申请人： Erkki Ruoslahti , Renata Pasqualini
发明人： Erkki Ruoslahti , Renata Pasqualini
IPC分类号： A61K31/195 , A61K38/00 , A61K47/48 , C07K7/06 , C07K7/08 , G01N33/53 , A61K38/08 , A61K38/10
CPC分类号： C07K7/06 , A61K31/195 , A61K38/00 , A61K47/6425 , C07K7/08 , Y10S977/808 , Y10S977/911 , Y10S977/912
摘要： The present invention provides molecules that selectively home to various normal organs or tissues, including to lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut; and provides molecules that selectively home to tumor bearing organs or tissues, including to pancreas bearing a pancreatic tumor or to lung bearing a lung tumor. The invention also provides conjugates, comprising an organ or tissue homing molecule linked to a moiety. Such a moiety can be, for example, a therapeutic agent or a detectable agent. In addition, the invention provides methods of using an organ homing molecule of the invention to identify a particular organ or tissue by contacting the organ or tissue with a molecule of the invention. The invention also provides methods to diagnose or treat a pathology of the lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut by administering to a subject having or suspected of having a pathology a molecule that homes to the selected organ or tissue. The invention further provides methods of identifying a target molecule in lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut.

6. 发明授权

US06784153B1 Methods of homing molecules to lung using membrane dipeptidase 失效
标题翻译：使用膜二肽酶将分子归巢到肺的方法
公开(公告)号：US06784153B1
公开(公告)日：2004-08-31
申请号：US09676475
申请日：2000-09-29
申请人： Daniel Rajotte , Renata Pasqualini , Erkki Ruoslahti
发明人： Daniel Rajotte , Renata Pasqualini , Erkki Ruoslahti
IPC分类号： A61K3800
CPC分类号： C07K7/06 , A61K31/195 , A61K38/00 , A61K47/6425 , C07K7/08 , Y10S977/808 , Y10S977/911 , Y10S977/912
摘要： The present invention provides a method of identifying a membrane dipeptidase (MDP)-binding homing molecule that selectively homes to lung endothelium. The method includes the steps of contacting MDP with one or more molecules; and determining specific binding of a molecule to the MDP, where the presence of specific binding identifies the molecule as a MDP-binding homing molecule that selectively homes to lung endothelium. Such MDP-binding homing molecules can be linked to a moiety and, when administered to a subject as a conjugate, can selectively direct the moiety to lung endothelium in the subject.
摘要翻译：本发明提供了鉴定选择性地适应于肺内皮的膜二肽酶（MDP）结合归巢分子的方法。该方法包括使MDP与一种或多种分子接触的步骤; 并确定分子与MDP的特异性结合，其中特异性结合物的存在将该分子鉴定为选择性地置于肺内皮的MDP结合归巢分子。这种MDP结合的归巢分子可以连接到部分上，并且当作为结合物施用于受试者时，可以选择性地将该部分导向受试者的肺内皮。

7. 发明授权

US06610651B1 Molecules that home to various selected organs or tissues 失效
标题翻译：归属于各种选定器官或组织的分子
公开(公告)号：US06610651B1
公开(公告)日：2003-08-26
申请号：US09722250
申请日：2000-11-22
申请人： Erkki Ruoslahti , Renata Pasqualini
发明人： Erkki Ruoslahti , Renata Pasqualini
IPC分类号： A61K3802
CPC分类号： C07K7/06 , A61K31/195 , A61K38/00 , A61K47/6425 , C07K7/08 , Y10S977/808 , Y10S977/911 , Y10S977/912
摘要： The present invention provides molecules that selectively home to various normal organs or tissues, including to lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut; and provides molecules that selectively home to tumor bearing organs or tissues, including to pancreas bearing a pancreatic tumor or to lung bearing a lung tumor. The invention also provides conjugates, comprising an organ or tissue homing molecule linked to a moiety. Such a moiety can be, for example, a therapeutic agent or a detectable agent. In addition, the invention provides methods of using an organ homing molecule of the invention to identify a particular organ or tissue by contacting the organ or tissue with a molecule of the invention. The invention also provides methods to diagnose or treat a pathology of the lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut by administering to a subject having or suspected of having a pathology a molecule that homes to the selected organ or tissue. The invention further provides methods of identifying a target molecule in lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut.
摘要翻译：本发明提供了选择性地归属于各种正常器官或组织，包括肺，胰腺，皮肤，视网膜，前列腺，卵巢，淋巴结，肾上腺，肝脏或肠道的分子; 并提供选择性地置于携带肿瘤的器官或组织，包括携带胰腺肿瘤的胰腺或携带肺肿瘤的肺的分子。本发明还提供缀合物，其包含与部分连接的器官或组织归巢分子。这样的部分可以是例如治疗剂或可检测剂。此外，本发明提供使用本发明的器官归巢分子通过使器官或组织与本发明的分子接触来鉴定特定器官或组织的方法。本发明还提供了通过对具有或怀疑具有病理学病理学的受试者进行诊断或治疗肺，胰腺，皮肤，视网膜，前列腺，卵巢，淋巴结，肾上腺，肝脏或肠道的病理学的方法到选定的器官或组织。本发明还提供鉴定肺，胰腺，皮肤，视网膜，前列腺，卵巢，淋巴结，肾上腺，肝脏或肠内的靶分子的方法。

8. 发明授权

US06576239B1 Angiogenic homing molecules and conjugates derived therefrom 失效
标题翻译：血管生成的归巢分子和衍生自其的共轭物
公开(公告)号：US06576239B1
公开(公告)日：2003-06-10
申请号：US08926914
申请日：1997-09-10
申请人： Erkki Ruoslahti , Renata Pasqualini
发明人： Erkki Ruoslahti , Renata Pasqualini
IPC分类号： A61K3900
CPC分类号： G01N33/5011 , A61K47/64 , G01N33/57492 , G01N2333/70546 , G01N2333/948
摘要： The present invention provides tumor homing molecules, which selectively home to a tumor. The invention also provides methods of using a tumor homing molecule to target an agent such as a drug to a selected tumor or to identify the target molecule expressed by the tumor. The invention also provides methods of targeting a tumor containing angiogenic vasculature by contacting the tumor with a molecule that specifically binds an &agr;v-containing integrin. The invention further provides molecules that can selectively home to angiogenic vasculature. In addition, the invention provides a target molecule, which is specifically bound by a tumor homing molecule and is expressed by angiogenic vasculature. The invention also provides antibodies that bind to the target molecule and peptidomimetics that competitively inhibit binding of a ligand to the target molecule.
摘要翻译：本发明提供了肿瘤归巢分子，其选择性地归巢于肿瘤。本发明还提供使用肿瘤归巢分子将药物如药物靶向所选择的肿瘤或鉴定由肿瘤表达的靶分子的方法。本发明还提供了通过使肿瘤与特异性结合含alphav的整联蛋白的分子接触来靶向含有血管生成脉管系统的肿瘤的方法。本发明进一步提供可以选择性地归属于血管生成脉管系统的分子。此外，本发明提供了靶分子，其特异性地被肿瘤归巢分子结合并且由血管生成脉管系统表达。本发明还提供了结合靶分子的抗体和竞争性抑制配体与靶分子结合的肽模拟物。

9. 发明授权

US06180084B2 NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same 失效
标题翻译： NGR受体和鉴定使用其的血管生成脉管系统归巢的肿瘤归巢分子的方法
公开(公告)号：US06180084B2
公开(公告)日：2001-01-30
申请号：US09139802
申请日：1998-08-25
申请人： Erkki Ruoslahti , Renata Pasqualini
发明人： Erkki Ruoslahti , Renata Pasqualini
IPC分类号： A61K4900
CPC分类号： G01N33/5011 , G01N33/57492 , G01N2333/70546 , G01N2333/948
摘要： The present invention provides a method of identifying a tumor homing molecule that homes to angiogenic vasculature by contacting a substantially purified NGR receptor with one or more molecules and determining specific binding of a molecule to the NGR receptor, where the presence of specific binding identifies the molecule as a tumor homing molecule that homes to angiogenic vasculature. The invention also provides a method of directing a moiety to angiogenic vasculature in a subject by administering to the subject a conjugate including a moiety linked to a tumor homing molecule that exhibits specific binding to an NGR receptor, whereby the moiety is directed to angiogenic vasculature. In addition, the invention provides a method of imaging the angiogenic vasculature of a tumor in a subject by administering to the subject a conjugate having a detectable moiety linked to a tumor homing molecule that exhibits specific binding to an NGR receptor and detecting the conjugate.
摘要翻译：本发明提供了一种通过使基本上纯化的NGR受体与一个或多个分子接触并确定分子与NGR受体的特异性结合来鉴定归属于血管生成脉管系统的肿瘤归巢分子的方法，其中特异性结合物的存在识别分子作为血管生成脉管系统的肿瘤归巢分子。本发明还提供了通过向受试者施用包含与表达与NGR受体特异性结合的肿瘤归巢分子连接的部分的缀合物，从而将部分引导至血管生成脉管系统，从而将受试者部分引导至血管生成脉管系统的方法。此外，本发明提供了通过向受试者施用具有连接于显示与NGR受体特异性结合并检测缀合物的肿瘤归巢分子的可检测部分的缀合物来成像受试者中肿瘤的血管生成脉管系统的方法。

10. 发明申请

US20090297450A1 Tumor homing molecules, conjugates derived therefrom, and methods of using same 审中-公开
公开(公告)号：US20090297450A1
公开(公告)日：2009-12-03
申请号：US11977834
申请日：2007-10-26
申请人： Erkki Ruoslahti , Renata Pasqualini
发明人： Erkki Ruoslahti , Renata Pasqualini
IPC分类号： A61K49/00 , C40B30/04 , A61K38/00 , A61K39/395 , A61K38/08
CPC分类号： G01N33/5011 , A61K47/64 , G01N33/57492 , G01N2333/70546 , G01N2333/948
摘要： The present invention provides tumor homing molecules, which selectively home to a tumor. The invention also provides methods of using a tumor homing molecule to target an agent such as a drug to a selected tumor or to identify the target molecule expressed by the tumor. The invention also provides methods of targeting a tumor containing angiogenic vasculature by contacting the tumor with a molecule that specifically binds an αv-containing integrin. The invention further provides molecules that can selectively home to angiogenic vasculature. In addition, the invention provides a target molecule, which is specifically bound by a tumor homing molecule and is expressed by angiogenic vasculature. The invention also provides antibodies that bind to the target molecule and peptidomimetics that competitively inhibit binding of a ligand to the target molecule.

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