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31. 发明授权

US5340924A Method for heat treatment of lactoferrin without losing physiological activities thereof 失效
标题翻译：乳铁蛋白的热处理方法，而不会失去其生理活性
公开(公告)号：US5340924A
公开(公告)日：1994-08-23
申请号：US860224
申请日：1992-03-27
申请人： Mamoru Tomita , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Hiroaki Abe , Eiji Nagao
发明人： Mamoru Tomita , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Hiroaki Abe , Eiji Nagao
IPC分类号： A23J1/20 , A23J3/08 , C07K14/79 , C07K3/12 , C07K15/00 , C07K15/14 , C07K15/22
CPC分类号： A23J1/20 , A23J3/08 , C07K14/79 , Y10S530/832
摘要： A method for treatment of a matter which contains moisturized or liquified lactoferrin which has been isolated from mammalian milk, processed mammalian milk and by-products in mammalian milk-processing, without losing the physiological activities of lactoferrin, which comprises adjusting pH of said moisturized or liquefied lactoferrin contained in said matter within an acidic range between 2.0 and 6.0 both inclusive by adding acid or aqueous solution of acid when the pH of said moisturized or liquefied lactoferrin is out of said pH range, and heating said matter in the range from 60.degree. C. to 130.degree. C. for a span of time which may assure 60% or more of undenaturization rate of lactoferrin.
摘要翻译：一种处理含有保湿或液化的乳铁蛋白的物质的方法，其已从哺乳动物乳，加工的哺乳动物乳和哺乳动物乳加工中的副产物中分离出来，而不损失乳铁蛋白的生理活性，其包括调节所述保湿或当所述保湿或液化的乳铁蛋白的pH在所述pH范围之外时，通过加入酸或酸的水溶液，在所述物质中含有的液化乳铁蛋白在2.0至6.0之间的酸性范围内，并且将所述物质加热到60℃ 在130℃下，可以确保乳铁蛋白的未饱和化率达到60％以上。

32. 发明授权

US5314873A Milk-protein hydrolyzates and compositions for use as hair and skin treating agent 失效
标题翻译：乳蛋白水解物和用作头发和皮肤处理剂的组合物
公开(公告)号：US5314873A
公开(公告)日：1994-05-24
申请号：US701866
申请日：1991-05-17
申请人： Mamoru Tomita , Takesi Kitazawa , Seiji Kawaura , Yasuo Fukuwatari , Masanobu Nojiri
发明人： Mamoru Tomita , Takesi Kitazawa , Seiji Kawaura , Yasuo Fukuwatari , Masanobu Nojiri
IPC分类号： A61K8/64 , A61K8/98 , A61K38/00 , A61K38/01 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q19/00 , C07K4/12 , C07K14/47 , A61K37/02 , C07K1/12 , C07K3/10
CPC分类号： C07K14/4732 , A61K38/018 , A61K8/64 , A61K8/986 , A61Q19/00 , A61Q5/00 , C07K4/12 , A61Q5/02 , A61Q5/12 , Y10S530/832 , Y10S530/833
摘要： A milk-protein hydrolyzate consisting of a mixture of peptides and free amino acids having proliferation activating property on human cutaneous cells but not having antigenicity of the milk-protein may be obtained by enzymatic hydrolysis of milk protein. The peptides of the hydrolyzate have molecular weights less than 1000 daltons, and the hydrolyzate has a free aromatic amino acid/total aromatic amino acid ratio of at least 90%. Fractionation of the milk protein hydrolyzate yields a fraction consisting of a mixture of peptides. The fraction has a proliferation activating property on human cutaneous cells but does not have the antigenicity of the milk protein. The fraction contains aromatic amino acids in an amount of less than 5% by weight of total amino acids. Both the hydrolyzate and the fraction can be formulated into cosmetic compositions for application to the hair and skin.
摘要翻译：可以通过乳蛋白的酶水解获得由肽和游离氨基酸混合物组成的乳蛋白水解产物，其在人皮肤细胞上具有增殖活化性质但不具有乳蛋白的抗原性。水解产物的肽具有小于1000道尔顿的分子量，并且水解产物具有至少90％的游离芳族氨基酸/总芳族氨基酸比例。乳蛋白水解产物的分级产生由肽混合物组成的级分。该级分在人皮肤细胞上具有增殖活化性质，但不具有乳蛋白的抗原性。该级分含有少于总氨基酸重量的5％的芳香族氨基酸。水解产物和级分均可配制成用于头发和皮肤的化妆品组合物。

33. 发明授权

US5304633A Fragments of lactoferrin having potent antimicrobial activity 失效
标题翻译：乳铁蛋白片段具有很强的抗菌活性
公开(公告)号：US5304633A
公开(公告)日：1994-04-19
申请号：US755161
申请日：1991-09-05
申请人： Mamoru Tomita , Kohzo Kawase , Mitsunori Takase , Wayne R. Bellamy , Kohji Yamauchi , Hiroyuki Wakabayashi
发明人： Mamoru Tomita , Kohzo Kawase , Mitsunori Takase , Wayne R. Bellamy , Kohji Yamauchi , Hiroyuki Wakabayashi
IPC分类号： A23L3/3526 , A61K8/64 , A61K38/00 , A61P31/04 , A61Q11/00 , A61Q15/00 , A61Q17/00 , A61Q19/10 , C07K7/08 , C07K14/00 , C07K14/79 , C07K14/825 , C12P21/06 , A61K37/02 , C07K5/12 , C07K7/10
CPC分类号： C07K14/79 , A61K8/64 , A61Q11/00 , A61Q15/00 , A61Q17/005 , A61Q19/10 , A61K38/00
摘要： An antimicrobial peptide containing at least the following amino acid sequence (a), (b), (c) or (d), an antimicrobial agent containing the said antimicrobial peptide as active components at a concentration of at least 5 ppm (weight), an antimicrobial composition the said antimicrobial peptide and a method for processing products which uses the antimicrobial agent containing the said antimicrobial peptide. ##STR1##
摘要翻译：含有至少以下氨基酸序列（a），（b），（c）或（d））的抗微生物肽含有浓度为至少5ppm（重量）的所述抗微生物肽作为活性成分的抗微生物剂，所述抗微生物肽的抗微生物组合物和使用含有所述抗微生物肽的抗微生物剂的产品加工方法。（*化学结构*）（*化学结构*）LYS-Cys * -Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly-Ala-Pro- Ser-Ile-Thr-Cys * -Val-：（b）（*化学结构*）（*化学结构*）（*化学结构*）Lys-Cys * -Phe-Gln-Trp-Gln-Arg-Asn- -Met-Arg-Lys-Val-Arg-Gly-Pro-Pro-Val-Ser-Cys * -Ile-（d）（*化学结构*）

34. 发明授权

US5304251A Crystalline lactulose trihydrate and a method for its manufacture 失效
标题翻译：结晶乳果糖三水合物及其制造方法
公开(公告)号：US5304251A
公开(公告)日：1994-04-19
申请号：US926308
申请日：1992-08-10
申请人： Mamoru Tomita , Seiichi Shimamura , Yoshitaka Tamura , Teruhiko Mizota , Satoshi Nakano , Itsuko Suzawa
发明人： Mamoru Tomita , Seiichi Shimamura , Yoshitaka Tamura , Teruhiko Mizota , Satoshi Nakano , Itsuko Suzawa
IPC分类号： A23L27/30 , C07H1/00 , C07H3/04 , C13B30/02 , C13K13/00 , C13F3/00 , C07H3/00 , C08B37/00
CPC分类号： C07H3/04 , A23L27/33 , C07H1/00 , C13K13/002
摘要： A crystalline lactulose trihydrate having molecular formula of C.sub.12 H.sub.22 O.sub.11.3H.sub.2 O and a method for its manufacture, which comprises crystallization from a lactulose syrup at a temperature of 2.degree.-20.degree. C., the starting lactulose syrup having a lactulose content of 70-90% of a total solid matters by weight, and having been concentrated to the total solid matters of 65-75% by weight and a ratio of lactose to water of less than 10% by weight.
摘要翻译：分子式为C12H22O11.3H2O的结晶乳果糖三水合物及其制造方法，其包括在2℃-20℃的温度下从乳果糖糖浆中结晶，所述起始乳果糖糖浆的乳果糖含量为70-90％的总固体重量，并且已经浓缩至总固体物质的65-75重量％，乳糖与水的比例小于10重量％。

35. 发明授权

US5219838A Method for inhibiting tyrosinase activity in treatment of skin 失效
标题翻译：抑制皮肤治疗中酪氨酸酶活性的方法
公开(公告)号：US5219838A
公开(公告)日：1993-06-15
申请号：US884051
申请日：1992-05-15
申请人： Mamoru Tomita , Seiichi Shimamura , Hiroshi Miyakawa , Susumu Kobayashi
发明人： Mamoru Tomita , Seiichi Shimamura , Hiroshi Miyakawa , Susumu Kobayashi
IPC分类号： A23J3/34 , A61K8/64 , A61K38/00 , A61K38/01 , A61Q19/02
CPC分类号： A61K38/005 , A23J3/343 , A61K38/018 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： An agent for tyrosinase inhibition which contains the effective quantity of enzymatic hydrolyzates of milk proteins, having a decomposition rate from 6% to 55% as expressed by the percentage of formol nitrogen to total nitrogen.
摘要翻译：酪氨酸酶抑制剂，其含有有效量的乳蛋白质的酶水解产物，其分解速率由甲醛氮与总氮的百分比表示为6％至55％。

36. 发明授权

US4015020A Tartar removal by electrodialysis and potassium level control in wine 失效
标题翻译：通过电渗析去除鞑靼葡萄酒中的钾水平控制
公开(公告)号：US4015020A
公开(公告)日：1977-03-29
申请号：US572726
申请日：1975-04-29
申请人： Taro Nagasawa , Mamoru Tomita , Yoshitaka Tamura , Teruhiko Mizota
发明人： Taro Nagasawa , Mamoru Tomita , Yoshitaka Tamura , Teruhiko Mizota
IPC分类号： C12G3/08
CPC分类号： C12G3/085
摘要： A method of treating wine, comprising introducing crude wine to both the dilution and concentration chambers of an electrodialysis apparatus; operating said apparatus so that the potassium concentration of the wine in the dilution chamber falls to below 500 mg/liter and the potassium content of the wine in the concentration chamber is increased into the range 1000 to 2000 mg/liters; cooling the wine from the concentration chamber to below 10.degree. C and adding tartaric acid crystals to said wine in order to adjust the pH into the range of 2.8 to 3.2 thereby precipitating tartar; separating the tartar from the wine and admixing said wine with wine emerging from the dilution chamber of the electrodialysis apparatus in a ratio such that the potassium content of the resulting mixture is below 500 mg/liter.
摘要翻译：一种处理葡萄酒的方法，包括将粗酒引入电渗析装置的稀释和浓缩室; 操作所述装置，使得稀释室中的葡萄酒的钾浓度降至500mg /升以下，浓缩室中酒的钾含量增加到1000-2000mg /升; 将葡萄酒从浓缩室冷却至10℃以下，并将酒石酸晶体加入到所述葡萄酒中，以将pH调节至2.8至3.2的范围，从而沉淀出牙垢; 将酒石与葡萄酒分离，并将所述葡萄酒与电渗析装置的稀释室中出现的葡萄酒混合，使得所得混合物的钾含量低于500mg /升。

37. 发明授权

US3995070A Process for preparing a casein micelle 失效
标题翻译：制备酪蛋白胶束的方法
公开(公告)号：US3995070A
公开(公告)日：1976-11-30
申请号：US481237
申请日：1974-06-20
申请人： Taro Nagasawa , Mamoru Tomita , Yoshitaka Tamura , Tomokazu Obayashi
发明人： Taro Nagasawa , Mamoru Tomita , Yoshitaka Tamura , Tomokazu Obayashi
IPC分类号： A23J3/10 , C12C7/18 , A23C9/00
CPC分类号： A23J3/10
摘要： A casein powder, which has excellent solubility and is capable of forming a casein micelle having similar turbidity and heat stability as the casein micelle of cow's milk, when it is dissolved in water to reconstitute cow's milk, skim milk or other dairy products, can be obtained by dissolving an organic acid salt and/or polyphosphate, in an amount as represented by the formula:log y = 0.0384x + (0.70 .+-. 0.25)whereby y is mg of organic acid salt and/or polyphosphate per gram of casein protein, and x is mg of calcium ion per gram of casein protein, in a casein solution, obtained by dissolving an acid casein in an alkali. The casein solution is then mixed with a calcium salt solution in an amount such that the quantity of calcium ion present is 20 to 40 mg per gram of casein protein at a temperature of below 50.degree. C. The pH of the resulting mixed solution is adjusted to 6.5 to 7.1, an emulsifier is added thereto, and the solution is gradually heated to a temperature of at least 65.degree. C while stirring to form a casein micelle. Finally, the micelle is pasteurized, concentrated and dried to form a powder.
摘要翻译：具有优异的溶解度并且能够形成具有与牛奶的酪蛋白胶束相似的浊度和热稳定性的酪蛋白胶束当溶解在水中以重构牛奶，脱脂乳或其它乳制品时，可以是通过以下式表示的量溶解有机酸盐和/或多磷酸盐获得：

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