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31. 发明专利

AU2015274451B2 Residence structures and related methods 未知
公开(公告)号：AU2015274451B2
公开(公告)日：2019-06-20
申请号：AU2015274451
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD JR LOWELL L , ECKHOFF PHILIP A , BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY
IPC分类号： C08F8/00 , C08G63/682
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

32. 发明专利

AU2021203086A1 RESIDENCE STRUCTURES AND RELATED METHODS 未知
公开(公告)号：AU2021203086A1
公开(公告)日：2021-06-10
申请号：AU2021203086
申请日：2021-05-14
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD JR LOWELL L , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
摘要： - 1 Abstract Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal 5 to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, 10 mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the 15 structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure 20 comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

33. 发明专利

AU2019269638A1 Quick release capsules 未知
公开(公告)号：AU2019269638A1
公开(公告)日：2020-11-19
申请号：AU2019269638
申请日：2019-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , NOVO NORDISK AS , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , DELLAL DAVID , STEIGER CHRISTOPH WINFRIED JOHANNES , ROXHED NICLAS , CAFFAREL SALVADOR ESTER , SOARES VANCE , MINAHAN DANIEL , FREDERIKSEN MORTEN REVSGAARD
IPC分类号： A61J3/07 , A61M31/00
摘要： Articles for rapid release of components including, for example, quick release capsules, are generally provided. Advantageously, in some embodiments, the articles described herein may be configured to prevent fluid from contacting a component contained therein (e.g., tissue interfacing component) or payload contained therein until a desired time, e.g., the time at which the component is configured to release from the article to a location internal to a subject (e.g., localize to a tissue wall in the subject). In some embodiments, the article comprises a first compartment and a second compartment not in fluid communication with the first compartment. In some embodiments, the first compartment and second compartment are fluidically isolated. For example, in some cases, the first compartment comprises a mechanism for releasing a component contained within the article and the second compartment comprises the component.

34. 发明专利

PH12019502537A1 SELF-RIGHTING SYSTEMS AND RELATED COMPONENTS AND METHODS 未知
公开(公告)号：PH12019502537A1
公开(公告)日：2020-07-13
申请号：PH12019502537
申请日：2019-11-12
申请人： BRIGHAM & WOMENS HOSPITAL INC , MASSACHUSETTS INST TECHNOLOGY , NOVO NORDISK AS
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S , WATER JORRIT JEROEN , FREDERIKSEN MORTEN REVSGAARD , KRISTIANSEN BO ULDALL , JESPERSEN MIKKEL OLIVER , POULSEN METTE , HERSKIND PETER , JENSEN BRIAN
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

35. 发明专利

AU2015274456B2 Self-assembled residence devices and related methods 未知
公开(公告)号：AU2015274456B2
公开(公告)日：2020-03-26
申请号：AU2015274456
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , LIN JIAQI , DICICCIO ANGELA , GLETTIG DEAN LIANG , WOOD JR LOWELL L , ECKHOFF PHILIP A
IPC分类号： A61M29/04 , A61M31/00
摘要： Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.

36. 发明专利

CL2019003269A1 Sistemas de derecho automático y componentes relacionados y procedimientos. 未知
公开(公告)号：CL2019003269A1
公开(公告)日：2020-03-20
申请号：CL2019003269
申请日：2019-11-14
申请人： MASSACHUSETTS INST TECHNOLOGY , NOVO NORDISK AS , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S , WATER JORRIT JEROEN , FREDERIKSEN MORTEN REVSGAARD , KRISTIANSEN BO ULDALL , JESPERSEN MIKKEL OLIVER , POULSEN METTE , HERSKIND PETER , JENSEN BRIAN
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： Se proporcionan de manera general artículos autoenderezable, como cápsulas autoenderezable para la administración a un sujeto. En algunas modalidades, el artículo autoenderezable puede configurarse de modo que el artículo pueda orientarse en relación con una superficie (por ejemplo, una superficie de un tejido de un sujeto). Los artículos autoenderezables descritos en el presente documento pueden comprender una o más superficies de enganche de tejido configuradas para contactarse (por ejemplo, interactuar con, inyectarse, anclarse) con una superficie (por ejemplo, una superficie de un tejido de un sujeto). En algunas modalidades, el artículo autoenderezable puede tener una forma particular y/o distribución de densidad (o masa) que, por ejemplo, permite el comportamiento de autoenderezado del artículo. En algunas modalidades, el artículo autoenderezable puede comprender un componente de interfaz de tejido y/o un agente farmacéutico (por ejemplo, para la administración del agente farmacéutico activo a una ubicación interior del sujeto). En algunos casos, tras el contacto del tejido con la superficie de contacto con el tejido del artículo, el artículo autoenderezable puede configurarse para liberar uno o más componentes de interfaz del tejido. En algunos casos, el componente de interfaz de tejido está asociado con un componente autoaccionable. Por ejemplo, el artículo autoenderezable puede comprender un componente autoaccionable configurado, tras la exposición a un fluido, para liberar el componente de interfaz de tejido del artículo autoenderezable. En algunos casos, el componente de interfaz de tejido puede comprender y/o estar asociado con el agente farmacéutico (por ejemplo, para la entrega a una ubicación interna de un sujeto).

37. 发明专利

CO2019012773A2 Sistemas autoenderezables y componentes y métodos relacionados 未知
公开(公告)号：CO2019012773A2
公开(公告)日：2020-02-18
申请号：CO2019012773
申请日：2019-11-15
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC , NOVO NORDISK AS
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S , WATER JORRIT JEROEN , FREDERIKSEN MORTEN REVSGAARD , KRISTIANSEN BO ULDALL , JESPERSEN MIKKEL OLIVER , POULSEN METTE , HERSKIND PETER , JENSEN BRIAN
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： RESUMEN Se proporcionan de manera general artículos autoenderezable, como cápsulas autoenderezable para la administración a un sujeto. En algunas modalidades, el artículo autoenderezable puede configurarse de modo que el artículo pueda orientarse en relación con una superficie (por ejemplo, una superficie de un tejido de un sujeto). Los artículos autoenderezables descritos en el presente documento pueden comprender una o más superficies de enganche de tejido configuradas para contactarse (por ejemplo, interactuar con, inyectarse, anclarse) con una superficie (por ejemplo, una superficie de un tejido de un sujeto). En algunas modalidades, el artículo autoenderezable puede tener una forma particular y/o distribución de densidad (o masa) que, por ejemplo, permite el comportamiento de autoenderezado del artículo. En algunas modalidades, el artículo autoenderezable puede comprender un componente de interfaz de tejido y/o un agente farmacéutico (por ejemplo, para la administración del agente farmacéutico activo a una ubicación interior del sujeto). En algunos casos, tras el contacto del tejido con la superficie de contacto con el tejido del artículo, el artículo autoenderezable puede configurarse para liberar uno o más componentes de interfaz del tejido. En algunos casos, el componente de interfaz de tejido está asociado con un componente autoaccionable. Por ejemplo, el artículo autoenderezable puede comprender un componente autoaccionable configurado, tras la exposición a un fluido, para liberar el componente de interfaz de tejido del artículo autoenderezable. En algunos casos, el componente de interfaz de tejido puede comprender y/o estar asociado con el agente farmacéutico (por ejemplo, para la entrega a una ubicación interna de un sujeto).

38. 发明专利

AU2018269704A1 Self-righting systems, methods, and related components 未知
公开(公告)号：AU2018269704A1
公开(公告)日：2019-11-28
申请号：AU2018269704
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BENSEL TAYLOR , LANGER ROBERT S , TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

39. 发明专利

AU2018269550A1 Components with high API loading 未知
公开(公告)号：AU2018269550A1
公开(公告)日：2019-11-28
申请号：AU2018269550
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61M37/00 , A61M31/00
摘要： Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt% versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, Gl mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component.

40. 发明专利

CA3083939A1 GASTRIC RESIDENT ELECTRONICS 未知
公开(公告)号：CA3083939A1
公开(公告)日：2019-06-06
申请号：CA3083939
申请日：2018-11-28
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , TRAVERSO CARLO GIOVANNI , KONG YONG LIN
IPC分类号： A61B5/07 , A61B5/00
摘要： Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject. In some embodiments, the device has a modular design, combining an electronic component(s) with materials configured for controlled and/or tunable degradation/dissolution to determine the time at which (gastric) residence is lost and the device exits the location internal to the subject. For example, in some embodiments, the resident structure comprises an electronic component and one or more additional components associated with the electronic component such that the resident structure is configured to be retained at a location internal to a subject for greater than or equal to 24 hours.

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