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31. 发明申请

US20090030403A1 Methods and Systems for Attenuating the Tolerance Response to a Drug 审中-公开
标题翻译：减轻药物耐受反应的方法和系统
公开(公告)号：US20090030403A1
公开(公告)日：2009-01-29
申请号：US11829821
申请日：2007-07-27
申请人： Kent W. Leyde
发明人： Kent W. Leyde
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , Y02A90/22 , Y02A90/26
摘要： Methods are provided for modulating a drug response comprising determining that a patient has an elevated or reduced susceptibility for a neurological event; outputting a signal that indicates to the patient to administer an acute dosage of a pharmacological agent that is sufficient to modulate the patient's susceptibility for the neurological event, wherein the drug response is modulated. Systems are also provided for treating epilepsy comprising an electrode array configured to receive a signal from a patient; a processing assembly configured to receive and process the signal to determine the patient's susceptibility for a neurological event; an output assembly configured to produce an output that indicates to the patient to administer an acute dosage of a pharmacological agent that is sufficient to reduce the patient's susceptibility for the neurological event, wherein the drug response to the pharmacological agent is attenuated.
摘要翻译：提供了用于调节药物应答的方法，包括确定患者对神经性事件的易感性升高或降低; 输出指示给患者的信号，以施用足以调节患者对神经系统事件的敏感性的药物的急性剂量，其中调节药物反应。还提供了用于治疗癫痫的系统，其包括构造成从患者接收信号的电极阵列; 配置成接收和处理信号以确定患者对神经性事件的易感性的处理组件; 输出组件，其被配置为产生输出，其向患者指示施用足以降低患者对神经系统事件的易感性的急性剂量的药理学试剂，其中对药理学试剂的药物反应减弱。

32. 发明授权

US06178357B1 Electrode pad system and defibrillator electrode pad that reduces the risk of peripheral shock 有权
标题翻译：电极垫系统和除颤器电极垫，减少外围冲击的风险
公开(公告)号：US06178357B1
公开(公告)日：2001-01-23
申请号：US09143701
申请日：1998-08-28
申请人： Bradford E. Gliner , Stephen M. Dillon , Kent W. Leyde
发明人： Bradford E. Gliner , Stephen M. Dillon , Kent W. Leyde
IPC分类号： A61N105
CPC分类号： A61N1/046 , A61N1/0492
摘要： This invention is directed to a medical electrode system having a flexible substrate with two electrodes in electrical communication disposed at either end along its length. The electrode system also has one or more sensors for detecting the rate and pressure at which CPR is administered. The electrode is adjustable in length and protects the user from the potential of incidental shock when using the electrode in conjunction with a defibrillator.
摘要翻译：本发明涉及一种具有柔性基底的医疗电极系统，其中两个电极沿着其长度设置在两端。电极系统还具有一个或多个用于检测施用CPR的速率和压力的传感器。电极的长度是可调节的，并且当使用电极与除颤器一起使用时，可以保护使用者避免偶然的冲击的可能性。

33. 发明授权

US5650750A Common mode signal and circuit fault detection in differential signal detectors 失效
标题翻译：差分信号检测器中的共模信号和电路故障检测
公开(公告)号：US5650750A
公开(公告)日：1997-07-22
申请号：US398377
申请日：1995-03-03
申请人： Kent W. Leyde , Thomas D. Lyster , Daniel J. Powers
发明人： Kent W. Leyde , Thomas D. Lyster , Daniel J. Powers
IPC分类号： H03F3/45
CPC分类号： H03F3/45479 , H03F2200/261
摘要： The present invention is an apparatus and method for detecting differential mode signals in an environment where differential mode signals co-exist, and might be corrupted by, common mode signals. The most basic apparatus of the present invention essentially comprises first and second input leads through which both differential mode and common mode signals are input; a first amplifier block having a gain that is substantially one; and at least an inverting node and a non-inverting node connected to the first and second input leads. The output of the amplifier block is fed back to the input of the non-inverting node of the amplifier block in a manner to increase differential mode impedance while maintaining a low common mode impedance. Various embodiments of the basic presently claimed circuitry provides for additional methods of monitoring the level of common-mode signal introduced to the apparatus and other fault detection functions.
摘要翻译：本发明是一种用于在差分模式信号共存并可能被共模信号损坏的环境中检测差模信号的装置和方法。本发明最基本的装置基本上包括输入差模和共模信号的第一和第二输入引线; 第一放大器块，其具有实质上一个的增益; 以及至少连接到第一和第二输入引线的反相节点和非反相节点。放大器模块的输出以增加差分模式阻抗的方式反馈到放大器模块的非反相节点的输入，同时保持低共模阻抗。基本的当前要求保护的电路的各种实施例提供监视引入到该装置的共模信号的电平和其他故障检测功能的附加方法。

34. 发明授权

US08868172B2 Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders 有权
标题翻译：用于向患者推荐用于管理癫痫和其他神经障碍的适当动作的方法和系统
公开(公告)号：US08868172B2
公开(公告)日：2014-10-21
申请号：US11321897
申请日：2005-12-28
申请人： Kent W. Leyde , Daniel J. Dilorenzo
发明人： Kent W. Leyde , Daniel J. Dilorenzo
IPC分类号： A61B5/04 , A61N1/372 , A61B5/0476 , A61N1/36 , A61B5/00 , A61B5/048
CPC分类号： A61B5/4094 , A61B5/0476 , A61B5/048 , A61B5/7264 , A61B5/7275 , A61N1/36082 , A61N1/37247 , A61N1/37258 , G06F19/00
摘要： The present invention provides methods and system for managing neurological disorders such as epilepsy. In one embodiment, the method comprises measuring one or more signals from a patient and processing the one or more signals to characterize a patient's propensity for a future seizure. The characterized propensity for the seizure is thereafter used to determine an appropriate action for managing or treating the predicted seizure; and a recommendation is communicated to the patient that is indicative of the appropriate action.
摘要翻译：本发明提供了用于治疗诸如癫痫的神经障碍的方法和系统。在一个实施例中，该方法包括测量来自患者的一个或多个信号并处理一个或多个信号以表征患者将来发作的倾向。其特征是缉获倾向之后用于确定管理或治疗预期癫痫发作的适当行动; 并且向患者传达指示适当动作的建议。

35. 发明授权

US08725243B2 Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders 有权
标题翻译：用于推荐对患者进行适当药理学治疗以治疗癫痫和其他神经障碍的方法和系统
公开(公告)号：US08725243B2
公开(公告)日：2014-05-13
申请号：US11321898
申请日：2005-12-28
申请人： Daniel J. Dilorenzo , Kent W. Leyde
发明人： Daniel J. Dilorenzo , Kent W. Leyde
IPC分类号： A61B5/04
CPC分类号： A61B5/4094 , A61B5/024 , A61B5/0476 , A61B5/4833 , A61B5/7264 , A61B5/7275 , A61M5/1723 , A61N1/36064 , A61N1/36082 , A61N1/37258 , G06F19/00
摘要： The present invention provides systems and methods for managing epilepsy. In one embodiment, a method of the present invention characterize a patient's propensity for a future epileptic seizure and communicates to the patient and/or a health care provider a therapy recommendation. The therapy recommendation is typically a function of the patient's propensity for the future epileptic seizure.
摘要翻译：本发明提供了用于治疗癫痫的系统和方法。在一个实施方案中，本发明的方法表征患者对未来癫痫发作的倾向，并且向患者和/或医疗保健提供者传达治疗推荐。治疗推荐通常是患者对未来癫痫发作倾向的功能。

36. 发明申请

US20080114417A1 Systems and methods of reducing artifact in neurological stimulation systems 失效
标题翻译：减少神经刺激系统神经的系统和方法
公开(公告)号：US20080114417A1
公开(公告)日：2008-05-15
申请号：US11599179
申请日：2006-11-14
申请人： Kent W. Leyde
发明人： Kent W. Leyde
IPC分类号： A61N1/36
CPC分类号： A61N1/36082
摘要： The present invention relates to neurological systems and methods of use which acquire physiological signals from a subject and stimulate the subject. The system is adapted to control the timing at which the system acquires the physiological signals from the subject and the timing of the stimulation signal to reduce the amount of stimulation induced artifact that is acquired by the system.
摘要翻译：本发明涉及从受试者获取生理信号并刺激受试者的神经系统和使用方法。该系统适于控制系统获取来自对象的生理信号和刺激信号的定时的定时，以减少由系统获取的刺激引起的伪影的量。

37. 发明授权

US06693431B1 Battery system and method of determining battery condition 失效
标题翻译：电池系统及确定电池状况的方法
公开(公告)号：US06693431B1
公开(公告)日：2004-02-17
申请号：US09141707
申请日：1998-08-28
申请人： Kent W. Leyde , Daniel J. Powers
发明人： Kent W. Leyde , Daniel J. Powers
IPC分类号： G01N27416
CPC分类号： A61N1/3975 , G01R31/3606 , G01R31/3648 , H02J7/0013
摘要： A battery system including a main battery cell having a first capacity; a sense battery cell connected in series with the main battery cell, the sense battery cell having a second capacity less than the first capacity; and a battery capacity indicator monitoring a parameter of the sense battery cell. A method of determining a battery condition in a battery operated device, the method including providing a battery system, the battery system comprising a main battery cell having a first capacity and a sense battery cell, the sense battery cell having a second capacity less than the first capacity, the main battery cell and the sense battery cell being coupled in series; monitoring a parameter of the sense battery cell; and determining a condition of the main battery cell from the monitored sense battery cell parameter.
摘要翻译：一种电池系统，包括具有第一容量的主电池单元; 感测电池单元，与所述主电池单元串联连接，所述感测电池单元具有小于所述第一容量的第二容量; 以及监视感测电池单元的参数的电池容量指示器。一种确定电池供电装置中的电池状况的方法，所述方法包括提供电池系统，所述电池系统包括具有第一容量的主电池单元和感测电池单元，所述感测电池单元具有小于第一容量，主电池单元和感测电池单元串联耦合; 监测感测电池单元的参数; 以及从所监视的感测电池单元参数确定所述主电池单元的状态。

38. 发明授权

US06662056B2 Cartridge for storing an electrode pad 有权
标题翻译：用于存放电极垫的墨盒
公开(公告)号：US06662056B2
公开(公告)日：2003-12-09
申请号：US09852431
申请日：2001-05-09
申请人： Anthony G. Picardo , Christine Janae , Thomas Solosko , Steven T. Mydynski , Ian G. MacDuff , Jon M. Bishay , Kent W. Leyde , Carlton B. Morgan
发明人： Anthony G. Picardo , Christine Janae , Thomas Solosko , Steven T. Mydynski , Ian G. MacDuff , Jon M. Bishay , Kent W. Leyde , Carlton B. Morgan
IPC分类号： A61N104
CPC分类号： A61N1/0472 , A61N1/046 , A61N1/048 , A61N1/0492 , A61N1/39 , A61N2001/37294
摘要： A cartridge is provided for storing one or more electrode pads such as a defibrillator electrode pad. The cartridge includes a housing having a rigid portion, a storage space disposed within the housing, and a storage-space opening that allows one to remove/insert the electrode pad or pads from/into the storage space. Because it has a housing with a rigid portion, such a cartridge can better protect one or more electrode pads from handling damage. Furthermore, one can construct the cartridge such that it is attachable to a medical device such as an AED. This allows an operator to carry or store the medical device, cartridge, and one or more electrode pads as a single unit. In addition, one can construct the cartridge such that the one or more electrode pads can be pre-connected to the medical device. This can eliminate connecting the one or more electrode pads to the medical device during an emergency.
摘要翻译：提供了用于存储一个或多个电极焊盘（例如除颤器电极焊盘）的盒。盒包括具有刚性部分的壳体，设置在壳体内的存储空间，以及允许将电极垫或垫从存储空间中移出/插入的存储空间开口。因为它具有刚性部分的壳体，所以这种盒可以更好地保护一个或多个电极垫不受处理损坏。此外，可以构造盒，使得其可附接到诸如AED的医疗装置。这允许操作者将医疗装置，药筒和一个或多个电极垫作为单个装置携带或储存。此外，可以构造盒，使得一个或多个电极垫可以预先连接到医疗装置。这可以在紧急情况期间消除将一个或多个电极焊盘连接到医疗装置。

39. 发明授权

US06539264B1 Percutaneous electrical therapy system with sharp point protection 失效
标题翻译：经皮电疗治疗系统具有尖锐保护
公开(公告)号：US06539264B1
公开(公告)日：2003-03-25
申请号：US09451547
申请日：1999-12-01
申请人： Jon M. Bishay , Paul Leonard , Kent W. Leyde
发明人： Jon M. Bishay , Paul Leonard , Kent W. Leyde
IPC分类号： A61N104
CPC分类号： A61N1/0551 , A61N1/0502 , A61N1/36017 , A61N1/36021 , A61N1/375
摘要： A percutaneous electrical therapy system includes sharp point protection. In one embodiment, the system includes a control unit; an electrode assembly adapted to deliver electrical therapy to a patient, where the electrode assembly has an electrode electrically connectable to the control unit, the electrode having a sharp point at a distal end adapted to be inserted into the patient's tissue; and a sharp point protection assembly operable with the electrode assembly for reducing the risk of unintended exposure to the electrode's point. The system can also include an electrode assembly and sharp point protection assembly for a percutaneous electrical therapy system, as described above, apart from the control unit. In another embodiment, a method of performing percutaneous electrical therapy can include providing an electrode assembly having an electrode, the electrode having a sharp point at a distal end; inserting the sharp point of the electrode into a patient's tissue without exposing the sharp point to anyone but the patient; and applying an electrical signal to the electrode from a control unit.
摘要翻译：经皮电疗系统包括尖锐点保护。在一个实施例中，系统包括控制单元; 电极组件，其适于将电疗法递送到患者，其中所述电极组件具有可电连接到所述控制单元的电极，所述电极在适于插入患者组织的远端具有尖锐点; 以及可与电极组件一起操作的尖锐点保护组件，用于减少意外暴露于电极点的风险。除了控制单元之外，系统还可以包括用于经皮电疗系统的电极组件和尖锐点保护组件，如上所述。在另一个实施例中，执行经皮电疗法的方法可以包括提供具有电极的电极组件，所述电极在远端具有尖锐点; 将电极的尖锐点插入病人的组织中，而不会将尖锐点暴露于除病人之外的任何人; 以及从控制单元向电极施加电信号。

40. 发明授权

US09259591B2 Housing for an implantable medical device 有权
标题翻译：可植入医疗器械的外壳
公开(公告)号：US09259591B2
公开(公告)日：2016-02-16
申请号：US12343386
申请日：2008-12-23
申请人： David Brown , Christopher Genau , Kent W. Leyde , Shan Gaw , Jeffrey Stewart
发明人： David Brown , Christopher Genau , Kent W. Leyde , Shan Gaw , Jeffrey Stewart
IPC分类号： A61N1/378 , A61N1/375 , A61N1/372
CPC分类号： A61N1/3787 , A61N1/37223 , A61N1/375 , A61N1/3758
摘要： An implantable medical device having a concave ceramic housing component; a concave metal housing component attached to the ceramic housing component to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure. Another aspect of the invention provides an implantable medical device having a ceramic housing component; a metal housing component; a circumferential sealing member attached to a periphery of the ceramic housing component and to a periphery of the metal housing component to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure. Still another aspect of the invention provides an implantable medical device with a first metal housing component; a second metal housing component, the second metal housing component forming an opening; a ceramic housing component disposed in the opening, the first metal housing component, the second metal housing component and the ceramic housing component cooperating to form a hermetically sealed enclosure; and an electronic trans-housing magnetic flux component disposed within the enclosure.
摘要翻译：一种具有凹形陶瓷壳体部件的可植入医疗装置; 连接到陶瓷壳体部件的凹入金属壳体部件以形成密封的外壳; 以及设置在所述外壳内的电子跨壳体磁通部件。本发明的另一方面提供一种具有陶瓷壳体部件的可植入医疗装置; 金属外壳部件; 周向密封构件，其附接到陶瓷壳体部件的周边和金属壳体部件的周边，以形成密封的外壳; 以及设置在所述外壳内的电子跨壳体磁通部件。本发明的另一方面提供一种具有第一金属壳体部件的可植入医疗装置; 第二金属壳体部件，所述第二金属壳体部件形成开口; 设置在所述开口中的陶瓷壳体部件，所述第一金属壳体部件，所述第二金属壳体部件和所述陶瓷壳体部件协作以形成气密密封的壳体; 以及设置在所述外壳内的电子跨壳体磁通部件。

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