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31. 发明授权

US4419352A Pyranoquinolinones and analogs thereof 失效
标题翻译：吡喃喹啉酮及其类似物
公开(公告)号：US4419352A
公开(公告)日：1983-12-06
申请号：US236329
申请日：1981-02-20
申请人： David Cox , Hugh Cairns , Nigel Chadwick , John L. Suschitzky
发明人： David Cox , Hugh Cairns , Nigel Chadwick , John L. Suschitzky
IPC分类号： A61K31/435 , A61K31/495 , A61P11/06 , A61P37/08 , C07D215/00 , C07D215/48 , C07D239/72 , C07D239/90 , C07D311/24 , C07D335/06 , C07D491/04 , C07D491/052 , C07D495/04 , A61K31/47 , A61K31/535 , C07D413/14
CPC分类号： C07D491/04 , C07D215/48 , C07D239/90 , C07D311/24 , C07D335/06 , C07D495/04 , Y10S514/826 , Y10S514/914 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/934
摘要： There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --CZC(G.sub.1).dbd.(G.sub.2)--Z--,R.sub.4, R.sub.9 and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, alkyl, halogen, alkenyl, --NO.sub.2, --NR.sub.1 R.sub.2, --OR.sub.3, --S(O).sub.n R.sub.3 ; or alkyl substituted by hydroxy, amino, alkoxy or carbonyl oxygen,n is 0, 1 or 2,R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen, alkyl, --CONHR.sub.3, phenyl or phenyl substituted by alkyl or halogen, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclic ring,R.sub.3 represents hydrogen, alkyl, alkenyl or phenyl,one of G.sub.1 and G.sub.2 is hydrogen and the other is a group E,each E, which may be the same or different, is --COOH, a 5-tetrazolyl group, or a carboxamidotetrazole group,each Z, which may be the same or different, is oxygen or sulphur, andone or two of the atoms, a, b, c and d are nitrogen atoms and the remainder are carbon atoms, R.sup.9 having no significance when two of a, b, c and d are nitrogen,(with certain exclusions)and pharmaceutically acceptable derivatives thereof.There are also described methods for making the compounds and pharmaceutical, e.g. anti-allergic, compositions and mixtures containing them.
摘要翻译：描述了式I，其中相邻的一对R 5，R 6，R 7和R 8形成链-CZC（G1）=（G2）-Z-，R4，R9和R5的其余部分的式I化合物， R 6，R 7和R 8可以相同或不同，各自表示氢，烷基，卤素，烯基，-NO 2，-NR 1 R 2，-OR 3，-S（O）n R 3; 或被羟基，氨基，烷氧基或羰基氧取代的烷基，n为0,1或2，可以相同或不同的R 1和R 2各自表示氢，烷基，-CONHR 3，苯基或被烷基或卤素取代的苯基，或R1和R2与它们所连接的氮原子一起形成5或6元杂环，R 3表示氢，烷基，链烯基或苯基，G1和G2之一是氢，另一个是基团E，每个 E可以相同或不同，为-COOH，5-四唑基或羧酰胺基四唑基，各Z可以相同或不同，为氧或硫，一个或两个原子为 b，c和d为氮原子，其余为碳原子，当a，b，c和d中的两个为氮时，R 9为无意义（具有某些排除）及其药学上可接受的衍生物。还描述了制备化合物和药物的方法。抗过敏剂，组合物和含有它们的混合物。

32. 外观设计

USD948329S1 Fastener 有权
公开(公告)号：USD948329S1
公开(公告)日：2022-04-12
申请号：US29652494
申请日：2020-09-03
申请人： David Cox
设计人： David Cox

33. 发明授权

US08934098B2 Fast-indexing filter wheel and method of use 有权
标题翻译：快速分度过滤轮及使用方法
公开(公告)号：US08934098B2
公开(公告)日：2015-01-13
申请号：US12873132
申请日：2010-08-31
申请人： David Cox , Marc Haberstroh , Patrick Kinney , Albert Carrillo , Jon Hoshizaki , Maryam Shariati , Howard King , Joe Lee , Matthew Chan
发明人： David Cox , Marc Haberstroh , Patrick Kinney , Albert Carrillo , Jon Hoshizaki , Maryam Shariati , Howard King , Joe Lee , Matthew Chan
IPC分类号： G01N21/25 , C12Q1/68 , B01F13/00 , B01F13/02 , B01J19/00 , B01L3/00 , G01N35/00 , G01N35/10 , G02B21/34
CPC分类号： C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
摘要： Various embodiments of a sequencing system capable of rapidly imaging samples at multiple wavelengths are provided herein. In one embodiment, the system includes a fast-indexing filter wheel having a plurality of excitation and emission filters capable of being rapidly rotated into and out of communication with an excitation source (e.g., an arc lamp, a laser. For example, the filter wheel can be configured to index in an amount of time falling within a range of about 40 ms to about 60 ms, preferably 50 ms. The system can also be configured to account for vibrations resulting from the quick starts and stops of the fast-indexing filter wheel as well as vibrations resulting from other sources. Various methods of rapidly imaging a sample at multiple wavelengths are also provided herein.
摘要翻译：本文提供了能够快速成像多个波长的样品的测序系统的各种实施例。在一个实施例中，该系统包括具有多个激发和发射滤波器的快速分度滤光轮，该激发和发射滤光片能够快速旋转进入激发源（例如，弧光灯，激光器）轮可以被配置成以大约40ms至大约60ms，优选为50ms的范围内的时间量进行索引。该系统还可以被配置为考虑快速启动和停止快速索引所产生的振动滤光轮以及由其他光源产生的振动。本文还提供了在多个波长下快速成像样品的各种方法。

34. 发明申请

US20140313316A1 ADJUSTABLE VARIABLE RESOLUTION INSPECTION SYSTEMS AND METHODS USING MULTIPLE IMAGE SENSORS 审中-公开
标题翻译：可调节的可变分辨率检测系统和使用多个图像传感器的方法
公开(公告)号：US20140313316A1
公开(公告)日：2014-10-23
申请号：US14167959
申请日：2014-01-29
申请人： Mark S. Olsson , Scott Powell , Stephanie Bench , Ray Merewhether , David Cox , Eric Chapman
发明人： Mark S. Olsson , Scott Powell , Stephanie Bench , Ray Merewhether , David Cox , Eric Chapman
IPC分类号： H04N7/18 , H04N5/232 , H04N5/225
CPC分类号： H04N7/183 , H04N5/2258 , H04N5/232 , H04N5/2355 , H04N2005/2255
摘要： Camera heads having multiple image sensors, configured to provide digitally articulated images or video, at adjustable resolutions and/or offsets and orientations, to a camera control unit (CCU) or other electronic computing system for display, storage, and/or transmission to other systems are disclosed.
摘要翻译：具有多个图像传感器的相机头被配置为以可调节分辨率和/或偏移和取向提供数字关节图像或视频到相机控制单元（CCU）或其他电子计算系统，用于显示，存储和/或传输到其他系统被公开。

35. 发明申请

US20120159468A1 SOFTWARE DEPLOYMENT TO MULTIPLE COMPUTING DEVICES 审中-公开
标题翻译：软件部署到多个计算设备
公开(公告)号：US20120159468A1
公开(公告)日：2012-06-21
申请号：US12972566
申请日：2010-12-20
申请人： Madhur Joshi , Crystal Hoyer , David Cox , Mohammed Parvez Shaikh , Emily B. Repperger , Yamini Jagadeesan , Muhammad Bilal Aslam , Clea Allington , Yishai Galatzer
发明人： Madhur Joshi , Crystal Hoyer , David Cox , Mohammed Parvez Shaikh , Emily B. Repperger , Yamini Jagadeesan , Muhammad Bilal Aslam , Clea Allington , Yishai Galatzer
IPC分类号： G06F9/445 , G06F9/44 , G06F15/16
CPC分类号： G06F8/71 , G06F8/61
摘要： A particular method includes storing a manifest file and a parameters file at a data store. The manifest file and the parameters file are associated with a software deployment package. An application associated with the software deployment package is published to a first remote computing device and to a second remote computing device. The method includes receiving first parameter values from the first remote computing device and receiving second parameter values from the second remote computing device. The first parameter values are stored in a first region of the data store that is specific to the first computing device. The second parameter values are stored in a second region of the data store that is specific to the second computing device.
摘要翻译：一种特定的方法包括将清单文件和参数文件存储在数据存储中。清单文件和参数文件与软件部署包相关联。与软件部署包相关联的应用被发布到第一远程计算设备和第二远程计算设备。该方法包括从第一远程计算设备接收第一参数值并从第二远程计算设备接收第二参数值。第一参数值被存储在特定于第一计算设备的数据存储区的第一区域中。第二参数值存储在特定于第二计算设备的数据存储区的第二区域中。

36. 发明申请

US20120067718A1 METHOD AND APPARATUS FOR PRODUCING THREE DIMENSIONAL NANO AND MICRO SCALE STRUCTURES 审中-公开
标题翻译：用于生产三维纳米和微尺度结构的方法和装置
公开(公告)号：US20120067718A1
公开(公告)日：2012-03-22
申请号：US13260430
申请日：2010-03-29
申请人： David Cox
发明人： David Cox
IPC分类号： C23C14/46 , C23F1/04 , B44C1/22
CPC分类号： H01J37/3056 , G01N1/286 , H01J2237/2583 , H01J2237/30483 , H01J2237/3114 , H01J2237/3174 , H01J2237/31745 , H01J2237/31749
摘要： A three-dimensional milling method and apparatus is disclosed for milling micrometre and a nanometre scale three-dimensional structures. The apparatus includes an ion column operable to generate a milling beam onto a substrate held on an instrument stage. A patterning computer is operable to control the ion column to generate varying ion beam and/or dwell times or to produce a plurality of milling passes, in which subsequent passes overlap previous passes at least partially to create three-dimensional structures. Optionally, an SEM column may be provided.
摘要翻译：公开了一种三维研磨方法和装置，其用于研磨微米级和纳米级三维结构。该装置包括可操作以在保持在仪器台上的基板上产生铣削光束的离子柱。图案化计算机可操作以控制离子柱以产生变化的离子束和/或停留时间或产生多个铣削通道，其中随后的通道至少部分地与先前通过重叠以产生三维结构。可选地，可以提供SEM柱。

37. 发明申请

US20110128545A1 Fast-Indexing Filter Wheel and Method of Use 有权
标题翻译：快速分度滤芯轮和使用方法
公开(公告)号：US20110128545A1
公开(公告)日：2011-06-02
申请号：US12873132
申请日：2010-08-31
申请人： David Cox , Marc Haberstroh , Patrick Kinney , Albert Carrillo , Jon Hoshizaki , Maryam Shariati , Howard King , Joe Lee , Matthew Chan
发明人： David Cox , Marc Haberstroh , Patrick Kinney , Albert Carrillo , Jon Hoshizaki , Maryam Shariati , Howard King , Joe Lee , Matthew Chan
IPC分类号： G01N21/25 , G02B5/22
CPC分类号： C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
摘要： Various embodiments of a sequencing system capable of rapidly imaging samples at multiple wavelengths are provided herein. In one embodiment, the system includes a fast-indexing filter wheel having a plurality of excitation and emission filters capable of being rapidly rotated into and out of communication with an excitation source (e.g., an arc lamp, a laser. For example, the filter wheel can be configured to index in an amount of time falling within a range of about 40 ms to about 60 ms, preferably 50 ms. The system can also be configured to account for vibrations resulting from the quick starts and stops of the fast-indexing filter wheel as well as vibrations resulting from other sources. Various methods of rapidly imaging a sample at multiple wavelengths are also provided herein.
摘要翻译：本文提供了能够快速成像多个波长的样品的测序系统的各种实施例。在一个实施例中，该系统包括具有多个激发和发射滤波器的快速分度滤光轮，该激发和发射滤光片能够快速旋转进入激发源（例如，弧光灯，激光器）轮可以被配置成以大约40ms至大约60ms，优选为50ms的范围内的时间量进行索引。该系统还可以被配置为考虑快速启动和停止快速索引所产生的振动滤光轮以及由其他光源产生的振动。本文还提供了在多个波长下快速成像样品的各种方法。

38. 发明申请

US20100317330A1 METHOD OF ENABLING A SERVICE AT A COMMUNICATION NETWORK NODE 有权
标题翻译：在通信网络节点上启用服务的方法
公开(公告)号：US20100317330A1
公开(公告)日：2010-12-16
申请号：US12867934
申请日：2008-02-18
申请人： Mikael Klein , Christer Boberg , David Cox , Sofie Lassborn
发明人： Mikael Klein , Christer Boberg , David Cox , Sofie Lassborn
IPC分类号： H04W4/00
CPC分类号： G06Q99/00 , G06Q10/10 , H04L67/16 , H04L67/24 , H04M3/42161 , H04M3/42365
摘要： A method enabling a service at a communication network node and a network node adapted to execute the method is provided, wherein a first request, requesting for one or more operations to be associated with a symbol, is received from a first user. The request comprises an instruction, identifying one or more operations. The request triggers the generating of a unique symbol identity, and the creation of a symbol record, associated with the symbol identity, wherein the symbol record, linking the symbol identity to the one or more operations. At the node the symbol identity is also associated with the generated symbol, which is created by a symbol server and forwarded to the first user. Once the symbol has been received by the node in a second request, the symbol identity corresponding to the symbol is retrieved from the symbol server, and the service is enabled by executing the one or more operations according to the symbol record identified by the symbol identity.
摘要翻译：提供一种在通信网络节点和适于执行该方法的网络节点中实现服务的方法，其中从第一用户接收请求与符号相关联的一个或多个操作的第一请求。该请求包括识别一个或多个操作的指令。该请求触发生成唯一的符号标识，以及创建与符号标识相关联的符号记录，其中符号记录将符号标识链接到一个或多个操作。在节点处，符号标识也与由符号服务器创建并转发给第一用户的生成符号相关联。一旦节点在第二请求中已经接收到符号，则从符号服务器检索对应于符号的符号标识符，并且通过根据符号标识识别的符号记录执行一个或多个操作来启用该服务。

39. 发明申请

US20100096300A1 Chutes for Sorting and Inspection Apparatus 有权
标题翻译：分拣和检验仪器的滑槽
公开(公告)号：US20100096300A1
公开(公告)日：2010-04-22
申请号：US12254713
申请日：2008-10-20
申请人： Stewart Mills , David Cox
发明人： Stewart Mills , David Cox
IPC分类号： B65G11/00 , G01M19/00
CPC分类号： B65G11/083
摘要： A chute for inspection and sorting apparatus has first and second flat sections, with the lower end of the first section being disposed over the second section to form a step from which product falls onto the second section. Additional sections may be included. In one variant a third channelled section is included, with the lower end of the second section being disposed over the third section forming a second step from which product falls onto the third section.
摘要翻译：用于检查和分拣装置的滑槽具有第一和第二平坦部分，第一部分的下端设置在第二部分上，以形成产品落入第二部分的台阶。可能包括其他部分。在一个变型中，包括第三通道部分，其中第二部分的下端设置在第三部分之上，形成产品落在第三部分上的第二步骤。

40. 发明申请

US20070092889A1 Parkinson's disease-related disease compositions and methods 审中-公开
标题翻译：帕金森病相关疾病的组成和方法
公开(公告)号：US20070092889A1
公开(公告)日：2007-04-26
申请号：US11446599
申请日：2006-06-02
申请人： David Cox , Demetrius Maraganore , Dennis Ballinger , Krishna Pant , Timothy Lesnick
发明人： David Cox , Demetrius Maraganore , Dennis Ballinger , Krishna Pant , Timothy Lesnick
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： Compositions and methods for use in the therapeutic and preventative treatment, study, diagnosis and prognosis of PD-related disease are disclosed. Also provided are kits and reagents for prognosis and diagnosis of PD-related disease and related conditions.
摘要翻译：公开了用于PD相关疾病的治疗和预防性治疗，研究，诊断和预后的组合物和方法。还提供了用于PD相关疾病和相关病症的预后和诊断的试剂盒和试剂。

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