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1. 发明授权

US4419352A Pyranoquinolinones and analogs thereof 失效
标题翻译：吡喃喹啉酮及其类似物
公开(公告)号：US4419352A
公开(公告)日：1983-12-06
申请号：US236329
申请日：1981-02-20
申请人： David Cox , Hugh Cairns , Nigel Chadwick , John L. Suschitzky
发明人： David Cox , Hugh Cairns , Nigel Chadwick , John L. Suschitzky
IPC分类号： A61K31/435 , A61K31/495 , A61P11/06 , A61P37/08 , C07D215/00 , C07D215/48 , C07D239/72 , C07D239/90 , C07D311/24 , C07D335/06 , C07D491/04 , C07D491/052 , C07D495/04 , A61K31/47 , A61K31/535 , C07D413/14
CPC分类号： C07D491/04 , C07D215/48 , C07D239/90 , C07D311/24 , C07D335/06 , C07D495/04 , Y10S514/826 , Y10S514/914 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/934
摘要： There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --CZC(G.sub.1).dbd.(G.sub.2)--Z--,R.sub.4, R.sub.9 and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, alkyl, halogen, alkenyl, --NO.sub.2, --NR.sub.1 R.sub.2, --OR.sub.3, --S(O).sub.n R.sub.3 ; or alkyl substituted by hydroxy, amino, alkoxy or carbonyl oxygen,n is 0, 1 or 2,R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen, alkyl, --CONHR.sub.3, phenyl or phenyl substituted by alkyl or halogen, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclic ring,R.sub.3 represents hydrogen, alkyl, alkenyl or phenyl,one of G.sub.1 and G.sub.2 is hydrogen and the other is a group E,each E, which may be the same or different, is --COOH, a 5-tetrazolyl group, or a carboxamidotetrazole group,each Z, which may be the same or different, is oxygen or sulphur, andone or two of the atoms, a, b, c and d are nitrogen atoms and the remainder are carbon atoms, R.sup.9 having no significance when two of a, b, c and d are nitrogen,(with certain exclusions)and pharmaceutically acceptable derivatives thereof.There are also described methods for making the compounds and pharmaceutical, e.g. anti-allergic, compositions and mixtures containing them.
摘要翻译：描述了式I，其中相邻的一对R 5，R 6，R 7和R 8形成链-CZC（G1）=（G2）-Z-，R4，R9和R5的其余部分的式I化合物， R 6，R 7和R 8可以相同或不同，各自表示氢，烷基，卤素，烯基，-NO 2，-NR 1 R 2，-OR 3，-S（O）n R 3; 或被羟基，氨基，烷氧基或羰基氧取代的烷基，n为0,1或2，可以相同或不同的R 1和R 2各自表示氢，烷基，-CONHR 3，苯基或被烷基或卤素取代的苯基，或R1和R2与它们所连接的氮原子一起形成5或6元杂环，R 3表示氢，烷基，链烯基或苯基，G1和G2之一是氢，另一个是基团E，每个 E可以相同或不同，为-COOH，5-四唑基或羧酰胺基四唑基，各Z可以相同或不同，为氧或硫，一个或两个原子为 b，c和d为氮原子，其余为碳原子，当a，b，c和d中的两个为氮时，R 9为无意义（具有某些排除）及其药学上可接受的衍生物。还描述了制备化合物和药物的方法。抗过敏剂，组合物和含有它们的混合物。

2. 发明授权

US4474787A 7,6 Dioxo-4H,6H-pyrano[3,2-g]quinoline dicarboxylic acids and anti-allergic use thereof 失效
标题翻译： 7,6二氧代-4H，6H-吡喃并[3,2-g]喹啉二羧酸及其抗过敏用途
公开(公告)号：US4474787A
公开(公告)日：1984-10-02
申请号：US344982
申请日：1982-02-02
申请人： Hugh Cairns , David Cox
发明人： Hugh Cairns , David Cox
IPC分类号： C07D215/48 , C07D311/24 , C07D491/04 , C07D491/052 , C08J7/00 , A61K31/47
CPC分类号： C07D491/04 , C07D215/48 , C07D311/24
摘要： There are described compounds of formula I ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.CE--O--, and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or --NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2, which are the same or different, are each hydrogen or alkyl,Rg is hydrogen, alkyl, alkenyl or phenyl-alkyl, andE is --COOH, a 5-tetrazolyl group or an (N-tetrazol-5-yl) carboxamido group,and pharmaceutically acceptable derivatives thereof.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
摘要翻译：描述了式I的化合物，其中相邻的一对R 5，R 6，R 7和R 8形成链-COCH = CE-O-，其余的R5，R6，R7和R8可以是相同或不同，各自表示氢，羟基，烷基，卤素，烯基，烷氧基或-NR 1 R 2，其中R 1和R 2相同或不同，各自为氢或烷基，R g为氢，烷基，烯基或苯基 - 烷基，E为-COOH，5-四唑基或（N-四唑-5-基）甲酰胺基及其药学上可接受的衍生物。还描述了制备化合物和药物的方法，例如。抗过敏剂，含有这些化合物的组合物。

3. 发明申请

US20060253236A1 Method of detecting vehicle speed sensor failure 有权
标题翻译：检测车速传感器故障的方法
公开(公告)号：US20060253236A1
公开(公告)日：2006-11-09
申请号：US11121829
申请日：2005-05-04
申请人： Jeffery Hawkins , Hugh Cairns
发明人： Jeffery Hawkins , Hugh Cairns
IPC分类号： G01M17/00
CPC分类号： G01P21/02 , G07C5/0816
摘要： A method of detecting vehicle speed sensor failures is disclosed. The method is intended to prevent or discourage tampering with a vehicle's speed limiting system. The method includes the steps of determining whether the transmission is in neutral or whether the transmission is in its converter mode to prevent false indications of speed sensor failure under certain circumstances.
摘要翻译：公开了一种检测车速传感器故障的方法。该方法旨在防止或阻止篡改车辆限速系统。该方法包括以下步骤：确定传输是否处于中立状态，或者传输是否处于其转换器模式，以防止在某些情况下速度传感器故障的错误指示。

4. 发明授权

US4228173A Thiopyrano-benzopyrans, compositions and method of use thereof 失效
标题翻译：噻喃 - 苯并吡喃，组合物及其使用方法
公开(公告)号：US4228173A
公开(公告)日：1980-10-14
申请号：US58609
申请日：1979-07-18
申请人： Hugh Cairns , Anthony H. Ingall
发明人： Hugh Cairns , Anthony H. Ingall
IPC分类号： A61K31/38 , A61K31/382 , A61K31/41 , A61P11/00 , A61P27/00 , A61P37/08 , C07D335/06 , C07D495/02 , C07D495/04 , A61K31/28 , C07D497/04
CPC分类号： C07D495/04 , C07C323/00 , C07D335/06
摘要： There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.CE--O--, and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or --NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2, which are the same or different, are each hydrogen or alkyl, andE is --COOH, a 5-tetrazolyl group or an (N-tetrazol-5-yl) carboxamido group,and pharmaceutically acceptable derivatives thereof.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.
摘要翻译：描述了式I的化合物，其中相邻的一对R 5，R 6，R 7和R 8形成链-COCH = CE-O-，其余的R5，R6，R7和R8，其可以是相同或不同，各自表示氢，羟基，烷基，卤素，烯基，烷氧基或-NR 1 R 2，其中相同或不同的R 1和R 2各自为氢或烷基，并且E为-COOH，a 5 - 四唑基或（N-四唑-5-基）甲酰胺基及其药学上可接受的衍生物。还描述了制备化合物和药物的方法，例如。抗过敏，含有它们的组合物。

5. 发明授权

US4064256A Benzopyranyltetrazoles as antiasthma agents 失效
标题翻译：苯并吡喃基四唑作为抗哮喘药
公开(公告)号：US4064256A
公开(公告)日：1977-12-20
申请号：US539437
申请日：1975-01-03
申请人： Joachim Augstein , Hugh Cairns , Dennis Hunter , John King
发明人： Joachim Augstein , Hugh Cairns , Dennis Hunter , John King
IPC分类号： A61K31/41 , C07D311/24 , C07D335/06 , C07F1/00
CPC分类号： C07D335/06 , C07C321/00 , C07C323/00 , C07D311/24 , C07F1/005 , Y10S514/826
摘要： There are described compounds of formula I, ##STR1## in which R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, are hydrogen, alkyl C2 to 6, alkoxy C2 to 8, hydroxy-alkoxy C3 to 8, and R.sub.5 may be hydroxy, provided that one or two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are other than hydrogen, and pharmaceutically acceptable derivatives thereof. The compounds of formula I are indicated for use in the treatment of asthma, and pharmaceutical compositions containing them and processes for their preparation are also described.
摘要翻译：描述了式I的化合物，其中R 5，R 6，R 7和R 8可以相同或不同，为氢，烷基C2至6，烷氧基C2至8，羟基 - 烷氧基C3至8，并且R 5可以是羟基，条件是R 5，R 6，R 7和R 8中的一个或两个不是氢，及其药学上可接受的衍生物。式I化合物用于治疗哮喘，还描述了含有它们的药物组合物及其制备方法。

6. 发明授权

US4055654A 6,8-Di-t-butyl-4-oxo-4H-1-benzopyran-2-carboxylic acid and derivative for the prevention of asthmatic symptoms 失效
标题翻译： 6,8-二叔丁基-4-氧代-4H-1-苯并吡喃-2-羧酸及其用于预防哮喘症状的衍生物
公开(公告)号：US4055654A
公开(公告)日：1977-10-25
申请号：US646025
申请日：1976-01-02
申请人： Hugh Cairns , Albert Chambers , Thomas Brian Lee
发明人： Hugh Cairns , Albert Chambers , Thomas Brian Lee
IPC分类号： C07D307/12 , A61K31/35
CPC分类号： C07C45/67 , C07C45/46 , C07C45/71 , C07D307/12 , Y10S514/826
摘要： There are described certain mono-chromone-2-carboxylic acids of formula, ##STR1## having one substituent in the 5 or 6 position or having 2 or more substituents in the 5,6,7 or 8 positions. There are also described processes for making the compounds and pharmaceutical compositions, for the treatment of asthma, containing the compounds.
摘要翻译：描述了具有5或6位具有一个取代基或在5,6,7或8位具有2个以上取代基的式的某些单色酮-2-羧酸。还描述了制备用于治疗含有化合物的哮喘的化合物和药物组合物的方法。

7. 发明授权

US4211788A Compounds 失效
标题翻译：化合物
公开(公告)号：US4211788A
公开(公告)日：1980-07-08
申请号：US904794
申请日：1978-05-11
申请人： Hugh Cairns , Anthony R. Payne
发明人： Hugh Cairns , Anthony R. Payne
IPC分类号： C07D311/94 , A61K31/355 , C07D311/22
CPC分类号： C07C45/60 , C07C45/62 , C07C45/67 , C07C45/71 , C07D311/94
摘要： There are described compounds of formula I, ##STR1## in which E is a --COOH, a 5-tetrazolyl or an (N-tetrazol-5-yl) carboxamido group,R.sub.3 is hydrogen or alkyl,an adjacent pair of W, X, Y and Z form a 5 membered chain comprising alkylene groups and optionally one or two oxygen atoms, the chain optionally being substituted by one or two alkyl groups,the remaining substituents W, X, Y or Z are hydrogen; halogen; alkyl optionally substituted by one or more of the groups hydroxy, halogen, carbonyl oxygen, phenyl, or alkoxy; alkenyl optionally substituted by phenyl; hydroxy; alkoxy; alkanoyloxy; alkenyloxy; nitro; --NR.sub.1 R.sub.2 or hydroxyalkoxy,R.sub.1 and R.sub.2, which may be the same or different, are each hydrogen or alkyl,and pharmaceutically acceptable derivatives thereof.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
摘要翻译：描述了式I的化合物，其中E是-COOH，5-四唑基或（N-四唑-5-基）甲酰氨基，R 3是氢或烷基，相邻的一对W， X，Y和Z形成包含亚烷基和任选的一个或两个氧原子的5元链，该链任选被一个或两个烷基取代，其余的取代基W，X，Y或Z是氢; 卤素; 任选被一个或多个羟基，卤素，羰基氧，苯基或烷氧基取代的烷基; 任选被苯基取代的烯基; 羟基; 烷氧基烷酰氧基; 链烯氧基硝基 -NR1R2或羟基烷氧基，R1和R2可以相同或不同，各自为氢或烷基，及其药学上可接受的衍生物。还描述了制备化合物和药物的方法，例如。抗过敏剂，含有这些化合物的组合物。

8. 发明授权

US4156726A 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds 失效
标题翻译：用作抗过敏化合物的4-氧代-2-羧基喹啉衍生物
公开(公告)号：US4156726A
公开(公告)日：1979-05-29
申请号：US635615
申请日：1975-11-26
申请人： Roger C. Brown , Hugh Cairns , Anthony R. Payne
发明人： Roger C. Brown , Hugh Cairns , Anthony R. Payne
IPC分类号： C07D215/26 , C07D215/28 , C07D215/32 , C07D215/48 , C07D221/08 , C07D221/10 , C07D471/04 , A61K31/47
CPC分类号： C07D471/04 , C07D215/48 , C07D221/08 , C07D221/10
摘要： There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, OR AN ADJACENT PAIR OF R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.C(COOH)NRh--,Or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,Or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
摘要翻译：描述式I的化合物，其中R 5至R 8可以是多种取代基，或者R 5，R 6，R 7和R 8的相邻对形成链-COCH = C（COOH）NR h - ，OR R 5，R 6，R 7和R 8中的一个形成式II，其中R a，R b和R c具有与R 5，R 6，R 7和R 8相同的含义的基团，X是任选中断或取代的烃链， Rg和Rh可以相同或不同，分别为烷基，烯基，苯基 - 烷基，烷酰基，苯甲酰基或苯基烷酰基，OR Rg和R 8和/或式II中的Rh和R c一起形成链 - （CH 2）n - ，n为2,3或4。

9. 发明授权

US4085115A Carboxamido tetrazoles 失效
标题翻译：卡巴酰胺四唑
公开(公告)号：US4085115A
公开(公告)日：1978-04-18
申请号：US674732
申请日：1976-04-06
申请人： Joachim Augstein , Hugh Cairns , Norman Harold Rogers
发明人： Joachim Augstein , Hugh Cairns , Norman Harold Rogers
IPC分类号： C07D493/04 , C07D257/04 , A61K31/41
CPC分类号： C07D493/04
摘要： There are described compounds of formula Ix, ##STR1## IN WHICH ONE OR MORE ADJACENT PAIRS OF P, Q, R and T represent a chain of formula XX, ##STR2## or a group of formula X, ##STR3## in which Ba and Bb represent the pair of groups:- a carbon-carbon bond and --CRa.dbd.CRb--; or an adjacent pair of P, Q, R and T represent a group of formula XI, ##STR4## Ra and Rb and those of P, Q, R and T which do not form a chain of formula XX or a group of formula X or XI may be the same or different and each represents hydrogen; alkyl; alkoxy; alkenyl; alkenyloxy; alkyl or alkoxy, substituted by a hydroxy, alkoxy, aryl or halo group; amino; mono- or di-lower alkylamino; aminoalkoxy; aminoalkoxy substituted by a lower alkyl group; nitro; hydroxy; halogen; acyl; or aryloxy.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.
摘要翻译：描述了式Ix的化合物，其中P，Q，R和T的一个或多个相邻对表示式XX的链， XX或一组式X， X在其中Ba和Bb代表一对基团： - 碳 - 碳键和-CRa = CRb-; 或相邻的一对P，Q，R和T表示式XI，XIAa和Rb的基团，以及不形成式XX链或式 X或XI可以相同或不同，各自表示氢; 烷基; 烷氧基烯基; 链烯氧基被羟基，烷氧基，芳基或卤代基取代的烷基或烷氧基; 氨基; 单 - 或二 - 低级烷基氨基; 氨基烷氧基被低级烷基取代的氨基烷氧基; 硝基羟基; 卤素; 酰基; 或芳氧基。

10. 发明授权

US4335048A 5-(2-Hydroxypropoxy)-8-propyl-4H-1-benzopyran-4-one-2-carboxylic acid 失效
标题翻译： 5-（2-羟基丙氧基）-8-丙基-4H-1-苯并吡喃-4-酮-2-羧酸
公开(公告)号：US4335048A
公开(公告)日：1982-06-15
申请号：US122284
申请日：1980-02-19
申请人： Hugh Cairns , Richard Hazard , John King , Thomas B. Lee
发明人： Hugh Cairns , Richard Hazard , John King , Thomas B. Lee
IPC分类号： C07D311/24
CPC分类号： C07D311/24 , Y10S514/826
摘要： There is described the compound of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. Processes for making the compound and pharmaceutical, e.g. anti-asthmatic, compositions containing it are also described.
摘要翻译：描述了式I化合物及其药学上可接受的衍生物。制备化合物和药物的方法，例如还描述了抗哮喘药，含有它的组合物。

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