专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20130045335A1 Multiplexed Electrospray Deposition Apparatus 有权
公开(公告)号：US20130045335A1
公开(公告)日：2013-02-21
申请号：US13657220
申请日：2012-10-22
申请人： Parijat Bhatnagar , Harold G. Craighead
发明人： Parijat Bhatnagar , Harold G. Craighead
IPC分类号： B05B5/025 , B01J19/08
CPC分类号： B05B5/0255 , B05B5/005 , B05B5/025 , B05B5/08
摘要： Multiplexed electrospray deposition apparatus capable of delivering picoliter volumes of one or more substances is disclosed. The apparatus may include a unitary planar dispenser etched from a silicon wafer through microfabrication or micromachining technology. The apparatus may be used as a deposition tool for making protein microarrays in a noncontact mode. Upon application of potential difference in the range of 7-9 kV, the substances may be dispensed directly, not through a collimating mask, onto a substrate with microhydrogel features functionalized with an anchoring agent.

32. 发明申请

US20120245047A1 DEVICE AND METHODS FOR MOLECULAR ANALYSIS 有权
标题翻译：用于分子分析的装置和方法
公开(公告)号：US20120245047A1
公开(公告)日：2012-09-27
申请号：US13389259
申请日：2010-08-06
申请人： Harold G. Craighead , Benjamin R. Cipriany , Stephen Levy , Paul Soloway
发明人： Harold G. Craighead , Benjamin R. Cipriany , Stephen Levy , Paul Soloway
IPC分类号： C12M1/36 , C40B60/12 , C12Q1/06 , G01N21/25 , C40B30/04
CPC分类号： C12Q1/68 , B01L3/502761 , B01L2200/0663 , B01L2300/0654 , C12Q1/6827 , C12Q2537/164 , C12Q2565/629 , C12Q2565/631 , C12Q2561/113
摘要： Systems and methods are provided for high speed sorting of objects in a continuous body of fluid. The object can be analyzed within one or more interrogation volumes that allow for simultaneous or time-correlated measurement of the object's properties. A processor can interpret the properties of the object and then measured and then direct the object to one of a plurality of downstream flow paths. In some embodiments, the sorting of the object is based on two or more properties of the object. The sorting process can be repeated to create a network of sorting events.
摘要翻译：提供了系统和方法用于在连续的流体中高速分类物体。可以在一个或多个询问卷内分析对象，允许同时或时间相关的测量对象的属性。处理器可以解释对象的属性，然后测量然后将对象引导到多个下游流路径中的一个。在一些实施例中，对象的排序基于对象的两个或多个属性。可以重复排序过程以创建排序事件的网络。

33. 发明申请

US20120097832A1 ELECTROSPUN LIGHT-EMITTING FIBERS 有权
标题翻译： ELECTROSPUN发光纤维
公开(公告)号：US20120097832A1
公开(公告)日：2012-04-26
申请号：US13337977
申请日：2011-12-27
申请人： Jose M. Moran-Mirabal , Harold G. Craighead , George G. Malliaras , Hector D. Abruna , Jason D. Slinker
发明人： Jose M. Moran-Mirabal , Harold G. Craighead , George G. Malliaras , Hector D. Abruna , Jason D. Slinker
IPC分类号： G01J1/42 , H01B1/00 , H05B33/14 , D01F9/00 , B82Y30/00
CPC分类号： C09K11/06 , B82Y20/00 , C09K11/02 , C09K2211/1007 , C09K2211/1029 , C09K2211/185 , D01D5/0007 , D01F1/04 , D01F1/06 , G02B6/02033 , G02B6/107
摘要： The invention teaches electrospun light-emitting fibers made from ionic transition metal complexes (‘iTMCs”) such as [Ru(bpy)3]2+(PF6−)2]/PEO mixtures with dimensions in the 10.0 nm to 5.0 micron range and capable of highly localized light emission at low operating voltages such as 3-4 V with turn-on voltages approaching the band-gap limit of the organic semiconductor that may be used as point source light emitters on a chip.
摘要翻译：本发明教导了由离子过渡金属络合物（“iTMC”）例如[Ru（bpy）3] 2+（PF 6 - ）2] / PEO混合物制成的电纺丝发光纤维，其尺寸在10.0nm至5.0微米范围内，能够在诸如3-4V的低工作电压下具有高度局部化的发光，其接通电压接近可用作芯片上的点光源发光体的有机半导体的带隙极限。

34. 发明申请

US20120028811A1 DEVICE FOR RAPID IDENTIFICATION OF NUCLEIC ACIDS FOR BINDING TO SPECIFIC CHEMICAL TARGETS 审中-公开
标题翻译：用于快速鉴定用于结合特定化学目标的核酸的装置
公开(公告)号：US20120028811A1
公开(公告)日：2012-02-02
申请号：US13059223
申请日：2009-08-17
申请人： Harold G. Craighead , John T. Lis , Seungmin Park , So Youn Kim , Jiyoung Ahn , Minjoung Jo
发明人： Harold G. Craighead , John T. Lis , Seungmin Park , So Youn Kim , Jiyoung Ahn , Minjoung Jo
IPC分类号： C40B10/00 , C07H21/00 , B32B37/14 , G03F7/20 , B32B37/02 , C40B60/08 , C40B40/06
CPC分类号： C12Q1/6811 , B01L3/502707 , B01L3/502715 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2300/069 , B01L2300/0816 , B01L2300/0861 , B01L2300/0883 , B01L2300/1827 , B01L2400/0487 , C12Q1/686 , C12Q2525/205 , Y10T156/10 , C12Q2565/629 , C12Q2541/101
摘要： The present invention relates to microfluidic chips and their use in SELEX. The microfluidic chip preferably includes a reaction chamber that contains a high surface area material that contains target. One preferred high surface area material is a sol-gel derived material. Methods of making the microfluidic chips are described herein, as are uses of these devices to select aptamers against the target.
摘要翻译：本发明涉及微流控芯片及其在SELEX中的应用。微流体芯片优选包括含有包含靶的高表面积材料的反应室。一种优选的高表面积材料是溶胶 - 凝胶衍生材料。这里描述了制造微流体芯片的方法，以及这些装置用于选择针对靶的适体的方法。

35. 发明授权

US08049580B2 MEMS controlled oscillator 有权
标题翻译： MEMS控制振荡器
公开(公告)号：US08049580B2
公开(公告)日：2011-11-01
申请号：US12938126
申请日：2010-11-02
申请人： Robert B. Reichenbach , Keith Aubin , Maxim Zalalutdinov , Jeevak M. Parpia , Harold G. Craighead
发明人： Robert B. Reichenbach , Keith Aubin , Maxim Zalalutdinov , Jeevak M. Parpia , Harold G. Craighead
IPC分类号： H03H9/00 , H01P7/00
CPC分类号： H03H9/02401 , G01S7/032 , H01Q3/26 , H03H3/0072 , H03H9/2436
摘要： An array of micromechanical oscillators have different resonant frequencies based on their geometries. In one embodiment, a micromechanical oscillator has a resonant frequency defined by an effective spring constant that is modified by application of heat. In one embodiment, the oscillator is disc of material supported by a pillar of much smaller diameter than the disc. The periphery of the disc is heated to modify the resonant frequency (or equivalently the spring constant or stiffness) of the disc. Continuous control of the output phase and frequency may be achieved when the oscillator becomes synchronized with an imposed sinusoidal force of close frequency. The oscillator frequency can be detuned to produce an easily controlled phase differential between the injected signal and the oscillator feedback. A phased array radar may be produced using independent phase controllable oscillators.
摘要翻译：微机械振荡器阵列根据其几何形状具有不同的谐振频率。在一个实施例中，微机械振荡器具有由通过施加热来修改的有效弹簧常数限定的谐振频率。在一个实施例中，振荡器是由比该盘小得多的直径支柱支撑的材料盘。加热盘的周边以改变盘的共振频率（或等效地为弹簧常数或刚度）。当振荡器与施加的接近频率的正弦力同步时，可以实现输出相位和频率的连续控制。振荡器频率可以失谐，以在注入的信号和振荡器反馈之间产生容易控制的相位差。可以使用独立的相位可控振荡器来产生相控阵雷达。

36. 发明申请

US20110101475A1 CMOS INTEGRATED MICROMECHANICAL RESONATORS AND METHODS FOR FABRICATING THE SAME 有权
标题翻译： CMOS集成微机电谐振器及其制造方法
公开(公告)号：US20110101475A1
公开(公告)日：2011-05-05
申请号：US13000650
申请日：2009-06-26
申请人： Jeevak M. Parpia , Harold G. Craighead , Joshua D. Cross , Bojan Robert Ilic , Maxim K. Zalalutdinov , Jeffrey W. Baldwin , Brian H. Houston
发明人： Jeevak M. Parpia , Harold G. Craighead , Joshua D. Cross , Bojan Robert Ilic , Maxim K. Zalalutdinov , Jeffrey W. Baldwin , Brian H. Houston
IPC分类号： H01L29/84 , H01L21/77
CPC分类号： B81C1/00246 , B81B2201/0271 , Y10T29/49007
摘要： The present invention is directed to a CMOS integrated micromechanical device fabricated in accordance with a standard CMOS foundry fabrication process. The standard CMOS foundry fabrication process is characterized by a predetermined layer map and a predetermined set of fabrication rules. The device includes a semiconductor substrate formed or provided in accordance with the predetermined layer map and the predetermined set of fabrication rules. A MEMS resonator device is fabricated in accordance with the predetermined layer map and the predetermined set of fabrication rules. The MEMS resonator device includes a micromechanical resonator structure having a surface area greater than or equal to approximately 20 square microns. At least one CMOS circuit is coupled to the MEMS resonator member. The at least one CMOS circuit is also fabricated in accordance with the predetermined layer map and the predetermined set of fabrication rules.
摘要翻译：本发明涉及根据标准CMOS铸造制造工艺制造的CMOS集成微机械装置。标准CMOS铸造制造工艺的特征在于预定的层图和预定的制造规则集合。该器件包括根据预定层图形成或提供的半导体衬底以及预定的一组制造规则。根据预定层图和预定的制造规则集合制造MEMS谐振器装置。 MEMS谐振器装置包括具有大于或等于约20平方微米的表面积的微机械谐振器结构。至少一个CMOS电路耦合到MEMS谐振器构件。至少一个CMOS电路也是根据预定的层映射和预定的一组制造规则制造的。

37. 发明授权

US07843283B2 MEMS controlled oscillator 有权
标题翻译： MEMS控制振荡器
公开(公告)号：US07843283B2
公开(公告)日：2010-11-30
申请号：US11598097
申请日：2006-11-09
申请人： Robert B. Reichenbach , Keith Aubin , Maxim Zalalutdinov , Jeevak M. Parpia , Harold G. Craighead
发明人： Robert B. Reichenbach , Keith Aubin , Maxim Zalalutdinov , Jeevak M. Parpia , Harold G. Craighead
IPC分类号： H03H9/00 , H01P7/00
CPC分类号： H03H9/02401 , G01S7/032 , H01Q3/26 , H03H3/0072 , H03H9/2436
摘要： An array of micromechanical oscillators have different resonant frequencies based on their geometries. In one embodiment, a micromechanical oscillator has a resonant frequency defined by an effective spring constant that is modified by application of heat. In one embodiment, the oscillator is disc of material supported by a pillar of much smaller diameter than the disc. The periphery of the disc is heated to modify the resonant frequency (or equivalently the spring constant or stiffness) of the disc. Continuous control of the output phase and frequency may be achieved when the oscillator becomes synchronized with an imposed sinusoidal force of close frequency. The oscillator frequency can be detuned to produce an easily controlled phase differential between the injected signal and the oscillator feedback. A phased array radar may be produced using independent phase controllable oscillators.
摘要翻译：微机械振荡器阵列根据其几何形状具有不同的谐振频率。在一个实施例中，微机械振荡器具有由通过施加热来修改的有效弹簧常数限定的谐振频率。在一个实施例中，振荡器是由比该盘小得多的直径支柱支撑的材料盘。加热盘的周边以改变盘的共振频率（或等效地为弹簧常数或刚度）。当振荡器与施加的接近频率的正弦力同步时，可以实现输出相位和频率的连续控制。振荡器频率可以失谐，以在注入的信号和振荡器反馈之间产生容易控制的相位差。可以使用独立的相位可控振荡器来产生相控阵雷达。

38. 发明申请

US20090072728A1 ELECTROSPUN LIGHT-EMITTING FIBERS 有权
标题翻译： ELECTROSPUN发光纤维
公开(公告)号：US20090072728A1
公开(公告)日：2009-03-19
申请号：US12233340
申请日：2008-09-18
申请人： Jose M. Moran-Mirabal , Harold G. Craighead , George G. Malliaras , Hector D. Abruna , Jason D. Slinker
发明人： Jose M. Moran-Mirabal , Harold G. Craighead , George G. Malliaras , Hector D. Abruna , Jason D. Slinker
IPC分类号： H01J1/62 , B29D11/00
CPC分类号： C09K11/06 , B82Y20/00 , C09K11/02 , C09K2211/1007 , C09K2211/1029 , C09K2211/185 , D01D5/0007 , D01F1/04 , D01F1/06 , G02B6/02033 , G02B6/107
摘要： The invention teaches electrospun light-emitting fibers made from ionic transition metal complexes (“iTMCs”) such as [Ru(bpy)3]2+(PF6.)2]/PEO mixtures with dimensions in the 10.0 nm to 5.0 micron range and capable of highly localized light emission at low operating voltages such as 3-4 V with turn-on voltages approaching the band-gap limit of the organic semiconductor that may be used as point source light emitters on a chip.
摘要翻译：本发明教导了由离子过渡金属络合物（“iTMC”）例如[Ru（bpy）3] 2+（PF 6）2] / PEO混合物制成的电纺丝发光纤维，其尺寸在10.0nm至5.0μm的范围内，能够在诸如3-4V的低工作电压下具有高度局部化的发光，其接通电压接近可用作芯片上的点光源发光体的有机半导体的带隙极限。

39. 发明授权

US07267797B1 Nanofabricated photon tunneling based sensor 有权
标题翻译：基于纳米光子隧道的传感器
公开(公告)号：US07267797B1
公开(公告)日：2007-09-11
申请号：US10010939
申请日：2001-11-07
申请人： Harold G. Craighead , Jun Kameoka
发明人： Harold G. Craighead , Jun Kameoka
IPC分类号： B32B5/02 , B32B27/04 , B32B27/12 , G01N21/00 , G01N15/06
CPC分类号： G01N21/4133 , G01N21/0303 , G01N2021/0346 , Y10S977/834 , Y10S977/92 , Y10S977/953 , Y10S977/957 , Y10S977/958 , Y10T436/11
摘要： A system and method for detecting changes in the refractive index of a fluid in a small test volume. A change in the refractive index can indicate a change in the chemical composition of the fluid. The test volume has a depth comparable to or less than the wavelength of incident light. In one embodiment, an internal surface of the volume is coated with a binding partner selected to bind with a targeted molecule. When the targeted molecule binds to the binding partner, the optical properties of the system change. The refractive index is determined by illuminating the test volume with laser light and measuring transmitted or reflected light.
摘要翻译：用于检测小测试体积中的流体的折射率变化的系统和方法。折射率的变化可以指示流体的化学组成的变化。测试体积具有与入射光的波长相当或更小的深度。在一个实施方案中，体积的内表面被选择与靶向分子结合的结合配偶体包被。当目标分子与结合配偶体结合时，系统的光学性质发生变化。折射率通过用激光照射测试体积并测量透射或反射光来确定。

40. 发明授权

US06438279B1 Unitary microcapiliary and waveguide structure and method of fabrication 有权
标题翻译：单体微毛细管和波导结构及其制造方法
公开(公告)号：US06438279B1
公开(公告)日：2002-08-20
申请号：US09448413
申请日：1999-11-23
申请人： Harold G. Craighead , Mathieu E. Foquet , Warren Wright
发明人： Harold G. Craighead , Mathieu E. Foquet , Warren Wright
IPC分类号： G02B610
CPC分类号： G01N21/0303 , B01L3/5027 , G01N2021/0346 , G01N2021/058 , G02B6/10 , G02B6/136 , G02B2006/12173 , G02B2006/12176
摘要： Fabrication techniques for forming arbitrarily shaped fluid capillaries at dimensions below 1 &mgr;m and for forming optical waveguides in the same devices with the same fabrication processes include methods to make integral optical waveguide/fluid-flow systems for greater miniaturization, integration and parallelism of optical excitation and detection systems for the sampling of small volumes. Capillaries with widths below 1 &mgr;m dimensions are fabricated using photolithography and reactive ion etching on glass substrates or by provision of a sacrificial layer, having the configuration desired for a microchannel, covered by a high refractive index material in which a waveguide is formed. Removal of the sacrificial layer produces a microchannel aligned with the waveguide. Dye labeled DNA molecules are driven electrophoretically through the micrometer size channels light emission from and individual molecules can be observed.
摘要翻译：用于形成尺寸小于1um的任意形状的流体毛细管和用于在相同装置中用相同制造工艺形成光波导的制造技术包括制造用于光学激发的更小的化，集成和并行化的集成光波导/流体流动系统的方法，以及用于小体积取样的检测系统。宽度小于1um的尺寸的毛细管使用在玻璃基板上的光刻和反应离子蚀刻来制造，或通过提供具有由形成波导的高折射率材料覆盖的微通道所需的构造的牺牲层制造。去除牺牲层产生与波导对准的微通道。染料标记的DNA分子通过微米尺寸通道电泳驱动，可以观察到来自各个分子的光发射。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式