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31. 发明申请

US20090318899A1 METHOD AND DEVICE FOR LIPOSUCTION 审中-公开
标题翻译：用于排泄的方法和装置
公开(公告)号：US20090318899A1
公开(公告)日：2009-12-24
申请号：US12338941
申请日：2008-12-18
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61M1/00
CPC分类号： A61M1/0084 , A61B17/3203 , A61M1/0058 , A61M2202/08
摘要： Systems and methods for liposuction are disclosed that use a lipid-emulsifying fluid to produce fluid jet disruption and Venturi pumping of fat tissue. The device includes a flexible or rigid probe with an inlet lumen and an outlet lumen. The inlet lumen is in fluid communication with a pump capable of producing high pressures, e.g., 250-3500 psi. The pump is in fluid communication with a volume of a liquid such as sterile saline that may or may not contain a fat emulsifier. At the end of the inlet lumen is a conical constriction or a port that accelerates the emulsification fluid to high velocities. The high velocity jet stream creates a low pressure area that draws the fat tissue into proximity with the jet stream. The jet stream directly and through turbulent vortices breaks up the fat cells. The lipid of the fat cells is subsequently emulsified by the emulsification fluid.
摘要翻译：公开了用于吸脂的系统和方法，其使用脂质 - 乳化液来产生流体喷射干扰和文丘里泵送脂肪组织。该装置包括具有入口腔和出口腔的柔性或刚性探针。入口腔与能够产生高压（例如250-3500psi）的泵流体连通。泵与一定体积的液体流体连通，例如无菌盐水，其可以含有或不含有脂肪乳化剂。在入口管腔的末端是锥形收缩或将乳化液加速到高速度的端口。高速喷射流产生低压区域，其将脂肪组织吸引到喷射流附近。喷射流直接和通过湍流涡流分解脂肪细胞。脂肪细胞的脂质随后被乳化液乳化。

32. 发明申请

US20080300585A1 Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation 有权
标题翻译：用于进行冷冻或低温治疗的方法和装置，例如血管成形术，减少再狭窄或肺静脉细胞坏死以抑制心房颤动
公开(公告)号：US20080300585A1
公开(公告)日：2008-12-04
申请号：US11978888
申请日：2007-10-30
申请人： John D. Dobak, III , Hans W. Kramer , Steven A. Yon
发明人： John D. Dobak, III , Hans W. Kramer , Steven A. Yon
IPC分类号： A61B18/02
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/22002 , A61B2017/22054 , A61B2018/00023 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/126
摘要： The present invention provides an enhanced method and device to inhibit or reduce the rate of restenosis following angioplasty or stent placement. The invention involves placing a balloon tipped catheter in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place from a balloon angioplasty. A fluid such as a perfluorocarbon may be flowed into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. The catheter may also be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium.
摘要翻译：本发明提供了抑制或降低血管成形术或支架放置后再狭窄发生率的增强方法和装置。本发明涉及将气囊顶端的导管放置在血管成形术后立即通过球囊血管成形术处理或打开的区域中。可以具有双气囊结构的气囊可以通过引导导管并且已经从球囊血管成形术已经就位的导线传送。诸如全氟化碳的流体可以流入气囊中以冷冻邻近球囊的组织，这种冷却与再狭窄的减少有关。导管还可用于通过插入和充气气囊来减少心房颤动，使得球囊的外表面与邻近左心房的肺静脉部分的至少部分圆周接触。

33. 发明授权

US07211106B2 Selective organ cooling apparatus and method 有权
公开(公告)号：US07211106B2
公开(公告)日：2007-05-01
申请号：US10763542
申请日：2004-01-23
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F7/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： An endovascular heat transfer device which can have a smooth exterior surface, or a surface with ridges and grooves. The device can have a plurality of elongated, articulated segments, with each having such a surface. A flexible joint connects adjacent elongated, articulated segments. The flexible joints can be bellows or flexible tubes. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.

34. 发明授权

US07101386B2 Patient temperature regulation method and apparatus 失效
公开(公告)号：US07101386B2
公开(公告)日：2006-09-05
申请号：US10219735
申请日：2002-08-15
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61F7/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61B2018/0262 , A61F7/12 , A61F2007/0056 , A61F2007/126
摘要： A device and method for providing body cooling. The cooling device applies cooling to blood flowing in a vena cavae that is then distributed throughout the body. The cooling can be assisted by use of thermoregulatory drugs or warming devices to prevent shivering and vasoconstriction.

35. 发明授权

US06887262B2 Selective organ cooling apparatus and method 有权
标题翻译：选择性器官冷却装置及方法
公开(公告)号：US06887262B2
公开(公告)日：2005-05-03
申请号：US10251124
申请日：2002-09-19
申请人： John D. Dobak, III , Juan C. Lasheras
发明人： John D. Dobak, III , Juan C. Lasheras
IPC分类号： A61B17/00 , A61B18/02 , A61F7/00 , A61F7/12 , A61M25/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： A selective organ heat transfer device with deep irregularities in a turbulence-inducing exterior surface. The device can have a plurality of elongated, articulated segments, each having a turbulence-inducing exterior surface. A flexible joint connects adjacent elongated, articulated segments. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.
摘要翻译：湍流诱导外表面具有深度不规则的选择性器官传热装置。该装置可以具有多个细长的关节节段，每个节段具有引起湍流的外表面。柔性接头连接相邻的细长铰接段。内腔设置在传热段内。内腔能够将加压的工作流体输送到传热元件的远端。

36. 发明授权

US06869440B2 Method and apparatus for patient temperature control employing administration of anti-shivering agents 有权
公开(公告)号：US06869440B2
公开(公告)日：2005-03-22
申请号：US10216405
申请日：2002-08-09
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61F7/00 , A61F7/02 , A61F7/12 , A61M25/00
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0056 , A61F2007/0288 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： Embodiments of the invention provide a system for temperature control of the human body. The system includes an indwelling catheter with a tip-mounted heat transfer element. The catheter is fluidically coupled to a console that provides a heated or cooled heat transfer working fluid to exchange heat with the heat transfer element, thereby heating or cooling blood. The heated or cooled blood then heats or cools the patient's body or a selected portion thereof. In particular, strategies for providing cooling while reducing shivering are disclosed, including administration of various drugs and drug combinations.

37. 发明授权

US06843800B1 Patient temperature regulation method and apparatus 失效
标题翻译：患者温度调节方法和装置
公开(公告)号：US06843800B1
公开(公告)日：2005-01-18
申请号：US09373112
申请日：1999-08-11
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61F7/08 , A61B17/00 , A61B18/02 , A61F7/00 , A61F7/12 , A61K31/05 , A61K31/4168 , A61K31/4174 , A61K31/451 , A61K33/06 , A61M1/36 , A61P43/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61B2018/0262 , A61F7/12 , A61F2007/0056 , A61F2007/126
摘要： A device and method for providing body cooling. The cooling device applies cooling to blood flowing in a vena cavae that is then distributed throughout the body. The cooling can be assisted by use of thermoregulatory drugs or warming devices to prevent shivering and vasoconstriction.
摘要翻译：一种用于提供身体冷却的装置和方法。冷却装置对流过腔静脉的血液进行冷却，然后分布在整个身体内。冷却可以通过使用调温药物或加温装置来辅助，以防止发抖和血管收缩。

38. 发明授权

US06695873B2 Inflatable catheter for selective organ heating and cooling and method of using the same 有权
公开(公告)号：US06695873B2
公开(公告)日：2004-02-24
申请号：US10095753
申请日：2002-03-11
申请人： John D. Dobak, III , Juan C. Lasheras
发明人： John D. Dobak, III , Juan C. Lasheras
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/00292 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126
摘要： A catheter system and method are provided which change the temperature of a fluid, such as blood, by heat transfer. Selective cooling or heating of an organ may be performed by changing the temperature of the blood feeding the organ. The catheter system includes an inlet lumen and an outlet lumen structured and arranged to carry a working fluid having a temperature different from the adjacent blood. The outlet lumen is configured to induce turbulence in the adjacent fluid passing adjacent the outlet lumen.

39. 发明授权

US06679907B2 Method and device for applications of selective organ cooling 有权
标题翻译：选择性器官冷却应用的方法和装置
公开(公告)号：US06679907B2
公开(公告)日：2004-01-20
申请号：US10210819
申请日：2002-07-31
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126
摘要： The invention provides a method and device for heating or cooling a surrounding fluid in a feeding vessel. The device includes a catheter assembly capable of insertion to a selected feeding vessel in the vascular system of a patient. The assembly includes a heat transfer element at a distal end of the catheter assembly, the heat transfer element having a plurality of exterior surface irregularities shaped and arranged to create turbulence in a surrounding fluid, the surface irregularities having a depth at least equal to the boundary layer thickness of flow of the surrounding fluid in the feeding vessel. The assembly also includes a supply catheter to deliver a working fluid to an interior of the heat transfer element, a return catheter to return a working fluid from the interior of the heat transfer element, and a drug delivery catheter running substantially parallel to the axis of the catheter assembly. The method includes selectively controlling the temperature of a selected volume of blood in a patient by introducing a catheter assembly into a blood vessel feeding a selected volume of blood in a patient and delivering a working fluid through a supply catheter in the catheter assembly and returning the working fluid through a return catheter in the catheter assembly. Heat is transferred between a heat transfer element forming a distal end of the catheter assembly and the volume of blood in the feeding vessel. A liquid, such as a drug, is delivered through a drug delivery catheter to the volume of blood in the feeding vessel.
摘要翻译：本发明提供一种用于加热或冷却进料容器中的周围流体的方法和装置。该装置包括能够插入患者血管系统中的选定进料容器的导管组件。所述组件包括在所述导管组件的远端处的传热元件，所述传热元件具有多个外表面凹凸，其形状和布置成在周围流体中产生湍流，所述表面凹凸具有至少等于边界的深度进料容器中周围流体的流动层厚度。该组件还包括供应导管，用于将工作流体输送到传热元件的内部;返回导管，用于从工作流体从传热元件的内部返回;以及药物输送导管，其基本上平行于导管组件。该方法包括通过将导管组件引入供给患者中选定体积的血液的血管中并通过导管组件中的供应导管输送工作流体来选择性地控制患者中所选体积的血液的温度，工作流体通过导管组件中的返回导管。在形成导管组件的远端的传热元件和进料容器中的血液体积之间传递热量。诸如药物的液体通过药物输送导管递送到进料容器中的血液体积。

40. 发明授权

US06648908B2 Inflatable catheter for selective organ heating and cooling and method of using the same 有权
公开(公告)号：US06648908B2
公开(公告)日：2003-11-18
申请号：US10096294
申请日：2002-03-11
申请人： John D. Dobak, III , Juan C. Lasheras
发明人： John D. Dobak, III , Juan C. Lasheras
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/00292 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126
摘要： A catheter system and method are provided which change the temperature of a fluid, such as blood, by heat transfer. Selective cooling or heating of an organ may be performed by changing the temperature of the blood feeding the organ. The catheter system includes an inlet lumen and an outlet lumen structured and arranged to carry a working fluid having a temperature different from the adjacent blood. The outlet lumen is configured to induce turbulence in the adjacent fluid passing adjacent the outlet lumen.

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