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31. 发明授权

US07740877B2 Aliphatically modified biodegradable block copolymers as thermogelling polymers 有权
标题翻译：脂肪族改性的生物可降解嵌段共聚物作为热凝胶聚合物
公开(公告)号：US07740877B2
公开(公告)日：2010-06-22
申请号：US11784528
申请日：2007-04-06
申请人： Sung Wan Kim , Seongbong Jo , Jin Kim
发明人： Sung Wan Kim , Seongbong Jo , Jin Kim
IPC分类号： A61F2/02 , C08G63/08
CPC分类号： C08L67/04 , A61K9/0024 , A61K9/06 , A61K47/34 , C08G63/664
摘要： A thermogelling, aliphatically modified polymer for use in drug delivery is described. Illustrative embodiments include poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) hexanoate and poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) laurate. Another illustrative embodiment includes a composition having a thermogelling amount of an aliphatically modified poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) and an effective amount of a drug. The thermogelling polymers are made by bonding an aliphatic group to poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone). A method of use includes injecting a warm-blooded individual with a thermogelling amount of the aliphatically modified polymer and a drug.
摘要翻译：描述了用于药物递送的耐热凝胶，脂质改性聚合物。说明性实施方案包括聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）己酸酯和聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）月桂酸酯。另一个说明性实施方案包括具有热凝胶量的脂族改性聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）和有效量的药物。热胶凝聚合物通过将脂族基团与聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）结合而制备。一种使用方法包括用热胶凝量的脂质改性聚合物和药物注射温血个体。

32. 发明申请

US20100010067A1 ARGININE-CONJUGATED BIOREDUCIBLE POLY(DISULFIDE AMINE) POLYMERS FOR GENE DELIVERY SYSTEM 有权
标题翻译：用于基因输送系统的ARGININE-CONJUGATED BIOREDUCIBLE POLY（DISANCED AMINE）POLYMERS FOR GENE DELIVERY SYSTEM
公开(公告)号：US20100010067A1
公开(公告)日：2010-01-14
申请号：US12496568
申请日：2009-07-01
申请人： Sun Hwa Kim , Ji Hoon Jeong , Tae-il Kim , Sung Wan Kim , David A. Bull
发明人： Sun Hwa Kim , Ji Hoon Jeong , Tae-il Kim , Sung Wan Kim , David A. Bull
IPC分类号： A61K48/00 , C08G75/14 , C12N15/09
CPC分类号： A61K9/5146 , A61K47/34 , A61K47/59 , A61K47/595 , A61K47/6455 , A61K48/0041 , C12N15/111 , C12N2320/32
摘要： An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with siRNA. ABP is biodegraded under reducing conditions, such as in the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity. ABP is an effective delivery vehicle for gene silencing with siRNA and may be used for treating cancer.
摘要翻译：描述了精氨酸接枝的可生物还原的聚（二硫化胺）（“ABP”）作为有效和无毒的基因递送的试剂。 ABP用siRNA形成小于200nm的带正电荷的纳米颗粒。 ABP在还原条件下如细胞质中生物降解。与哺乳动物细胞中的聚乙烯亚胺相比，ABP的转染效率高得多，不显示细胞毒性。 ABP是用于siRNA基因沉默的有效递送载体，可用于治疗癌症。

33. 发明申请

US20090130752A1 BIODEGRADABLE POLY(DISULFIDE AMINE)S FOR GENE DELIVERY 审中-公开
标题翻译：生物可降解聚（氨基磺酸）S用于基因交付
公开(公告)号：US20090130752A1
公开(公告)日：2009-05-21
申请号：US12267015
申请日：2008-11-07
申请人： Sung Wan Kim , Mei Ou
发明人： Sung Wan Kim , Mei Ou
IPC分类号： C12N15/00 , C07C233/00 , C07H21/00 , C12N15/63 , C07H21/02
CPC分类号： C07C323/41 , C07H21/00 , C07H21/02 , C12N15/87
摘要： Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(CBA-DAE), poly(CBA-DAB), and poly(CBA-DAH). These compositions are made by Michael addition between N,N′-cystaminebisacrylamide and N-Boc-protected diamine monomers, followed by N-Boc deprotection. Complexes are formed by mixing the poly(disulfide amine)s with nucleic acid. Delivery of the nucleic acid into cells is carried out by contacting the cells with the nucleic acid/poly(disulfide amine) complexes.
摘要翻译：描述了聚（二硫化物胺），制备方法和使用方法。聚（二硫化物胺）的说明性实施方案包括聚（CBA-DAE），聚（CBA-DAB）和聚（CBA-DAH）。这些组合物是通过在N，N-半胱氨酸二亚甲基丙烯酰胺和N-Boc-保护的二胺单体之间加入Michael，然后进行N-Boc去保护来制备的。通过将聚（二硫化物胺）与核酸混合形成络合物。通过使细胞与核酸/聚（二硫化物胺）络合物接触来进行将细胞递送到细胞中。

34. 发明授权

US5853723A Targeting of peg antibody conjugates to islet cells 失效
标题翻译：将peg抗体缀合物靶向胰岛细胞
公开(公告)号：US5853723A
公开(公告)日：1998-12-29
申请号：US710653
申请日：1996-09-20
申请人： Harvey Jacobs , Sung Wan Kim , Virginie Menard
发明人： Harvey Jacobs , Sung Wan Kim , Virginie Menard
IPC分类号： A61K39/395 , A61K31/00 , A61K38/00 , A61K39/44 , A61K47/48 , A61P3/00 , A61P3/10 , C07K16/40 , A61K47/00
CPC分类号： A61K47/48215 , A61K39/44 , A61K47/48646 , C07K16/40 , A61K38/00 , C07K2317/55
摘要： A method for delaying onset of insulin dependent diabetes mellitus (IDDM) in an individual predisposed to developing the disease is disclosed. The method comprises administering a composition comprising an immunologically effective monoclonal antibody or fragment thereof against glutamic acid decarboxylase (GAD) coupled to a nonimmunogenic hydrophilic polymer that provides a hydration shell around the monoclonal antibody for inhibiting immune recognition thereof. Poly(ethylene glycol) is a preferred polymer. A method of reducing insulitis in an IDDM patient and a composition therefor are also described.
摘要翻译：公开了一种在发生该疾病的个体中延缓胰岛素依赖性糖尿病（IDDM）发病的方法。该方法包括施用包含免疫有效的单克隆抗体或其片段的组合物，其抗体与非免疫原性亲水性聚合物偶联的谷氨酸脱羧酶（GAD），所述非免疫原性亲水性聚合物在单克隆抗体周围提供水合壳以抑制其免疫识别。聚（乙二醇）是优选的聚合物。还描述了减少IDDM患者的胰岛炎的方法及其组合物。

35. 发明授权

US5679559A Cationic polymer and lipoprotein-containing system for gene delivery 失效
标题翻译：阳离子聚合物和含脂蛋白的系统用于基因递送
公开(公告)号：US5679559A
公开(公告)日：1997-10-21
申请号：US675120
申请日：1996-07-03
申请人： Jin-Seok Kim , Atsushi Maruyama , Toshihiro Akaike , Sung Wan Kim
发明人： Jin-Seok Kim , Atsushi Maruyama , Toshihiro Akaike , Sung Wan Kim
IPC分类号： C12N15/09 , A61K38/00 , A61K47/48 , C08L89/00 , C12N15/113 , C12N15/64 , C12N15/87 , C12N15/88
CPC分类号： C12N15/1135 , A61K47/48315 , A61K47/48838 , C12N15/87 , A61K38/00 , C12N2310/3513 , Y10T428/2984
摘要： A composition for delivery of a selected nucleic acid into a targeted host cell comprises a complex of a hydrophobized, positively charged, biocompatible polymer; a lipoprotein; and a selected nucleic acid. Hydrophobic and electrostatic interactions between the components provide for the formation of the condensed DNA-containing complex. Preferred embodiments of the complex have a slightly positive surface charge and an average diameter of about 200 nm. Plasmids and oligonucleotides can be efficiently delivered with such compositions. A method of delivering a selected nucleic acid to a host cell is also disclosed.
摘要翻译：用于将选择的核酸递送至靶宿主细胞的组合物包含疏水化，带正电荷的生物相容性聚合物的复合物; 脂蛋白和选择的核酸。组分之间的疏水和静电相互作用提供了形成含缩合DNA的复合物。络合物的优选实施方案具有略微正的表面电荷和约200nm的平均直径。可以用这样的组合物有效地递送质粒和寡核苷酸。还公开了将选择的核酸递送至宿主细胞的方法。

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