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31. 发明授权

US08057788B2 Placental stem cell populations 有权
标题翻译：胎盘干细胞群体
公开(公告)号：US08057788B2
公开(公告)日：2011-11-15
申请号：US11648813
申请日：2006-12-28
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： A01N63/00 , C12N5/00
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N5/0607 , C12N2500/25 , C12N2500/36 , C12N2500/42 , C12N2501/11 , C12N2501/135 , C12N2501/39 , C12N2533/52 , A61K2300/00
摘要： The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
摘要翻译：本发明提供胎盘干细胞和胎盘干细胞群体，以及培养，增殖和扩增胎盘干细胞的方法。本发明还提供了分离胎盘干细胞的方法。本发明还提供了在测定和移植中使用胎盘干细胞的方法。

32. 发明授权

US07943123B2 Placental stem cell populations 有权
公开(公告)号：US07943123B2
公开(公告)日：2011-05-17
申请号：US11648813
申请日：2006-12-28
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： A01N63/00 , C12N5/00
摘要： The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.

33. 发明申请

US20090226406A1 MODULATION OF STEM AND PROGENITOR CELL DIFFERENTIATION, ASSAYS, AND USES THEREOF 有权
标题翻译：干扰素和前体细胞分化的调节，其测定及其用途
公开(公告)号：US20090226406A1
公开(公告)日：2009-09-10
申请号：US12396397
申请日：2009-03-02
申请人： Robert J. Hariri , David I. Stirling , Laure A. Moutouth-De Parseval , Kyle W.H. Chan
发明人： Robert J. Hariri , David I. Stirling , Laure A. Moutouth-De Parseval , Kyle W.H. Chan
IPC分类号： A61K35/12 , A61P43/00
CPC分类号： A61K31/454 , A61K2035/124 , C12N5/0639 , C12N5/0642 , C12N5/0647 , C12N2501/125 , C12N2501/14 , C12N2501/22 , C12N2501/23 , C12N2501/25 , C12N2501/385 , C12N2501/70 , C12N2506/02
摘要： The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.
摘要翻译：本发明涉及调节哺乳动物干细胞和祖细胞分化的方法。本发明的方法可用于调节和控制特定细胞和组织谱系中哺乳动物，特别是人干细胞的分化和成熟。本发明的方法涉及某些小有机分子在特定细胞和组织谱系中调节干细胞或祖细胞群的分化的用途，特别是涉及来源于产后胎盘的胚胎样干细胞的分化或用于将早期祖细胞分化成粒细胞谱系。最后，本发明涉及这种分化的干细胞或祖细胞在移植和其他医学治疗中的用途。

34. 发明授权

US07311904B2 Tissue matrices comprising placental stem cells, and methods of making the same 有权
标题翻译：包含胎盘干细胞的组织基质及其制备方法
公开(公告)号：US07311904B2
公开(公告)日：2007-12-25
申请号：US10074976
申请日：2002-02-13
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： A01N63/00
CPC分类号： A61K35/50 , A61K35/12 , A61L27/3695 , A61L27/3834 , A61L2430/34 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12N5/0068 , C12N5/0605 , C12N5/0606 , C12N5/0663 , C12N5/0678 , C12N2509/00 , C12N2513/00 , C12N2533/90
摘要： A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove residual cord blood and seeding the collected stem cells onto or into a tissue matrix. The seeded tissue matrix is then implanted on or into a patient. The seeded tissue matrix made by the method of the present invention is also disclosed.
摘要翻译：公开了一种制造用于植入患者的组织基质的方法。该方法阐述了从胎盘收集胚胎干细胞，其已被处理以除去残留的脐带血，并将收集的干细胞接种到组织基质上或组织基质上。然后将接种的组织基质植入患者体内或进入患者体内。还公开了通过本发明的方法制备的接种的组织基质。

35. 发明授权

US4784638A Angled hole ventricular catheter and method of making same 失效
标题翻译：角孔心室导管及其制作方法
公开(公告)号：US4784638A
公开(公告)日：1988-11-15
申请号：US98097
申请日：1987-09-17
申请人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali G. Ghadjar
发明人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali G. Ghadjar
IPC分类号： A61M25/00 , A61M31/00
CPC分类号： A61M25/0015 , A61M25/007
摘要： A catheter for placement into the ventricular system of the brain of a subject comprising a flexible elongated body having a wall thickness sufficient to contain and transport fluid therein and having a forward end and tip for insertion into the ventricular system of the brain of a subject; and a plurality of spaced apertures located in the forward end of the body spaced from the tip, each of the apertures extending through the wall thickness at an angle such that a portion of the wall thickness is visible when viewing the aperture perpendicular to the longitudinal axis of the body, thereby to minimize abrasion of brain tissue upon insertion of the catheter and to prevent choroid plexus and ependymal tissue from growing into the catheter apertures, thereby providing improved flow of fluid into or from said ventricular system. Also, methods of using and apparatus for making such catheters are disclosed herein.
摘要翻译：一种用于放置到受试者的脑的心室系统中的导管，包括具有足以容纳和输送流体的壁厚的柔性细长主体，并且具有用于插入受试者脑部的心室系统的前端和尖端; 以及多个间隔开的孔，位于主体的与尖端间隔开的前端中，每个孔以一定角度延伸穿过壁厚，使得当观察垂直于纵向轴线的孔时壁厚的一部分是可见的从而在插入导管时最小化脑组织的磨损并且防止脉络丛和室管膜组织生长到导管孔中，由此提供流体进入或离开所述心室系统的改善的流动。此外，本文公开了使用方法和制造这种导管的装置。

36. 发明申请

US20150044177A1 TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS USING PLACENTAL STEM CELLS 有权
标题翻译：使用PLACENTAL STEM细胞治疗多发性横纹肌肉瘤
公开(公告)号：US20150044177A1
公开(公告)日：2015-02-12
申请号：US14343283
申请日：2012-09-10
申请人： Robert J. Hariri , Jodi P. Gurney
发明人： Robert J. Hariri , Jodi P. Gurney
IPC分类号： A61K35/50 , A61K45/06
CPC分类号： A61K35/50 , A61K45/06
摘要： Provided herein are methods of treatment of an individual having amyotrophic lateral sclerosis, comprising administering to the individual a therapeutically effective amount of placental stem cells, e.g., tissue culture surface-adherent placental stem cells (PDACs). In one aspect, provided herein is a method of treating amyotrophic lateral sclerosis (ALS) comprising administering to an individual having ALS a therapeutically effective amount of placental stem cells. In certain embodiments, “therapeutically effective” means an amount effective to reduce or ameliorate one or more symptoms of ALS.
摘要翻译：本文提供治疗患有肌萎缩性侧索硬化症的个体的方法，其包括向个体施用治疗有效量的胎盘干细胞，例如组织培养物表面粘附性胎盘干细胞（PDAC）。一方面，本文提供的是治疗肌萎缩性侧索硬化（ALS）的方法，其包括对具有治疗有效量的胎盘干细胞的具有ALS的个体施用。在某些实施方案中，“治疗有效”是指有效减少或改善一种或多种ALS症状的量。

37. 发明授权

US08895256B2 Immunomodulation using placental stem cells 有权
标题翻译：使用胎盘干细胞进行免疫调节
公开(公告)号：US08895256B2
公开(公告)日：2014-11-25
申请号：US13474378
申请日：2012-05-17
申请人： Casper Paludan , James Edinger , Ryhor Harbacheuski , RoseAnn Murray , Robert J. Hariri
发明人： Casper Paludan , James Edinger , Ryhor Harbacheuski , RoseAnn Murray , Robert J. Hariri
IPC分类号： A61K35/50 , C12N5/073 , C12N5/0775
CPC分类号： A61K35/50 , C12N5/0605 , C12N5/0668 , C12N2502/11
摘要： The present invention provides methods of immunomodulation using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on the basis of immunomodulation, and compositions comprising such cells and cell populations.
摘要翻译：本发明提供使用胎盘干细胞和胎盘干细胞群进行免疫调节的方法。本发明还提供了在免疫调节的基础上产生和选择胎盘细胞和细胞群的方法，以及包含这种细胞和细胞群的组合物。

38. 发明申请

US20140072538A1 TREATMENT OF RADIATION INJURY USING AMNION DERIVED ADHERENT CELLS 审中-公开
标题翻译：使用AMNION衍生的附加细胞治疗辐射损伤
公开(公告)号：US20140072538A1
公开(公告)日：2014-03-13
申请号：US13940920
申请日：2013-07-12
申请人： Aleksandar Francki , Ajai Pal , Robert J. Hariri , Vladimir Jankovic
发明人： Aleksandar Francki , Ajai Pal , Robert J. Hariri , Vladimir Jankovic
IPC分类号： A61K35/50
CPC分类号： A61K35/50
摘要： Provided herein are methods of treating individuals having suffered exposure to radiation, e.g., individuals having radiation injury, by administering to the individuals angiogenic cells from amnion, referred to as amnion derived adherent cells, or populations of, and compositions comprising, such cells.
摘要翻译：本文提供了通过对来自羊膜的称为羊膜来源的贴壁细胞的血管生成细胞或包含这些细胞的组合物以及包含这些细胞的组合物的个体进行治疗而暴露于辐射的个体，例如具有放射线损伤的个体的方法。

39. 发明授权

US08263065B2 Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells 有权
标题翻译：使用人胎盘灌注液和人胎盘来源的中间体天然杀伤细胞进行肿瘤抑制
公开(公告)号：US08263065B2
公开(公告)日：2012-09-11
申请号：US12240956
申请日：2008-09-29
申请人： Robert J. Hariri , Mohammad A. Heidaran , Lin Kang , Neerav Dilip Padliya , Ajai Pal , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
发明人： Robert J. Hariri , Mohammad A. Heidaran , Lin Kang , Neerav Dilip Padliya , Ajai Pal , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
IPC分类号： A01N63/00
CPC分类号： A61K35/17 , A61K35/50 , A61K45/06 , A61K2035/124 , C12N5/0646
摘要： Provided herein are placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells.
摘要翻译：本文提供胎盘灌洗液，胎盘灌洗液细胞和胎盘衍生的中间天然杀伤细胞及其组合。本文还提供了包含其的组合物，以及使用胎盘灌注液，胎盘灌洗液细胞和胎盘来源的中间体天然杀伤细胞及其组合的方法来抑制肿瘤细胞，癌细胞等的生长或增殖，并治疗患有肿瘤细胞的个体。

40. 发明授权

US07928280B2 Treatment of leg ulcers using placenta derived collagen biofabric 有权
标题翻译：使用胎盘衍生的胶原生物制剂治疗腿部溃疡
公开(公告)号：US07928280B2
公开(公告)日：2011-04-19
申请号：US11485840
申请日：2006-07-12
申请人： Robert J. Hariri , Janice M. Smiell
发明人： Robert J. Hariri , Janice M. Smiell
IPC分类号： A61F13/00
CPC分类号： A61L15/40 , A61F13/069 , A61F15/001 , A61F2013/0054 , A61F2013/00548 , A61F2013/0091 , A61F2013/00927 , A61K31/728 , A61K38/1841 , A61K38/1858 , A61K38/2292 , A61K38/363 , A61K38/39 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L26/0033 , A61L26/0057 , A61L27/3604 , A61L27/60 , A61L31/005 , A61L2300/252 , A61L2300/414 , A61L2430/34 , A61L2430/40 , Y10T428/249921 , A61K2300/00
摘要： The present invention provides a method of treating a leg ulcer comprising contacting the leg ulcer with a collagen biofabric. The leg ulcer may be a venous, arterial, diabetic or decubitus (pressure) ulcer. The invention further provides kits comprising one or more pieces of collagen biofabric for the treatment of a leg ulcer.
摘要翻译：本发明提供一种治疗腿部溃疡的方法，包括使腿部溃疡与胶原蛋白生物纤维接触。腿部溃疡可能是静脉，动脉，糖尿病或褥疮（压力）溃疡。本发明还提供了包含一种或多种用于治疗腿部溃疡的胶原生物制品的试剂盒。

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