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1. 发明授权

US09216200B2 Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells 有权
标题翻译：使用人胎盘灌注液和人胎盘来源的中间体天然杀伤细胞进行肿瘤抑制
公开(公告)号：US09216200B2
公开(公告)日：2015-12-22
申请号：US13584612
申请日：2012-08-13
申请人： Robert J. Hariri , Mohammad A. Heidaran , Lin Kang , Neerav Dilip Padliya , Ajai Pal , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
发明人： Robert J. Hariri , Mohammad A. Heidaran , Lin Kang , Neerav Dilip Padliya , Ajai Pal , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
IPC分类号： A01N63/00 , A61K35/17 , A61K35/50 , C12N5/0783 , A61K35/12
CPC分类号： A61K35/17 , A61K35/50 , A61K45/06 , A61K2035/124 , C12N5/0646
摘要： Provided herein are placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells.
摘要翻译：本文提供胎盘灌洗液，胎盘灌洗液细胞和胎盘衍生的中间天然杀伤细胞及其组合。本文还提供了包含其的组合物，以及使用胎盘灌注液，胎盘灌洗液细胞和胎盘来源的中间体天然杀伤细胞及其组合的方法来抑制肿瘤细胞，癌细胞等的生长或增殖，并治疗患有肿瘤细胞的个体。

2. 发明申请

US20140093488A1 TUMOR SUPPRESSION USING HUMAN PLACENTAL PERFUSATE AND HUMAN PLACENTA-DERIVED INTERMEDIATE NATURAL KILLER CELLS 有权
标题翻译：使用人类渗透性脂肪酸和人类普通中间体自然杀伤细胞的肿瘤抑制
公开(公告)号：US20140093488A1
公开(公告)日：2014-04-03
申请号：US13584612
申请日：2012-08-13
申请人： Robert J. Hariri , Mohammad A. Heidaran , Lin Kang , Neerav Dilip Padliya , Ajai Pal , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
发明人： Robert J. Hariri , Mohammad A. Heidaran , Lin Kang , Neerav Dilip Padliya , Ajai Pal , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
IPC分类号： A61K35/14
CPC分类号： A61K35/17 , A61K35/50 , A61K45/06 , A61K2035/124 , C12N5/0646
摘要： Provided herein are placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells.
摘要翻译：本文提供胎盘灌洗液，胎盘灌洗液细胞和胎盘衍生的中间天然杀伤细胞及其组合。本文还提供了包含其的组合物，以及使用胎盘灌注液，胎盘灌洗液细胞和胎盘来源的中间体天然杀伤细胞及其组合的方法来抑制肿瘤细胞，癌细胞等的生长或增殖，并治疗患有肿瘤细胞的个体。

3. 发明授权

US08263065B2 Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells 有权
标题翻译：使用人胎盘灌注液和人胎盘来源的中间体天然杀伤细胞进行肿瘤抑制
公开(公告)号：US08263065B2
公开(公告)日：2012-09-11
申请号：US12240956
申请日：2008-09-29
申请人： Robert J. Hariri , Mohammad A. Heidaran , Lin Kang , Neerav Dilip Padliya , Ajai Pal , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
发明人： Robert J. Hariri , Mohammad A. Heidaran , Lin Kang , Neerav Dilip Padliya , Ajai Pal , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
IPC分类号： A01N63/00
CPC分类号： A61K35/17 , A61K35/50 , A61K45/06 , A61K2035/124 , C12N5/0646
摘要： Provided herein are placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells.
摘要翻译：本文提供胎盘灌洗液，胎盘灌洗液细胞和胎盘衍生的中间天然杀伤细胞及其组合。本文还提供了包含其的组合物，以及使用胎盘灌注液，胎盘灌洗液细胞和胎盘来源的中间体天然杀伤细胞及其组合的方法来抑制肿瘤细胞，癌细胞等的生长或增殖，并治疗患有肿瘤细胞的个体。

4. 发明授权

US08926964B2 Methods of generating natural killer cells 有权
标题翻译：产生天然杀伤细胞的方法
公开(公告)号：US08926964B2
公开(公告)日：2015-01-06
申请号：US13182250
申请日：2011-07-13
申请人： Robert J. Hariri , Mohammad A. Heidaran , Stephen Jasko , Lin Kang , Eric Law , Ajai Pal , Bhavani Stout , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
发明人： Robert J. Hariri , Mohammad A. Heidaran , Stephen Jasko , Lin Kang , Eric Law , Ajai Pal , Bhavani Stout , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
IPC分类号： A01N63/00 , C12N5/00 , C12N5/0783 , A61K35/12
CPC分类号： C12N5/0646 , A61K35/17 , A61K2035/124 , C12N2500/05 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2500/84 , C12N2501/125 , C12N2501/145 , C12N2501/2302 , C12N2501/2303 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2501/59 , C12N2501/91 , C12N2501/998 , C12N2506/11
摘要： Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the NK cells produced by the method to an individual having the cancer or viral infection.
摘要翻译：本文提供了使用两步膨胀和分化方法生产天然杀伤细胞的方法。本文还提供了抑制肿瘤细胞增殖，治疗患有癌症或病毒感染的个体的方法，包括将通过该方法产生的NK细胞施用于具有癌症或病毒感染的个体。

5. 发明申请

US20120148553A1 METHODS OF GENERATING NATURAL KILLER CELLS 有权
标题翻译：产生自然杀伤细胞的方法
公开(公告)号：US20120148553A1
公开(公告)日：2012-06-14
申请号：US13182250
申请日：2011-07-13
申请人： Robert J. HARIRI , Mohammad A. Heidaran , Stephen Jasko , Lin Kang , Eric Law , Ajai Pal , Bhavani Stout , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
发明人： Robert J. HARIRI , Mohammad A. Heidaran , Stephen Jasko , Lin Kang , Eric Law , Ajai Pal , Bhavani Stout , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
IPC分类号： A61K35/14 , A61P35/02 , A61P35/00 , C12N5/0783 , C12N5/09
CPC分类号： C12N5/0646 , A61K35/17 , A61K2035/124 , C12N2500/05 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2500/84 , C12N2501/125 , C12N2501/145 , C12N2501/2302 , C12N2501/2303 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2501/59 , C12N2501/91 , C12N2501/998 , C12N2506/11
摘要： Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the NK cells produced by the method to an individual having the cancer or viral infection.
摘要翻译：本文提供了使用两步膨胀和分化方法生产天然杀伤细胞的方法。本文还提供了抑制肿瘤细胞增殖，治疗患有癌症或病毒感染的个体的方法，包括将通过该方法产生的NK细胞施用于具有癌症或病毒感染的个体。

6. 发明申请

US20110280849A1 TUMOR SUPPRESSION USING HUMAN PLACENTA-DERIVED INTERMEDIATE NATURAL KILLER CELLS AND IMMUNOMODULATORY COMPOUNDS 审中-公开
标题翻译：使用人类定型中间体自然杀伤细胞和免疫调节化合物的肿瘤抑制
公开(公告)号：US20110280849A1
公开(公告)日：2011-11-17
申请号：US13071437
申请日：2011-03-24
申请人： Xiaokui ZHANG , Lin Kang , Mohammad A. Heidaran , Stephen Jasko , Andrew Zeitlin , Ajai Pal , Robert J. Hariri
发明人： Xiaokui ZHANG , Lin Kang , Mohammad A. Heidaran , Stephen Jasko , Andrew Zeitlin , Ajai Pal , Robert J. Hariri
IPC分类号： A61K35/50 , A61K35/48 , A61P35/00 , A61K35/14
CPC分类号： A61K31/454 , A61K31/198 , A61K31/7076 , A61K35/17 , A61K2300/00
摘要： Provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising contacting the tumor cells, or administering to the individual, placental perfusate, placental perfusate cells, or natural killer cells, e.g., placenta-derived intermediate natural killer cells, with an immunomodulatory compound or thalidomide.
摘要翻译：本文提供了抑制肿瘤细胞增殖，治疗患有癌症或病毒感染的个体的方法，包括使肿瘤细胞接触或给予个体胎盘灌洗液，胎盘灌洗液细胞或天然杀伤细胞，例如来自胎盘的中间体自然杀伤细胞，具有免疫调节化合物或沙利度胺。

7. 发明授权

US09200253B1 Method of producing erythrocytes 有权
标题翻译：产生红细胞的方法
公开(公告)号：US09200253B1
公开(公告)日：2015-12-01
申请号：US12187337
申请日：2008-08-06
申请人： Mohammad A. Heidaran , Xiaokui Zhang , Lin Kang , Andrew Zeitlin , Vanessa R. Voskinarian-Berse , Stewart Ernest Abbott
发明人： Mohammad A. Heidaran , Xiaokui Zhang , Lin Kang , Andrew Zeitlin , Vanessa R. Voskinarian-Berse , Stewart Ernest Abbott
IPC分类号： C12N5/00 , C12N5/02 , C12N5/078
CPC分类号： C12N5/0641 , C12N2500/99 , C12N2501/105 , C12N2501/11 , C12N2501/125 , C12N2501/135 , C12N2501/14 , C12N2501/145 , C12N2501/22 , C12N2501/2303 , C12N2501/2306 , C12N2501/2311 , C12N2501/26 , C12N2501/999
摘要： Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perfusate in combination with hematopoietic cells from umbilical cord blood, wherein the method results in accelerated expansion and differentiation of the hematopoietic cells to more efficiently produce administrable erythrocytes. Further provided herein is a bioreactor in which hematopoietic cell expansion and differentiation takes place.
摘要翻译：本文提供了从造血细胞产生红细胞的方法，特别是来自胎盘灌洗液的造血细胞与来自脐带血的造血细胞结合，其中该方法导致造血细胞的加速扩增和分化，以更有效地产生可施用的红细胞。本文进一步提供的是其中发生造血细胞扩增和分化的生物反应器。

8. 发明申请

US20090104164A1 ANGIOGENIC CELLS FROM HUMAN PLACENTAL PERFUSATE 审中-公开
标题翻译：人类细胞来自人类的渗透性细胞
公开(公告)号：US20090104164A1
公开(公告)日：2009-04-23
申请号：US12239679
申请日：2008-09-26
申请人： Xiaokui Zhang , Mohammad A. Heidaran , Vanessa R. Voskinarian-Berse , Lin Kang , Henry Rendon Barragan
发明人： Xiaokui Zhang , Mohammad A. Heidaran , Vanessa R. Voskinarian-Berse , Lin Kang , Henry Rendon Barragan
IPC分类号： A61K35/12 , C12N5/06
CPC分类号： C12N5/0692 , C12N2501/115 , C12N2501/15 , C12N2501/70
摘要： Provided herein are the production of vasculogenic or angiogenic cells from placental perfusate. Also provided are methods of treating an individual having a cardiac or vascular insufficiency, disease, disorder or condition comprising administering to said individual placental perfusate, placental perfusate cells, or combinations of placental perfusate or perfusate cells with placental or non-placental hematopoietic stem cells or adherent placental stem cells.
摘要翻译：本文提供了从胎盘灌注液产生血管生成或血管生成细胞。还提供了治疗患有心脏或血管功能不全，疾病，障碍或病症的个体的方法，包括向所述个体胎盘灌洗液，胎盘灌洗液细胞或胎盘灌注液或灌注液细胞与胎盘或非胎盘造血干细胞或贴壁胎盘干细胞。

9. 发明申请

US20090136471A1 TREATMENT OF PREMATURE BIRTH COMPLICATIONS 审中-公开
标题翻译：治疗孕产妇出生体重
公开(公告)号：US20090136471A1
公开(公告)日：2009-05-28
申请号：US12267499
申请日：2008-11-07
申请人： Mohammad A. Heidaran , Robert J. Hariri , Kristine Erickson Johnson
发明人： Mohammad A. Heidaran , Robert J. Hariri , Kristine Erickson Johnson
IPC分类号： A61K35/12 , A61K35/14
CPC分类号： A61K35/51 , A61K31/714 , A61K33/26 , A61K35/18 , A61K35/50 , A61K38/1816 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods of treating one or more complications of premature birth suffered by premature infants, comprising administering to the premature infant umbilical cord blood stem cells and, optionally, placental stem cells. The present invention also provides methods of combining and administering, and compositions comprising, umbilical cord blood stem cells, particularly autologous cord blood cells, and placental stem cells for the treatment of premature infants.
摘要翻译：本发明提供了治疗早产儿早产的一种或多种并发症的方法，包括对早产儿脐带血干细胞和任选的胎盘干细胞施用。本发明还提供组合和给药的方法，以及包含脐带血干细胞，特别是自体脐带血细胞和用于治疗早产儿胎盘干细胞的组合物。

10. 发明授权

US08638256B2 Accuracy and performance of a hybrid positioning system 有权
标题翻译：混合定位系统的精度和性能
公开(公告)号：US08638256B2
公开(公告)日：2014-01-28
申请号：US12569106
申请日：2009-09-29
申请人： Farshid Alizadeh-Shabdiz , Mohammad A. Heidaran
发明人： Farshid Alizadeh-Shabdiz , Mohammad A. Heidaran
IPC分类号： G01S19/48
CPC分类号： G01S19/13 , G01S19/48
摘要： The present disclosure relates to a method for determining the position of a WLAN positioning system (WPS) and satellite positioning system (SPS) enabled device. The method can include determining an initial WPS position of the device using WPS, calculating an error region around the initial WPS position of the device, dividing the error region into a plurality of points, obtaining satellite measurements from at least two satellites in view of the device, determining a variation in a receiver clock bias for each point within the error region based on the satellite measurements from at least two satellites, selecting the point with the lowest variation in the receiver clock bias, and determining whether or not to use the point with the lowest variation in receiver clock bias to refine the initial WPS position of the device.
摘要翻译：本公开涉及一种用于确定WLAN定位系统（WPS）和卫星定位系统（SPS）使能设备的位置的方法。该方法可以包括使用WPS确定设备的初始WPS位置，计算设备的初始WPS位置周围的误差区域，将误差区域划分为多个点，从至少两个卫星获得卫星测量设备，基于来自至少两颗卫星的卫星测量确定误差区域内的每个点的接收机时钟偏差的变化，选择接收机时钟偏差中具有最低变化的点，以及确定是否使用该点接收机时钟偏差的变化最小，以改善器件的初始WPS位置。

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