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31. 发明授权

US07323458B1 Dihydrobenzodiazepins and their use for treating dyslipidemia 失效
标题翻译：二氢苯并二氮杂类及其用于治疗血脂异常的用途
公开(公告)号：US07323458B1
公开(公告)日：2008-01-29
申请号：US10019683
申请日：2000-07-04
申请人： Jean-Jacques Berthelon , Daniel Guerrier , Michel Brunet , Jean-Jacques Zeiller , Francis Contard , Fréderic Ausseil
发明人： Jean-Jacques Berthelon , Daniel Guerrier , Michel Brunet , Jean-Jacques Zeiller , Francis Contard , Fréderic Ausseil
IPC分类号： A61P7/00 , A61K31/55 , C07D243/04
CPC分类号： C07D401/12 , C07D243/04 , C07D405/12 , C07D413/12 , C07D487/04 , C07D513/04 , C07D513/14
摘要： The invention concerns a benzodiazepin derivative of formula (I) and their use for treating dyslipidemia, atherosclerosis, diabetes and its complications.
摘要翻译：本发明涉及式（I）的苯并二氮杂衍生物及其用于治疗血脂异常，动脉粥样硬化，糖尿病及其并发症的用途。

32. 发明授权

US5652252A Benzocycloheptenes 失效
标题翻译：苯并环庚烯
公开(公告)号：US5652252A
公开(公告)日：1997-07-29
申请号：US460866
申请日：1995-06-05
申请人： Jean Jacques Berthelon , Michel Brunet , Marc Noblet , Philippe Durbin , Daniel Guerrier , Trong Nghia Luong
发明人： Jean Jacques Berthelon , Michel Brunet , Marc Noblet , Philippe Durbin , Daniel Guerrier , Trong Nghia Luong
IPC分类号： C07D215/14 , A61K31/355 , A61K31/55 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/08 , A61P17/00 , A61P21/02 , A61P25/02 , C07C57/30 , C07C59/68 , C07D213/24 , C07D213/30 , C07D213/57 , C07D213/60 , C07D213/89 , C07D313/08 , C07D405/04 , C07D409/04 , C07D493/04 , A61K31/44 , C07D213/04
CPC分类号： C07D213/30 , C07D213/57 , C07D213/89 , C07D405/04 , C07D409/04 , C07D493/04 , Y02P20/55
摘要： The subject of the invention is compounds of general formula: ##STR1## in which: X represents O or CHR,R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which are identical or different, represent a hydrogen atom or a C.sub.1 -C.sub.7 alkyl group, it being possible for R.sub.1 to additionally form a bond with R;R.sub.5 represents a hydrogen atom, a hydroxyl group or R.sub.5, taken together with R.sub.7, forms a bond or a>O; group;R.sub.6 represents a group of formula: ##STR2## in which R.sub.10 and R.sub.11, taken together with the carbon atom to which they are attached, form a nitrogenous heterocyclic group,and their N-oxides and pharmaceutically acceptable salts.These compounds are powerful activators of potassium channels.
摘要翻译：本发明的主题是以下通式的化合物：其中：X表示O或CHR，R 1，R 2，R 3和R 4相同或不同，表示氢原子或C 1 -C 7烷基， R1可以另外与R形成键; R5代表氢原子，羟基或R5与R7一起形成键或a O; 组; R 6表示下式的基团：其中R 10和R 11与它们所连接的碳原子一起形成含氮杂环基，以及它们的N-氧化物和药学上可接受的盐。这些化合物是钾通道的强大激活剂。

33. 发明授权

US5447151A Powder inhaler with suction actuated locking means 失效
标题翻译：粉末吸入器，带吸力驱动锁定装置
公开(公告)号：US5447151A
公开(公告)日：1995-09-05
申请号：US39061
申请日：1993-04-02
申请人： Pascal Bruna , Michel Brunet
发明人： Pascal Bruna , Michel Brunet
IPC分类号： A61M11/00 , A61M15/00 , A61M16/00 , B05D7/14 , B65D83/06
CPC分类号： A61M15/0045 , A61M15/0023 , A61M15/0025 , A61M15/0043 , A61M15/0051 , A61M15/0055 , A61M15/0065 , A61M15/0078 , A61M15/0095 , A61M11/002 , A61M2202/064 , A61M2205/6081
摘要： A powder inhaler comprising a box (1) in which a suction channel (84) is formed enabling a user to inhale a powder, the inhaler being characterized in that it includes a pusher (2) associated with a return spring (83), actuation thereof enabling a dose of powder to be brought into a position enabling it to be sucked into the suction channel (84), and in that the box (1) includes a locking mechanism enabling the pusher (2) to be locked after it has been actuated, and enabling it to be unlocked when the user sucks up the dose of powder in the channel (84).
摘要翻译： PCT No.PCT / FR91 / 00777 Sec。 371日期：1993年4月2日 102（e）日期1993年4月2日PCT 1991年10月4日PCT PCT。出版物WO92 / 05823 日期：1992年4月16日。一种粉末吸入器，其包括盒（1），其中形成吸入通道（84），使得使用者能够吸入粉末，所述吸入器的特征在于，其包括与一个复位弹簧（83），其致动使得一定剂量的粉末能够进入其能够被吸入到吸入通道（84）中的位置，并且盒（1）包括使得推动器（2）能够固定的锁定机构，在其被致动之后被锁定，并且当使用者吸入通道（84）中的粉末剂量时使其能够被解锁。

34. 发明授权

US5261573A Manual precompression pump 失效
标题翻译：手动预压泵
公开(公告)号：US5261573A
公开(公告)日：1993-11-16
申请号：US761215
申请日：1991-09-17
申请人： Claude Jouillat , Michel Brunet
发明人： Claude Jouillat , Michel Brunet
IPC分类号： B05B11/00 , B67D5/40
CPC分类号： B05B11/0097 , B05B11/004 , B05B11/3018
摘要： A manual precompression pump for spraying or dispensing a fluid substance contained in a receptacle, said pump having a pump body (1) in which a hollow piston (2) slides the piston being extended by a hollow rod (3) including the seat (7a) for a closure valve member (6) urged towards said hollow rod by a spring (10), said spring pushing the valve member (6) and the piston (2) towards a rest position, said pump including a pump chamber (12) which is in communication with the receptacle when the valve member and the piston are in their rest positions, said pump chamber (12) being capable of being isolated from the receptacle by sealed interfitting of a first cylinder (8) integral with the valve member (6) and of a second cylinder (4) integral with the pump body, said pump being characterized in that a valve rod (7b) extends the valve member (6) through the hollow rod (3) to a distance H1 beyond the outside end of the hollow rod, and in that starting from the rest position of the valve member, the cylinder (8) integral with the valve member can be moved towards the cylinder (4) integral with the pump body through a distance H2 which is greater than H1 without the interfitting between the two cylinders becoming sealed.
摘要翻译：一种用于喷射或分配容纳在容器中的流体物质的手动预压缩泵，所述泵具有泵体（1），其中空心活塞（2）通过包括所述座（7a）的中空杆（3）延伸的活塞滑动），用于通过弹簧（10）朝向所述中空杆推动的关闭阀构件（6），所述弹簧将阀构件（6）和活塞（2）推向静止位置，所述泵包括泵室（12）当所述阀构件和所述活塞处于其静止位置时，所述泵室（12）能够与所述容器连通，所述泵室（12）能够通过与所述阀构件成一体的第一气缸（8）的密封接合而与所述容器隔离 6）和与泵体一体的第二缸（4），所述泵的特征在于，阀杆（7b）通过中空杆（3）将阀构件（6）延伸到超出外端的距离H1 的中空杆，并且从阀门的静止位置开始与阀构件成一体的气缸（8）可以朝着与泵体整体的气缸（4）移动，距离H2大于H1，而两个气缸之间的配合不会被密封。

35. 发明授权

US5127548A Medicinal spray device with two substance compartments separated by puncturable membrane 失效
标题翻译：具有可分离膜分离的两个物质间隔的医药喷雾装置
公开(公告)号：US5127548A
公开(公告)日：1992-07-07
申请号：US658611
申请日：1991-02-21
申请人： Michel Brunet , Claude Jouillat
发明人： Michel Brunet , Claude Jouillat
IPC分类号： A61J1/00 , A61J1/20 , A61M11/00 , B05B11/00 , B65D81/32
CPC分类号： A61J1/20 , B05B11/0078 , B65D81/3255 , A61M11/00
摘要： A device for administering a medicine in the form of a spray, the medicine being constituted by a mixture of at least two substances that must be stored separately prior to use, the device comprising a volume which is divided into two compartments by a membrane 2 suitable for puncturing or tearing. The volume is defined by a receptacle 1A, 1B which is generally tubular in shape, and which is open at both ends. A suction and spray pump 4 is crimped onto one end thereof while its opposite end has a free piston 6 slidably received in the tubular element 1B to reduce the inside volume thereof as the pump sucks the content out from the tubular element after the membrane has been punctured.
摘要翻译：一种用于施用喷雾形式的药物的装置，所述药物由至少两种必须在使用前分开储存的物质的混合物构成，所述装置包括通过适当的膜2分成两个隔室的体积用于穿刺或撕裂。容积由通常为管状的容器1A，1B限定，并且在两端敞开。吸入和喷射泵4被压接在其一端上，而其相对端具有可滑动地容纳在管状元件1B中的自由活塞6，以在膜已经被吸收之后泵从管状元件吸出内容物来减小其内部体积刺伤

36. 发明授权

US5121883A Pushbutton having a laterally directed internal nozzle for a high pressure fast rate spray pump 失效
标题翻译：具有高压快速喷雾泵的方向指示的内部喷嘴的按钮
公开(公告)号：US5121883A
公开(公告)日：1992-06-16
申请号：US672230
申请日：1991-03-20
申请人： Claude Jouillat , Michel Brunet
发明人： Claude Jouillat , Michel Brunet
IPC分类号： B05B1/10 , B05B11/00
CPC分类号： B05B11/3052
摘要： A hollow elongate pushbutton receives a nozzle rod 2, and is mounted at a mid-portion on the valve rod of a liquid spray pump intended to operate under pressures on the order of more than 100 bars, and at a repetition rate of 50 Hz or more. The center of gravity of the pushbutton and nozzle rod assembly lies on the axis of the valve rod, to avoid vibrations during use.
摘要翻译：中空细长按钮接收喷嘴杆2，并且安装在液体喷射泵的阀杆的中间部分，该液体喷射泵旨在在大于100巴的压力下操作，并且以50Hz的重复速率或更多。按钮和喷嘴杆组件的重心位于阀杆的轴线上，以避免使用过程中的振动。

37. 发明授权

US5105994A Precompression metering pump with a tongued collar to aid priming 失效
标题翻译：预先测量泵与一个TONGUED COLLAR以辅助PRIMING
公开(公告)号：US5105994A
公开(公告)日：1992-04-21
申请号：US637840
申请日：1991-01-07
申请人： Claude Jouillat , Michel Brunet
发明人： Claude Jouillat , Michel Brunet
IPC分类号： F04B9/14 , B05B11/00
CPC分类号： B05B11/3061 , B05B11/3018 , B05B11/0097
摘要： A prior art precompression metering pump which incorporates a differential piston forming part of the pump chamber inlet valve and its outlet valve is difficult to prime, especially in the case of metering paste products. In the improved pump there is disposed between the differential piston and the main piston of the pump a collar consisting of a ring from which project substantially axial tongues which are slightly inwardly inclined and each provided with a head. The collar moves inside the pump body so that normal operation proceeds as if it were not present. To prime the pump, however, the user depresses the collar until it contacts a step on the pump body. The tongues then bend so that their heads, interposed between the two pistons, move the latter apart (by a wedging effect or by a lever arm effect, or by a combination of the two). This is followed by mechanical opening of the pump chamber outlet valve whereby the air initially contained in the pump chamber escapes to the exterior.
摘要翻译：结合形成泵室入口阀和其出口阀的一部分的差动活塞的现有技术的预压计量泵尤其难以填充，特别是在计量浆料产品的情况下。在改进的泵中，在差动活塞和泵的主活塞之间设置有由环组成的套环，该环从该环突出大致轴向的舌状物，其稍微向内倾斜并且各自设置有头部。轴环在泵体内移动，使得正常操作如同不存在一样进行。然而，为了灌注泵，用户按压套环直到其接触泵体上的台阶。然后，舌头弯曲，使得它们的头部插入在两个活塞之间，使它们分开（通过楔形效应或杠杆臂效应或两者的组合）移动。之后是泵室出口阀的机械打开，由此最初容纳在泵室中的空气逸出到外部。

38. 发明授权

US5024355A Device for dispensing a liquid or a cream in small-volume drops, and an associated dispensing assembly 失效
标题翻译：用于在小体积滴下分配液体或奶油的装置，以及相关联的分配组件
公开(公告)号：US5024355A
公开(公告)日：1991-06-18
申请号：US454652
申请日：1989-12-20
申请人： Claude Jouillat , Michel Brunet
发明人： Claude Jouillat , Michel Brunet
IPC分类号： A61J1/05 , A61F9/00 , B05B11/00 , B65D47/18 , B65D83/00
CPC分类号： B05B11/0064 , A61F9/0008 , B05B11/0024 , B05B11/3054 , B05B11/309 , B05B11/3094 , B65D47/18 , B05B11/0037 , B05B11/0048
摘要： The present dispenser device is designed in particular for eye treatment and comprises a pump body including a pump chamber, a piston slidable within the chamber and extended beyond the chamber by a rod pierced by a channel capable of communicating with the chamber, and an endpiece fixed to the rod and having a dispensing orifice in line with the channel of the rod. In addition to the above conventional items, the dispenser has a chamber admission valve which is constituted by co-operation between the enclosure defining the pump chamber and the piston which engages therein or projects therefrom as the case may be. The co-operation is preferably via a sealing lip. This disposition makes it possible to dispense a drop whose volume as determined by the capacity of the chamber is very small. In addition, the piston is returned to its rest position with the admission valve closed by resilient means disposed between the pump body and the endpiece. This guarantees that only drop is dispensed at a time. Finally, an outlet valve is placed between the end of the channel in the rod and the dispensing orifice of the endpiece in order to ensure that a dispensed drop is slightly precompressed. The dispenser device is advantageously integrated in a dispenser assembly comprising a supply of substance to be dispensed together with a housing facilitating actuation of the assembly by a user. Some designs of assembly are particularly attractive, from the economic point of view, with respect to the process of being filled with the substance to be dispensed.
摘要翻译：本发明的分配装置特别设计用于眼睛治疗，并且包括泵体，泵主体包括泵室，可在腔室内滑动的活塞，并且通过能够与腔室连通的通道刺穿的杆延伸到腔室之外，并且具有与杆的通道一致的分配孔。除了上述常规项目之外，分配器具有腔室进入阀，其通过在限定泵室的壳体和接合于其中的活塞或根据情况可能从其突出的活塞之间的协作而构成。合作优选经由密封唇。这种配置使得可以分配由腔室的容量确定的体积的液滴非常小。此外，活塞返回到其静止位置，入口阀由设置在泵体和端件之间的弹性装置关闭。这样可以保证一次只能下降。最后，出口阀被放置在杆中的通道的端部和端部件的分配孔之间，以确保分配的液滴被稍微预压缩。分配器装置有利地集成在分配器组件中，该分配器组件包括要被分配在一起的物质的供应物，以便于用户对组件的致动。从经济的观点来看，一些装配设计特别有吸引力，就是要填充待分配物质的过程。

39. 发明授权

US4856677A Portioning device for paste or semi-liquid products 失效
标题翻译：用于糊状或半液体产品的分装置
公开(公告)号：US4856677A
公开(公告)日：1989-08-15
申请号：US86458
申请日：1987-08-18
申请人： Michel Brunet , Claude Jouillat
发明人： Michel Brunet , Claude Jouillat
IPC分类号： B05B11/00 , B65D47/34 , G01F11/02
CPC分类号： B05B11/3025 , B05B11/0043 , B05B11/3015 , B05B11/3018 , G01F11/025
摘要： The object of the invention is a combination of a portioning system and a flexible tube to contain and distribute a paste product or a cream. By pressing on the flexible tube, the system can be completely filled. Exact portions of the product can be obtained and the product is not exposed to the air, does not dry out and is not contaminated.
摘要翻译：本发明的目的是分配系统和柔性管的组合，以容纳和分配糊状产品或奶油。通过按压柔性管，系统可以完全充满。可以获得产品的精确部分，并且产品不暴露于空气中，不会干燥并且不被污染。

40. 发明授权

US4034067A Hydroxychlorides of aluminum and method 失效
标题翻译：铝的羟基氯化物和方法
公开(公告)号：US4034067A
公开(公告)日：1977-07-05
申请号：US687019
申请日：1976-05-17
申请人： Laurent Seigneurin , Michel Brunet
发明人： Laurent Seigneurin , Michel Brunet
IPC分类号： C01F7/56 , C02F1/52 , C01B7/00
CPC分类号： C02F1/5245 , C01F7/56 , C01P2004/61 , C01P2006/12
摘要： The preparation of a material consisting essentially or largely of aluminum hydroxychlorides having the general formula Al.sub.2 (OH).sub.X Cl.sub.6.sub.-X, in which X is a value up to 5 or more and obtained by reacting active alumina, secured by partial dehydration of hydrates of alumina, with hydrochloric acid or aluminum chloride in which the active alumina has a specific surface area of at least 200 m.sup.2 /g.
摘要翻译：基本上或大部分由具有通式Al 2（OH）XCl 6-X的羟基氯化铝组成的材料的制备，其中X是高达5或更高的值，并且通过使氧化铝的水合物部分脱水获得的活性氧化铝，其中活性氧化铝的比表面积为至少200m 2 / g的盐酸或氯化铝。

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