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31. 发明专利

JPH10160735A SANDWICH MEASURING METHOD 失效
公开(公告)号：JPH10160735A
公开(公告)日：1998-06-19
申请号：JP1774997
申请日：1997-01-16
申请人： MEIJI MILK PROD CO LTD
发明人： YANO AKIRA , YOKOYAMA MINEHIKO , IKEMATSU SHINYA , ODA MUNEHIRO , MURAMATSU TAKASHI , MURAMATSU TOSHIKO
IPC分类号： G01N33/53 , G01N33/531 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To obtain a sandwich measuring method in which a high-sensitivity measuring system can be constructed by a method wherein two kinds of polychlonal antibodies are used as a first antibody and a second antibody for a sandwich method. SOLUTION: A sandwich method is constructed in such a way that human MK is used as an antigen and that a rabbit and a chicken are used an immune animals. When epitopes on MK molecules recognized by two kinds of polyclonal antibodies derived from the rabbit and the chicken are compared, the two kinds of polyclonal antibodies recognize respectively different epitope groups on identical antigen molecules. When the polyclonal antibodies are used as a first antibody and a second antibody for the sandwich method, it is possible to establish the sandwich method similar to that of monoclonal antibodies. In addition, an antigen is a protein which is originally owened by an animal species, different animal species are immunized, and polyclonal antibodies are obtained from them. In addition, two kinds of animal species which are immunized are not limited to the rabbit and the chicken, and a combination of animal species in which epitopes are not overlapped can be used arbitrarily.

32. 发明专利

JPH09289877A CALCIUM-REINFORCING AGENT 失效
公开(公告)号：JPH09289877A
公开(公告)日：1997-11-11
申请号：JP5548497
申请日：1997-02-25
申请人： MEIJI MILK PROD CO LTD
发明人： ODA MUNEHIRO , IKEGAMI HIDEJI , KIDO ISAO , SAKUMA SADATOSHI , ITO HIROYUKI , WAKUTA JUNICHIRO
IPC分类号： A23L2/52 , A23L1/304 , A23L13/60 , A23L17/00 , A61K33/06 , A61P19/10 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain a calcium-reinforcing agent for food products and medicines which can stably disperse in water for a long period of time without sedimentation of the components by surface-treating hydroxy apatite with a solution containing citric acid or a citrate salt, or with a protein or a peptide. SOLUTION: Ultrafine particles of hydroxyapatite with a particle size of

33. 发明专利

JPH0987116A ANTIBACTERIAL AND ANTIFUNGAL COMPOSITION 失效
公开(公告)号：JPH0987116A
公开(公告)日：1997-03-31
申请号：JP24560695
申请日：1995-09-25
申请人： TOYO INK MFG CO , MEIJI MILK PROD CO LTD
发明人： TAKAHATA YOSHIKO , KUMADA MIKA , ODA MUNEHIRO , ITO HIROYUKI , SAKUMA SADATOSHI
IPC分类号： A01N55/02 , A01N25/10 , A01N25/22 , A01N33/04 , A01N33/08 , A01N59/16
摘要： PROBLEM TO BE SOLVED: To obtain an antibacterial and antifungal composition improved in storage stability and dispersion stability and having a wide antimicrobial spectrum by remarkably lowering the particle diameter of a slightly water-soluble compound comprising a complex containing a coordinated silver ion with a specific compound. SOLUTION: This antibacterial and antifungal composition contains both (A) a slightly water-soluble compound comprising a complex containing a coordinated silver ion and (B) a water-soluble amine. (C) A water-dispersible resin may be added to the system. The compound (A) is preferably a complex formed by coordinating a silver ion in a thiol group-containing compound. The thiol group-containing compound is e.g. thiosalicylic acid, and a source for supplying the silver ion is preferably a water-soluble silver salt. The component (B) includes triethanolamine and dimethylaminoethanol. The component (C) includes natural rubber, ethylene-propylene-diene rubber, polyethylene and urethane resins. The component (A), the component (B) and purified water are used in a ratio of 1/0.01/98 to 20/10/70. The component (A) and the component (B) are used in a solid content weight ratio of 0.01/100 to 10/100.

34. 发明专利

JPH08245325A GERM-PROOFING/MOULD-PROOFING COMPOSITION 失效
公开(公告)号：JPH08245325A
公开(公告)日：1996-09-24
申请号：JP5544495
申请日：1995-03-15
申请人： TOYO INK MFG CO , MEIJI MILK PROD CO LTD
发明人： TAKAHATA YOSHIKO , OGURA MIKA , ITO HIROYUKI , ODA MUNEHIRO , SUZUKI YASUNORI
IPC分类号： A01N25/10 , A01N59/16
摘要： PURPOSE: To obtain the subject composition having a wide range of antimicrobial spectrum, excellent in dispersion stability and preservability, useful for coatings, etc., comprising a water-soluble compound of a metallic element having germ-proofing/mould-proofing performance and a water-soluble resin. CONSTITUTION: This germ-proofing/mould-proofing composition comprises (A) such a water-soluble compound of a metallic element having germ-proofing/ mould-proofing performance that the countercation of a complex formed by coordinating a silver ion on a thiol group-contg. compound is e.g. K , Na , Ca or Ba and (B) a water-soluble resin such as PVA, and pref. furthermore, (C) a water-dispersible resin such as natural rubber. It is preferable that the weight ratio A/B/C be (0.1:20:80) to (50:60:40).

35. 发明专利

JPH0569506B2 失效
公开(公告)号：JPH0569506B2
公开(公告)日：1993-10-01
申请号：JP1339784
申请日：1984-01-30
申请人： MEIJI MILK PROD CO LTD
发明人： IMADA MASARU , YOSHAMA HIROSHI , ODA MUNEHIRO
IPC分类号： C12N9/64 , A61K35/12 , A61K35/13 , A61K38/00 , A61K38/02 , A61K38/36 , A61K38/46 , A61K38/48 , C12N9/72 , C12R1/91

36. 发明专利

JPS6353969B2 失效
公开(公告)号：JPS6353969B2
公开(公告)日：1988-10-26
申请号：JP10135181
申请日：1981-07-01
申请人： MEIJI MILK PROD CO LTD
发明人： TSUCHA FUMYASU , KANBE MICHIO , ODA MUNEHIRO , HASEGAWA HIDEO
IPC分类号： A61K31/715 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/04 , A61P43/00

37. 发明专利

JPS61124376A Method of cultivating normal epithelial cell 失效
标题翻译：培养正常上皮细胞的方法
公开(公告)号：JPS61124376A
公开(公告)日：1986-06-12
申请号：JP24619384
申请日：1984-11-22
申请人： Meiji Milk Prod Co Ltd
发明人： SATO JIRO , MIYAZAKI MASAHIRO , YABE TAMAE , MIYANO KEIKO , ODA MUNEHIRO
IPC分类号： C12N1/38 , C12N5/02 , C12N5/071 , C12P21/00
CPC分类号： C12N5/067 , C12N1/38 , C12N2501/999 , C12P21/00
摘要： PURPOSE: To obtain a normal epithelial cell capable of existing and being cultivated for a long period, by cultivating a normal epithelial cell in a medium containing a barbituric acid derivative.
CONSTITUTION: A normal epithelial cell (e.g., normal aged rat hepatic cell of primary culture) is dispersed into a basic medium containing about 20wt% bovine serum, 10μM dexamethasone, and 10μg/ml insulin, and inoculated in a density about of 7×10
4 cell/0.2ml/cm
3 into a plastic dish, and cultivated in a CO
2 gas culture medium (5% CO
2 gas concentration) at about 37°C. After it is cultivated for about 24 hours, a barbituric acid derivative (e.g., phenobarbital) is added to the medium so that its concentration in the medium is 3mM, and the cultivation is continued for about 49 days.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：通过在含有巴比妥酸衍生物的培养基中培养正常的上皮细胞，获得长期存在和培养的正常上皮细胞。构成：将正常上皮细胞（例如，原代培养物的正常老年大鼠肝细胞）分散在含有约20重量％牛血清，10muM地塞米松和10ug / ml胰岛素的基础培养基中，并以约7×10 4 >细胞/ 0.2ml / cm 3放入塑料盘中，并在约37℃下在CO 2气体培养基（5％CO 2气体浓度）中培养。培养约24小时后，向培养基中加入巴比妥酸衍生物（例如苯巴比妥），使其在培养基中的浓度为3mM，培养持续约49天。

38. 发明专利

JPS58203913A High polymer polysaccharide substance mps-82 and its use 失效
标题翻译：高聚物多糖物质MPS-82及其用途
公开(公告)号：JPS58203913A
公开(公告)日：1983-11-28
申请号：JP8729482
申请日：1982-05-25
申请人： Meiji Milk Prod Co Ltd
发明人： TAKETOMO TADAO , ODA MUNEHIRO , OOYAMA YOSHIO , KANBE MICHIO , TSUCHIYA FUMIYASU
IPC分类号： C08B37/00 , A61K31/70 , A61K35/74 , A61P35/00 , C12P19/04
摘要： NEW MATERIAL:High polymer polysaccharide substance MPS-82 having the following physical and chemical properties. Elemental analysis: C 38.03%, H: 6.52%, O: 55.21%, N: 0.24%. Molecular weight: 2.0S (S: Svedberg unit (ultracentrifugation). Melting point: 225°C (change in color)W270°C(decomposition). Specific rotatory power: [α]D
24 =+112±5° (c=0.25%). Solubility: soluble in water, insoluble in methanol, acetone, etc. Color reaction: positive in Molisch reaction and anthrone reaction. pH: 4.75. (0.5wt% aqueous solution). Appearance: white, fibrous state.
USE: An immuno activator. An antitumor agent.
PROCESS: A bacterium [e.g., Bifidobacterium longum No. 21-R (FERM-BP-126)] belonging to the genus Bifidobacterium, capable of producing high polymer polysaccharide substance MPS-82 substance is subjected to settled culture under anaerobic conditions, and after the cultivation is over, the desired substance is separated and purified by centrifugation, extraction, ion exchange chromatography, etc.
COPYRIGHT: (C)1983,JPO&Japio
摘要翻译：新材料：具有以下物理和化学性质的高分子多糖物质MPS-82。元素分析：C 38.03％，H：6.52％，O：55.21％，N：0.24％。分子量：2.0S（S：Svedberg单位（超速离心）熔点：225℃（颜色变化）-270℃（分解）比旋光度：αD 24 = + 112+ 或-5度（c = 0.25％）溶解性：溶于水，不溶于甲醇，丙酮等颜色反应：在Molisch反应和蒽酮反应中为阳性，pH：4.75。（0.5wt％水溶液）外观：白色纤维状态用途：免疫激活剂抗肿瘤剂方法：属于双歧杆菌属的双歧杆菌属细菌[例如长双歧杆菌21-R（FERM-BP-126）]，能够生产高分子多糖物质MPS-82物质在厌氧条件下进行沉降培养，培养结束后，通过离心，提取，离子交换色谱等分离和纯化所需物质。

39. 发明专利

JP2000256365A WATER-SOLUBLE SILVER COMPLEX 失效
公开(公告)号：JP2000256365A
公开(公告)日：2000-09-19
申请号：JP5553399
申请日：1999-03-03
申请人： MEIJI MILK PROD CO LTD
发明人： NOMIYA KENJI , ODA MUNEHIRO , SAKUMA SADATOSHI
IPC分类号： A61K31/28 , A01N59/16 , A61K31/00 , A61P31/00 , C07F1/10
摘要： PROBLEM TO BE SOLVED: To obtain a water-soluble silver complex that manifests a wide range of antibacterial and antifungal spectra, simultaneously is soluble in water and stable to light and useful as an active ingredient for antibacterial and antifungal compositions by coordinating specific ligands to silver ion. SOLUTION: This complex is prepared by coordinating (A) 2-pyrrolidone-5- carboxylic acid or (B) histidine to (C) silver ion. This complex is obtained by allowing the component A or B to react with the component C at a suitable pH in an aqueous solution, then adding an organic solvent, for example, ethanol for fractional separation of the product. As a source of the component C, silver nitrate or silver oxide (I) can be used. In the case where the component B is used as ligand, however, the use of silver oxide is required. The complex can be formed by reaction of 1 mole of silver with 1-2 moles of components A or B, however, in the case of the component A, the equimolar amount of silver is preferably used, while the component B is preferably used by two moles per mole of silver.

40. 发明专利

JPH09100202A ANTI-ORGANISM AGENT 失效
公开(公告)号：JPH09100202A
公开(公告)日：1997-04-15
申请号：JP27822095
申请日：1995-10-03
申请人： MEIJI MILK PROD CO LTD
发明人： TAKAHASHI MASAHIRO , KOJIMA YOSHIYUKI , ODA MUNEHIRO , SAKUMA SADATOSHI
IPC分类号： A01N25/04 , A01N25/08 , A01N37/18
摘要： PROBLEM TO BE SOLVED: To obtain an anti-organism agent having inhibitory effect on proliferation of various organisms such as algae causing troubles in many scenes such as paddy field, lake and marsh, lawn, etc., comprising a specific compound contained in essence of Guinea pepper for an inexpensive food as an active ingredient. SOLUTION: This anti-organism agent comprises a capsaicin of the formula (R is a 7-12C alkyl or alkenyl). Capsaicin [R is (CH2 )4 CH=CHCH(CH3 )2 ], dihydrocapsaicin, norcapsaicin, homocapsaicin, octanoic acid vanillylamide, etc., may be cited as the capsaicin. The anti-organism agent can be made into a cream by adding an emulsifying agent or into a dust by attaching the capsaicin to a solid carrier. The anti-organism agent has low load on environment and low toxicity to human body.

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