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    • 32. 发明申请
    • Pharmaceutical composition formulated for pre-gastric absorption of monoamine oxidase B inhibitors
    • 配制用于单胺氧化酶B抑制剂的胃前吸收的药物组合物
    • US20050106241A1
    • 2005-05-19
    • US10957947
    • 2004-10-04
    • Francesca BrewerEdward JohnsonAnthony Clarke
    • Francesca BrewerEdward JohnsonAnthony Clarke
    • A61K9/00A61K9/20A61K31/136A61K31/137
    • A61K9/0056A61K9/2095A61K31/136A61K31/137
    • The invention described herein provides a fast dispersing oral solid dosage form containing monoamine oxidase B inhibitor (MAO-B inhibitor) as the active ingredient, and method of treating disease therewith, such as Parkinson's disease. In one embodiment, the monoamine oxidase B inhibitor selegiline or its analogue can be the sole active ingredient in the composition administered. The dosage form composition is formulated to promote absorption through the buccal, sublingual, pharyngeal and/or esophageal mucous membrane tissue, such that at least 5% of the active ingredient is absorbed within one minute of placement in the oral cavity, as determined by a buccal absorption test. Monoamine oxidase B inhibitor compounds administered in accordance with the invention decrease the amount of undesirable metabolites associated with first pass effect of selegiline, for example, such as amphetamine and methamphetamine. The invention provides a number of other advantages over conventional orally administered tablet forms, including administration of monoamine oxidase B inhibitor compounds to patients that have difficulty swallowing.
    • 本文描述的本发明提供了含有单胺氧化酶B抑制剂(MAO-B抑制剂)作为活性成分的快速分散口服固体剂型,以及用于治疗疾病如帕金森病的方法。 在一个实施方案中,单胺氧化酶B抑制剂司来吉兰或其类似物可以是所施用组合物中的唯一活性成分。 配制剂型组合物以促进通过颊,舌下,咽和/或食管粘膜组织的吸收,使得至少5%的活性成分在放置在口腔中的一分钟内被吸收,如通过 颊吸收试验。 根据本发明施用的单胺氧化酶B抑制剂化合物减少与司来吉兰(例如苯丙胺和甲基苯丙胺)的首次通过效应相关的不合需要的代谢物的量。 本发明提供了与常规口服给药的片剂形式相比的许多其它优点,包括向吞咽困难的患者施用单胺氧化酶B抑制剂化合物。
    • 36. 发明申请
    • GARMENT HANGER HAVING SINGLE HANDED LOCKING DEVICE AND METHOD THEREFOR
    • 具有单手锁定装置的装饰品及其方法
    • US20100084442A1
    • 2010-04-08
    • US12247026
    • 2008-10-07
    • Edward JohnsonBuddy C. Stanley
    • Edward JohnsonBuddy C. Stanley
    • A41D27/22
    • A47G25/481
    • A garment hanger has a pair of clamping members. Each clamping member comprises a pair of planer end sections and a central curved section attached to the pair of planer end members. The pair of end sections of a first clamping member will touch a corresponding pair of end sections of a second clamping member and the central curved section of the first and second clamping members form an elongated oval when the pair of clamping members is placed together in a closed position. A locking device is attached to the central curved section of the first and second clamping members. The locking device secures the pair of clamping members together. When pressure is applied to the locking device, the locking device forces opens and separates the pair of clamping members. A hook assembly is attached to the locking device.
    • 衣架具有一对夹紧构件。 每个夹紧构件包括一对平面端部和连接到一对平面端部构件的中心弯曲部分。 第一夹持构件的一对端部部分将接触第二夹紧构件的相应的一对端部部分,并且当该对夹紧构件放置在一起时,第一和第二夹紧构件的中心弯曲部分形成细长的椭圆形 关闭位置。 锁定装置附接到第一和第二夹紧构件的中心弯曲部分。 锁定装置将一对夹紧构件固定在一起。 当对锁定装置施加压力时,锁定装置强制打开并分离该对夹紧构件。 钩组件附接到锁定装置。
    • 39. 发明授权
    • Space heating apparatus
    • 空间加热装置
    • US4357929A
    • 1982-11-09
    • US184356
    • 1980-09-05
    • Edward Johnson
    • Edward Johnson
    • F23D3/10F24C5/06F24C5/20F24C5/04F23D13/04
    • F24C5/06F24C5/20
    • A space heating apparatus includes a fuel tank and base assembly, a combustion chassis assembly supported on the base and supplied with combustion air for igniting and supporting a flame, and a top cover plate. The top cover plate includes a turret section providing a supporting surface for an upper cabinet assembly which is pivotally mounted on the turret. A mantle assembly is disposed in the cabinet to produce radiant heat and a portion extends down over the combustion chassis assembly. A slideable lower spill tray and an upper spill tray on the top cover plate provide ready access for detecting and cleaning kerosene spills, and for removing char and other debris.
    • 空间加热装置包括燃料箱和基座组件,支撑在基座上的燃烧底盘组件,并提供用于点燃和支撑火焰的燃烧空气以及顶盖板。 顶盖板包括转台部分,其提供用于上部柜组件的支撑表面,该上部机壳组件枢转地安装在转台上。 套管组件设置在机壳中以产生辐射热,并且部分在燃烧底盘组件上向下延伸。 顶盖板上的一个可滑动的下部溢出托盘和一个上部溢出托盘可以方便地检测和清洁煤油溢出物,以及清除炭和其他碎屑。