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31. 发明申请

US20050137471A1 Continuous glucose monitoring device 审中-公开
标题翻译：连续葡萄糖监测装置
公开(公告)号：US20050137471A1
公开(公告)日：2005-06-23
申请号：US10740056
申请日：2003-12-18
申请人： Hans-Peter Haar , Hans List , Felix Baader , Herbert Harttig , George Meacham
发明人： Hans-Peter Haar , Hans List , Felix Baader , Herbert Harttig , George Meacham
IPC分类号： A61B5/00 , G01N35/00 , A61K9/22
CPC分类号： A61B5/14528 , A61B5/14532 , A61B5/686 , A61B2562/0295 , Y10T436/110833
摘要： The present invention is generally directed towards devices for sensing a concentration of chemical constituents in body fluid such as interstitial fluid, including but not limited to glucose. The devices also relates to systems for measuring and reporting the concentration of body fluid constituents at time intervals shorter than the physiological response time, thereby providing effectively continuous concentration measurements. The device according to the present invention comprises a probe, a reservoir with perfusion fluid connected to an inlet of the probe, at least one test zones which comprise a reagent, to react with the analyte to produce a detectable change, a reader unit which reads test zones wetted with fluid containing the analyte, where the reader unit produces signals according to the concentration of the analyte in the fluid; and a processing unit for processing the signals and the concentration of the analyte.
摘要翻译：本发明通常涉及用于感测体液中诸如间质液体（包括但不限于葡萄糖）的化学成分浓度的装置。这些装置还涉及用于在比生理反应时间短的时间间隔测量和报告体液组分的浓度的系统，从而提供有效的连续浓度测量。根据本发明的装置包括探针，具有连接到探针的入口的灌注流体的储存器，包含试剂的至少一个测试区域，以与分析物反应以产生可检测的变化;读取器单元，其读取用含有分析物的流体润湿的测试区域，其中读取器单元根据流体中分析物的浓度产生信号; 以及用于处理信号和分析物浓度的处理单元。

32. 发明授权

US08444574B2 Lancing system for the extraction of a body fluid 有权
标题翻译：用于提取体液的Lancing系统
公开(公告)号：US08444574B2
公开(公告)日：2013-05-21
申请号：US12396838
申请日：2009-03-03
申请人： Hans List , Irio G. Calasso , Joachim Hoenes , Hans-Peter Haar , Uwe Kraemer , Herbert Harttig , Volker Zimmer
发明人： Hans List , Irio G. Calasso , Joachim Hoenes , Hans-Peter Haar , Uwe Kraemer , Herbert Harttig , Volker Zimmer
IPC分类号： A61B5/00 , A61B17/32 , A61B17/14 , B65D81/00
CPC分类号： A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150175 , A61B5/150389 , A61B5/150503 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15132
摘要： Lancing system comprising a needle and a lancing device The lancing device comprises a housing with a housing opening that is surrounded by a housing skin contact surface. A lancing depth reference element with a reference skin contact surface is adapted in such a manner that the reference skin contact surface at a reversal point of the lancing movement is in contact with the skin. The lancing depth is determined by the distance between the reference skin contact surface and the tip of the needle element at the reversal point of the lancing movement. The lancing depth reference element is in a stationary defined position relative to the reversal point of the lancing movement. The lancing depth reference element is adapted to stabilize the skin when pressed against the reference skin contact surface with respect to a skin deformation which occurs upon lancing of the skin.
摘要翻译：包括针和穿刺装置的牵引系统。该穿刺装置包括壳体，该外壳具有由壳体皮肤接触表面包围的壳体开口。具有参考皮肤接触表面的穿刺深度参考元件以使得在穿刺运动的反转点处的参考皮肤接触表面与皮肤接触的方式被适配。穿刺深度由穿刺运动的反转点处的参考皮肤接触表面和针元件的尖端之间的距离确定。穿刺深度参考元件相对于穿刺运动的反转点处于静止的限定位置。穿刺深度参考元件适于当相对于在皮肤穿刺时发生的皮肤变形而压靠参照皮肤接触表面时稳定皮肤。

33. 发明申请

US20130066356A1 PUNCTURING SYSTEM 审中-公开
标题翻译：打孔系统
公开(公告)号：US20130066356A1
公开(公告)日：2013-03-14
申请号：US13619459
申请日：2012-09-14
申请人： Hans List , Christian Hoerauf , Frank Deck , Thomas Weiss , Michael Keil , Guenther Schmelzeisen-Redeker , Heinrich Fruhstorfer , Hans-Peter Haar , Uwe Kraemer , Joachim Hoenes , Karl Miltner
发明人： Hans List , Christian Hoerauf , Frank Deck , Thomas Weiss , Michael Keil , Guenther Schmelzeisen-Redeker , Heinrich Fruhstorfer , Hans-Peter Haar , Uwe Kraemer , Joachim Hoenes , Karl Miltner
IPC分类号： A61B17/34
CPC分类号： A61B5/1519 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150412 , A61B5/150503 , A61B5/150824 , A61B5/150954 , A61B5/15113
摘要： The invention relates to a puncturing system for generating a puncture wound for obtaining a sample of a body fluid, comprising a press-on part to be pressed onto a body part in which a puncture wound is to be generated, a triggering means with which a user can trigger a puncturing motion of a puncturing element after the press-on part is pressed on, and a testing facility for determining a test parameter on which a sample-obtaining probability depends. A securing facility is also provided that, in a locked state, locks the triggering means and, in a triggering state, releases the triggering means such that a puncturing motion can be triggered by actuation thereof. The securing facility is transitioned from the locked state to the triggering state by the testing facility when the test parameter determined by the testing facility meets defined minimum requirements.
摘要翻译：本发明涉及一种用于产生用于获得体液样品的穿刺伤口的穿刺系统，包括：压制部件，其被压在其上将产生穿刺伤口的身体部位;触发装置，其中，用户可以在按下按压部分之后触发穿刺元件的穿刺运动，以及用于确定取样概率所依赖的测试参数的测试设备。还提供了一种固定装置，其处于锁定状态，锁定触发装置，并且在触发状态下释放触发装置，使得可以通过致动来触发穿刺运动。当由测试设备确定的测试参数达到规定的最低要求时，固定设施由测试设备从锁定状态转换到触发状态。

34. 发明授权

US08251922B2 Analysis system for automatic skin prick analysis 有权
标题翻译：自动皮肤点刺分析系统
公开(公告)号：US08251922B2
公开(公告)日：2012-08-28
申请号：US12755839
申请日：2010-04-07
申请人： Hans List , Hans-Peter Haar , George Bevan Kirby Meacham
发明人： Hans List , Hans-Peter Haar , George Bevan Kirby Meacham
IPC分类号： A61B5/00 , B65D81/00
CPC分类号： A61B5/150198 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150519 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/15146 , A61B5/15151 , A61B5/15163 , A61B5/15176 , A61B5/157
摘要： Analysis system for automatically performing a skin prick analysis by pricking the skin for producing a sample of body liquid and detecting an analyte contained in the sample. The analysis system comprises a magazine with a plurality of compartments each containing a lancing element and an analysis element, and a reusable hand-held instrument having a drive assembly. The drive assembly is adapted for driving at least the following movements by manually generated mechanical force: a coupling movement by which one of the lancing elements is coupled to the drive assembly; a puncturing and sample collection movement of one of the lancing elements contained in the magazine and coupled to the drive assembly; and a remaganizing movement by which the test element is transported back into the compartment of the magazine.
摘要翻译：用于通过穿刺皮肤以产生体液样品并检测样品中包含的分析物来自动执行皮肤点刺分析的分析系统。分析系统包括具有多个隔室的盒，每个隔间包含穿刺元件和分析元件，以及具有驱动组件的可重复使用的手持式器械。所述驱动组件适于通过手动产生的机械力来至少驱动以下运动：联接运动，通过所述联接运动，所述穿刺元件中的一个联接到所述驱动组件; 穿刺和样本收集运动，其中包含在所述盒中的所述穿刺元件之一并且联接到所述驱动组件; 以及将测试元件运送回料仓的隔间的再现运动。

35. 发明授权

US08114029B2 Test system for measuring the concentration of an analyte in a body fluid 有权
标题翻译：用于测量体液中分析物浓度的测试系统
公开(公告)号：US08114029B2
公开(公告)日：2012-02-14
申请号：US12619384
申请日：2009-11-16
申请人： Hans List , Hans-Peter Haar , George Bevan Kirby Meacham
发明人： Hans List , Hans-Peter Haar , George Bevan Kirby Meacham
IPC分类号： A61B5/00 , A61B17/14 , A61B17/32
CPC分类号： A61B5/150198 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150511 , A61B5/15107 , A61B5/15117 , A61B5/15146 , A61B5/15151 , A61B5/15161 , A61B5/15176
摘要： An actuator for driving a test element is disclosed. The test element can comprise a lancet for perforating the skin of a living organism. The actuator can comprise an engaging part for engaging and driving the test element in a lancing motion. The actuator can further comprise a lancing actuator and a lancing spring. The lancing actuator can bias the lancing spring by executing a forward movement and thereby can exert a biasing force on the engaging part. The actuator can further comprise a latch element. The latch element can be a force-sensitive latch element for exerting a retention force to hold back the engaging part. The retention force can counteract the biasing force. The latch element can release the engaging part when the biasing force exerted by the lancing actuator exceeds the retention force exerted by the latch element, thereby allowing the test element to perform the lancing motion.
摘要翻译：公开了用于驱动测试元件的致动器。测试元件可以包括用于穿孔活体的皮肤的刺血针。致动器可以包括用于以穿刺运动接合和驱动测试元件的接合部分。致动器还可包括穿刺致动器和穿刺弹簧。穿刺致动器可以通过执行向前运动来偏压穿刺弹簧，从而可以在接合部件上施加偏置力。致动器还可以包括闩锁元件。闩锁元件可以是用于施加保持力以阻止接合部分的力敏锁定元件。保持力可以抵消偏置力。当由穿刺致动器施加的偏压力超过由闩锁元件施加的保持力时，闩锁元件可以释放接合部件，从而允许测试元件执行穿刺运动。

36. 发明申请

US20110092855A1 Analysis system for automatic skin prick analysis 有权
标题翻译：自动皮肤点刺分析系统
公开(公告)号：US20110092855A1
公开(公告)日：2011-04-21
申请号：US12755839
申请日：2010-04-07
申请人： Hans List , Hans-Peter Haar , George Bevan Kirby Meacham
发明人： Hans List , Hans-Peter Haar , George Bevan Kirby Meacham
IPC分类号： A61B5/00 , A61B17/32
CPC分类号： A61B5/150198 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150519 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/15146 , A61B5/15151 , A61B5/15163 , A61B5/15176 , A61B5/157
摘要： Analysis system for automatically performing a skin prick analysis by pricking the skin for producing a sample of body liquid and detecting an analyte contained in the sample. The analysis system comprises a magazine with a plurality of compartments each containing a lancing element and an analysis element, and a reusable hand-held instrument having a drive assembly. The drive assembly is adapted for driving at least the following movements by manually generated mechanical force: a coupling movement by which one of the lancing elements is coupled to the drive assembly; a puncturing and sample collection movement of one of the lancing elements contained in the magazine and coupled to the drive assembly; and a remaganizing movement by which the test element is transported back into the compartment of the magazine.
摘要翻译：用于通过穿刺皮肤以产生体液样品并检测样品中包含的分析物来自动执行皮肤点刺分析的分析系统。分析系统包括具有多个隔室的盒，每个隔间包含穿刺元件和分析元件，以及具有驱动组件的可重复使用的手持式器械。所述驱动组件适于通过手动产生的机械力来至少驱动以下运动：联接运动，通过所述联接运动，所述穿刺元件中的一个联接到所述驱动组件; 穿刺和样本收集运动，其中包含在所述盒中的所述穿刺元件之一并且联接到所述驱动组件; 以及将测试元件运送回料仓的隔间的再现运动。

37. 发明申请

US20110009774A1 BODY FLUID SAMPLING DEVICE 有权
标题翻译：身体液体取样装置
公开(公告)号：US20110009774A1
公开(公告)日：2011-01-13
申请号：US12879500
申请日：2010-09-10
申请人： Irio Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
发明人： Irio Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
IPC分类号： A61B5/151
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150358 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/15045 , A61B5/150503 , A61B5/15151 , A61B5/15163
摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid. In one embodiment, the collection zone includes a plurality of holes, e.g., 3 or more holes, or 50 to 100 holes. The hole size may be small, e.g., having a diameter of 0.01 to 0.5 mm. The holes may or may not extend through the lancet. In some embodiments, the holes have a depth of 50 to 500 μm. In other embodiments, the collection zone is porous, or is a roughened area. The collection zone can take up a very small volume of body fluid, e.g., 3 to 10 nL, in a very short time period, e.g., less than 0.5 seconds. In other embodiments, the device further comprises a fluid receiving means spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially.
摘要翻译：体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件。在一个实施例中，收集区包括多个孔，例如3个或更多个孔，或50至100个孔。孔尺寸可以较小，例如具有0.01至0.5mm的直径。这些孔可以延伸穿过刺血针也可能不延伸穿过刺血针。在一些实施例中，孔的深度为50至500μm。在其它实施方案中，收集区是多孔的，或者是粗糙区域。收集区可以在非常短的时间段（例如小于0.5秒）内占据非常小体积的体液，例如3至10nL。在其他实施例中，该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液最初不会接触流体接收装置。

38. 发明授权

US07819822B2 Body fluid sampling device 有权
标题翻译：体液取样装置
公开(公告)号：US07819822B2
公开(公告)日：2010-10-26
申请号：US11470368
申请日：2006-09-06
申请人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilfried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
发明人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilfried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
IPC分类号： A61B5/00
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150358 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/15045 , A61B5/150503 , A61B5/15151 , A61B5/15163
摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid, and the device further comprising a fluid receiving means remote spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially. The collection zone takes up a very small volume of body fluid of about 10 to 500 nl in a very short time period of less than 0.5 seconds. The fluid receiving means may have a test zone for performing an analytical reaction. Fluid sample from the collection zone is automatically or manually transported to the fluid receiving means to contact the fluid with the test zone.
摘要翻译：体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件，并且该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液不会接触流体接收装置原来。收集区在小于0.5秒的非常短的时间段内占据非常小体积的体液约10至500nl。流体接收装置可以具有用于进行分析反应的测试区域。来自收集区的流体样品被自动或手动地输送到流体接收装置以使流体与测试区接触。

39. 发明申请

US20100063417A1 LANCING SYSTEM FOR THE EXTRACTION OF A BODY FLUID 有权
公开(公告)号：US20100063417A1
公开(公告)日：2010-03-11
申请号：US12396838
申请日：2009-03-03
申请人： Hans List , Irio G. Calasso , Joachim Hoenes , Hans-Peter Haar , Uwe Kraemer , Herbert Harttig , Volker Zimmer
发明人： Hans List , Irio G. Calasso , Joachim Hoenes , Hans-Peter Haar , Uwe Kraemer , Herbert Harttig , Volker Zimmer
IPC分类号： A61B5/151
CPC分类号： A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150175 , A61B5/150389 , A61B5/150503 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15132
摘要： Lancing system for extracting a body fluid from the skin of a human or animal comprising a needle element (3) for lancing the skin, a lancing device (2) which includes a lancet drive (15a), by which a lancing movement of the needle element (3) coupled with the lancet drive by means of a coupling mechanism (28) is driven in lancing direction, wherein the lancing device (2) comprises a housing (4) with a housing opening (5) at its in lancing direction front end and the housing opening (5) is surrounded by a housing skin contact surface (7) which is pressed against the skin when using the lancing device (2), the needle element (3) is moved on a predetermined lancing path in a lancing direction in a forward phase of the lancing movement until its tip (3c) enters the skin in order to create a wound and in a return phase of the lancing movement following the reaching of a reversal point corresponding to the lancing depth (S) in the skin is retracted again, a lancing depth reference element (8) with a reference skin contact surface (11) is provided to improve the reproducibility of the lancing depth (S), which is adapted and arranged in such a manner that the reference skin contact surface (11) at the reversal point of the lancing movement is in contact with the skin and the predetermined value of the lancing depth (S) is determined by the distance in lancing direction which prevails at the reversal point of the lancing movement between the reference skin contact surface (11) and the position of the tip (3c) of the needle element (3), at which at the time at which the tip (3c) of the needle element (3) in the forward phase of the lancing movement passes the reference skin contact surface (11) and enters a skin surface which is in contact with said reference skin contact surface, the lancing depth reference element (8) with the reference skin contact surface (11) is in a stationary defined position relative to the reversal point of the lancing movement and the lancing depth reference element (8) is adapted and arranged in such a manner that the skin when pressed against the reference skin contact surface (11) is stabilized with respect to a skin deformation which occurs upon lancing of the skin.

40. 发明申请

US20080262388A1 Puncturing System For Collecting Body Fluid Sample 有权
标题翻译：用于收集体液样品的穿刺系统
公开(公告)号：US20080262388A1
公开(公告)日：2008-10-23
申请号：US12122908
申请日：2008-05-19
申请人： Hans List , Hans-Peter Haar , George Bevan Kirby Meacham , Michael Eusemann
发明人： Hans List , Hans-Peter Haar , George Bevan Kirby Meacham , Michael Eusemann
IPC分类号： A61B5/15
CPC分类号： A61B5/15196 , A61B5/14514 , A61B5/150022 , A61B5/150152 , A61B5/150175 , A61B5/15019 , A61B5/150419 , A61B5/150519 , A61B5/15113 , A61B5/15117 , A61B5/15119 , A61B5/15128 , A61B5/1519 , A61B5/15194
摘要： The invention relates to a microsampler puncturing system for collecting a body fluid from a body part, comprising a sample collection unit having a piercing element, and a puncturing instrument having a drive, by which a sample collection unit is movable on a movement path for piercing the piercing element into the skin of the body part and withdraw it again by means of a piercing and retraction movement, a setting device for setting the puncturing depth of the piercing wound to be generated, and a control device for controlling the piercing and retraction movement having the following sequentially executed movement phases: a forward phase (V), in which the piercing element is pierced up to a defined puncturing depth (dm), a retraction phase (R1), in which the piercing element is partially retracted by a retraction distance (Δd) and is decelerated toward the end of the retraction phase (R1), so that it remains projecting into the skin at a defined residual puncturing depth (dr), and a collecting phase (S), in which the piercing element projects into the skin and a body fluid sample is absorbed by the sample collection unit. The setting device is adapted for the defined puncturing depth is settable independently of the chronological mean of the defined residual puncturing depth (dr), with reference to the collecting phase.
摘要翻译：本发明涉及一种用于从身体部分收集体液的微量取样器穿刺系统，包括具有穿刺元件的样本收集单元和具有驱动器的穿刺器械，通过该穿刺器具，样本收集单元可在用于穿刺的移动路径上移动刺穿元件进入身体部分的皮肤并通过穿刺和缩回运动再次撤回，用于设定要产生穿刺伤口的穿刺深度的设置装置，以及用于控制穿刺和缩回运动的控制装置具有以下顺序执行的移动阶段：穿刺元件被刺穿到限定的穿刺深度（dm）的正向相（V），其中穿刺元件被部分地缩回的收回相位（R 1）缩回距离（Deltad）并且朝向收缩阶段（R 1）的端部减速，使得其以限定的残余穿刺深度（dr）保持突出到皮肤中）和收集阶段（S），其中穿刺元件伸入皮肤并且体液样品被样品收集单元吸收。该设定装置适用于所设定的穿刺深度，可以独立于规定的残留穿刺深度（dr）的时间平均值参照收集阶段进行设定。

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