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31. 发明申请

WO1992019271A1 PERCUTANEOUS ADMINISTRATION AND ABSORPTION PROMOTER COMPOSITION AND EXTERNAL PREPARATION FOR PERCUTANEOUS ADMINISTRATION 审中-公开
标题翻译： PERCUTANEOUS ADMINISTRATION AND ABSORPTION PROMOTER COMPOSITION AND EXTERNAL Preparation for PERCUTANEOUS ADMINISTRATION
公开(公告)号：WO1992019271A1
公开(公告)日：1992-11-12
申请号：PCT/JP1992000194
申请日：1992-02-24
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , SATO, Syuji; , MUKAE, Katsuya; , HIGASHI, Yoshinobu; , SUZUKI, Tatsuaki; , MIZUMACHI, Mitsuhiro; , SAKAGUCHI, Hirofumi;
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K47/10
CPC分类号： A61K47/10 , A61K9/0014 , A61K47/14
摘要： A percutaneous administration and absorption promoter composition which can remarkably promote the percutaneous absorption of pharmacologically active substances, characterized by containing a hydrophobic substance, water and a lower alcohol. An external preparation for percutaneous administration which permits pharmacologically active substances to be percutaneously administered efficiently to thereby attain a therapeutic effect, characterized by containing a pharmacologically active substance, a hydrophobic substance, water and a lower alcohol.
摘要翻译：一种能够显着促进药理活性物质的经皮吸收的经皮给药吸收促进剂组合物，其特征在于含有疏水性物质，水和低级醇。用于经皮给药的外用制剂，其允许有效地经皮施用药理活性物质，从而获得治疗效果，其特征在于含有药理活性物质，疏水性物质，水和低级醇。

32. 发明申请

WO1987004434A1 NOVEL INDENOTHIAZOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：新的茚并噻唑衍生物及其制备方法
公开(公告)号：WO1987004434A1
公开(公告)日：1987-07-30
申请号：PCT/JP1987000021
申请日：1987-01-14
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , TSUJI, Masayoshi , NAKAWAGA, Akira , INOUE, Hisataka , HACHIYA, Terumi , TANOUE, Yoshihiro , IKESUE, Koichi , SAITA, Masaru , MIZOGUCHI, Takenobu , AOKI, Tetsuo , SATO, Hironobu , NODA, Kanji
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： C07D277/60
CPC分类号： C07D277/60 , C07D417/12
摘要： Indenothiazole derivatives represented by general formula (Ia) (wherein X and Y, which may be the same or different, each represents hydrogen, halogen, lower alkyl or lower alkoxy, n represents an integer of 0 to 4, R1 represents hydrogen, lower alkyl or unsubstituted or substituted phenyl, R2 represents lower alkyl, cycloalkyl, lower alkoxy, unsubstituted or substituted phenoxy, unsubstituted or substituted phenyl, alkenyl, heterocyclic group or cyclic amino group, R3 represents hydrogen, lower alkyl or acyl, or R2 and R3 may be bound to each other to form a cyclic amino group), and tautomers (Ib) of general formula (Ia) (provided that R3 represents hydrogen) are disclosed.

33. 发明申请

WO1998025592A1 TRANSDERMAL PREPARATION CONTAINING SEROTONIN RECEPTOR ANTAGONIST 审中-公开
标题翻译：含有丝氨酸蛋白酶受体拮抗剂的透皮制剂
公开(公告)号：WO1998025592A1
公开(公告)日：1998-06-18
申请号：PCT/JP1997004358
申请日：1997-11-28
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , HIRANO, Munehiko , MAKI, Masayoshi , SUZUKI, Tatsuaki
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K09/70
CPC分类号： A61K9/7053 , A61K9/7076 , A61K9/7092 , A61K31/4178 , A61K31/4184 , A61K31/439 , A61K31/538
摘要： A device for percutaneous treatment by a serotonin receptor antagonist, comprising at least three layers including A) a drug-impermeable backing layer, B) a drug storage layer provided between the backing layer and a drug release layer and containing a serotonin receptor antagonist, and C) a drug release layer constituted of a pressure-sensitive adhesive layer capable of controlling the release of a drug.
摘要翻译：一种用于经5-羟色胺受体拮抗剂经皮处理的装置，包括至少三层，包括A）药物不可渗透背衬层，B）设置在背衬层和药物释放层之间并含有5-羟色胺受体拮抗剂的药物储存层，以及 C）由能够控制药物释放的压敏粘合剂层构成的药物释放层。

34. 发明申请

WO1997010840A1 ANTI-INFLAMMATORY ANTISENSE DRUG 审中-公开
标题翻译：抗炎药物抗药物
公开(公告)号：WO1997010840A1
公开(公告)日：1997-03-27
申请号：PCT/JP1996002682
申请日：1996-09-18
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , LTT INSTITUTE, CO., LTD. , SATO, Shuji , GOTO, Takeshi , WADA, Akira , SUZUKI, Yousuke , KAWAI, Shinichi , MIZUSHIMA, Yutaka
发明人： HISAMITSU PHARMACEUTICAL CO., INC. , LTT INSTITUTE, CO., LTD.
IPC分类号： A61K38/14
CPC分类号： A61K31/70 , A61K47/60 , A61K47/62 , A61K48/00
摘要： An anti-inflammatory antisense drug which comprises a complex of a synthetic polyamino acid consisting of repeated sequences of lysine and serine residues or polyethylene glycol modifications thereof and an antisens oligonucleotide complementary to the partial or whole base sequence of an mRNA encoding physiologically active substances participating in human inflammatory diseases such as interleukin-1 beta , tumor necrotizing factor or alpha -cyclooxygenase. This drug enables efficacious treatment of inflammatory diseases such as rheumatoid arthritis, paradentitis, nephritis, ulcerous colitis, arterial sclerosis and psoriasis, septic shock, Crohn's disease, AIDS, intractable hepatic diseases, pathologies in association with liver transplant, etc.
摘要翻译：一种抗炎反义药物，其包含由重复的赖氨酸和丝氨酸残基序列组成的合成聚氨基酸或其聚乙二醇修饰物的复合物，以及与编码参与其中的生理活性物质的mRNA的部分或全部碱基序列互补的反义寡核苷酸人类炎症性疾病如白细胞介素-1β，肿瘤坏死因子或α-环氧合酶。这种药物能够有效治疗炎性疾病如类风湿性关节炎，慢性肾炎，肾炎，溃疡性结肠炎，动脉硬化和银屑病，败血性休克，克罗恩病，艾滋病，难治性肝病，与肝移植有关的病理等。

35. 发明申请

WO1997006848A1 ELECTRODE STRUCTURE FOR IONTOPHORESIS 审中-公开
标题翻译：电极结构
公开(公告)号：WO1997006848A1
公开(公告)日：1997-02-27
申请号：PCT/JP1995001619
申请日：1995-08-14
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , MORI, Kenji , KONNO, Takeshi
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61N01/30
CPC分类号： A61N1/0436 , A61N1/0432 , A61N1/044 , A61N1/30
摘要： An electrode structure for iontophoresis having a polarizable electrode and a non-polarizable electrode in combination, switching between both electrodes being free at the time of energization. Through suitably switching between both electrodes as an electrode structure for iontophoresis, the electrode structure can safely and adequately feed a physiologically active substance and medicines into an organism in dermal and mucosal administrations and effectively feed the physiologically active substance and medicines through skin and mucosa without generating a stimulus.
摘要翻译：一种用于离子电渗疗法的电极结构，其具有可极化电极和不可极化电极的组合，两个电极在通电时自由切换。通过适当地切换两个电极之间的离子电渗疗法的电极结构，电极结构可以安全地和充分地将生理活性物质和药物喂入皮肤和粘膜给药的生物体中，并通过皮肤和粘膜有效地喂养生理活性物质和药物，而不产生刺激。

36. 发明申请

WO1997004789A1 TABLETS CONTAINING ANION EXCHANGE RESIN 审中-公开
标题翻译：含有阴离子交换树脂的片剂
公开(公告)号：WO1997004789A1
公开(公告)日：1997-02-13
申请号：PCT/JP1996002189
申请日：1996-08-02
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , GOTO, Takeshi , MENO, Tatsuya
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K31/785
CPC分类号： A61K9/2054 , A61K9/2009 , A61K31/785
摘要： A drug composition comprising an anion exchange resin, silicon dioxide, crystalline cellulose and a pharmaceutically acceptable carrier, more precisely tablets containing an anion exchange resin prepared by mixing a premix comprising an anion exchange resin, silicon dioxide and crystalline cellulose without the addition of water and tableting the obtained mixture. More desirably, the drug composition or tablets as described above wherein the anion exchange resin is a non-cross-linked type one represented by general formula (I), wherein R1 is C7-C10 aralkyl or C1-C20 alkyl; R2 and R3 are each independently C1-C4 lower alkyl; R4 is hydrogen or C1-C4 lower alkyl; X is a physiologically acceptable counter ion; n is an integer of 1 or 3; and p is an average degree of polymerization of 10 to 10,000.
摘要翻译：一种药物组合物，其包含阴离子交换树脂，二氧化硅，结晶纤维素和药学上可接受的载体，更准确地说，含有阴离子交换树脂的片剂，其通过将不含添加水的阴离子交换树脂，二氧化硅和结晶纤维素混合预混物而制备，压片得到的混合物。更优选地，如上所述的药物组合物或片剂，其中阴离子交换树脂是由通式（I）表示的非交联型，其中R 1是C 7 -C 10芳烷基或C 1 -C 20烷基; R2和R3各自独立地为C1-C4低级烷基; R4是氢或C1-C4低级烷基; X是生理上可接受的抗衡离子; n为1或3的整数; p为10〜10,000的平均聚合度。

37. 发明申请

WO1996030367A1 PIPERIDINE DERIVATIVES 审中-公开
标题翻译：哌啶衍生物
公开(公告)号：WO1996030367A1
公开(公告)日：1996-10-03
申请号：PCT/JP1996000796
申请日：1996-03-27
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , TANOUE, Yoshihiro , BEPPU, Koichi , OKAYAMA, Akira , SAKAMOTO, Osami
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： C07D405/12
CPC分类号： C07D405/12
摘要： Piperidine derivatives represented by general formula (I) or pharmaceutically acceptable acid addition salts thereof: wherein n represents an integer of 0 or 1; X represents CH2, O or CH-CH3; R represents hydrogen, halogeno, lower alkyl, hydroxy, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, substituted aminosulfonyl or nitro; and R1 and R2 may be the same or different and each represents hydrogen or lower alkyl. The compound has an antagonism on Substance P and is useful as a preventive or remedy for asthma, vomitting, etc.
摘要翻译：由通式（I）表示的哌啶衍生物或其药学上可接受的酸加成盐：其中n表示0或1的整数; X表示CH 2，O或CH-CH 3; R代表氢，卤代，低级烷基，羟基，低级烷氧基，低级烷硫基，低级烷基亚磺酰基，低级烷基磺酰基，取代的氨基磺酰基或硝基; 并且R 1和R 2可以相同或不同，各自表示氢或低级烷基。该化合物对物质P具有拮抗作用，可用作哮喘，呕吐等的预防或补救措施。

38. 发明申请

WO1996029422A1 NUCLEIC ACID CARRIER 审中-公开
标题翻译：核酸载体
公开(公告)号：WO1996029422A1
公开(公告)日：1996-09-26
申请号：PCT/JP1996000654
申请日：1996-03-15
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , KUSUNOKI, Takuma , IIJIMA, Osamu , SUZUKI, Yousuke
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： C12N15/87
CPC分类号： C12N15/87
摘要： A novel carrier for the introduction of a nucleic acid into cells and a regulator containing this carrier and the nucleic acid for promoting the introduction of the nucleic acid into the cells. This carrier comprises a toxin B chain protein and a substance capable of binding to the nucleic acid.
摘要翻译：用于将核酸引入细胞的新载体和含有该载体的调节剂和用于促进将核酸引入细胞的核酸。该载体包含毒素B链蛋白和能够结合核酸的物质。

39. 发明申请

WO1996029349A1 MONOCLONAL ANTIBODY SPECIFICALLY RECOGNIZING ADENO-ASSOCIATED VIRUS CAP PROTEIN 审中-公开
标题翻译：单克隆抗体特异性识别腺相关病毒CAP蛋白
公开(公告)号：WO1996029349A1
公开(公告)日：1996-09-26
申请号：PCT/JP1996000655
申请日：1996-03-15
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , SHIMADA, Takashi , KUMA, Hidekazu , SUZUKI, Yousuke
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： C07K16/08
CPC分类号： G01N33/6878 , C07K16/081 , G01N33/56983 , G01N2333/075
摘要： A monoclonal antibody specifically recognizing the adeno-associated virus CAP protein and produced by hybridomas which have been formed through fusion between lymphocytes prepared from a mammal immunized with the adeno-associated virus CAP protein or a recombinant of the protein as an antigen and a myeloma cell line. Because of being a novel antibody and capable of specifically recognizing the adeno-associated virus CAP protein, the antibody is applicable to the detection of the adeno-associated virus and the purification of an adeno-associated virus vector for gene therapy.
摘要翻译：特异性识别由腺病毒CAP蛋白免疫的哺乳动物的淋巴细胞或作为抗原的蛋白重组体和骨髓瘤细胞产生的通过融合形成的杂交瘤产生的腺相关病毒CAP蛋白的单克隆抗体线。由于是一种能够特异性识别腺相关病毒CAP蛋白的新型抗体，该抗体适用于腺相关病毒的检测和用于基因治疗的腺相关病毒载体的纯化。

40. 发明申请

WO1996028565A1 NOVEL GENE RECOMBINANT 审中-公开
标题翻译：新基因重组
公开(公告)号：WO1996028565A1
公开(公告)日：1996-09-19
申请号：PCT/JP1996000658
申请日：1996-03-15
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , SHIMADA, Takashi , AKIYAMA, Katsuhiko , SUZUKI, Yousuke
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N2740/16043 , C12N2740/16052
摘要： A recombinant human immunodeficiency virus vector having the DNA sequence coding for cytotoxins.
摘要翻译：具有编码细胞毒素的DNA序列的重组人免疫缺陷病毒载体。

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