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1. 发明申请

WO2007058392A9 HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF 审中-公开
标题翻译：杂环化合物和药物应用
公开(公告)号：WO2007058392A9
公开(公告)日：2007-07-05
申请号：PCT/JP2006323637
申请日：2006-11-21
申请人： JAPAN TOBACCO INC , UENO HIROSHI , SHIMADA TAKASHI , AOYAGI KOUICHI , KATOH SUSUMU , SHINKAI HISASHI , MOTOMURA TAKAHISA , KOMODA YASUMASA , OTSUBAKI TOMOKO , SOEJIMA YUKI , KAWAHARA IICHIRO
发明人： UENO HIROSHI , SHIMADA TAKASHI , AOYAGI KOUICHI , KATOH SUSUMU , SHINKAI HISASHI , MOTOMURA TAKAHISA , KOMODA YASUMASA , OTSUBAKI TOMOKO , SOEJIMA YUKI , KAWAHARA IICHIRO
IPC分类号： C07D237/26 , A61K31/502 , A61K31/5025 , A61K31/55 , A61K38/21 , A61K45/00 , A61P1/16 , A61P31/14 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/10 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
CPC分类号： C07D237/26 , A61K31/502 , A61K31/5025 , A61K31/55 , A61K38/21 , A61K45/06 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/10 , C07D417/10 , C07D471/04 , C07D487/04 , C07D495/04 , A61K2300/00
摘要： It is intended to provide a novel heterocyclic compound having an HCV entry inhibition activity and a medicinal application thereof. The invention relates to the use of the heterocyclic compound represented by the general formula [1]: [wherein Q 1 represents N= or the like, Q 2 represents N or the like, Q 3 represents N= or the like, Q 4 represents N or the like, Q 5 represents N or the like, R 1 represents a hydrogen atom or the like, R 2 represents a hydrogen atom or the like, the ring A represents a monocyclic aryl group which may have a substituent or the like and the ring B represents a monocyclic aryl group which may have a substituent or the like], a pharmaceutically acceptable salt thereof for the production of a therapeutic agent for hepatitis C and so on.
摘要翻译：旨在提供具有HCV进入抑制活性的新型杂环化合物及其药学应用。本发明涉及由通式[1]表示的杂环化合物的用途：[其中Q 1表示N =等，Q 2表示N或类似地，Q 3表示N =等，Q 4表示N等，Q 5表示N等，R 3， SUP> 1表示氢原子等，R 2表示氢原子等，环A表示可以具有取代基等的单环芳基，环B表示可以具有取代基的单环芳基等]，其药学上可接受的盐用于生产丙型肝炎治疗剂等。

2. 发明申请

WO1996029393A1 RECOMBINANT HUMAN IMMUNODEFICIENCY VIRUS-PRODUCING CELL 审中-公开
标题翻译：重组人免疫缺陷病毒生产细胞
公开(公告)号：WO1996029393A1
公开(公告)日：1996-09-26
申请号：PCT/JP1996000653
申请日：1996-03-15
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , SHIMADA, Takashi , AKIYAMA, Katsuhiko , KUMA, Hidekazu , SUZUKI, Yousuke
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： C12N05/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/16043 , C12N2740/16052
摘要： Recombinant human immunodeficiency virus-producing cells which are obtained by introducing a recombinant human immunodeficiency virus helper plasmid containing at least the sequences of gag, pol and env genes encoded by the human immunodeficiency virus genome and lacking the packaging signal into animal cells and sustain these genes in a stable state. The cells make it possible to more efficiently and stably prepare HIV vectors in large amounts.
摘要翻译：通过引入至少含有由人免疫缺陷病毒基因组编码的gag，pol和env基因的序列的重组人免疫缺陷病毒辅助质粒而获得的重组人免疫缺陷病毒产生细胞，并且将包装信号缺乏并维持这些基因处于稳定状态。细胞使得可以更有效地和稳定地制备大量的HIV载体。

3. 发明申请

WO1996028188A2 METHOD OF TRANSMITTING TARGET-ORIENTED SUBSTANCES 审中-公开
标题翻译：发送目标靶向物质的方法
公开(公告)号：WO1996028188A2
公开(公告)日：1996-09-19
申请号：PCT/JP1996000657
申请日：1996-03-15
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , SHIMADA Takashi , AKIYAMA, Katsuhiko , SUZUKI, Yousuke
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K48/00
CPC分类号： A61K31/70 , A61K47/50 , A61K48/00

4. 发明申请

WO1996029349A1 MONOCLONAL ANTIBODY SPECIFICALLY RECOGNIZING ADENO-ASSOCIATED VIRUS CAP PROTEIN 审中-公开
标题翻译：单克隆抗体特异性识别腺相关病毒CAP蛋白
公开(公告)号：WO1996029349A1
公开(公告)日：1996-09-26
申请号：PCT/JP1996000655
申请日：1996-03-15
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , SHIMADA, Takashi , KUMA, Hidekazu , SUZUKI, Yousuke
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： C07K16/08
CPC分类号： G01N33/6878 , C07K16/081 , G01N33/56983 , G01N2333/075
摘要： A monoclonal antibody specifically recognizing the adeno-associated virus CAP protein and produced by hybridomas which have been formed through fusion between lymphocytes prepared from a mammal immunized with the adeno-associated virus CAP protein or a recombinant of the protein as an antigen and a myeloma cell line. Because of being a novel antibody and capable of specifically recognizing the adeno-associated virus CAP protein, the antibody is applicable to the detection of the adeno-associated virus and the purification of an adeno-associated virus vector for gene therapy.
摘要翻译：特异性识别由腺病毒CAP蛋白免疫的哺乳动物的淋巴细胞或作为抗原的蛋白重组体和骨髓瘤细胞产生的通过融合形成的杂交瘤产生的腺相关病毒CAP蛋白的单克隆抗体线。由于是一种能够特异性识别腺相关病毒CAP蛋白的新型抗体，该抗体适用于腺相关病毒的检测和用于基因治疗的腺相关病毒载体的纯化。

5. 发明申请

WO1996028565A1 NOVEL GENE RECOMBINANT 审中-公开
标题翻译：新基因重组
公开(公告)号：WO1996028565A1
公开(公告)日：1996-09-19
申请号：PCT/JP1996000658
申请日：1996-03-15
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , SHIMADA, Takashi , AKIYAMA, Katsuhiko , SUZUKI, Yousuke
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N2740/16043 , C12N2740/16052
摘要： A recombinant human immunodeficiency virus vector having the DNA sequence coding for cytotoxins.
摘要翻译：具有编码细胞毒素的DNA序列的重组人免疫缺陷病毒载体。

6. 发明申请

WO1995030755A1 RECOMBINANT HUMAN IMMUNODEFICIENCY VIRUS VECTOR AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：重组人免疫缺陷病毒载体及其生产方法
公开(公告)号：WO1995030755A1
公开(公告)日：1995-11-16
申请号：PCT/JP1995000893
申请日：1995-05-10
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , SHIMADA, Takashi , AKIYAMA, Katsuhiko
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： C12N15/49
CPC分类号： C12N15/86 , C12N2740/16043
摘要： A recombinant HIV vector which retains the foreign DNA sequence antagonistic against HIV growth and/or gene expression and wherein the U3 domain of the LTR sequence on the genome 5' side has been replaced by the promoter sequence of a cytomegalovirus. As this vector can express an anti-HIV sequence of, for example, antisense, ribozyme or TAR decoy in HIV-infected cells without fail, it is useful as a material for gene therapy of HIV infection.
摘要翻译：保留与HIV生长和/或基因表达拮抗的外源DNA序列的重组HIV载体，其中基因组5'侧的LTR序列的U3结构域被巨细胞病毒的启动子序列替代。由于该载体可以在HIV感染的细胞中表达例如反义，核酶或TAR诱饵的抗HIV序列，因此它可用作HIV感染的基因治疗的材料。

7. 发明申请

WO1998029470A1 POLYESTER ELASTOMERS, PROCESSES FOR PREPARING THE SAME, AND COMPOSITIONS OF THE SAME 审中-公开
标题翻译：聚酯弹性体，其制备方法及其组合物
公开(公告)号：WO1998029470A1
公开(公告)日：1998-07-09
申请号：PCT/JP1997004890
申请日：1997-12-26
申请人： DAICEL CHEMICAL INDUSTRIES, LTD. , WATANABE, Kazushi , WATANABE, Jun , SHIMADA, Takashi
发明人： DAICEL CHEMICAL INDUSTRIES, LTD.
IPC分类号： C08G63/91
CPC分类号： C08L67/02 , C08G18/4018 , C08G18/4202 , C08G18/4266 , C08G18/44 , C08G63/16 , C08G63/64 , C08G63/672 , C08K5/41 , C08K5/49 , C08L63/00 , C08L67/00 , C08L67/025 , C08L69/005 , C08L2666/18 , C08L2666/22 , C08L2666/14
摘要： A polyester elastomer comprising a crystalline aromatic polyester as a hard component, at least one polymer selected from among an aliphatic polyester, a polyether and a polycarbonate as a soft component, and further a polyisocyanate, a polyepoxide and a polybasic acid or an anhydride thereof, or a process for preparing a polyester elastomer comprising the above hard component, soft component, and dibasic acid or anhydride thereof; a polyester elastomer comprising a polyalkylene naphthalate and an aliphatic polyester, and a process for preparing the same; a composition comprising 30 to 90 % by weight of a polyester elastomer and 70 to 10 % by weight of an epoxy-modified polymer (the total amount of the elastomer and the polymer being 100 % by weight); a molding made from a resin comprising an aromatic polyester as a hard component and at least one polymer selected from among an aliphatic polyester, a polyether and a polycarbonate as a soft component; and a polyester elastomer comprising different aliphatic polyesters respectively as a hard component and a soft component, and a process for preparing the same.
摘要翻译：包含作为硬组分的结晶芳族聚酯，至少一种选自脂族聚酯，聚醚和作为软组分的聚碳酸酯的聚合物的聚酯弹性体，以及多异氰酸酯，聚环氧化物和多元酸或其酸酐，或包含上述硬组分，软组分和二元酸或其酸酐的聚酯弹性体的制备方法; 包含聚萘二甲酸亚烷基酯和脂族聚酯的聚酯弹性体及其制备方法; 含有30〜90重量％的聚酯弹性体和70〜10重量％的环氧改性聚合物（弹性体和聚合物的总量为100重量％）的组合物; 由包含芳族聚酯作为硬组分的树脂和至少一种选自脂族聚酯，聚醚和作为软组分的聚碳酸酯的聚合物制成的模制品; 和分别作为硬成分和软成分的不同脂肪族聚酯的聚酯弹性体及其制造方法。

8. 发明申请

WO1996028560A1 NOVEL CELL STRAINS 审中-公开
标题翻译：新细胞株
公开(公告)号：WO1996028560A1
公开(公告)日：1996-09-19
申请号：PCT/JP1996000656
申请日：1996-03-15
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , SHIMADA, Takashi , AKIYAMA, Katsuhiko , KUMA, Hidekazu , SUZUKI, Yousuke
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： C12N15/64
CPC分类号： C12N15/86 , C12N2750/14143
摘要： A recombinant adeno-associated virus helper plasmid in which the ITR sequence on the genome 5' side and the ITR sequence on the genome 3' side of the wild type adeno-associated virus have been replaced by the ITR sequence of the Adenovirus; recombinant adeno-associated virus vector-producing cells having the above-mentioned recombinant adeno-associated virus helper plasmid stably integrated into the genome thereof via transfection of animal cells with the helper plasmid; and a process for producing the recombinant adeno-associated virus vector with the use of these recombinant adeno-associated virus vector-producing cells as the packaging cells.
摘要翻译：重组腺相关病毒辅助质粒，其中基因组5'侧的ITR序列和野生型腺相关病毒的基因组3'侧的ITR序列已被腺病毒的ITR序列替代; 具有通过用辅助质粒转染动物细胞而稳定整合到其基因组中的上述重组腺相关病毒辅助质粒的重组腺相关病毒载体产生细胞; 以及使用这些重组腺相关病毒载体产生细胞作为包装细胞来生产重组腺相关病毒载体的方法。

9. 发明专利

JPH10180000A CLEANING SERVICE SYSTEM 失效
公开(公告)号：JPH10180000A
公开(公告)日：1998-07-07
申请号：JP34556596
申请日：1996-12-25
申请人： SHIMADA TAKASHI
发明人： SHIMADA TAKASHI
IPC分类号： D06F95/00 , G06Q50/00 , G06Q50/10
摘要： PROBLEM TO BE SOLVED: To provide a cleaning service system which makes great improvements in hygiene and store's image. SOLUTION: In a store such as a convenience store, they form a point-charge list A showing the number of payment points, 1, corresponding to a cleaning charge for each item such as a clothe which can be cleaned, and charge tickets B each of which consists of a sheet of point slips 2. The point-charge list A is displayed for users or a number of point-charge lists A are given out to the users. Each user buys the charge ticket B in advance, finds out, from the charge list, the number of points, 1, corresponding to the item needing cleaning, and cuts the point slips 2 corresponding to the number of points, 1, off the charge ticket B. The user have their items collected together with the point slips by an unmanned accepting system provided outside the store, and after the items are cleaned the user receives the cleaned items in the store, in a service-only place where they handle no food.

10. 发明专利

JPH0749990A SEMAPHORE FOR SAFE PASS AT INTERSECTION FOR EMERGENCY VEHICLE 失效
公开(公告)号：JPH0749990A
公开(公告)日：1995-02-21
申请号：JP23108293
申请日：1993-08-07
申请人： SHIMADA TAKASHI
发明人： SHIMADA TAKASHI
IPC分类号： G08G1/087
摘要： PURPOSE:To provide an antenna, a receiver and a rotary lamp on a semaphore at an intersection, to transmit the radio wave signals by radio from an emergency vehicle to actuate the rotary lamp and to inform other vehicles of the approach of the emergency vehicle, and to make the drivers drive their vehicles based on the traffic rules at an intersection in order to evade such a case where the emergency vehicle has an accident at an intersection against another vehicle that does not observe the laws and is unable to fullfil its purpose. CONSTITUTION:An emergency vehicle transmits the radio wave signals of a very high frequency band through its transmitter and also transmits the radio waves to a directive antenna through a cable. Then an antenna, a cable and a receiver attached to a semaphore receive the radio waves transmitted from the emergency vehicle. Thus a rotary lamp is actuated independently of the semaphore so that other vehicles are aware of the approach of the emergency vehicle at an intersection.

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