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31. 发明申请

US20070259354A1 OPTIMIZED TRPM8 NUCLEIC ACID SEQUENCES AND THEIR USE IN CELL BASED ASSAYS AND TEST KITS TO IDENTIFY TRPM8 MODULATORS 审中-公开
标题翻译：优化的TRPM8核酸序列及其在基于细胞的测定中的用途以及鉴定TRPM8调节剂的测试工具
公开(公告)号：US20070259354A1
公开(公告)日：2007-11-08
申请号：US11536394
申请日：2006-09-28
申请人： Guy Servant , Paul Brust , Bryan Moyer , Min Lu , Fernando Echeverri , David Dahan , Mark Zoller , Mark Williams , Rachel Kimmich , Poonit Kamdar , Tanya Ditschun , Andrew Patron
发明人： Guy Servant , Paul Brust , Bryan Moyer , Min Lu , Fernando Echeverri , David Dahan , Mark Zoller , Mark Williams , Rachel Kimmich , Poonit Kamdar , Tanya Ditschun , Andrew Patron
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C12N15/85 , C12N5/10
CPC分类号： C07K14/705
摘要： Modified human TRPM8 nucleic acid sequences which are efficiently expressed in human cells and cell-based assays and test kits containing same are provided. These assays identify TRPM8 modulators using cells that express a modified human TRPM8 nucleic acid sequence according to the invention, wherein said sequence has been modified relative to a wild-type human TRPM8 nucleic acid sequence in order to optimize ion channel expression in desired cells. Assays using these modified TRPM8 sequences have been shown to identify compounds that modulate the human TRPM8 ion channel better or comparably to known coolants such as menthol and icilin.
摘要翻译：提供了在人细胞中有效表达的修饰的人TRPM8核酸序列和基于细胞的测定和含有其的测试试剂盒。这些测定使用表达根据本发明的修饰的人TRPM8核酸序列的细胞鉴定TRPM8调节剂，其中所述序列相对于野生型人类TRPM8核酸序列已被修饰，以优化所需细胞中的离子通道表达。已经显示使用这些修饰的TRPM8序列的测定来鉴定与已知的冷却剂如薄荷醇和icilin更好或相当地调节人类TRPM8离子通道的化合物。

32. 发明授权

US07273549B2 Membrane contactor apparatus including a module having hollow fiber membranes 有权
标题翻译：膜接触器装置包括具有中空纤维膜的模块
公开(公告)号：US07273549B2
公开(公告)日：2007-09-25
申请号：US10764058
申请日：2004-01-23
申请人： Dennis Williams , Mark Williams
发明人： Dennis Williams , Mark Williams
IPC分类号： B01D63/04
CPC分类号： B01D63/021 , B01D19/0031 , B01D63/02 , B01D63/04 , B01D63/043 , B01D2313/04 , B01D2313/08
摘要： An apparatus including a first hollow fiber membrane module, baffle assembly, and fluid source. The module includes a plurality of elongated hollow fiber membranes located generally in adjacent, parallel relationship to each other. Each of the membranes includes a generally cylindrical wall having a first end and a second end. The module also includes a module housing that supports the membranes. The module is configured to be positionable within the conduit and further to be matable with a similarly configured module. The baffle assembly is located within the conduit and configured to direct the flow of a first fluid through the module. The fluid source directs a second fluid to flow through the membranes from the first end to the second end. A predetermined substance is transmitted through the membranes' walls, to modify the concentration of the predetermined substance in the first fluid.
摘要翻译：一种包括第一中空纤维膜组件，挡板组件和流体源的设备。模块包括多个细长的中空纤维膜，这些膜通常彼此相邻且平行的关系。每个膜包括具有第一端和第二端的大致圆柱形的壁。该模块还包括支撑膜的模块外壳。该模块被配置为可定位在导管内并且还可以配置有类似配置的模块。挡板组件位于管道内并且构造成引导第一流体的流动通过模块。流体源引导第二流体从第一端流到第二端流过膜。预定物质透过膜的壁，以改变第一流体中预定物质的浓度。

33. 发明申请

US20070174600A1 Interface for communicating physical presence requests 审中-公开
标题翻译：用于传送物理存在请求的接口
公开(公告)号：US20070174600A1
公开(公告)日：2007-07-26
申请号：US11292768
申请日：2005-12-02
申请人： Mark Williams , Paul England , Xian Ke
发明人： Mark Williams , Paul England , Xian Ke
IPC分类号： G06F9/00
CPC分类号： G06F21/316 , G06F21/629 , G06F2221/2149
摘要： In order to facilitate the execution of a command in a pre-OS environment, functionality is provided in the OS environment which allows information regarding a requested command to be communicated to the pre-OS environment. A user request for a command is received, and the user is given information regarding the procedure for execution of the command. The OS communicates to the pre-OS environment certain information, for example by writing to specific memory locations accessible by the pre-OS environment. When the pre-OS environment is activated, the information is used in order to facilitate the user's execution of the command. Information can be transmitted back to the OS, for presentation to the user or further action by the pre-OS environment.
摘要翻译：为了便于在OS前环境中执行命令，在OS环境中提供功能，其允许关于所请求命令的信息被传送到OS前的环境。接收到用户对命令的请求，并向用户提供关于执行命令的过程的信息。操作系统通过写入到操作系统之前的环境可访问的特定存储器位置来向操作系统前的操作环境通信某些信息。当前OS环境被激活时，使用该信息以便于用户执行该命令。信息可以被传送回操作系统，用于呈现给用户或者由操作系统之前的环境进一步的动作。

34. 发明申请

US20070020381A1 40-O-(2-hydroxy)ethyl-rapamycin coated stent 有权
标题翻译： 40-O-（2-羟基）乙基 - 雷帕霉素涂层支架
公开(公告)号：US20070020381A1
公开(公告)日：2007-01-25
申请号：US11527893
申请日：2006-09-26
申请人： Syed Hossainy , Gordon Stewart , Mark Williams , Jeff Royal , Paul Consigny , Dorie Happ , Kurt Scheinpflug , Ty Hu
发明人： Syed Hossainy , Gordon Stewart , Mark Williams , Jeff Royal , Paul Consigny , Dorie Happ , Kurt Scheinpflug , Ty Hu
IPC分类号： A61L33/00
CPC分类号： A61F2/844 , A61F2250/0067 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606
摘要： A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.
摘要翻译：公开了一种用于降低活性剂从可植入装置（例如支架）的释放速率的方法和涂层。

35. 发明申请

US20060218320A1 Using a USB host controller security extension for controlling changes in and auditing USB topology 失效
标题翻译：使用USB主机控制器安全扩展来控制USB拓扑的更改和审核
公开(公告)号：US20060218320A1
公开(公告)日：2006-09-28
申请号：US11090582
申请日：2005-03-25
申请人： Idan Avraham , Kenneth Ray , Mark Williams , David Wooten
发明人： Idan Avraham , Kenneth Ray , Mark Williams , David Wooten
IPC分类号： G06F13/38
CPC分类号： G06F21/554 , G06F21/55 , G06F2221/2101
摘要： Protecting computer systems from attacks that attempt to change USB topology and for ensuring that the system's information regarding USB topology is accurate is disclosed. A software model is defined that, together with secure USB hardware, provides an ability to define policies using which USB traffic can be properly monitored and controlled. The implemented policy provides control over USB commands through a combination of software evaluation and hardware programming. Legitimate commands are evaluated and “allowed” to be sent to a USB device by a host controller. Illegitimate commands are evaluated and blocked. Additionally, the USB topology is audited to verify that the system's topology map matches the actual USB topology.
摘要翻译：公开了保护计算机系统免受试图改变USB拓扑并确保系统有关USB拓扑的信息准确的攻击。定义了一种软件模型，它与安全USB硬件一起提供了一种定义可以正确监控和控制哪个USB流量的策略的能力。实施的策略通过软件评估和硬件编程的组合来提供对USB命令的控制。评估合法的命令，并通过主机控制器将“允许”命令发送到USB设备。非法命令被评估和阻止。另外，USB拓扑被审计，以验证系统的拓扑图匹配实际的USB拓扑。

36. 发明申请

US20060151449A1 Parallel-beam scanning for surface patterning of materials 失效
公开(公告)号：US20060151449A1
公开(公告)日：2006-07-13
申请号：US11027579
申请日：2004-12-30
申请人： Raymond Warner , Earl Masterson , Lynn Millar , John MacCrisken , Mark Williams
发明人： Raymond Warner , Earl Masterson , Lynn Millar , John MacCrisken , Mark Williams
IPC分类号： B23K26/00
CPC分类号： G02B26/101 , B23K26/0006 , B23K26/08 , B23K26/082 , B23K26/352 , B23K26/354 , B23K26/40 , B23K2101/40 , B23K2103/50 , B23K2103/56
摘要： A system and method for parallel-beam scanning a surface. An energetic beam source emits an energetic collimated beam which is received by an optical device, comprising: one or more optical media, operable to receive the emitted beam, such as two pairs of coordinated mirrors or a right prism, and at least one actuator coupled to the one or more optical media, and operable to rotate each of the one or more optical media around a respective axis to perform a parallel displacement of the beam in a respective direction, wherein the respective direction, the beam, and the respective axis are mutually orthogonal. The optical device is operable to direct the beam to illuminate a sequence of specified regions of a surface.

37. 发明申请

US20050276985A1 Composite article having a tie layer and method of making the same 审中-公开
标题翻译：具有粘结层的复合制品及其制造方法
公开(公告)号：US20050276985A1
公开(公告)日：2005-12-15
申请号：US10864838
申请日：2004-06-09
申请人： Mark Muggli , Brian Spiewak , Craig Hoff , Katherine Graham , Kevin Doyle , Maria Dillon , Mark Williams , Todd Williams , Travis Hoium , Matthew Michel
发明人： Mark Muggli , Brian Spiewak , Craig Hoff , Katherine Graham , Kevin Doyle , Maria Dillon , Mark Williams , Todd Williams , Travis Hoium , Matthew Michel
IPC分类号： B32B3/00 , B32B3/26 , B32B7/12 , B32B27/08
CPC分类号： B32B27/08 , B32B1/08 , B32B3/26 , B32B7/08 , B32B7/12 , B32B27/18 , B32B37/06 , B32B37/153 , B32B2250/03 , B32B2250/24 , B32B2305/72 , B32B2309/105 , B32B2327/12 , B32B2398/20 , Y10T428/3154 , Y10T428/31928
摘要： Composite articles have two polymeric layers of different compositions bonded together by adhesive and mechanical means.
摘要翻译：复合制品具有通过粘合剂和机械方法粘合在一起的两种不同组成的聚合物层。

38. 发明申请

US20050275131A1 Mechanical interlocking die 审中-公开
标题翻译：机械联锁模
公开(公告)号：US20050275131A1
公开(公告)日：2005-12-15
申请号：US10864839
申请日：2004-06-09
申请人： Travis Hoium , Brian Spiewak , Maria Dillon , Craig Hoff , Mark Williams
发明人： Travis Hoium , Brian Spiewak , Maria Dillon , Craig Hoff , Mark Williams
IPC分类号： B29C45/00 , B29C47/00 , B29C47/06 , B29C47/14 , B29C47/20 , B29C49/00 , B29C47/30
CPC分类号： B29C48/3366 , B29C45/00 , B29C48/022 , B29C48/07 , B29C48/09 , B29C48/10 , B29C48/21 , B29C48/22 , B29C48/30 , B29C48/305 , B29C48/307 , B29C48/32 , B29C48/335 , B29C49/00 , B29K2027/12 , B29K2027/18 , B29K2077/00 , B29L2007/002 , B29L2009/00 , B29L2023/22 , B29L2031/30
摘要： A mechanical interlocking die has a first surface, a second surface, a plurality of extrusion features, and a plurality of channels. The first surface and the second surface each extend in a longitudinal direction. Each of the extrusion features includes a base portion extending in a cross-sectional plane from the first surface, wherein the cross-sectional plane is substantially normal to the longitudinal direction, and an arm portion extending at an angle in the cross-sectional plane from the base portion. Each channel extends at an angle to the longitudinal direction from the second surface, and is disposed between a pair of extrusion features.
摘要翻译：机械互锁模具具有第一表面，第二表面，多个挤压特征以及多个通道。第一表面和第二表面各自在纵向方向上延伸。每个挤出特征包括从第一表面在截面平面中延伸的基部，其中横截面基本上垂直于纵向方向，并且臂部分在横截面平面内以一定角度延伸，基部。每个通道从第二表面沿纵向方向成一定角度，并且设置在一对挤压特征之间。

39. 发明授权

US06959378B2 Reconfigurable processing system and method 有权
标题翻译：可重构的处理系统和方法
公开(公告)号：US06959378B2
公开(公告)日：2005-10-25
申请号：US10004246
申请日：2001-11-02
申请人： John R. Nickolls , Scott D. Johnson , Mark Williams , Ethan Mirsky , Kambdur Kirthiranjan , Amrit Raj Pant , Lawrence J. Madar, III
发明人： John R. Nickolls , Scott D. Johnson , Mark Williams , Ethan Mirsky , Kambdur Kirthiranjan , Amrit Raj Pant , Lawrence J. Madar, III
IPC分类号： G06F9/302 , G06F9/318 , G06F9/32 , G06F9/345 , G06F15/78 , G06F9/30 , G06F19/00
CPC分类号： G06F9/3001 , G06F9/30181 , G06F9/325 , G06F9/345 , G06F9/3455 , G06F15/8061
摘要： A reconfigurable processing system executes instructions and configurations in parallel. Initially, a first instruction loads configurations into configuration registers. The configuration field of a subsequently fetched instruction selects a configuration register. The instruction controls and controls of the configuration in the selected configuration register are decoded and modified as specified by the instruction. The controls provide data operands to the execution units which process the operands and generate results. Scalar data, vector data, or a combination of scalar and vector data can be processed. The processing is controlled by instructions executed in parallel with configurations invoked by configuration fields within the instructions. Vectors are processed using a vector register file which stores vectors. A vector address unit identifies addresses of vector elements in the vector register file to be processed. For each vector, vector address units provide addresses which stride through each element of each vector.
摘要翻译：可重构处理系统并行执行指令和配置。最初，第一条指令将配置加载到配置寄存器中。随后取出的指令的配置字段选择配置寄存器。所选配置寄存器中的配置的指令控制和控制按照指令进行解码和修改。控件向处理操作数并生成结果的执行单元提供数据操作数。可以处理标量数据，向量数据或标量和向量数据的组合。处理由与指令中的配置字段调用的配置并行执行的指令控制。使用存储向量的向量寄存器文件处理向量。向量地址单元标识要处理的向量寄存器文件中的向量元素的地址。对于每个向量，向量地址单元提供跨越每个向量的每个元素的地址。

40. 发明申请

US20050164335A1 Methods and organisms for production of b6 vitamers 审中-公开
标题翻译：生产b6维生素的方法和生物
公开(公告)号：US20050164335A1
公开(公告)日：2005-07-28
申请号：US10508768
申请日：2003-03-21
申请人： R Yocum , Mark Williams , Janice Pero
发明人： R Yocum , Mark Williams , Janice Pero
IPC分类号： C12N1/12 , C12N1/18 , C12N1/21 , C12N9/00 , C12N9/10 , C12N15/52 , C12P17/12 , C12P25/00
CPC分类号： C12N9/00 , C12N15/52 , C12P17/12
摘要： The present invention features methods of producing B6 vitamers that involve culturing an organism overexpressing an enzyme that catalyzes a step in the biosynthesis of a B6 vitamer under conditions such that a B6 vitamer is produced. The present invention further features methods of producing B6 vitamers that involve culturing recombinant microorganisms having increased activity of at least one B6 vitamer biosynthetic enzyme, e.g., YaaD or YaaE, or a homologue thereof, or Epd, PdxA, PdxJ, PdxF, PdxB, PdxH, and/or Dxs, or a homologue thereof.
摘要翻译：本发明的特征在于生产B6维生素的方法，其涉及培养在产生B6维生素的条件下过量表达催化B6维生素生物合成步骤的酶的生物体的培养。本发明还涉及生产B6维生素的方法，其涉及培养具有增加至少一种B6维生素生物合成酶的活性的重组微生物，例如YaaD或YaaE或其同源物，或Epd，PdxA，PdxJ，PdxF，PdxB，PdxH ，和/或Dxs，或其同源物。

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