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31. 发明授权

US5822422A Method and apparatus for controlling an exchange 失效
标题翻译：用于控制交换的方法和装置
公开(公告)号：US5822422A
公开(公告)日：1998-10-13
申请号：US710812
申请日：1996-09-23
申请人： Detlef Daase , Karl-Heinz Legat , Bernd Stahl
发明人： Detlef Daase , Karl-Heinz Legat , Bernd Stahl
IPC分类号： G06F13/00 , H04M3/00 , H04Q3/545
CPC分类号： H04Q3/5455
摘要： A method of controlling an exchange (NE), and a communications system which comprises at least one such exchange (NE) and a management system (OS). The exchange (NE) is controlled by a number of application programs. The application programs are assigned to two different control units (CONTR1; CONTR2), namely a first and a second control unit (CONTR1; CONTR2), with different operating system platforms. One part of the application programs runs on an operating system platform of the first control unit (CONTR1), which is specifically adapted for the performance of switching functions. The other part of the application programs which is assigned to the second control unit (CONTR2), runs on a universal operating system platform. In this case the application programs of the first control unit (CONTR1) cooperate with the application programs of the second control unit (CONTR2) to provide switching functions.
摘要翻译：一种控制交换（NE）的方法，以及包括至少一个此类交换（NE）和管理系统（OS）的通信系统。交易所（NE）由多个应用程序控制。应用程序分配给两个不同的控制单元（CONTR1; CONTR2），即第一个和第二个控制单元（CONTR1; CONTR2），具有不同的操作系统平台。应用程序的一部分在第一控制单元（CONTR1）的操作系统平台上运行，该平台专门用于切换功能的执行。分配给第二控制单元（CONTR2）的应用程序的另一部分在通用操作系统平台上运行。在这种情况下，第一控制单元（CONTR1）的应用程序与第二控制单元（CONTR2）的应用程序协作以提供切换功能。

32. 发明授权

US09168267B2 Uronic acid and probiotics of Lactobacillus paracasei and Bifidobacterium breve for in vivo treatment of infection 有权
标题翻译：副干酪乳杆菌和短双歧杆菌的尿酸和益生菌用于体内治疗感染
公开(公告)号：US09168267B2
公开(公告)日：2015-10-27
申请号：US11912084
申请日：2006-04-18
申请人： Adrianus Johannes Maria Vriesema , Jan Knol , Bernd Stahl
发明人： Adrianus Johannes Maria Vriesema , Jan Knol , Bernd Stahl
IPC分类号： A61K31/702 , A61K35/745 , A61K35/747 , A23L1/30
CPC分类号： A61K31/702 , A23L33/135 , A61K35/745 , A61K35/747 , A61K2300/00
摘要： The present invention relates to compositions containing probiotic bacteria and uronic acid oligosaccharides. The compositions can suitably be used as infant nutrition and advantageously reduce the incidence of infection.
摘要翻译：本发明涉及含有益生菌和糖醛酸寡糖的组合物。组合物可适当地用作婴儿营养，并有利地降低感染的发生率。

33. 发明授权

US08591919B2 Synergistic mixture of beta-galacto-oligosaccharides with beta-1,3 and beta -1,4/1,6 linkages 有权
标题翻译： β-半乳寡糖与β-1,3和β-1,4 / 1,6键的协同混合
公开(公告)号：US08591919B2
公开(公告)日：2013-11-26
申请号：US13377464
申请日：2010-06-14
申请人： Bernd Stahl , Alma Jildou Nauta
发明人： Bernd Stahl , Alma Jildou Nauta
IPC分类号： A61K31/738
CPC分类号： A61K31/702 , A23L33/135 , A23L33/21 , A23L33/40 , A61K35/745
摘要： The present invention relates to a nutritional composition comprising at least two different beta-galacto-oligosaccharides (BGOS) A and B wherein the majority of linkages between two galactose residues in BGOS A are beta 1,4 and/or beta 1,6, and the majority of linkages between two galactose residues in BGOS B are beta 1,3. Such mixtures show superior effects on the immune system and are particularly suitable for infant nutrition.
摘要翻译：本发明涉及包含至少两种不同的β-半乳寡聚糖（BGOS）A和B的营养组合物，其中BGOS A中两个半乳糖残基之间的大部分连接是β1,4和/或β1,6，以及 BGOS B中两个半乳糖残基之间的大部分连接是β1,3。这样的混合物对免疫系统表现出优异的效果，并且特别适用于婴儿营养。

34. 发明申请

US20130072667A1 USE OF RGM AND ITS MODULATORS 有权
标题翻译： RGM及其调制器的使用
公开(公告)号：US20130072667A1
公开(公告)日：2013-03-21
申请号：US13493005
申请日：2012-06-11
申请人： Bernhard K. Mueller , Philippe P. Monnier , Paolo Macchi , Friedrich Bonhoeffer , Bernd Stahl , Matthias Mann , Jens S. Anderson
发明人： Bernhard K. Mueller , Philippe P. Monnier , Paolo Macchi , Friedrich Bonhoeffer , Bernd Stahl , Matthias Mann , Jens S. Anderson
IPC分类号： C07K14/47 , C07K14/465
CPC分类号： C07K14/47 , A61K38/1709 , A61K2039/505 , C07K14/465 , C07K14/4702 , C07K16/28
摘要： The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with seizures or associated with angiogenic disorders or disorders of the cardio-vascular system.
摘要翻译：本发明涉及具有或包含本文公开的氨基酸序列或其功能片段或衍生物或编码所述多肽或片段或衍生物的多核苷酸的调节剂用于制备药物组合物的用途预防，减轻或治疗与癫痫相关的脊椎动物神经组织的退化或损伤相关的疾病或病症或与心血管系统的血管生成障碍或病症有关。

35. 发明授权

US08252769B2 Intestinal barrier integrity 有权
标题翻译：肠屏障完整性
公开(公告)号：US08252769B2
公开(公告)日：2012-08-28
申请号：US11571122
申请日：2004-06-06
申请人： Eric Alexander Franciscus van Tol , Linette Eustachia Maria Willemsen , Marleen Antoinette Koetsier , Christopher Beermann , Bernd Stahl
发明人： Eric Alexander Franciscus van Tol , Linette Eustachia Maria Willemsen , Marleen Antoinette Koetsier , Christopher Beermann , Bernd Stahl
IPC分类号： A61K31/715 , A61K31/202
CPC分类号： A23L29/04 , A23L29/30 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K31/202 , A61K31/702 , A23V2200/32 , A23V2200/304 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/28 , A23V2250/5062
摘要： The invention concerns a method for stimulating barrier integrity in a mammal by administering to a mammal a composition comprising: eicosapentaenoic acid (EPA), docosahexacnoic acid (DHA) and arachidonic acid (ARA), and at least two distinct oligosaccharides.
摘要翻译：本发明涉及通过向哺乳动物施用包含二十碳五烯酸（EPA），二十二碳六烯酸（DHA）和花生四烯酸（ARA）以及至少两种不同的寡糖的组合物来刺激哺乳动物的屏障完整性的方法。

36. 发明授权

US08048997B2 Process for drying uronic acid oligosaccharides 失效
标题翻译：干燥糖醛酸寡糖的方法
公开(公告)号：US08048997B2
公开(公告)日：2011-11-01
申请号：US11912097
申请日：2006-04-21
申请人： Martin Van Eert , Bernd Stahl , Antonie Van Baalen
发明人： Martin Van Eert , Bernd Stahl , Antonie Van Baalen
IPC分类号： A61K31/732 , A61K31/715 , A61K31/702 , C08B37/06 , C07H1/00
CPC分类号： C08L5/06 , A23G3/34 , A23L29/231 , C07H1/00 , C07H3/06 , C08J3/122 , C08J2305/06 , Y10T428/2982
摘要： The present invention relates to a process for spray drying uronic acid oligosaccharides and to a powder compositions thus obtained. Typically the powder composition comprises between 25 and 100 wt.% uronic acid oligosaccharide with a DP between 2 and 50 based on total weight of uronic acid, with and an average particle size between 20 μm and 100 μm.
摘要翻译：本发明涉及一种喷雾干燥糖醛酸寡糖的方法以及由此获得的粉末组合物。通常，粉末组合物包含25至100重量％的糖醛酸寡糖，其DP为2至50，基于糖醛酸的总重量，平均粒径为20μm至100μm。

37. 发明授权

US07939118B2 Oligosaccharide mixture 有权
标题翻译：寡糖混合物
公开(公告)号：US07939118B2
公开(公告)日：2011-05-10
申请号：US10148193
申请日：2000-12-07
申请人： Bernd Stahl , Günther Böhm , Berndt Finke , Gilda Georgi , Jürgen Jelinek , Joachim J. Schmitt
发明人： Bernd Stahl , Günther Böhm , Berndt Finke , Gilda Georgi , Jürgen Jelinek , Joachim J. Schmitt
IPC分类号： C13K1/06
CPC分类号： A61K45/06 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23V2002/00 , A61K31/702 , A61K35/20 , A61K2300/00 , A23V2250/28
摘要： An oligosaccharide mixture based on oligosaccharides from one or several animal milks composed of two or more monosaccharide units. The oligosaccharide mixture comprises at least two oligosaccharide fractions which are each composed of at least two different oligosaccharides. Lactose does not pertain thereto and the total spectrum of the oligosaccharides in the oligosaccharide mixture differs from those present in animal milk or animal milks, wherefrom the oligosaccharide fractions are extracted and that a) if the oligosaccharides are extracted from only one animal milk, the proportion of neutral oligosaccharides to acidic oligosaccharides is 90-60:10-40 weight %, or b) if the oligosaccharides are extracted from at least two animal milks, the oligosaccharides extracted from two different animal milks each make up 10 weight % of the total amount of oligosaccharides present in the oligosaccharide mixture. The oligosaccharide mixture approximates human milk with respect to its positive properties.
摘要翻译：基于由两个或更多个单糖单元组成的一个或几个动物奶的寡糖的寡糖混合物。寡糖混合物包含至少两种各自由至少两种不同寡糖组成的寡糖部分。乳糖与其无关，低聚糖混合物中寡糖的总光谱与动物乳或动物奶中存在的低聚糖的总光谱不同，其中提取寡糖部分，并且a）如果寡糖仅从一种动物乳提取，则比例的中性寡糖与酸性寡糖的比例为90-60：10-40重量％，或b）如果从至少两只动物奶中提取低聚糖，则从两种不同动物奶中提取的寡糖各自占总量的10重量％的寡糖混合物中存在的寡糖。寡糖混合物相对于其正性质接近人乳。

38. 发明授权

US07919479B2 Antiadhesive carbohydrates 有权
标题翻译：防粘碳水化合物
公开(公告)号：US07919479B2
公开(公告)日：2011-04-05
申请号：US11511500
申请日：2006-08-29
申请人： Bernd Stahl , Gunther Boehm
发明人： Bernd Stahl , Gunther Boehm
IPC分类号： A61K31/702 , A61K31/733 , A61K31/732
CPC分类号： A61K31/7012 , A23L5/00 , A23L29/231 , A23L29/256 , A23L29/30 , A23L33/00 , A23L33/10 , A23L33/125 , A61K31/702 , A61K31/715
摘要： Provided is a pharmaceutical or dietetic product, which serves for reducing and/or blocking the adhesion of pathogenic substances and organisms to eucaryontic cells, in particular mammal cells. Said preparation contains at least one carbohydrate having an uronic acid unit on one of the ends thereof. 10 to 100% of the present, terminal uronic acid units pertaining to the carbohydrates are provided with a double bond that is especially situated between the C4 and C5 atom.
摘要翻译：提供了一种药物或饮食产品，其用于减少和/或阻断致病物质和生物体对真核细胞特别是哺乳动物细胞的粘附。所述制剂包含至少一种在其一个端部具有糖醛酸单元的碳水化合物。本发明的碳原子数为10〜100％的末端糖醛酸单元具有特别位于C4和C5原子之间的双键。

39. 发明授权

US07601364B2 Carbohydrate mixtures 有权
标题翻译：碳水化合物混合物
公开(公告)号：US07601364B2
公开(公告)日：2009-10-13
申请号：US11649879
申请日：2007-01-05
申请人： Gunther Sawatzki , Bernd Stahl
发明人： Gunther Sawatzki , Bernd Stahl
IPC分类号： A61K47/00 , A01N43/04 , A61K31/715
CPC分类号： A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/21 , A23L33/40 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/733 , A61K31/7004 , A61K2300/00
摘要： A carbohydrate mixture for dietetic foods and pharmaceuticals containing several carbohydrates is provided. The carbohydrate mixture comprises two different, substantially soluble carbohydrate components A and B, which remain undigested in the gastrointestinal tract and enter the large intestine without being resorbed. Component A comprises at least one monosaccharide, at least one oligosaccharide (disaccharide to hexasaccharide), or a mixture thereof. Component B comprises a polysaccharide or a mixture of two or more polysaccharides. Component A constitutes 5 to 95 wt-% and Component B constitutes 5 to 95 wt-% of the sum of the Components; and at least 80 wt-% of the carbohydrates/saccharides of Components A and B have a prebiotic effect. The inventive carbohydrate mixture exhibits not only a nutritive effect, but also stimulates health-promoting microorganisms present in the natural flora of the large intestine.
摘要翻译：提供饮食食品和含有几种碳水化合物的药物的碳水化合物混合物。碳水化合物混合物包含两种不同的，基本上可溶的碳水化合物组分A和B，其在胃肠道中未消化并进入大肠而不被再吸收。组分A包含至少一种单糖，至少一种寡糖（二糖与六糖）或其混合物。组分B包含多糖或两种或多种多糖的混合物。组分A占5至95重量％，组分B占组分总和的5至95重量％; 并且组分A和B的至少80wt％的碳水化合物/糖具有益生元效应。本发明的碳水化合物混合物不仅显示营养作用，而且还刺激存在于大肠的天然菌群中的健康促进微生物。

40. 发明授权

US07498318B1 Food for diabetics 失效
标题翻译：糖尿病食物
公开(公告)号：US07498318B1
公开(公告)日：2009-03-03
申请号：US10129095
申请日：2000-11-10
申请人： Bernd Stahl , Michael Kliem , Sandra Farwer , Gunther Sawatzki , Gunther Boehm
发明人： Bernd Stahl , Michael Kliem , Sandra Farwer , Gunther Sawatzki , Gunther Boehm
IPC分类号： A61K31/718
CPC分类号： C12Y204/01019 , A23L5/00 , A23L29/30 , A23L33/125 , A23L33/20 , A23L33/21 , C12P19/14 , C12P19/18 , C12Y204/01024
摘要： Provided is a carbohydrate mixture comprising at least one modified carbohydrate from a base body and a carbohydrate residue coupled therewith. The base body concerned is either a digestible glucose-containing carbohydrate in the form of a digestible glucan or a non-digestible reserve carbohydrate, skeletal carbohydrate or a low-molecular component thereof. By coupling the base body with a carbohydrate residue, the glucose release from the inventive carbohydrate mixture is reduced by at least 10%, determined in an in-vivo digestion system on the basis of pancreatine and compared with a carbohydrate mixture containing the same amount by weight of non-modified carbohydrates. By means of the inventive carbohydrate mixture, the postprandial blood glucose concentration after eating can be moderated. The glucose can thus be metabolized by diabetics in spite of the existing lack of insulin. The inventive carbohydrate mixtures can be used in food for diabetics and in pharmaceuticals.
摘要翻译：提供了包含至少一种来自碱体的修饰的碳水化合物和与其偶联的碳水化合物残基的碳水化合物混合物。所涉及的基体是可消化葡萄糖或不可消化的储备碳水化合物，骨骼碳水化合物或其低分子组分形式的可消化的含葡萄糖的碳水化合物。通过将基体与碳水化合物残基偶联，将本发明的碳水化合物混合物的葡萄糖释放量减少至少10％，在基于胰腺的体内消化系统中测定，并与含有相同量的碳水化合物混合物非改性碳水化合物的重量。通过本发明的碳水化合物混合物，饮食后餐后血糖浓度可以缓和。糖可以由糖尿病代谢，尽管目前缺乏胰岛素。本发明的碳水化合物混合物可用于糖尿病患者和药物中。

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