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1. 发明授权

US07939118B2 Oligosaccharide mixture 有权
标题翻译：寡糖混合物
公开(公告)号：US07939118B2
公开(公告)日：2011-05-10
申请号：US10148193
申请日：2000-12-07
申请人： Bernd Stahl , Günther Böhm , Berndt Finke , Gilda Georgi , Jürgen Jelinek , Joachim J. Schmitt
发明人： Bernd Stahl , Günther Böhm , Berndt Finke , Gilda Georgi , Jürgen Jelinek , Joachim J. Schmitt
IPC分类号： C13K1/06
CPC分类号： A61K45/06 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23V2002/00 , A61K31/702 , A61K35/20 , A61K2300/00 , A23V2250/28
摘要： An oligosaccharide mixture based on oligosaccharides from one or several animal milks composed of two or more monosaccharide units. The oligosaccharide mixture comprises at least two oligosaccharide fractions which are each composed of at least two different oligosaccharides. Lactose does not pertain thereto and the total spectrum of the oligosaccharides in the oligosaccharide mixture differs from those present in animal milk or animal milks, wherefrom the oligosaccharide fractions are extracted and that a) if the oligosaccharides are extracted from only one animal milk, the proportion of neutral oligosaccharides to acidic oligosaccharides is 90-60:10-40 weight %, or b) if the oligosaccharides are extracted from at least two animal milks, the oligosaccharides extracted from two different animal milks each make up 10 weight % of the total amount of oligosaccharides present in the oligosaccharide mixture. The oligosaccharide mixture approximates human milk with respect to its positive properties.
摘要翻译：基于由两个或更多个单糖单元组成的一个或几个动物奶的寡糖的寡糖混合物。寡糖混合物包含至少两种各自由至少两种不同寡糖组成的寡糖部分。乳糖与其无关，低聚糖混合物中寡糖的总光谱与动物乳或动物奶中存在的低聚糖的总光谱不同，其中提取寡糖部分，并且a）如果寡糖仅从一种动物乳提取，则比例的中性寡糖与酸性寡糖的比例为90-60：10-40重量％，或b）如果从至少两只动物奶中提取低聚糖，则从两种不同动物奶中提取的寡糖各自占总量的10重量％的寡糖混合物中存在的寡糖。寡糖混合物相对于其正性质接近人乳。

2. 发明授权

US07858595B2 Anti-infectious carbohydrates 失效
标题翻译：抗感染性碳水化合物
公开(公告)号：US07858595B2
公开(公告)日：2010-12-28
申请号：US10490102
申请日：2002-09-25
申请人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jörg Slaghuis
发明人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jörg Slaghuis
IPC分类号： A61K31/715 , A61K31/70 , C07H5/06 , C07H1/00 , A23G3/00
CPC分类号： A61K31/702 , A61K31/715
摘要： Neutral straight-chain or branched oligosaccharides for preventing the invasion and infection of mammal cells by pathogens and for fighting diseases caused by such pathogens are disclosed. Food, dietetic products and pharmaceutical agents containing oligosaccharides consist of a base unit of formula (I), and between 0 and 19 other units of formula (II), which are linked directly or indirectly to the base unit. Gal represents a galactose monosaccharide unit; Glc represents a glucose monosaccharide unit; HexNAc rpresents an N-acetylated galactosamine or glucosamine monosaccharide unit (GalNAc or GlcNAc); R independently represent a β 1-3 or β 1-6 glycosidic link to HexNAc monosaccharide of the next [Gal-HexNAc] unit (II), and on a terminal [Gal-HexNAc] unit, or R are not present; and a terminal [Gal-HexNAc] unit, wherein R represent a deoxyhexose radical, can have another deoxyhexose radical on the HexNAc monosaccharide unit.
摘要翻译：公开了用于防止病原体侵染和感染哺乳动物细胞并用于与这种病原体引起的疾病的中性直链或支链寡糖。含有寡糖的食品，饮食产品和药剂由式（I）的基本单元和0至19个式（II）的其它单元直接或间接连接到基础单元组成。 Gal代表半乳糖单糖单位; Glc表示葡萄糖单糖单元; HexNAc表示N-乙酰化的半乳糖胺或葡糖胺单糖单元（GalNAc或GlcNAc）; R独立地代表一个 1-3或＆bgr; 1-6糖苷键连接到下一个[Gal-HexNAc]单元（II）的HexNAc单糖和末端[Gal-HexNAc]单元或R不存在; 和末端[Gal-HexNAc]单元，其中R表示脱氧己糖基团，可以在HexNAc单糖单元上具有另一脱氧己糖基团。

3. 发明申请

US20050070464A1 Sialic carbohydrates 审中-公开
标题翻译：唾液碳水化合物
公开(公告)号：US20050070464A1
公开(公告)日：2005-03-31
申请号：US10502049
申请日：2003-01-31
申请人： Bernd Stahl , Sorge Kelm , Gunther Boehm , Berndt Finke , Joachim Schmitt
发明人： Bernd Stahl , Sorge Kelm , Gunther Boehm , Berndt Finke , Joachim Schmitt
IPC分类号： A23C9/20 , A23F3/30 , A23L1/09 , A23L1/29 , A61P37/00 , C07H7/027 , C07H17/04 , A61K38/16 , A61K31/739
CPC分类号： C07H17/04 , A23C9/20 , A23F3/30 , A23L29/30 , A23L33/125 , A23L33/40 , A23V2002/00 , A23V2250/5438 , C07H7/027 , A23V2250/156 , A23V2250/70 , A23V2250/0644
摘要： The invention relates to the use of sialic carbohydrates of general formula (I), containing at least one carbohydrate unit of general formula (II) for the immune modulation, immune suppression and in the prevention and treatment of infections in humans and animals. In said formula (II), Sia represents a sialic acid or a sialic acid derivative in an α2-3 bond, Gal represents a galactose-monosaccharide-unit, HexNac represents an N-acetylated galactosamine or glucosamine-monosaccharide-unit (GalNAc or GlcNAc), Hex represents a galactose- or glucose-monosaccharide-unit (Gal or Glc), C represents HexNac or Hex or is absent, n represents 1-50, V represents OH, a carbohydrate radical or a connecting point on a support T, with the proviso that if V represents OH, n represents 1, and if V represents a carbohydrate radical or a support T, n represents the number of carbohydrate unites of general formula (II) directly connected to said carbohydrate radical or support, X represents a sialic acid or a sialic acid derivative, wherein a second sialic acid or a sialic acid derivative or more sialic acid or sialic acid derivatives can be connected to an α2-8 bond, a phosphate, a sulphate, or carboxyl-group or a monosaccharide having a phosphate, sulphate, or carboxyl group and only one of the radicals X is present.
摘要翻译：本发明涉及含有至少一种通式（II）的碳水化合物单元的通式（I）的唾液酸碳水化合物用于免疫调节，免疫抑制和预防和治疗人和动物感染的用途。在所述式（II）中，Sia表示α2-3键中的唾液酸或唾液酸衍生物，Gal表示半乳糖 - 单糖单元，HexNac表示N-乙酰化的半乳糖胺或葡糖胺单糖单元（GalNAc或GlcNAc ），Hex表示半乳糖或葡萄糖单糖单元（Gal或Glc），C表示HexNac或Hex或不存在，n表示1-50，V表示OH，碳水化合物基团或载体T上的连接点，条件是如果V表示OH，n表示1，并且如果V表示碳水化合物基团或载体T，则n表示与所述碳水化合物基团或载体直接连接的通式（II）的碳水化合物单元的数目，X表示唾液酸或唾液酸衍生物，其中第二唾液酸或唾液酸衍生物或更多的唾液酸或唾液酸衍生物可以连接到α2-8键，磷酸盐，硫酸盐或羧基或单糖上，其具有磷酸盐，硫酸盐，或羧基，并且仅存在基团X中的一个。

4. 发明申请

US20050222080A1 Cycloglycans suitable to inhibit mammalian infection 审中-公开
标题翻译：适合抑制哺乳动物感染的抗生素
公开(公告)号：US20050222080A1
公开(公告)日：2005-10-06
申请号：US10502059
申请日：2003-01-20
申请人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jorg Slaghuis , Gunther Boehm
发明人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jorg Slaghuis , Gunther Boehm
IPC分类号： A61K31/715 , A61K31/724
CPC分类号： A61K31/715 , Y02A50/473
摘要： Described is the use of in particular homopolymer cycloglycans having a ring-shaped base structure of 2 to 40 monosaccharides in the ring, for preventing the invasion and infection of mammal cells by pathogens, and for combating diseases caused by such pathogens, and food compositions, dietetic compositions and pharmaceutical compositions containing these cycloglycans.
摘要翻译：描述了特别是在环中具有2至40个单糖的环状基本结构的均聚物环糊精的用途，用于防止病原体侵染和感染哺乳动物细胞，以及用于防治由这种病原体引起的疾病，以及食物组合物，饮食组合物和含有这些循环体的药物组合物。

5. 发明申请

US20050004070A1 Anti-infectious carbohydrates 失效
标题翻译：抗感染性碳水化合物
公开(公告)号：US20050004070A1
公开(公告)日：2005-01-06
申请号：US10490102
申请日：2002-09-25
申请人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jorg Slaghuis
发明人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jorg Slaghuis
IPC分类号： A61K31/702 , A61K31/715 , A61P31/00 , A61K31/739 , C08B37/00
CPC分类号： A61K31/702 , A61K31/715
摘要： Neutral straight-chain or branched oligosaccharides for preventing the invasion and infection of mammal cells by pathogens and for fighting diseases caused by such pathogens are disclosed. Food, dietetic products and pharmaceutical agents containing oligosaccharides consist of a base unit of formula (I), and between 0 and 19 other units of formula (II), which are linked directly or indirectly to the base unit. Gal represents a galactose monosaccharide unit; Glc represents a glucose monosaccharide unit; HexNAc rpresents an N-acetylated galactosamine or glucosamine monosaccharide unit (GalNAc or GlcNAc); R independently represent a β 1-3 or β 1-6 glycosidic link to HexNAc monosaccharide of the next [Gal-HexNAc] unit (II), and on a terminal [Gal-HexNAc] unit, or R are not present; and a terminal [Gal-HexNAc] unit, wherein R represent a deoxyhexose radical, can have another deoxyhexose radical on the HexNAc monosaccharide unit.
摘要翻译：公开了用于防止病原体侵染和感染哺乳动物细胞并用于与这种病原体引起的疾病的中性直链或支链寡糖。含有寡糖的食品，饮食产品和药剂由式（I）的基本单元和0至19个式（II）的其它单元直接或间接连接到基础单元组成。 Gal代表半乳糖单糖单位; Glc表示葡萄糖单糖单元; HexNAc表示N-乙酰化的半乳糖胺或葡糖胺单糖单元（GalNAc或GlcNAc）; R独立地表示与下一个[Gal-HexNAc]单元（II）的HexNAc单糖的β1-3或β1-6糖基连接，并且在末端[Gal-HexNAc]单元上，或R不存在; 和末端[Gal-HexNAc]单元，其中R表示脱氧己糖基团，可以在HexNAc单糖单元上具有另一脱氧己糖基团。

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