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31. 发明申请

US20060229583A1 Drug solution filling plastic ampoule and process for producing the same 有权
标题翻译：药液灌装塑胶安瓿及其制作方法
公开(公告)号：US20060229583A1
公开(公告)日：2006-10-12
申请号：US10554094
申请日：2004-04-19
申请人： Katsuyoshi Nagao , Hideshi Okamoto , Masamitsu Izumi , Fujio Inoue
发明人： Katsuyoshi Nagao , Hideshi Okamoto , Masamitsu Izumi , Fujio Inoue
IPC分类号： A61M35/00 , A61B19/00
CPC分类号： B65B3/022 , A61J1/067 , A61M2207/00 , B29C49/04 , B65D1/095
摘要： The present invention provides a drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption/adsorption preventing capability, and a production method for the plastic ampoule. The drug solution filling plastic ampoule (10) according to the present invention includes a container body (11), a fusion-bonded portion (13) which seals a mouth (12) of the container body, and a wrench-off holder tab (14) connected to the fusion-bonded portion. The ampoule (10) is formed from a parison including two or more layers, at least one of which is a functional layer having at least one characteristic property selected from the group consisting of a gas permeation preventing capability, a steam permeation preventing capability, a light ray permeation preventing capability, a drug permeation preventing capability and a drug absorption/adsorption preventing capability. That is, the parison is extruded from a multilayer blow forming die, and then held between lower split mold pieces to be formed into the container body (11). After a drug solution (15) is filled in the container body (11), the mouth (12) is held between upper split mold pieces to form the fusion-bonded portion (13) and the holder tab (14). Thus, the plastic ampoule is provided.
摘要翻译：本发明提供一种具有气体，蒸汽和光线阻隔性，药物渗透防止能力和吸收/吸附防止能力的药液填充塑料安瓿，以及塑料安瓿的制造方法。根据本发明的填充塑料安瓿（10）的药液包括容器主体（11），密封容器主体的口部（12）的熔接部分（13）和扳手保持器突片 14）连接到熔接部分。安瓿（10）由包括两层或更多层的型坯形成，其中至少一层是具有选自以下的至少一种特性的功能层：气体渗透防止能力，防蒸汽渗透能力，光线透过防止能力，药物渗透防止能力和药物吸收/吸附防止能力。也就是说，型坯从多层吹塑成形模挤出，然后保持在下成型模具片之间，形成容器本体（11）。在药液（15）被填充到容器主体（11）中之后，口（12）被保持在上模制件之间，以形成熔接部分（13）和夹持片（14）。因此，提供塑料安瓿。

32. 发明授权

US5922461A Method for inhibiting adsorption of container-derived contaminants on drugs and contamination-inhibitory containers 失效
标题翻译：抑制容器来源的污染物对药物和污染抑制容器的吸附的方法
公开(公告)号：US5922461A
公开(公告)日：1999-07-13
申请号：US849618
申请日：1997-06-05
申请人： Fujio Inoue , Masamitsu Izumi , Satoru Hayashi , Chieko Yoshida
发明人： Fujio Inoue , Masamitsu Izumi , Satoru Hayashi , Chieko Yoshida
IPC分类号： A61J1/00 , B65D81/20 , B65D81/24 , C09K15/04
CPC分类号： B65D81/2069 , A61J1/00 , B65D81/24 , Y10S206/828 , Y10T428/1314 , Y10T428/1352 , Y10T428/292
摘要： This invention provides a method for inhibiting adsorption of container-derived contaminants on a powdery or solid drug which comprises establishing a lower alcohol vapor phase within a container made, at least in part, of rubber or a plastic material. The method inhibits adsorption of container-derived substances on a drug to preclude development of insoluble particulate matter owing to said adsorption in an aqueous solution prepared extemporaneously without causing loss of the drug and avoiding the toxic effect of decomposition or degradation of the drug, thus insuring a long-term trouble-free stable shelf-life of the drug.
摘要翻译： PCT No.PCT / JP95 / 02487。 371日期：1997年6月5日 102（e）日期1997年6月5日PCT提交1995年12月4日PCT公布。公开号WO96 / 17578 日期1996年6月13日本发明提供了一种抑制容器衍生的污染物对粉末或固体药物的吸附的方法，其包括在至少部分由橡胶或塑料材料制成的容器内建立低级醇汽相。该方法抑制容器衍生物质对药物的吸附，以防止由于在临时制备的水溶液中的所述吸附而引起的不溶性颗粒物质的发生，而不会引起药物的损失并避免药物的分解或降解的毒性作用，从而确保药物的长期无故障稳定保质期。

33. 发明授权

US5811047A Polyolefin packaging material for drug packaging, method of production thereof and containers for drug packaging 失效
标题翻译：用于药物包装的聚烯烃包装材料，其生产方法和用于药物包装的容器
公开(公告)号：US5811047A
公开(公告)日：1998-09-22
申请号：US617311
申请日：1996-03-18
申请人： Fujio Inoue , Masamitsu Izumi , Shigetoshi Kashiyama , Hiroshi Tanaka
发明人： Fujio Inoue , Masamitsu Izumi , Shigetoshi Kashiyama , Hiroshi Tanaka
IPC分类号： A61J1/00 , A61J1/05 , A61J1/10 , C08F6/00 , C08J5/18 , C08L23/08 , C08L23/12 , B01D3/06
CPC分类号： C08F6/005 , C08J5/18 , C08L23/0815 , A61J1/10 , C08J2323/08 , C08L23/12
摘要： The invention provides a polyolefin drug packaging material characterized in that the content, in the polyolefin, of substances containing 12 to 26 carbon atoms is not more than 150 ppm. The packaging material of the invention is useful because the risk of its reacting with and adversely affecting the drug packaged therewith is minimum.
摘要翻译：本发明提供一种聚烯烃药物包装材料，其特征在于聚烯烃中含有12-26个碳原子的物质的含量不超过150ppm。本发明的包装材料是有用的，因为其与包装的药物的反应和不利影响的风险是最小的。

34. 发明授权

US5610170A Package form for bicarbonate-containing powdery pharmaceutical compositions and a method of stabilizing the compositions 失效
标题翻译：含碳酸氢盐粉末药物组合物的包装形式和稳定组合物的方法
公开(公告)号：US5610170A
公开(公告)日：1997-03-11
申请号：US307804
申请日：1995-03-14
申请人： Fujio Inoue , Masamitsu Izumi , Satoru Hayashi
发明人： Fujio Inoue , Masamitsu Izumi , Satoru Hayashi
IPC分类号： A61J1/00 , A61J3/07 , A61M1/16 , B65D75/38 , B65D81/24 , B65D81/26
CPC分类号： A61J1/00 , A61M1/167 , B65D75/38 , B65D81/24 , B65D81/266
摘要： The invention provides a method and a package form for insuring a stabilized bicarbonate-containing pharmaceutical composition, the method comprises filling the bicarbonate-containing powdery pharmaceutical composition in a moisture- and gas-permeable plastic container, wrapping the so-filled container in a moisture- and gas-impermeable plastic wrapper and carrying out at least one procedure selected from the group consisting of the procedure of introducing a carbon dioxide gas into a space between the container and wrapper, the procedure of disposing a carbon dioxide-liberating deoxygenating agent in the space and the procedure of disposing a desiccant previously saturated with carbon dioxide gas by way of adsorption in the space. In accordance with the invention, the inherent objects of incorporating the bicarbonate can be accomplished without inducing the aging and degradation of the bicarbonate-containing powdery pharmaceutical composition.
摘要翻译： PCT No.PCT / JP94 / 00041 Sec。 371日期：1995年3月14日 102（e）1995年3月14日PCT PCT 1994年1月14日PCT公布。 WO94 / 16663 PCT出版物日期1994年8月4日本发明提供了一种用于确保含稳定碳酸氢盐的药物组合物的方法和包装形式，所述方法包括将含碳酸氢盐的粉末状药物组合物填充在透湿气体的塑料容器中，填充容器在防潮和不透气的塑料包装中并且执行至少一种选自以下的步骤：将二氧化碳气体引入到容器和包装物之间的空间中的方法，将二氧化碳 - 在空间中释放脱氧剂，并且通过在空间中通过吸附处理先前饱和二氧化碳气体的干燥剂的步骤。根据本发明，可以在不引起含碳酸氢盐的粉末状药物组合物的老化和降解的情况下实现掺入碳酸氢盐的固有目的。

35. 发明授权

US09086064B2 Solvent delivery pump 有权
标题翻译：溶剂输送泵
公开(公告)号：US09086064B2
公开(公告)日：2015-07-21
申请号：US13449660
申请日：2012-04-18
申请人： Yoshiaki Aso , Kumiko Jingu , Fujio Inoue
发明人： Yoshiaki Aso , Kumiko Jingu , Fujio Inoue
IPC分类号： F04B53/14 , F04B13/00 , F04B53/16
CPC分类号： F04B53/143 , F04B13/00 , F04B53/162
摘要： A plunger seal has a cylindrical protruding portion on its front face. A base end portion of the protruding portion has a recessed curved shape having a certain curvature. In a portion of a pump head, where the plunger seal is mounted, a seal insertion portion into which the protruding portion of the plunger seal is to be fitted is formed as a cylindrical recessed portion. An opening edge portion of the seal insertion portion has a protruding curved shape having the same curvature as the base end portion of the protruding portion of the plunger seal.
摘要翻译：柱塞密封件在其前表面上具有圆柱形突出部分。突出部的基端部具有一定曲率的凹曲面形状。在安装柱塞密封件的泵头的一部分中，形成有用于装配活塞密封件的突出部分的密封插入部分作为圆柱形凹进部分。密封插入部的开口边缘部具有与柱塞密封件的突出部的基端部相同的曲率的突出弯曲形状。

36. 发明授权

US08985144B2 Low-pressure gradient device 有权
标题翻译：低压梯度装置
公开(公告)号：US08985144B2
公开(公告)日：2015-03-24
申请号：US13330839
申请日：2011-12-20
申请人： Yoshiaki Aso , Fujio Inoue
发明人： Yoshiaki Aso , Fujio Inoue
IPC分类号： G01N1/38 , B01F5/06 , G01N30/34
CPC分类号： G01N30/34 , Y10T137/85978 , Y10T137/87684
摘要： A plurality of suctioning flow paths for suctioning mobile phases meet each other at a meeting portion. The meeting portion is connected to an inlet flow path communicating with an inlet of a reciprocating pump. The suctioning flow paths are respectively provided with solenoid valves for opening and closing the respective flow paths. The suctioning flow paths are respectively provided with orifices between the solenoid valves and the meeting portion. The orifices are sections of the respective suctioning flow paths having smaller diameters.
摘要翻译：用于抽吸流动相的多个吸入流动路径在会合部分处相互相遇。会议部分连接到与往复泵的入口连通的入口流动路径。抽吸流路分别设有用于打开和关闭相应流路的电磁阀。吸入流路分别设置有电磁阀和会议部之间的孔。孔是相应的抽吸流动路径的具有较小直径的部分。

37. 发明授权

US07880109B2 Classification apparatus and fine particle measuring apparatus 有权
标题翻译：分类仪器和微粒测量仪器
公开(公告)号：US07880109B2
公开(公告)日：2011-02-01
申请号：US12158650
申请日：2006-12-22
申请人： Daiji Okuda , Hiroshi Okuda , Fujio Inoue
发明人： Daiji Okuda , Hiroshi Okuda , Fujio Inoue
IPC分类号： B03C7/00
CPC分类号： G01N15/0266
摘要： A classification apparatus for classifying and separating particles having particle sizes within a predetermined range is disclosed. In a preferred embodiment of the classification apparatus, a center electrode (3) and an outside electrode (4) generate an electric field for classifying charged fine particles according to electric mobility. In the upper part of a housing (1), a sheath gas supply portion (7) is provided. An aerosol supply portion (11) has an introduction port (11a) provided on the outside electrode (4) side in a classification region (5), and supplies a charged aerosol at a constant flow rate through the introduction port (11a). On the downstream side in the flow of a sheath gas in the classification region (5), a larger-size particle discharge portion (13) is provided. The larger-size particle discharge portion (13) has a discharge port (13a) provided on the outside electrode (4) side, and discharges charged fine particles, which are contained in the classified charged aerosol and have particle sizes larger than a predetermined particle size, together with part of the sheath gas at a constant flow rate. A detector (18) is provided downstream of the housing (1) to detect the number of remaining charged fine particles contained in the sheath gas introduced thereinto as the quantity of electricity.
摘要翻译：公开了一种用于分级和分离粒度在预定范围内的颗粒的分级装置。在分级装置的优选实施例中，中心电极（3）和外部电极（4）产生用于根据电迁移率对带电微粒进行分类的电场。在壳体（1）的上部设有护套气体供给部（7）。气溶胶供给部（11）具有在分类区域（5）中设置在外侧电极（4）侧的引入口（11a），并且通过引入口（11a）以恒定的流量供给带电荷的气溶胶。在分类区域（5）中的护套气体的流动的下游侧，设置有较大尺寸的粒子排出部（13）。较大尺寸的颗粒排放部分（13）具有设置在外部电极（4）侧的排出口（13a），并且排出包含在分类的带电气溶胶中的带电微粒，其粒径大于预定颗粒与一部分鞘气一起以恒定流速进行。检测器（18）设置在壳体（1）的下游，以检测引入到其中的鞘气中所含的剩余带电微粒的数量作为电量。

38. 发明授权

US07760356B2 Optical measuring device and method, and nanoparticle measuring method and device 有权
标题翻译：光学测量装置及方法及纳米颗粒测量方法及装置
公开(公告)号：US07760356B2
公开(公告)日：2010-07-20
申请号：US11661492
申请日：2005-07-15
申请人： Naoji Moriya , Shinichro Totoki , Yuzo Nagumo , Yukihisa Wada , Naofumi Sakauchi , Fujio Inoue , Masahiro Takebe , Makiko Masutomi
发明人： Naoji Moriya , Shinichro Totoki , Yuzo Nagumo , Yukihisa Wada , Naofumi Sakauchi , Fujio Inoue , Masahiro Takebe , Makiko Masutomi
IPC分类号： G01N15/02
CPC分类号： G01N21/4788 , G01N15/0211 , G01N15/0227 , G01N2013/003 , G01N2015/0038 , G01N2015/0294
摘要： The invention provides an optical measuring device capable of performing measuring using a transient diffraction grating by only adjusting probe light, and a nanoparticle measuring device using the same principle as the optical measuring device. An optical measuring device includes: a power supply 15; a container 11 that stores a sample; a pair of electrodes 13 and 14 that generate an electric force line distribution in which areas having high electric force line density and areas having low electric force line density are regularly arranged; a dielectrophoresis control unit 19 that controls the generation of a transient diffraction grating using dielectrophoresis of particles in the sample caused by applying the voltage to the pair of electrodes 13 and 14 and a variation in the transient diffraction grating due to the diffusion of the particles in the sample according to a variation in the applied voltage; a light source 16 emitting light to the transient diffraction grating; and a plurality of photodetectors 18 detecting diffracted light generated by the transient diffraction grating. In the optical measuring device, the particles are evaluated on the basis of a variation in the intensity of the diffracted light generated by the transient diffraction grating. Further, for example, the particle diameter of a nanoparticle is measured by the same principle as the optical measuring device uses. As a result, it is possible to increase the intensity of a signal and to improve the sensitivity and the S/N ratio, as compared to a dynamic scattering method.
摘要翻译：本发明提供一种光学测量装置，该光学测量装置能够仅通过调节探测光来进行使用瞬态衍射光栅的测量，以及使用与光学测量装置相同原理的纳米粒子测量装置。光学测量装置包括：电源15; 存储样品的容器11; 产生电力线分布的一对电极13,14，其中规定排列具有高电力线密度的区域和具有低电力线密度的区域; 介电电泳控制单元19，其使用通过向一对电极13和14施加电压引起的样品中的颗粒的介电电泳，以及由于颗粒的扩散引起的瞬态衍射光栅的变化来控制瞬态衍射光栅的产生样品根据施加电压的变化; 将光发射到瞬态衍射光栅的光源16; 以及检测由瞬变衍射光栅产生的衍射光的多个光检测器18。在光学测量装置中，基于由瞬变衍射光栅产生的衍射光的强度的变化来评估颗粒。此外，例如，通过与光学测量装置使用的原理相同的原理来测量纳米颗粒的粒径。结果，与动态散射方法相比，可以增加信号的强度并提高灵敏度和S / N比。

39. 发明申请

US20060163373A1 Thermostat device 有权
标题翻译：恒温器
公开(公告)号：US20060163373A1
公开(公告)日：2006-07-27
申请号：US10563429
申请日：2005-05-17
申请人： Fujio Inoue
发明人： Fujio Inoue
IPC分类号： G05D23/13 , G05D23/12
CPC分类号： G05D23/022 , F01P7/16 , F01P2070/00
摘要： To optimize the valve seat shape of the valve housing such that the resistance to passage of cooling water can be diminished in a housing type thermostat device. The valve seat shape further on the downstream side in the direction of flow of the cooling water than the valve seat 22 where an umbrella-shaped valve body 12 is seated, which is an internal wall face forming a cooling water passage 21 within the valve housing 20, is formed in a shape such that, in the valve open condition, the cross-sectional area of the passage that is formed between the inlet seal 32 of the valve seat and the top face 41 of the valve body gradually decreases on the cooling water inlet 31 side with reference to the maximum passage cross-sectional area on the upstream side in the flow direction of the cooling water, and such that the area of the passage at the face perpendicular to the top face gradually increases on the cooling water outlet 33 side so that cooling water flows along the top face of the valve body.
摘要翻译：为了优化阀壳体的阀座形状，使得在壳体式恒温装置中可以减小冷却水通过的阻力。阀座形状还比冷却水流动方向的下游侧多于阀座22，其中伞形阀体12位于其中，该阀座22是在阀壳体内形成冷却水通道21的内壁面 20形成为使得在阀打开状态下，形成在阀座的入口密封件32与阀体的顶面41之间的通道的横截面积在冷却时逐渐减小水入口31侧，相对于冷却水的流动方向上游侧的最大通道截面积，使得与冷却水出口垂直的顶面的通路面积逐渐增大 33侧，使得冷却水沿着阀体的顶面流动。

40. 发明申请

US20050224592A1 Thermostat 有权
标题翻译：恒温器
公开(公告)号：US20050224592A1
公开(公告)日：2005-10-13
申请号：US10518087
申请日：2004-01-26
申请人： Fujio Inoue
发明人： Fujio Inoue
IPC分类号： F01P7/16 , F16K11/02 , F16K31/00 , F16K31/68 , G05D23/13 , G05D23/02 , F16K17/38 , G05D23/00
CPC分类号： F01P7/16 , F16K31/002 , G05D23/134 , Y10T137/7737
摘要： The object of the present invention is to obtain a thermostat device capable of improving the workability and assemblability, reducing costs, and downsizing the entire device with a minimum number of components. This thermostat device has a first valve disc 22 for opening and closing a first fluid passage 3b, and a second valve disc 23 for opening and closing a second fluid passage 3d, and constituted so as to open either the first fluid channel or second fluid channel and close the other by making the valve discs move integrally in conjunction with the operation of an operating member 21 in accordance with the temperature change of the fluid. The operating member has a case 31 which seals in one end side thereof a thermal expansion body 32 having a property of expanding and contracting in accordance with a temperature change, and retains a piston 33 from the opening of the other end side thereof in a freely reciprocable manner. The outward flange unit 36 provided to the opening on the other end side of the case is made to be the first valve disc.
摘要翻译：本发明的目的是获得能够以最少数量的部件提高整个装置的可加工性和组装性，降低成本和小型化的恒温装置。该恒温装置具有用于打开和关闭第一流体通道3b的第一阀盘22和用于打开和关闭第二流体通道3d的第二阀盘23，并且构造成打开第一流体通道或第二流体通道流体通道，并且通过使阀盘与流体的温度变化的操作结合操作件21一起移动而一体地移动。操作构件具有壳体31，其在其一端侧具有根据温度变化具有膨胀和收缩性能的热膨胀体32，并且将活塞33的另一端侧的开口自由地保持互惠的方式。设置在壳体的另一端侧的开口的向外凸缘单元36被制成第一阀盘。

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