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1. 发明授权

US07760356B2 Optical measuring device and method, and nanoparticle measuring method and device 有权
标题翻译：光学测量装置及方法及纳米颗粒测量方法及装置
公开(公告)号：US07760356B2
公开(公告)日：2010-07-20
申请号：US11661492
申请日：2005-07-15
申请人： Naoji Moriya , Shinichro Totoki , Yuzo Nagumo , Yukihisa Wada , Naofumi Sakauchi , Fujio Inoue , Masahiro Takebe , Makiko Masutomi
发明人： Naoji Moriya , Shinichro Totoki , Yuzo Nagumo , Yukihisa Wada , Naofumi Sakauchi , Fujio Inoue , Masahiro Takebe , Makiko Masutomi
IPC分类号： G01N15/02
CPC分类号： G01N21/4788 , G01N15/0211 , G01N15/0227 , G01N2013/003 , G01N2015/0038 , G01N2015/0294
摘要： The invention provides an optical measuring device capable of performing measuring using a transient diffraction grating by only adjusting probe light, and a nanoparticle measuring device using the same principle as the optical measuring device. An optical measuring device includes: a power supply 15; a container 11 that stores a sample; a pair of electrodes 13 and 14 that generate an electric force line distribution in which areas having high electric force line density and areas having low electric force line density are regularly arranged; a dielectrophoresis control unit 19 that controls the generation of a transient diffraction grating using dielectrophoresis of particles in the sample caused by applying the voltage to the pair of electrodes 13 and 14 and a variation in the transient diffraction grating due to the diffusion of the particles in the sample according to a variation in the applied voltage; a light source 16 emitting light to the transient diffraction grating; and a plurality of photodetectors 18 detecting diffracted light generated by the transient diffraction grating. In the optical measuring device, the particles are evaluated on the basis of a variation in the intensity of the diffracted light generated by the transient diffraction grating. Further, for example, the particle diameter of a nanoparticle is measured by the same principle as the optical measuring device uses. As a result, it is possible to increase the intensity of a signal and to improve the sensitivity and the S/N ratio, as compared to a dynamic scattering method.
摘要翻译：本发明提供一种光学测量装置，该光学测量装置能够仅通过调节探测光来进行使用瞬态衍射光栅的测量，以及使用与光学测量装置相同原理的纳米粒子测量装置。光学测量装置包括：电源15; 存储样品的容器11; 产生电力线分布的一对电极13,14，其中规定排列具有高电力线密度的区域和具有低电力线密度的区域; 介电电泳控制单元19，其使用通过向一对电极13和14施加电压引起的样品中的颗粒的介电电泳，以及由于颗粒的扩散引起的瞬态衍射光栅的变化来控制瞬态衍射光栅的产生样品根据施加电压的变化; 将光发射到瞬态衍射光栅的光源16; 以及检测由瞬变衍射光栅产生的衍射光的多个光检测器18。在光学测量装置中，基于由瞬变衍射光栅产生的衍射光的强度的变化来评估颗粒。此外，例如，通过与光学测量装置使用的原理相同的原理来测量纳米颗粒的粒径。结果，与动态散射方法相比，可以增加信号的强度并提高灵敏度和S / N比。

2. 发明申请

US20080192252A1 Optical Measuring Device and Method, and Nanoparticle Measuring Method and Device 有权
标题翻译：光学测量装置及方法及纳米粒子测量方法及装置
公开(公告)号：US20080192252A1
公开(公告)日：2008-08-14
申请号：US11661492
申请日：2005-07-15
申请人： Naoji Moriya , Shinichiro Totoki , Yuzo Nagumo , Yukihisa Wada , Naofumi Sakauchi , Fujio Inoue , Masahiro Takebe , Makiko Masutomi
发明人： Naoji Moriya , Shinichiro Totoki , Yuzo Nagumo , Yukihisa Wada , Naofumi Sakauchi , Fujio Inoue , Masahiro Takebe , Makiko Masutomi
IPC分类号： G01N21/00
CPC分类号： G01N21/4788 , G01N15/0211 , G01N15/0227 , G01N2013/003 , G01N2015/0038 , G01N2015/0294
摘要： The invention provides an optical measuring device capable of performing measuring using a transient diffraction grating by only adjusting probe light, and a nanoparticle measuring device using the same principle as the optical measuring device. An optical measuring device includes: a power supply 15; a container 11 that stores a sample; a pair of electrodes 13 and 14 that generate an electric force line distribution in which areas having high electric force line density and areas having low electric force line density are regularly arranged; a dielectrophoresis control unit 19 that controls the generation of a transient diffraction grating using dielectrophoresis of particles in the sample caused by applying the voltage to the pair of electrodes 13 and 14 and a variation in the transient diffraction grating due to the diffusion of the particles in the sample according to a variation in the applied voltage; a light source 16 emitting light to the transient diffraction grating; and a plurality of photodetectors 18 detecting diffracted light generated by the transient diffraction grating. In the optical measuring device, the particles are evaluated on the basis of a variation in the intensity of the diffracted light generated by the transient diffraction grating. Further, for example, the particle diameter of a nanoparticle is measured by the same principle as the optical measuring device uses. As a result, it is possible to increase the intensity of a signal and to improve the sensitivity and the S/N ratio, as compared to a dynamic scattering method.
摘要翻译：本发明提供一种光学测量装置，该光学测量装置能够仅通过调节探测光来进行使用瞬态衍射光栅的测量，以及使用与光学测量装置相同原理的纳米粒子测量装置。光学测量装置包括：电源15; 存储样品的容器11; 产生电力线分布的一对电极13,14，其中规定排列具有高电力线密度的区域和具有低电力线密度的区域; 介电电泳控制单元19，其使用通过向一对电极13和14施加电压引起的样品中的颗粒的介电电泳，以及由于颗粒的扩散引起的瞬态衍射光栅的变化来控制瞬态衍射光栅的产生样品根据施加电压的变化; 将光发射到瞬态衍射光栅的光源16; 以及检测由瞬变衍射光栅产生的衍射光的多个光检测器18。在光学测量装置中，基于由瞬变衍射光栅产生的衍射光的强度的变化来评估颗粒。此外，例如，通过与光学测量装置使用的原理相同的原理来测量纳米颗粒的粒径。结果，与动态散射方法相比，可以增加信号的强度并提高灵敏度和S / N比。

3. 发明授权

US07911610B2 Optical measuring device 有权
标题翻译：光学测量装置
公开(公告)号：US07911610B2
公开(公告)日：2011-03-22
申请号：US11996057
申请日：2006-01-17
申请人： Naoji Moriya , Yuzo Nagumo , Yukihisa Wada , Naofumi Sakauchi , Fujio Inoue , Masahiro Takebe , Kenji Takubo , Shinichiro Totoki
发明人： Naoji Moriya , Yuzo Nagumo , Yukihisa Wada , Naofumi Sakauchi , Fujio Inoue , Masahiro Takebe , Kenji Takubo , Shinichiro Totoki
IPC分类号： G01N21/00
CPC分类号： G01N15/0211 , G01N21/4788 , G01N2021/1721
摘要： The present invention relates to an optical measuring device which includes container for storing a sample, and an electrode pair for generating an electric field distribution upon impression of a voltage by an electrical power supply, thereby generating or extinguishing diffraction grating formed by a density modulation of particles within the sample. The particles within the sample are evaluated based upon a temporal change of an intensity of a diffracted light beam obtained by irradiating a light beam upon the diffraction grating formed by the density modulation of the particles. The electrodes constituting the electrode pair are configured to have a comb-like electrode teeth that are parallel with each other and are arranged such that the electrode teeth of one electrode are inserted between the electrode teeth of the other electrode. From such configuration, an optical measuring device of a high sensitivity and excellent S/N ratio can be obtained.
摘要翻译：本发明涉及一种光学测量装置，该光学测量装置包括用于存储样品的容器和用于通过电源印制电压而产生电场分布的电极对，由此产生或熄灭由密度调制形成的衍射光栅样品内的颗粒。基于通过对通过颗粒的密度调制形成的衍射光栅照射光束而获得的衍射光束的强度的时间变化来评估样品内的颗粒。构成电极对的电极被构造为具有彼此平行的梳状电极齿，并且被布置成使得一个电极的电极齿插入另一个电极的电极齿之间。由此，可以得到灵敏度高，S / N比优异的光学测量装置。

4. 发明申请

US20090251695A1 OPTICAL MEASURING DEVICE 有权
标题翻译：光学测量装置
公开(公告)号：US20090251695A1
公开(公告)日：2009-10-08
申请号：US11996057
申请日：2006-01-17
申请人： Naoji Moriya , Yuzo Nagumo , Yukihisa Wada , Naofumi Sakauchi , Fujio Inoue , Masahiro Takebe , Kenji Takubo , Shinichiro Totoki
发明人： Naoji Moriya , Yuzo Nagumo , Yukihisa Wada , Naofumi Sakauchi , Fujio Inoue , Masahiro Takebe , Kenji Takubo , Shinichiro Totoki
IPC分类号： G01N15/02 , G01N21/47
CPC分类号： G01N15/0211 , G01N21/4788 , G01N2021/1721
摘要： Within a container 1 which is storing a sample is generated a regularly arranged electric field distribution by an impression of a voltage upon an electrode pair 2 provided within the container 1, thereby generating diffraction grating formed by a density modulation of particles within the sample within the container 1, there is obtained information upon a diffusion of the particles based upon a temporal change in an extinction process of an intensity of a diffracted light beam obtained by irradiating a light beam upon the diffraction grating formed by the density modulation of the particles, the electrodes 21, 22 constituting the electrode pair 2 are configured to have multiple linear electrode teeth 21a, 22a parallel with each other, the electrodes 21, 22 are arranged such that the electrode teeth 21a of one electrode 21 are inserted between the electrode teeth 22a of the other electrode 22, thereby increasing the width of the diffraction grating formed by the density modulation of the particles, and a ratio of a component of the diffracted light beam thereof included in an entire diffracted light beam is increased to increase sensitivity of a measurement. As a result, there is provided an optical measuring device which can measure the information upon the diffusion of the particles movably dispersed within a medium at a high sensitivity and with an excellent S/N ratio.
摘要翻译：在存储样品的容器1内通过设置在容器1内的电极对2上的电压印制产生规则排列的电场分布，从而产生通过在样品内的颗粒的密度调制形成的衍射光栅容器1根据粒子的密度调制形成的衍射光栅照射光束而获得的衍射光束的强度的消光处理中的时间变化，获得了粒子扩散的信息，构成电极对2的电极21,22被配置为具有彼此平行的多个线状电极齿21a，22a，电极21,22被布置成使得一个电极21的电极齿21a插入到电极齿22a 另一个电极22，从而增加由t的密度调制形成的衍射光栅的宽度并且包括在整个衍射光束中的衍射光束的分量的比率增加，以增加测量的灵敏度。结果，提供了一种光学测量装置，其可以以高灵敏度和良好的S / N比来测量可移动地分散在介质中的颗粒的扩散的信息。

5. 发明授权

US08313628B2 Method and apparatus for evaluating dielectrophoretic intensity of microparticle 失效
标题翻译：评估微粒介质电泳强度的方法和装置
公开(公告)号：US08313628B2
公开(公告)日：2012-11-20
申请号：US12374048
申请日：2006-07-19
申请人： Yoshio Tsunazawa , Yukihisa Wada , Naoji Moriya , Kenji Takubo , Shinichiro Totoki , Haruo Shimaoka
发明人： Yoshio Tsunazawa , Yukihisa Wada , Naoji Moriya , Kenji Takubo , Shinichiro Totoki , Haruo Shimaoka
IPC分类号： B03C5/02
CPC分类号： G01N21/4788 , B03C5/005 , B03C5/026 , G01N2015/0003 , G01N2015/0038
摘要： A distribution of AC electric field regularly arranged in a cell is formed while storing a sample having particles dispersed in a medium in the cell, whereby the particles are dielectrically migrated in the medium to generate a diffraction grating by density distribution of the particles. Diffracted light generated by irradiating the diffraction grating by density distribution with measuring light is detected, and evaluation of dielectrophoretic intensities of the particles and/or the medium is performed from the detection result. According to this method, evaluation of dielectrophoretic characteristics can be performed without adhering a phosphor to particles, and since even a particle small in size can achieve a detection level by collecting a number of such particles to form a diffraction grating, dielectric characteristics of microparticles of several nanometers in diameter can be thus quantitatively measured with high sensitivity.
摘要翻译：形成规则排列在电池中的AC电场的分布，同时将具有分散在介质中的粒子的样品储存在电池中，由此在介质中介电迁移，从而通过颗粒的密度分布产生衍射光栅。检测通过用测量光通过密度分布照射衍射光栅而产生的衍射光，并根据检测结果评估颗粒和/或介质的介电电泳强度。根据该方法，可以在不将荧光体附着于粒子的情况下进行介电电泳特性的评价，并且，即使通过收集多个这样的粒子来形成衍射光栅，尺寸小的粒子也能够达到检测水平，所以微粒的介电特性因此可以高灵敏度定量测量直径几纳米。

6. 发明申请

US20100012496A1 METHOD AND APPARATUS FOR EVALUATING DIELECTROPHORETIC INTENSITY OF MICROPARTICLE 失效
标题翻译：评估微电极的电磁强度的方法和装置
公开(公告)号：US20100012496A1
公开(公告)日：2010-01-21
申请号：US12374048
申请日：2006-07-19
申请人： Yoshio Tsunazawa , Yukihisa Wada , Naoji Moriya , Kenji Takubo , Shinichiro Totoki , Haruo Shimaoka
发明人： Yoshio Tsunazawa , Yukihisa Wada , Naoji Moriya , Kenji Takubo , Shinichiro Totoki , Haruo Shimaoka
IPC分类号： G01N15/00 , B01D57/02 , G01N15/02 , G01N21/47
CPC分类号： G01N21/4788 , B03C5/005 , B03C5/026 , G01N2015/0003 , G01N2015/0038
摘要： A distribution of AC electric field regularly arranged in a cell is formed while storing a sample having particles dispersed in a medium in the cell, whereby the particles are dielectrically migrated in the medium to generate a diffraction grating by density distribution of the particles. Diffracted light generated by irradiating the diffraction grating by density distribution with measuring light is detected, and evaluation of dielectrophoretic intensities of the particles and/or the medium is performed from the detection result. According to this method, evaluation of dielectrophoretic characteristics can be performed without adhering a phosphor to particles, and since even a particle small in size can achieve a detection level by collecting a number of such particles to form a diffraction grating, dielectric characteristics of microparticles of several nanometers in diameter can be thus quantitatively measured with high sensitivity.
摘要翻译：形成规则排列在电池中的AC电场的分布，同时将具有分散在介质中的粒子的样品储存在电池中，由此在介质中介电迁移，从而通过颗粒的密度分布产生衍射光栅。检测通过用测量光通过密度分布照射衍射光栅而产生的衍射光，并根据检测结果评估颗粒和/或介质的介电电泳强度。根据该方法，可以在不将荧光体附着于粒子的情况下进行介电电泳特性的评价，并且，即使通过收集多个这样的粒子来形成衍射光栅，尺寸小的粒子也能够达到检测水平，所以微粒的介电特性因此可以高灵敏度定量测量直径几纳米。

7. 发明申请

US20100149532A1 METHOD AND APPARATUS FOR OPTICAL MEASUREMENT 审中-公开
标题翻译：用于光学测量的方法和装置
公开(公告)号：US20100149532A1
公开(公告)日：2010-06-17
申请号：US12600649
申请日：2007-05-18
申请人： Naoji Moriya
发明人： Naoji Moriya
IPC分类号： G01N15/02 , G01N21/47
CPC分类号： G01N11/00 , G01N13/00 , G01N2011/008 , G01N2013/003 , G01N2015/0038 , G01N2015/0216
摘要： In the case of generating a diffraction grating resulting from the density distribution of particles by applying a spatially periodic electric field to a sample having particles dispersed movably in a medium, measuring diffracted light obtained by exposing the diffraction grating to a parallel light flux, and calculating the diffusion coefficient and/or size of the particles from the temporal change in the intensity of the diffracted light, the diffraction grating is exposed to multiple types of parallel light fluxes having mutually different wavelengths simultaneously or sequentially, the diffracted light is measured separately for each wavelength, and the measurement results are used selectively for calculation of the diffusion coefficient and/or size of the particles, and whereby the measurement can be carried out accurately without being affected by a plasmon resonance phenomenon even for metal particles.
摘要翻译：在通过对具有可移动地分散在介质中的颗粒的样品施加空间周期性电场而产生由颗粒的密度分布产生的衍射光栅的情况下，测量通过将衍射光栅曝光到平行光通量而获得的衍射光，并计算从衍射光强度的时间变化引起的粒子的扩散系数和/或尺寸，衍射光栅同时或顺序地暴露于具有相互不同波长的多种平行光束，衍射光分别测量波长，并且测量结果被选择性地用于计算颗粒的扩散系数和/或尺寸，并且由此即使对于金属颗粒也不会受到等离子体共振现象的影响，可以精确地进行测量。

8. 发明申请

US20090128809A1 METHOD OF ANALYSIS IN OPTICAL MEASUREMENTS 失效
标题翻译：光学测量中的分析方法
公开(公告)号：US20090128809A1
公开(公告)日：2009-05-21
申请号：US12281097
申请日：2006-02-28
申请人： Naoji Moriya
发明人： Naoji Moriya
IPC分类号： G01N15/02 , G01N21/17
CPC分类号： G01N15/0211 , G01N21/4788 , G01N2011/008 , G01N2015/0216
摘要： The method of the present invention generates a regularly lined electric field inside a container 1 retaining a sample formed by dispersing particle groups in a liquid by a voltage being applied to an electrode pair 2 provided in the container 1, generates a diffraction grating by a density distribution of the particle groups in the sample inside the container 1, and when acquiring a diffusion coefficient of particles from a temporal variation of intensity in a disappearing process of a diffracted light obtained by irradiating a beam of light to the diffraction grating generated by the density distribution of the particle groups, performs a particle size analysis of the particle groups by using an approximate analysis expression of a diffracted light attenuation, I(t)=∝exp[−2q2Dt] which uses q=2π/Λ defined by a particle concentration modulation period Λ in the density distribution diffraction grating of the particle groups, and the Einstein-Stokes relation. And if particle groups having a known particle size are dispersed in a liquid to be measured and similar measurements are performed, viscosity analysis of the liquid to be measured can be performed.
摘要翻译：本发明的方法在容器1内部产生规则排列的电场，该容器1保持通过施加到设置在容器1中的电极对2的电压将颗粒群分散在液体中而形成的样品，通过密度产生衍射光栅在容器1内的样品中的粒子群的分布，并且当通过将光束照射到由密度产生的衍射光栅获得的衍射光的消失过程中从强度的时间变化中获得粒子的扩散系数时通过使用由粒子浓度定义的q = 2pi /λλ的衍射光衰减I（t）=αexp[-2q2Dt]的近似分析表达式，对粒子群的分布进行粒子群的粒度分析粒子群密度分布衍射光栅中的调制周期Lambda以及爱因斯坦 - 斯托克斯关系。如果将具有已知粒径的粒子分散在被测定液体中，进行同样的测定，则可以进行待测液体的粘度分析。

9. 发明授权

US08164749B2 Optical measurement apparatus and electrode pair thereof 有权
标题翻译：光学测量装置及其电极对
公开(公告)号：US08164749B2
公开(公告)日：2012-04-24
申请号：US12672393
申请日：2007-08-08
申请人： Naoji Moriya
发明人： Naoji Moriya
IPC分类号： G01N21/00
CPC分类号： G01N15/0205 , G01N15/0211
摘要： In an apparatus in which an electrode pair formed of two electrodes including multiple mutually parallel linear electrode pieces is provided in a container for storing particles dispersed movably in a medium to form an spatially regularly arranged electric field, the particles are migrated in the container due to the formation of the electric field by the application of a voltage to the electrode pair to generate a diffraction grating resulting from density distribution of the particles, diffracted light obtained by applying light to the diffraction grating is measured, and a particle size analysis or the like is performed from the temporal change in the diffracted light in the free diffusion process of the particles by stoppage or modulation of the application of the voltage, by making width L of the electrode pieces of the electrode pair and a space distance S between the electrode pieces as follows: L/(L+S)≦0.3, steep attenuation of the diffracted light intensity is not generated at the initial stage of the diffusion of the particles to accurately measure the particle size distribution.
摘要翻译：在将包含多个相互平行的直线电极片的两个电极形成的电极对设置在用于存储能够可移动地分散在介质中以形成空间上规则排列的电场的颗粒的容器中的情况下，由于通过向电极对施加电压来形成电场，以产生由颗粒的密度分布产生的衍射光栅，通过将光施加到衍射光栅获得的衍射光，并进行粒度分析等通过使电极对的电极片的宽度L和电极片之间的间隔距离S通过停止或调制施加电压而在粒子的自由扩散过程中的衍射光的时间变化中进行如下：L /（L + S）＆nlE; 0.3，不产生衍射光强度的陡峭衰减 d在颗粒扩散的初始阶段以精确测量粒度分布。

10. 发明授权

US08107074B2 Analytical method for optical measurement 有权
标题翻译：光学测量分析方法
公开(公告)号：US08107074B2
公开(公告)日：2012-01-31
申请号：US12665576
申请日：2007-06-21
申请人： Naoji Moriya
发明人： Naoji Moriya
IPC分类号： G01N15/02
CPC分类号： G01N15/0211 , G01N21/4788 , G01N2021/1721
摘要： An electric field spatially-regularly arranged is applied to particles movably dispersed in a medium to migrate particles. The resulting density distribution of the particles generates a diffraction grating. In the annihilation process of the diffraction grating through the stop or modulation of the application of the electric field, intensity of diffracted light from the diffraction grating is measured to obtain the size of particles. In the above measurement method, the square root or natural logarithm of the measured value of the diffracted light intensity is used for the analysis to evaluate with high convergence the dispersiveness of the particle size with using the least squares method even in the case of particles of dispersive diameter or the case where particles to be measured include particles of different sizes.
摘要翻译：将空间上规则排列的电场施加到可移动地分散在介质中以移动颗粒的颗粒上。所得颗粒的密度分布产生衍射光栅。在通过停止或调制施加电场的衍射光栅的湮灭过程中，测量来自衍射光栅的衍射光的强度以获得粒子的尺寸。在上述测定方法中，使用衍射光强度的测量值的平方根或自然对数进行分析，即使在粒子的粒子的情况下也以高收敛率评价粒径的分散性分散直径或要测量的颗粒包括不同尺寸的颗粒的情况。

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