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31. 发明申请

US20110015725A1 COATED MEDICAL DEVICE 审中-公开
标题翻译：涂层医疗器械
公开(公告)号：US20110015725A1
公开(公告)日：2011-01-20
申请号：US12892177
申请日：2010-09-28
申请人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61F2/82
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

32. 发明申请

US20100331817A1 THERAPEUTIC AGENT DELIVERY DEVICE WITH A DUAL BALLOON HAVING DISTAL TAPER APERTURES 有权
标题翻译：带双向气囊的治疗剂递送装置
公开(公告)号：US20100331817A1
公开(公告)日：2010-12-30
申请号：US12825965
申请日：2010-06-29
申请人： Darin G. Schaeffer , William F. Moore
发明人： Darin G. Schaeffer , William F. Moore
IPC分类号： A61M25/10
CPC分类号： A61M25/1011 , A61M25/104 , A61M2025/1013 , A61M2025/105 , A61M2025/1052
摘要： The present disclosure generally provides a multiple balloon assembly used as part of the distal region of a medical device that is capable of delivering a therapeutic agent into a body vessel having bodily fluid. The multiple balloon assembly comprises an inner balloon and an outer balloon. The outer balloon further comprises a proximal taper region, a middle region, and a distal taper region. The inflation of the inner balloon causes the middle region of the outer balloon to contact the inner wall of the body vessel, thereby, occluding the flow of fluid through the body vessel. The proximal taper region and the distal taper region are configured such that they do not touch the inner wall of the body vessel. One of the distal taper and proximal taper regions has a plurality of apertures configured to allow for the therapeutic agent to be delivered into the body vessel at a predetermined rate. A medical device that incorporates the multiple balloon assembly of the present disclosure, as well as a method for using the medical device and multiple balloon assembly are further disclosed.
摘要翻译：本公开通常提供多个气囊组件，其被用作医疗装置的远侧区域的一部分，其能够将治疗剂递送到具有体液的身体容器中。多球囊组件包括内球囊和外球囊。外球囊还包括近端锥形区域，中间区域和远端锥形区域。内球囊的膨胀导致外球囊的中间区域接触身体血管的内壁，从而阻塞通过体血管的流体流动。近端锥形区域和远端锥形区域构造成使得它们不接触身体血管的内壁。远端锥形和近端锥形区域中的一个具有多个孔，其构造成允许治疗剂以预定速率输送到体内容器。还公开了一种结合本公开的多球囊组件的医疗装置，以及用于使用医疗装置和多气囊组件的方法。

33. 发明申请

US20090171283A1 METHOD OF BONDING A DILATION ELEMENT TO A SURFACE OF AN ANGIOPLASTY BALLOON 审中-公开
标题翻译：将放射性元素与血管平滑肌的表面结合的方法
公开(公告)号：US20090171283A1
公开(公告)日：2009-07-02
申请号：US11965499
申请日：2007-12-27
申请人： Darin G. Schaeffer , Kimberly D. Roberts
发明人： Darin G. Schaeffer , Kimberly D. Roberts
IPC分类号： A61M25/10
CPC分类号： A61M25/104 , A61M25/1034 , A61M2025/1031
摘要： A balloon catheter with dilation elements and method of fabricating thereof is provided that may be used to dilate and/or cut hardened regions of a body vessel. The balloon catheter is provided with dilation elements that extend along a surface of a balloon. One or both ends of the dilation element is inserted through corresponding apertures formed in the balloon neck. After inserting the one or both ends through the corresponding apertures, the ends are bonded into the material of the catheter shaft and the balloon.
摘要翻译：提供具有扩张元件的气囊导管及其制造方法，其可用于扩张和/或切割身体血管的硬化区域。球囊导管设置有沿气球表面延伸的扩张元件。扩张元件的一端或两端通过形成在气囊颈部中的相应孔插入。在将一个或两个端部插入相应的孔中之后，端部被接合到导管轴和气囊的材料中。

34. 发明申请

US20080183268A1 COATED IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US20080183268A1
公开(公告)日：2008-07-31
申请号：US11965385
申请日：2007-12-27
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees , Thomas G. Kozma , David D. Grewe , Darin G. Schaeffer , JiChao Sun
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees , Thomas G. Kozma , David D. Grewe , Darin G. Schaeffer , JiChao Sun
IPC分类号： A61F2/82
CPC分类号： A61F2/885 , A61F2/0077 , A61F2250/0068
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, where the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 may be posited over the bioactive material layer 18, where the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 以及至少一层生物活性材料层18，其被定位在涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以位于生物活性材料层18上，其中多孔层包括聚合物，并且通过其提供生物活性材料的受控释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

35. 发明申请

US20080086084A1 BALLOON CATHETER 有权
标题翻译：气球导管
公开(公告)号：US20080086084A1
公开(公告)日：2008-04-10
申请号：US11858658
申请日：2007-09-20
申请人： Darin G. Schaeffer , David G. Burton
发明人： Darin G. Schaeffer , David G. Burton
IPC分类号： A61M29/02
CPC分类号： A61M25/1029 , A61M25/1034 , A61M25/104 , A61M2025/1031 , A61M2025/1063
摘要： An balloon catheter is provided with an improved neck portion. The neck portion of the balloon is used to attach the end of the balloon to a catheter. Before attaching the balloon to the catheter, the neck portion is lengthened and thinned out to make the neck portion more flexible. Heat shrink tubing may be used to apply pressure to the neck portion to force the material of the neck portion to flow along a mandrel inserted into the neck portion.
摘要翻译：气囊导管设置有改进的颈部。气囊的颈部用于将气囊的端部附接到导管。在将气囊附接到导管之前，颈部被延长并变薄，使得颈部更柔韧。热收缩管可用于向颈部施加压力，以迫使颈部的材料沿着插入颈部的心轴流动。

36. 发明授权

US08795288B2 Access device 有权
标题翻译：访问设备
公开(公告)号：US08795288B2
公开(公告)日：2014-08-05
申请号：US11874444
申请日：2007-10-18
申请人： Jeffry S. Melsheimer , Darin G. Schaeffer
发明人： Jeffry S. Melsheimer , Darin G. Schaeffer
IPC分类号： A61F11/00
CPC分类号： A61M25/0662 , A61B17/3415 , A61B2017/00243 , A61F2/95
摘要： A device for providing access to a treatment site within the body of a patient includes a tubular member having a first, generally elongated configuration for introduction into the body of the patient, and deployable therein to a second configuration. The second configuration includes an axially displaced segment along the distal portion of the tubular member. The tubular member includes a side port oriented along the axially displaced segment, and further includes a lumen communicating with the side port. The lumen and side port are sized for passage therethrough of an interventional device for delivery to the treatment site.
摘要翻译：用于提供对患者体内的治疗部位的通路的装置包括管状构件，其具有用于引入患者体内的第一大体上细长的构造，并且可部署到第二构造中。第二构造包括沿着管状构件的远端部分的轴向移位的段。管状构件包括沿轴向移位的段定向的侧端口，并且还包括与侧端口连通的管腔。管腔和侧端口的尺寸设置成用于通过其介入装置，用于输送到治疗部位。

37. 发明授权

US08784602B2 Balloon catheter for delivering a therapeutic agent 有权
标题翻译：用于递送治疗剂的气球导管
公开(公告)号：US08784602B2
公开(公告)日：2014-07-22
申请号：US13477774
申请日：2012-05-22
申请人： Darin G. Schaeffer , David Christian Lentz
发明人： Darin G. Schaeffer , David Christian Lentz
IPC分类号： A61M25/00
CPC分类号： A61M25/10 , A61M25/1027 , A61M2025/0004 , A61M2025/1013 , A61M2025/105 , A61M2025/1056
摘要： Catheter balloon assemblies (10) for delivering a therapeutic agent to a body vessel are provided, as well as related methods of manufacturing and methods of treatment. The catheter balloon assemblies may include a concentrically disposed dual balloon assembly at the distal portion of the catheter having an inner balloon (44), a porous outer balloon (42) concentrically arrayed around the inner balloon and a catheter shaft (30) adapted to deliver a therapeutic agent to the body vessel through the apertures in the outer balloon. Radial outward expansion of the inner balloon may urge the outer balloon into contact with the wall of a body vessel, where the therapeutic agent may be delivered from the catheter shaft through apertures in the outer balloon directly to the wall of the body vessel. Preferably, the catheter balloon assemblies include a stiffening' member (210) within the proximal portion and/or a plurality of lumens lined with a fluorinated hydrocarbon to independently inflate the inner balloon, deliver the therapeutic agent through the outer balloon and house a wire guide (50). The catheter balloon assemblies may provide improved tractability and/or pushability characteristics.
摘要翻译：提供了用于将治疗剂递送至身体血管的导管气囊组件（10），以及相关的制造方法和治疗方法。导管球囊组件可以包括在导管的远端部分处的同心设置的双球囊组件，其具有内球囊（44），围绕内球囊同心排列的多孔外球囊（42）和适于递送的导管轴通过外球囊中的孔，向身体血管施加治疗剂。内球囊的径向向外膨胀可以促使外球囊与体血管的壁接触，其中治疗剂可以通过外球囊中的孔直接从导管轴输送到身体血管的壁。优选地，导管球囊组件包括近端部分内的加强构件（210）和/或内衬有氟化烃的多个内腔，以独立地使内球囊膨胀，将治疗剂输送通过外气囊并容纳导线（50）。导管球囊组件可以提供改善的易处理性和/或可推动性特征。

38. 发明申请

US20130158559A1 DEVICE AND METHOD FOR MIXING AND DISPENSING A BONE CEMENT MIXTURE 有权
公开(公告)号：US20130158559A1
公开(公告)日：2013-06-20
申请号：US13331370
申请日：2011-12-20
申请人： Darin G. Schaeffer
发明人： Darin G. Schaeffer
IPC分类号： A61B17/58
CPC分类号： B01F13/0023 , A61B17/8822 , A61B17/8825 , A61B17/8833 , B01F11/0071 , B01F15/00506 , B01F15/0213 , B01F15/0226 , B01F15/0237 , B01F15/0278 , B01F2215/0029
摘要： In at least one embodiment of the present invention, a device for mixing and dispensing a bone cement mixture is provided. The device comprises a first chamber and a second chamber. The first chamber is for containing a first bone cement component. The second chamber is for containing a second bone cement component. A valve is in fluid communication with the first and second chambers. A first and a second plunger are respectively within the first and second chambers and are configured to actuate within their respective chambers. When the valve is in a first position actuating the first plunger advances the first bone cement component into the second chamber to form the bone cement mixture.

39. 发明申请

US20120232477A1 SHORT WIRE CABLE CATHETER 有权
标题翻译：短导线电缆
公开(公告)号：US20120232477A1
公开(公告)日：2012-09-13
申请号：US13498373
申请日：2010-09-22
申请人： Darin G. Schaeffer
发明人： Darin G. Schaeffer
IPC分类号： A61M25/10 , B23P17/00 , A61M25/098
CPC分类号： A61M25/104 , A61F2/958 , A61F2/966 , A61F2250/0007 , A61M25/1036 , A61M2025/0183
摘要： A balloon catheter device (1700) includes an elongate catheter shaft comprising multifilar cable tubing (1706) having a proximal portion and a distal portion. The proximal portion includes a coating (1708) that allows the shaft to provide a patent fluid passage. The distal cable tube end includes a connection structure (1723) configured to provide desirable strength, pushability, and trackability.
摘要翻译：气囊导管装置（1700）包括细长的导管轴，其包括具有近端部分和远端部分的多芯电缆管道（1706）。近端部分包括允许轴提供专利流体通道的涂层（1708）。远端电缆管端包括被配置为提供期望的强度，推动性和可追踪性的连接结构（1723）。

40. 发明授权

US08257422B2 Over-the-wire detachment mechanism 有权
标题翻译：超线脱离机构
公开(公告)号：US08257422B2
公开(公告)日：2012-09-04
申请号：US12543941
申请日：2009-08-19
申请人： Darin G. Schaeffer , Jeffry S. Melsheimer
发明人： Darin G. Schaeffer , Jeffry S. Melsheimer
IPC分类号： A61F2/06
CPC分类号： A61M39/10 , A61M25/01 , A61M2039/0232 , A61M2039/0291
摘要： A detachment mechanism, and methods of use, for use in delivering a medical device preferably over a guidewire are provided. The detachment mechanism includes a first and second engagement member. The members are configured to receive the guidewire and have a first end attached to the control member and the device, respectively, a second end, and a notch formed in the body to form an interlocking tooth. The notch is sized to receive the interlocking tooth of the other member. The members are interlockable to couple the medical device to the control member and to allow the guidewire to pass therethrough. The notch can be angled to permit easier detachment between the members and for better torqueability and pushability/pullability between the control member and the medical device. The members can also include a bend region configured to enhance bendability along a portion of the members.
摘要翻译：提供了一种用于优选地通过导线递送医疗装置的分离机构和使用方法。分离机构包括第一和第二接合构件。所述构件构造成接收所述导丝，并且具有分别附接到所述控制构件和所述装置的第一端和形成在所述主体中以形成互锁齿的凹口的第一端。凹口的尺寸被设计成接收另一个构件的互锁齿。构件可互锁以将医疗装置连接到控制构件并允许导丝通过。凹口可以成角度以允许在构件之间更容易地分离，并且在控制构件和医疗装置之间具有更好的可逆性和可推动性/可拉伸性。构件还可以包括弯曲区域，该弯曲区域被构造成增强沿着构件的一部分的弯曲性。

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