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31. 发明授权

US08859565B2 Compound for inhibiting type 5 phosphodiesterase and preparation method thereof 有权
标题翻译：抑制5型磷酸二酯酶的化合物及其制备方法
公开(公告)号：US08859565B2
公开(公告)日：2014-10-14
申请号：US13512524
申请日：2010-07-30
申请人： Nan Zhang , Rong Zhong
发明人： Nan Zhang , Rong Zhong
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04 , C07C59/265
CPC分类号： C07D487/04 , A61K31/519 , C07C59/265
摘要： The present invention discloses a compound of formula (I) and citrate thereof as type 5 phosphodiesterase inhibitor, a preparation method thereof, and a pharmaceutical composition including the compound of formula (I) and citrate thereof. The experimental results of the present invention prove that the compound of formula (I) and citrate thereof can inhibit activity of type 5 phosphodiesterase, and can be used for treating erectile dysfunction, inhibiting platelet aggregation and treating thrombosis, decreasing pulmonary hypertension and treating cardiovascular diseases, treating asthma and treating diabetes gastroparesis.
摘要翻译：本发明公开了式（I）化合物及其柠檬酸盐作为5型磷酸二酯酶抑制剂及其制备方法，以及含有式（I）化合物及其柠檬酸盐的药物组合物。本发明的实验结果证明，式（I）化合物及其柠檬酸盐可抑制5型磷酸二酯酶的活性，可用于治疗勃起功能障碍，抑制血小板聚集和治疗血栓形成，降低肺动脉高压和治疗心血管疾病治疗哮喘和治疗糖尿病胃轻瘫。

32. 发明申请

US20130062525A1 Positron Emission Tomography Block Detector Interconnect 有权
标题翻译：正电子发射断层扫描检测器互连
公开(公告)号：US20130062525A1
公开(公告)日：2013-03-14
申请号：US13229797
申请日：2011-09-12
申请人： James Frank Caruba , Niraj K. Doshi , John W. Young , Nan Zhang
发明人： James Frank Caruba , Niraj K. Doshi , John W. Young , Nan Zhang
IPC分类号： G01T1/20 , G01T1/164
CPC分类号： G01T1/1648
摘要： Using standard or “off the shelf” cable to interconnect between the PET block detector and the detector circuit may save substantial costs given the number of PMTs in a PET system. Given space constraints, simple maintenance with reduced risk of disturbing cabling is desired, making ongoing use of standard cabling without adding further cabling desired. To implement digital gain control, a further communication is provided between the PET detector block and the detector circuit. Since the standard cable may not have additional wires for such communications and to reduce timing degradation, the PMT signals are combined, such as generating position and energy signals at the PET detector block. The four PMT signals are reduced to three signals without reduction in function, allowing a fourth twisted pair of wires in a CAT5 cable to be used for digital gain control.
摘要翻译：使用标准或现货电缆在PET块检测器和检测器电路之间进行互连可以节省大量成本，因为PET系统中PMT的数量。鉴于空间限制，需要简单的维护，减少干扰布线的风险，不断增加布线需求，不断使用标准布线。为了实现数字增益控制，在PET检测器块和检测器电路之间提供进一步的通信。由于标准电缆可能没有用于这种通信的附加电线并且减少定时劣化，所以组合PMT信号，例如在PET检测器块处产生位置和能量信号。四个PMT信号减少到三个信号，而不会降低功能，允许CAT5电缆中的第四根双绞线用于数字增益控制。

33. 发明申请

US20130004371A1 Analytical Cartridge with Fluid Flow Control 有权
标题翻译：具有流体流量控制的分析盒
公开(公告)号：US20130004371A1
公开(公告)日：2013-01-03
申请号：US13608408
申请日：2012-09-10
申请人： Zhiliang Wan , Nan Zhang
发明人： Zhiliang Wan , Nan Zhang
IPC分类号： G01N21/75
CPC分类号： G01N33/558 , B01L3/502746 , B01L3/502753 , B01L2200/04 , B01L2200/0631 , B01L2200/16 , B01L2300/0654 , B01L2300/069 , B01L2300/0819 , B01L2300/0883 , B01L2300/0887 , B01L2300/165 , B01L2400/0406 , Y10T137/0318
摘要： Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.
摘要翻译：使用毛细管流分析样品的分析柱，系统和方法。垂直梯度样品过滤将滤液提供到孵育室，由孵育室出口处的流动调节器控制一段时间。流量调节器可以包括没有侧壁的蛇形毛细管流动路径。孵育的滤液可以在预定时间后从孵育室流出到检测通道。检测室可以在多孔基底中包括一个或多个分析区域，用于从相同的样品检测相同盒上的两种或更多种分析物。

34. 发明申请

US20110301385A1 CATALYST FOR OLEFIN POLYMERIZATION AND METHOD OF PREPARATION THEREOF 有权
标题翻译：烯烃聚合催化剂及其制备方法
公开(公告)号：US20110301385A1
公开(公告)日：2011-12-08
申请号：US13153997
申请日：2011-06-06
申请人： Licai Wang , Zhanxian Gao , Wei Li , Guotong Zheng , Qingxin Dong , Riping Liu , Xiaohuan Wang , Nan Zhang , Jingzhuang Wang , Shimian Cai
发明人： Licai Wang , Zhanxian Gao , Wei Li , Guotong Zheng , Qingxin Dong , Riping Liu , Xiaohuan Wang , Nan Zhang , Jingzhuang Wang , Shimian Cai
IPC分类号： C07C41/01
CPC分类号： C07C37/11 , C07C41/16 , C07C39/15 , C07C43/2055
摘要： A catalyst for olefin polymerization and method of preparing the same are disclosed.
摘要翻译：公开了一种用于烯烃聚合的催化剂及其制备方法。

35. 发明申请

US20100009430A1 Analytical cartridge with fluid flow control 有权
标题翻译：具有流体流量控制的分析筒
公开(公告)号：US20100009430A1
公开(公告)日：2010-01-14
申请号：US12456247
申请日：2009-06-12
申请人： Zhiliang Wan , Nan Zhang
发明人： Zhiliang Wan , Nan Zhang
IPC分类号： C12M1/00 , G01N33/53 , G01N21/01 , F17D1/00
CPC分类号： G01N33/558 , B01L3/502746 , B01L3/502753 , B01L2200/04 , B01L2200/0631 , B01L2200/16 , B01L2300/0654 , B01L2300/069 , B01L2300/0819 , B01L2300/0883 , B01L2300/0887 , B01L2300/165 , B01L2400/0406 , Y10T137/0318
摘要： Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.
摘要翻译：使用毛细管流分析样品的分析柱，系统和方法。垂直梯度样品过滤将滤液提供到孵育室，由孵育室出口处的流动调节器控制一段时间。流量调节器可以包括没有侧壁的蛇形毛细管流动路径。孵育的滤液可以在预定时间后从孵育室流出到检测通道。检测室可以在多孔基底中包括一个或多个分析区域，用于从相同的样品检测相同盒上的两种或更多种分析物。

36. 发明申请

US20090311217A1 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开
标题翻译： 3-取代的1H-吲哚化合物，它们作为MTOR激酶和PI3激酶抑制剂使用，以及它们的合成
公开(公告)号：US20090311217A1
公开(公告)日：2009-12-17
申请号：US12473605
申请日：2009-05-28
申请人： Matthew Gregory Bursavich , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Thai Hiep Nguyen , Sabrina Lombardi , David Malwitz , Natasja Brooijmans , Derek Cecil Cole , Adam Matthew Gilbert , Pawel Wojciech Nowak , Kaapjoo Park , Sasmita Das , Hwei-Ru Tsou , Aranapakam Mudumbai Venkatesan , Mercy Adufa Otteng , Gary Harold Birnberg , Gloria Jean MacEwan
发明人： Matthew Gregory Bursavich , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Thai Hiep Nguyen , Sabrina Lombardi , David Malwitz , Natasja Brooijmans , Derek Cecil Cole , Adam Matthew Gilbert , Pawel Wojciech Nowak , Kaapjoo Park , Sasmita Das , Hwei-Ru Tsou , Aranapakam Mudumbai Venkatesan , Mercy Adufa Otteng , Gary Harold Birnberg , Gloria Jean MacEwan
IPC分类号： A61K31/404 , C07D405/02 , C07D403/14 , C07D413/02 , A61K31/496 , A61K31/5377 , A61K38/21 , A61K39/395 , A61P35/00
CPC分类号： C07D405/14 , C07D405/06
摘要： The invention relates to 3-substituted-1H-indole compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
摘要翻译：本发明涉及式I的3-取代-1H-吲哚化合物或其药学上可接受的盐，其中组分变量如本文所定义，包含该化合物的组合物，以及制备和使用该化合物的方法。

37. 发明申请

US20090227041A1 Centrifugal fluid analyzer rotor 有权
标题翻译：离心流体分析仪转子
公开(公告)号：US20090227041A1
公开(公告)日：2009-09-10
申请号：US12321359
申请日：2009-01-16
申请人： Mark Wang , Nan Zhang
发明人： Mark Wang , Nan Zhang
IPC分类号： G01N1/10
CPC分类号： G01N35/00069 , G01N2035/00257 , G01N2035/00495 , Y10T436/2575
摘要： This invention provides rotors and methods of precisely metering a sample fluid and mixing the sample with a reagent. The rotors have a metering tube of defined volume that fills until sample flow is stopped by surface tension of a meniscus at a capillarity port, while excess sample is stripped from the metering tube inlet by centripetal force of the spinning rotor. By spinning the rotor at a higher speed, a reagent can be forced from a reagent chamber to contact the meniscus, breaking the surface tension and allowing the metered sample to mix with the reagent.
摘要翻译：本发明提供了精确计量样品流体并将样品与试剂混合的转子和方法。转子具有限定体积的计量管，其填充直到样品流在毛细管端口处由弯月面的表面张力停止，而多余的样品通过旋转转子的向心力从计量管入口剥离。通过以更高的速度旋转转子，试剂可以被迫从试剂室接触弯液面，破坏表面张力并允许计量的样品与试剂混合。

38. 发明申请

US20090192147A1 [a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开
标题翻译： [a] - 兴奋剂化合物，它们作为mTOR激酶和PI3激酶抑制剂使用，以及它们的合成
公开(公告)号：US20090192147A1
公开(公告)日：2009-07-30
申请号：US12363013
申请日：2009-01-30
申请人： Semiramis Ayral-Kaloustian , Nan Zhang , Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Thai Hiep Nguyen , James Thomas Anderson
发明人： Semiramis Ayral-Kaloustian , Nan Zhang , Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Thai Hiep Nguyen , James Thomas Anderson
IPC分类号： A61K31/5383 , C07D471/00 , A61K31/437 , C07D487/00 , A61K31/4985
CPC分类号： C07D498/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D498/14 , C07D513/04 , C07D513/14
摘要： The invention relates to [a]-fused indole compounds of the Formula II, or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein. The invention also relates to compositions comprising the compounds of Formula II, and methods for making and using the compounds.
摘要翻译：本发明涉及式[II]的[a] - 吲哚化合物或其药学上可接受的盐，其中组分变量如本文所定义。本发明还涉及包含式II化合物的组合物，以及制备和使用该化合物的方法。

39. 发明授权

US07509544B2 Data repair and synchronization method of dual flash read only memory 有权
标题翻译：双闪存数据修复和同步方式只读存储器
公开(公告)号：US07509544B2
公开(公告)日：2009-03-24
申请号：US11710694
申请日：2007-02-26
申请人： Nan Zhang , Yan-Peng Yang , Tom Chen , Win-Harn Liu
发明人： Nan Zhang , Yan-Peng Yang , Tom Chen , Win-Harn Liu
IPC分类号： G11C29/00 , G06F11/00
CPC分类号： G06F11/1417 , G06F11/1658 , G06F11/1666 , G06F11/2056
摘要： A data repair and synchronization method of dual flash ROM is provided, which includes a first flash ROM and a second flash ROM that store the same system data, wherein one of the first flash ROM and the second flash ROM is used to perform a data repair on the other flash ROM with damaged data and perform a data synchronization between the two flash ROMs, thereby ensuring that once the data in one flash ROM is damaged during the system operation, the complete system data stored in the other flash ROM is used to recover the damaged operating system and the files in the system. Meanwhile, through performing the data synchronization periodically, important configuration files in the system stored in the two flash ROMs are kept to be updated and completed.
摘要翻译：提供了一种双闪存ROM的数据修复和同步方法，其包括存储相同系统数据的第一闪存ROM和第二闪存ROM，其中第一闪存ROM和第二闪存ROM中的一个用于执行数据修复在另一个具有损坏数据的闪存ROM中，并且在两个闪存ROM之间执行数据同步，从而确保一旦在系统操作期间一个闪存ROM中的数据被损坏，则存储在另一个闪存ROM中的完整系统数据被用于恢复受损的操作系统和系统中的文件。同时，通过周期性地执行数据同步，保存存储在两个闪存ROM中的系统中的重要配置文件被更新和完成。

40. 发明申请

US20080214844A1 Icaritin and desmethylicaritin as anti-cancer agents 审中-公开
标题翻译：伊卡林和去甲基赖氨酸作为抗癌剂
公开(公告)号：US20080214844A1
公开(公告)日：2008-09-04
申请号：US11657214
申请日：2007-01-23
申请人： Nan Zhang , Stuart K. Calderwood
发明人： Nan Zhang , Stuart K. Calderwood
IPC分类号： C07D311/30
CPC分类号： A61K31/352
摘要： The antiproliferative effects of Icaritin or Desmethylicaritin on cancer cell lines, both in vitro, and in vivo, are disclosed. Experimental data show that Icaritin and Desmethylicaritin dramatically inhibit the growth of most malignant cells. In addition, both Icaritin and Desmethylicaritin have significant Anti-agiogenesis properties, inhibiting or eliminating entirely the development of new malignant cells. Further, no obvious side effects including nausea, hair loss or body weight loss were found in the animals treated with Icaritin or Desmethylicaritin, making both highly effective anti cancer drugs.
摘要翻译：披露了Icaritin或Desmethylicaritin对体外和体内癌细胞系的抗增殖作用。实验数据显示，Icaritin和Desmethylicaritin显着抑制大多数恶性细胞的生长。此外，Icaritin和Desmethylicaritin都具有显着的抗血管生成特性，完全抑制或消除新的恶性细胞的发展。此外，在使用伊卡林或去甲卡巴汀治疗的动物中没有发现包括恶心，脱发或体重减轻的明显副作用，从而成为高效抗癌药物。

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